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1.
The vitamin A status of 101 pregnant women attending clinic at the University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria was assessed based on 24 h dietary recall, serum retinol concentration, history of night blindness, physical appearance and clinical eye signs. The study revealed that the mean dietary vitamin A intake of the respondents (2645.31 +/- 188.91 microg RE) and their mean serum retinol concentration (31.18 +/- 2.94 microg dL(-1)) were significantly (p < 0.05) higher than the FAO/WHO recommended intake and cutoff level for VAD. No case of night blindness, physical signs and symptoms, or clinical eye signs attributable to VAD was observed. There was a significant (p < 0.01) correlation between the amount of 24 h vitamin A intake of the women and their serum retinol concentration (r = 0.31). Also, women who had above 50% of their vitamin A intake from provitamin A sources had a significantly (p < 0.05) lower serum retinol concentration (23.10 +/- 21.12 microg dL(-1)) than those who had above 50% intake from preformed sources (49.54 +/- 42.63 microg dL(-1)) and those with about equal intake from both sources (55.75 +/- 30.80 microg dL(-1)). There was a significant (p < 0.05) and steady decline in serum retinol concentration in the women from the first trimester (37.79 +/- 6.65 microg dL(-1)), through the second trimester (35.12 +/- 4.72 microg dL(-1)), to the third trimester (21.54 +/- 1.46 microg dL(-1)) of pregnancy.  相似文献   

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4.
Preeclampsia is a disease regarding with altered vascular reactivity leading to hypertension of the mother and metabolic alterations in the fetus. This study aimed to assess nitric oxide and bleeding time following administration of magnesium sulfate to preeclamtic patients compared to normotensive pregnant women. A total of 112 subjects (56 preeclamtic patients and 56 normotensive pregnant controls) were enrolled in this case-control study. Cases and controls were matched for age, BMI, gestational age, parity and gravidity. Total concentration of nitrite and nitrate (NOx) was measured before and during magnesium sulfate (MgSO4) treatment using a modified Griess-based method. RESULTS: Systolic and diastolic blood pressures were significantly decreased during MgSO4 treatment in preeclamtic patients (p < 0.0001). NOx levels were significantly increased in preeclamtic women after MgSO4 administration (33.7 +/- 18.5 vs. 50.2 +/- 21.6, p < 0.0001) but it was not seen in normotensive parturients (52.4 +/- 28.9 vs. 57.3 +/- 21.7, p = 0.362). The bleeding time was scarcely increased following magnesium sulfate treatment in preeclamptic patients compared to normotensive pregnant women but it was not significant (p = 0.18). In addition, there was only a significantly reverse correlation between NOx levels and systolic or diastolic blood pressure in preeclamtic parturients after MgSO4 treatment (r = -0384; p = 0.003 and r = -0.29; p = 0.03, respectively). This study demonstrates that administrating MgSO4 to preeclamtic patients induced significant changes in NOx production which had a major role in modulating vasculature changes in preeclamsia.  相似文献   

5.
Changes of cervical ultrasonographic physical parameters and their association with outcome of cerclage have not been fully elucidated. This study aimed at evaluating association between ultrasonographic physical cervical shapes before and after McDonald cerclage with the length of pregnancy. Cervical length, width and funneling rate were assessed by transvaginal ultrasonography before and after the procedure. Mean pre-cerclage cervical length, width and funneling rate were 29.28 +/- 5.54, 19.92 +/- 10.30 mm and 12.90 +/- 18.87%, respectively. The mean post-cerclage cervical length, diameter and funneling rate were 31.68 +/- 4.21, 9.78 +/- 13.86 and 4.32 +/- 10.89%, respectively (p < 0.001 for all pre- and post-cerclage changes). The mean post-cerclage duration of pregnancy was 19.78 +/- 5.94 weeks. There were significant direct correlations between the pre-and post-cerclage cervical lengths with pregnancy duration (r = 0.24, p = 0.04 and r = 0.44, p < 0.001, respectively). There were significant indirect correlations between the pre- and post-cerclage funneling rate with pregnancy duration (r = -0.30, p = 0.01 and r = -0.20, p = 0.01, respectively). Similar correlations were not significant for the cervical widths. This study showed that the pre- and post-cerclage ultrasonographically determined cervical length and funneling are good predictors of pregnancy duration.  相似文献   

