共查询到20条相似文献，搜索用时 531 毫秒
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2003年10月日本和意大利相继报道了疯牛病非典型病例的发现,其发病年龄、组织病理学变化、致病因子痒病相关朊蛋白(PrPSc)的模式与生物学特性,均有别于典型的疯牛病病例,因而怀疑疯牛病存在新的感染途径,并担心可能存在隐藏的病例.建议密切注视国外疯牛病流行态势,从严采取进口限制措施,严防疯牛病传入;树立疯牛病防疫意识和风险意识,加强疯牛病防制宣传,群策群力,切实做好国内动物的疯牛病调查、监测和防制工作;对疯牛病非典型病例要有一个正确的认识,不要谈"非"色变,以免引起不必要的社会恐慌. 相似文献
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疯牛病是公认的对人类经济社会和公共卫生安全具有严重破坏力的一种人畜共患病,严重威胁着食品安全,同时制约着国际畜产品贸易,各国均有必要严格监控国内的疯牛病安全风险,限制疯牛病病原体在全球范围的扩散,降低疯牛病对人类社会的潜在危害。当前,仍无法直接确诊活体牛患有疯牛病,兽医病理学家主要通过检测牛尸体脑部组织或检测牛尸体脑组织中的变异朊蛋白进行疯牛病确诊。 相似文献
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Bovine spongiform encephalopathy: diagnostic significance of vacuolar changes in selected nuclei of the medulla oblongata 总被引：5，自引：0，他引：5
G A Wells R D Hancock W A Cooley M S Richards R J Higgins G P David 《The Veterinary record》1989,125(21):521-524
The adequacy of a histopathological diagnosis of bovine spongiform encephalopathy (BSE) based exclusively on observations of neuroparenchymal vacuolation in three specific neuroanatomic nuclei was tested by using a standard coronal section of medulla oblongata cut at the obex. The agreement between the observations and the definitive histopathological diagnosis was assessed in each of 684 bovine brains - 563 confirmed cases of BSE, 20 with changes which did not diagnose BSE conclusively and 101 in which the lesions of BSE were not detected. When the assessment was confined to the solitary tract nucleus and the spinal tract nucleus of the trigeminal nerve a positive result was obtained in 99.6 per cent of confirmed cases of BSE and only 1 per cent of brains in which lesions of BSE were not detected gave a false positive result. Thus an initial examination of the single section, together with an examination of representative areas of the rest of the brain when no unequivocal lesion was found, provided a satisfactory method for the routine diagnosis of BSE. 相似文献
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M H Groschup 《DTW. Deutsche tier?rztliche Wochenschrift》1999,106(8):329-331
The feeding of meat and bone meal which was contaminated with bovine spongiform encephalopathy (BSE) infectivity led to a huge epidemic in the British cattle population. After the emergence of a new variant form of Creutzfeldt-Jakob diseases (nvCJD) in 1996, European consumers lost confidence in beef meat. Given the coincidence by time and place and disease and agent specific characteristics, it must be assumed that nvCJD is caused by the transmission of BSE agent to man. This article gives an overview over the characteristics and diagnosis of transmissible spongiform encephalopathies, namely BSE and nvCJD, in animals and man. 相似文献
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Clauss M Sauter-Louis C Chaher E Pottgiesser C Goebel S Selhorst T Wichmann HE Klee W Kienzle E 《The Veterinary record》2006,158(15):509-513
In order to identify the management and feeding practices that might have contributed to the occurrence of bovine spongiform encephalopathy (BSE) in Bavaria, Germany, information from 110 dairy farms on which a case of BSE had been reported was compared with information derived from a questionnaire sent to approximately 10,000 Bavarian farms on which no case of BSE had been reported up to February 2003. Representative information was obtained from 4006 dairy farms. The results indicated that in comparison with these control farms a higher proportion of the BSE farms had also kept pigs or poultry, although the difference was not significant, and that a significantly higher proportion of the BSE farms had fed proprietary concentrates and/or milk replacers to their calves. 相似文献
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J. S. Agerholm H. V. Krogh T. K. Nielsen S. Ammendrup H. Dalsgaard 《Acta veterinaria Scandinavica》1993,34(1):99
Bovine spongiform encephalopathy (BSE), a transmissible spongiform encephalopathy in cattle, was first described in England by Wells et al. (1987). The infection occurs mainly due to digestion of feedstuffs containing ruminant derived protein in form of meat and bone meal contaminated with a scrapie-like agent (Wilesmith et al. 1991). Later, cases of BSE were diagnosed in the Republic of Ireland, Oman, France, and Switzerland (Marinovic & Senn 1991). This report describes the first case of BSE in Denmark. 相似文献
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Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States. 总被引：3，自引：0，他引：3
Jürgen A Richt Robert A Kunkle David Alt Eric M Nicholson Amir N Hamir Stefanie Czub John Kluge Arthur J Davis S Mark Hall 《Journal of veterinary diagnostic investigation》2007,19(2):142-154
Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy of cattle, first detected in 1986 in the United Kingdom and subsequently in other countries. It is the most likely cause of variant Creutzfeldt-Jakob disease (vCJD) in humans, but the origin of BSE has not been elucidated so far. This report describes the identification and characterization of two cases of BSE diagnosed in the United States. Case 1 (December 2003) exhibited spongiform changes in the obex area of the brainstem and the presence of the abnormal form of the prion protein, PrP(Sc), in the same brain area, by immunohistochemistry (IHC) and Western blot analysis. Initial suspect diagnosis of BSE for case 2 (November 2004) was made by a rapid ELISA-based BSE test. Case 2 did not exhibit unambiguous spongiform changes in the obex area, but PrP(Sc) was detected by IHC and enrichment Western blot analysis in the obex. Using Western blot analysis, PrP(Sc) from case 1 showed molecular features similar to typical BSE isolates, whereas PrP(Sc) from case 2 revealed an unusual molecular PrP(Sc) pattern: molecular mass of the unglycosylated and monoglycosylated isoform was higher than that of typical BSE isolates and case 2 was strongly labeled with antibody P4, which is consistent with a higher molecular mass. Sequencing of the prion protein gene of both BSE-positive animals revealed that the sequences of both animals were within [corrected] the range of the prion protein gene sequence diversity previously reported for cattle. 相似文献
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Vidal E Marquez M Raeber AJ Meissner K Oesch B Pumarola M 《Veterinary journal (London, England : 1997)》2008,177(3):448-451
The Prionics-Check PrioSTRIP is a rapid chromatographic immunoassay for bovine spongiform encephalopathy (BSE) approved by the European Union in 2004. In this study, the PrioSTRIP was used to analyse PrP(BSE) in 16 different brain areas of nine confirmed BSE cases. The levels of PrP(BSE) in the different brain areas were plotted to give the brain PrP(BSE) distribution curve (BPDC) and compared with the BPDC obtained previously by Western blotting and enzyme-linked immunosorbent assay (ELISA) methods on the same samples. The distribution of PrP(BSE) in different areas of the brain was similar, irrespective of the test applied, indicating that each test could be used for the characterisation of BSE cases. 相似文献
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Konold T Sivam SK Ryan J Gubbins S Laven R Howe MJ 《Veterinary journal (London, England : 1997)》2006,171(3):438-444
Clinical signs associated with bovine spongiform encephalopathy (BSE) were studied in 1008 casualty slaughter cattle over 30 months of age to compare the results with the BSE status as determined by postmortem tests. The clinical BSE status was assessed using seven different criteria based on various publications. Only one (0.10%) out of 997 casualty slaughter cattle with a matching postmortem test result was positive for BSE. The BSE case was identified by only two case definitions tailored specifically to recumbent cases. The variety and often equivocal definition of clinical signs associated with BSE is reflected by the difference in the criteria that usually identified different animals as BSE suspects. The BSE status may be more difficult to assess in recumbent animals that do not allow a full clinical examination, and BSE may not be suspected if another disease is present that may mask signs of BSE. 相似文献
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Cockcroft PD 《Veterinary journal (London, England : 1997)》2004,167(2):175-180
This paper describes a method which enables the similarity of diseases based upon their physical sign frequencies to be defined relative to bovine spongiform encephalopathy (BSE). The means of the absolute differences between the sign frequencies of BSE and the differential diagnoses were used as measure of similarity. Four sets of signs were compared. The most useful quantitative measurement of difference between the diseases was achieved when only the variant signs were used. Diseases that have a high similarity to BSE when the variant signs are compared are more likely to have case presentations that approximate to those found in BSE. These are the diseases that are most likely to be confused with BSE by clinicians. Previously published BSE differential diagnoses from clinical opinion and brain histopathology are reported and compared to the diseases used in this study. 相似文献
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Vidal E Márquez M Costa C Tortosa R Domènech A Serafín A Pumarola M 《Veterinary journal (London, England : 1997)》2007,174(1):196-199
Molecular profiling of the proteinase K resistant prion protein (PrP(res)) is a technique that has been applied to the characterisation of transmissible spongiform encephalopathy (TSE) strains. An interesting example of the application of this technique is the ability to differentiate, at the experimental level, between bovine spongiform encephalopathy (BSE) and scrapie infection in sheep, and to distinguish between classical and atypical BSE and scrapie cases. Twenty-six BSE cases and two scrapie cases from an active TSE surveillance program and diagnosed at the PRIOCAT, TSE Reference Laboratory (Centre de Recerca en Sanitat Animal, Universitat Autònoma de Barcelona, Catalunya, Spain) were examined by Western blotting. Molecular profiling was achieved by comparing the glycosylation profile, deglycosylated PrP molecular weight and 6H4/P4 monoclonal antibody binding ratio. The results obtained during the characterisation of these field cases indicated an absence of atypical BSE cases in Catalunya. 相似文献
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Bovine spongiform encephalopathy and human health 总被引：1，自引：0，他引：1
D M Taylor 《The Veterinary record》1989,125(16):413-415
Because bovine spongiform encephalopathy (BSE) has probably been caused by accidental transmission of the transmissible agent of sheep scrapie there is concern that humans may be at risk from BSE. Epidemiological and experimental evidence is examined which suggests that this is unlikely. 相似文献