6.
Pregnancy anemia and pregnancy-induced hypertension (PIH) are common and potentially dangerous disorder in human pregnancy, and nutritional status of pregnant women is one of the leading causes. Chlorella contains large quantities of folate, vitamin B-12 and iron, and can help improve anemia and hypertensive disorder. Our objective was to investigate the preventive effects of Chlorella supplement on pregnancy anemia and PIH in Japanese pregnant women. A total of 70 pregnant women were placed into the control group (n = 38) or the Chlorella group (n = 32). The subjects in the Chlorella group were supplemented daily from 12th–18th wk of gestation until delivery with 6 g of Chlorella supplement. The proportion of anemic (hemoglobin level < 11 g/dL) subjects in the Chlorella group were significantly lower compared with the control group at the second and third trimesters. Additionally, in the Chlorella group, the incidences of proteinuria and edema, signs of PIH, were significantly lower during the third trimester. These results suggest that Chlorella supplementation significantly reduces the risk of pregnancy associated anemia, proteinuria and edema. Chlorella supplement may be useful as a resource of natural folate, vitamin B-12 and iron for pregnant women.  相似文献   

7.
The goal of this study was to investigate the role of procalcitonin (PCT) in diagnosis of neonatal sepsis and its correlation with C-Reactive Protein (CRP). One hundred and seventeen neonates with the gestational age > or = 35 weeks with clinically suspected diagnosis of neonatal sepsis were studied during one year from 2007 in Tabriz Children's Hospital. Conventional sepsis workup was done in all cases and the diagnosis of neonatal sepsis was proved based on the results of blood culture. The serum procalcitonin was measured by quantitative Chemo-luminance methods and the results were compared with CRP levels between the neonates with and without proven sepsis. The results showed among in 117 neonates with suspected sepsis 27 (23.1%) cases have positive blood culture (proven sepsis). The mean levels of PCT in neonates with and without proven sepsis was 4.42 +/- 6.66 vs. 2.06 +/- 4.03 ng mL(-1) and CRP 33.98 +/- 36.81 vs. 12.30 +/- 20.42 mg L(-1) were significantly higher in neonates with proven sepsis (p = 0.026 and p < 0.001). The sensitivity, specificity, positive predictive value and negative predictive value of PCT (more than 2 ng mL(-1)) were 66.7, 50, 28.6, 83.3 and CRP (more than 3.5 mg L(-1)) were 70.4, 72.2, 43.2 and 89%, respectively, in diagnosis of neonatal sepsis. There was a meaningful correlation between the level of PCT and CRP in the sepsis group (r = 0.797, p < 0.001). The results of the current study showed that more relying on the level of PCT and CRP for planning the management of neonates with suspected sepsis is not logical, but a negative result may be helpful in ruling it out.  相似文献   

8.
Type 2 diabetes is a metabolic disorder that is strongly associated with cardiovascular risk. Inflammation is a potential risk factor for cardiovascular disease. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on insulin sensitivity and some inflammatory indicators in type 2 diabetic patients were studied. A randomized double-blind clinical trial on 50 men and women with type 2 diabetes was done for 8 weeks. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into two groups, an intervention and control group. They received, 100 mg kg-1nettle extract or placebo in three portions a day for 8 weeks. Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-alpha), High Sensitive C-Reactive protein (hs-CRP) and Fasting Insulin concentration were measured. Insulin Sensitivity was calculated, at the beginning and the end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, IL-6 and hs-CRP showed a significant decrease in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has decreasing effects on IL-6 and hs-CRP in patients with type 2 diabetes after eight weeks intervention.  相似文献   

9.
Hemophilus influenza type b (Hib) infection has a high morbidity and mortality rate especially in children less than 5 years of age. The incidence of Hib disease in Iran is not known and Hib vaccine is not included in the National Immunization Program. The aim of the present study was to investigate the level of antibody to Hib of children five years or younger living in Jahrom, Iran. Three hundred eighty six children 5 years or younger were selected by random sampling method. A blood samples were taken from those children. Anti-Hib IgG antibody (anti-PRP) level was determined in the serum by using anti-Hemophilus influenza IgG EIA kit (IBL, Germany). An anti-PRP antibody levels of 0.15 microg mL(-1) and over were accepted as the natural immunity. The mean concentration of Hib antibody was 0.94 +/- 0.480 microg mL(-1). Natural immunity was determined in three hundred and twenty six (84.5%) of the children. The proportion of natural immunity was increased from 64.9% among children = 12 month old to 95.2% in children aged 49-60 month (p < 0.001). The exposure rate of children with Hib was higher than expected, even in children who were just a few months old. Present data revealed need to be introducing Hib conjugate vaccine in the National Immunization Programs.  相似文献   

10.
Oxidative stress and changes in antioxidant status have been implicated in the pathogenesis of malaria. To assess the antioxidant level ofbilirubin and uric acid associated with falciparum malaria infection, 60 untreated patients (30 men and 30 women) in Douala, Cameroon were screened for the study. Sixty five healthy individuals (29 men and 36 women) were used as controls. Total and conjugated bilirubin were calculated using Jendrassik-Grof method while uric acid was determined using Barham-Trinder method. It was observed that total and conjugated bilirubins were significantly (p < 0.001) higher in malaria patients (10.722 +/- 4.043 and 3.627 +/- 1.571 mg L(-1), respectively) when compared to control (6.830 +/- 2.436 and 1.777 +/- 0.729 mg L(-1)) and these bilirubin levels increased significantly with parasite count (p < 0.050). There was also significant increased (p = 0.021) of uric acid in malaria patients (56.262 +/- 13.963 mg L(-1)) compared to controls (49.838 +/- 15.419 mg L(-1)). No significant differences based on sex were observed on uric acid, parasite count, total and conjugated bilirubins in malaria patients. Positive correlations were obtained between parasite count and total bilirubin (r = 0.320, p < 0.050), conjugated bilirubin (r = 0.477, p < 0.001), uric acid (r = 0.060, p > 0.050) and between total and conjugated bilirubin (r = 0.729, p < 0.001). From this study, it has been hypothesized that the augmentation of plasma level ofbilirubin and uric acid could provide more protection against oxidative stress induced by malaria.  相似文献   

11.
This investigation is the first report in Jordan, aimed for in vitro evaluation of six fungicides and their combinations, to control the post harvest green mold (Penicillium digitatum) of citrus fruits. Thirty one different concentrations (0.01-3000 microg mL(-1)) of each fungicide, in addition to 6 combined concentrations from each of 7 fungicide mixtures, were tested using Agar well diffusion method against four fungal strains. Regression analysis, one way ANOVA and Post Hoc Multiple comparisons were carried out to test the significance of these treatments. Results of regression analysis indicated significant correlation (p < 0.01) between fungicide concentration (microg mL(-1)) and inhibition zone (mm) of tested strains. All applied fungicides have resulted in complete inhibition of fungal growth in the four tested strains with MIC values ranging from 5 to 2700 microg mL(-1). Canvil and Ranvil of the DMI family were the most effective against tested strains (except strain dg6) where an MIC in the range of 5 to 150 microg mL(-1) was required. Benomyl has worked effectively with the least MIC values against the four tested strains. The obtained Benomyl's MIC values were: 20, 40, 300 and 40 microg ml(-1) against strains dg2, dg4, dg5 and dg6, respectively. One way analysis of variance indicated that the following fungicide mixtures: Benomyl/Canvil; Topsin/Vydan; Blin/Canvil; Topsin/Blin and Topsin/Canvil had significantly (p < 0.001) affected the sizes of inhibition zones, in strains dg2, dg2 and dg5, dg2 and dg4, dg2 and dg4, respectively. Scheffe multiple comparisons analysis showed that there were significant differences (p < 0.001) between the combined concentrations of 50:50 microg mL(-1) or 100:100 microg mL(-1) of Benomyl/Canvil mixture and the rest of tested concentrations where complete inhibition of growth was achieved at a combination of 100:500 microg mL(-1). The mixtures of Benomyl/Canvil and Blin/Canvil were the most effective against strains where, wither complete inhibition or the largest inhibition zones were obtained at the least (50:50 microg mL(-1)) combined concentrations.  相似文献   

12.
To evaluate the impact of preemptive local analgesia at the incision site for postoperative pain in patients undergoing disc operation. In this prospective, randomized, double-blinded, placebo-controlled study 166 patients were assigned to either lidocaine (n = 83) or placebo (n = 83) groups. The incision site was infiltrated with either 20 mL of 2% lidocaine and 0.9% saline in lidocaine group or 0.9% saline before the incision. Morphine (5 mg) was used for postoperative pain treatment. Postoperative pain was measured with Visual Analog Scale (VAS) in 6, 12, 24 and 48 h. Data were analyzed with SPSS software, using Chi-square and t-tests. The groups were matched for age, sex, type of operation, mean length of hospital stay and mean length of operation. Statistical analysis revealed no significant difference in visual analog scores of pain severity at 6, 12, 24 and 48 h after surgery between lidocaine and placebo groups (6 h: 38.22 +/- 26.87 vs. 34.52 +/- 24.43, p = 0.35; 12 h: 33.26 +/- 28.83 vs. 28.01 +/- 24.71, p = 0.20; 24 h: 26.71 +/- 23.31 vs. 22.85 +/- 22.48, p = 0.27; 48 h 16.35 +/- 10.16 vs. 15.23 +/- 8.90 p = 0.45). The amount of narcotics used post operatively had no meaningful difference in the groups (lidocaine 10.07 +/- 8.24 mg vs. placebo 10.54 +/- 9.31 mg p = 0.73). Preemptive analgesia with lidocaine 2% used subcutaneously before skin incision has no effect in reducing postoperative pain, narcotics demand and duration of hospital stay.  相似文献   

13.
李博  屠幼英  徐纪英 《茶叶》2009,35(2):87-90
为研究茶树花对SD大鼠母体及胎仔的致畸毒性,将交配成功的SD孕鼠随机分为4组,每组至少12只。设供试茶树花提取物0．50、1．00、2．00g／kg三个剂量组及阴性对照组,分别在妊娠的7～16天灌胃给予。妊娠期间记录孕鼠体重,于妊娠第20天断头处死孕鼠,记录着床数、活胎数、死胎数和吸收胎数;检查胎鼠外观、内脏和骨骼,并称胎鼠体重,量体长。结果显示,除低剂量组（0．50g／kg）胎鼠体长显著高于对照组外（P〈0．01）,其余剂量组对孕鼠和胎鼠的各项毒效应观察指标与对照组相比均无显著差异。表明在本试验条件下,茶树花对孕鼠生长和胚胎发育无不良影响和致畸作用。  相似文献   

14.
One of the most common strategies in the treatment of cognitive disorders is enhancing the acetylcholine level in the brain through the inhibition of acetylcholinesterase. Despite the effectiveness of current modern drugs, more attention has been paid for finding new anticholinesterase agents from medicinal plants. Zatraia multiflora Boiss. is an endemic plant to Iran which has different uses in traditional medicine as anti-inflammatory, antimicrobial, anti spasmodic. We intended to evaluate the in vitro anticholinesterase and free radical scavenging activity of the essential oil and methanolic extract of Z. multiflora. The essential oil and methanolic extract of the plant were evaluated for anticholinesterase activity using modified Ellman method. The free radical scavenging effect of the samples were studied by using of the diphenylpicrylhydrazyl (DPPH). IC50 and the percent of inhibition of acetylcholinesterase was calculated from regression equation. The results showed that both the essential oil and methanolic extract of the plant exhibited high anticholinesterase activity (95.3 +/- 3.4 and 87.9 +/- 2.2% inhibition, respectively) which was similar to eserine (96.2 +/- 1.7% inhibition). The IC50 value of essential oil was determined as 0.97 +/- 0.12 microg mL(-1) in comparison to eserine (0.13 +/- 0.02 microg mL(-1)). The results of antioxidant assay showed that both the essential oil and methanolic extract potentially inhibit DPPH free radical (94.8 +/- 2.4 and 93.2 +/- 1.7% inhibition, respectively). The essential oil and methanolic extract of Z. multiflora have beneficial effect in health promotion and this plant would be good candidate for further studies.  相似文献   

15.
Ovine embryos were produced by maturation, fertilization and in vitro culture (IVM/IVF/IVC) of oocytes collected from slaughtered prepubertal ewes. At 24 h post IVM, oocytes were fertilized with fresh semen collected from Lori-Bakhtiari breed at a concentration of 1.0 x l0(6) sperm mL(-1). The presumptive ova/embryos were transferred into the embryo culture medium at 22-24 h post IVF. Following 4 to 7 day in culture, embryos (at morula and blastocyst stage, respectively) were transferred surgically to the uterine horn of synchronized recipients. Pregnancy was diagnosed at day 30 by hormonal assay and at days 55 and 140 of gestation by ultrasonography and pregnancies were allowed to go to term. A total of nine ewes received 27 embryos (3 embryos/ewe). Five ewes received 15 embryos at morula stage and four ewes received 12 embryos at blastocyst stage. From those received morula stage embryos one was pregnant on day 30 (20%), though no pregnancy was diagnosed on each of days 55 and 140. While from those received blastocyst stage embryos, three ewes were pregnant on day 30 (75%) and two ewes (50%) remained pregnant on each of days 55 and 140. In conclusion, day 4 IVM-IVF morula stage embryos had a lower survival rate than did day 7 IVM-IVF blastocysts embryos, following transfer to the synchronized recipient ewes.  相似文献   

16.
The aim of this research was to determine shelf life stability of un-pasteurized lemon juice filled in clear or dark green glass bottles. Presence of light, time and temperature affect the ascorbic acid retention in citrus juices. Bottles were stored at room temperature (27 +/- 3 degrees C) and in the refrigerator (3 +/- 1 degrees C). Total soluble solids, total titrable acidity and pH value were measured every three weeks and analysis was carried out on ascorbic acid content by means of titration method in the presence of 2,6-dichlorophenol indophenol. The study was carried out for 12 weeks after which slight changes in color, taste and apparent texture in some samples were observed and ascorbic acid content reduced by 50%. Soluble solids content, pH value and total acidity were 5.5 degrees Brix, 2.73 and 5 g/100 mL, respectively which appeared not to be significantly influenced by storage time or conditions. Ascorbic acid content initially at 38.50 mg/100 mL was sharply reduced to about 22 mg/100 mL within the first three weeks of storage. The final ascorbic acid content of all samples was about 15 mg/100 mL. The deteriorative reaction of ascorbic acid in the juice at all conditions followed a first-order kinetic model with activation energy of 137 cal mol(-1).  相似文献   

17.
The management of an Anterior Cruciate Ligament (ACL) avulsion is principally by surgery. There are two major techniques in this regard; fixation through open surgery (arthrotomy) or arthroscopically-assisted repair. These are not new in the literature; however, the debate regarding the better approach is still under debate. This study focused on comparing outcome and consequences of arthroscopically-assisted vs. open surgery in repairing ACL avulsion. In a randomized clinical trial, 44 patients with unilateral ACL avulsion were recruited in Tabriz Shohada teaching Centre during a 12 month period of time. These patients were randomized in two equal age and sex-matched groups underwent either arthroscopically-assisted or open ACL repair. The constructive technique was the same in both groups without using any graft. The minimum follow-up period was 6 months including 3 weeks, 3 months and 6 months postoperatively. Range of Motion (ROM), laxity, Anterior Drawer Test (ADT) result, duration of hospital stay, wound status, nonunion and return to previous work were compared between the two groups. Mean time of suture removal (p = 0.10), minimum and maximum ROM at months 3 (p = 0.43 and 0.22, respectively) and 6 (p = 0.73 and 0.77, respectively), ADT at months 3 and 6 (p = 0.16 for both), laxity at month 6 (p = 0.28) and wound status at week 3 (p = 0.35) were not significantly different between the two groups. There was no case of nonunion at month 6 in either group. The mean hospital stay was significantly shorter in the arthroscopy group (3.77 +/- 0.92 vs. 2.50 +/- 0.51 days; p < 0.001). The mean laxity score was significantly higher in the open surgery group at month 3 (4.82 +/- 0.59 vs. 4.45 +/- 0.60; p = 0.05). The rate of nonunion was significantly higher in the open surgery group at month 3 (40.9% vs. 9.1%; p = 0.02). Patients in the arthroscopically-assisted technique group returned sooner to previous work (17.41 +/- 1.53 vs. 14.82 +/- 0.96 weeks; p < 0.001). Based on our results, arthroscopically-assisted reconstruction of ACL avulsion is superior to open surgery.  相似文献   

18.
In the 1st phase of this study, thirty patients were investigated. Five milliliter stimulated saliva was collected just before and after MRI. The magnetic flux density was 0.23 T and the duration of exposure of patients to magnetic field was 30 minutes. In the 2nd phase, fourteen female healthy University students who had not used mobile phones before the study and did not have any previous amalgam restorations were investigated. Dental amalgam restoration was performed for all 14 students. Their urine samples were collected before amalgam restoration and at days 1, 2, 3 and 4 after restoration. The mean +/- SD saliva Hg concentrations of the patients before and after MRI were 8.6 +/- 3.0 and 11.3 +/- 5.3 microg L(-1), respectively (p < 0.01). A statistical significant (p < 0.05) higher concentration was observed in the students used mobile phone. The mean +/- SE urinary Hg concentrations of the students who used mobile phones were 2.43 +/- 0.25, 2.71 +/- 0.27, 3.79 +/- 0.25, 4.8 +/- 0.27 and 4.5 +/- 0.32 microg L(-1) before the amalgam restoration and at days 1, 2, 3 and 4, respectively. Whereas the respective Hg concentrations in the controls, were 2.07 +/- 0.22, 2.34 +/- 0.30, 2.51 +/- 0.25, 2.66 +/- 0.24 and 2.76 +/- 0.32 microg L(-1). It appears that MRI and microwave radiation emitted from mobile phones significantly release mercury from dental amalgam restoration. Further research is needed to clarify whether other common sources of electromagnetic field exposure may cause alterations in dental amalgam and accelerate the release of mercury.  相似文献   

19.
以5种不同的酸奶发酵剂(A~E)为研究对象,探索不同发酵剂制备的大豆酸奶的品质差异,为筛选优良的大豆酸奶发酵剂提供依据。研究中采用标准酸奶发酵工艺对不同酸奶发酵剂进行大豆酸奶的发酵,测定了发酵过程中p H、酸度随时间的变化以及发酵产物的质构和风味物质含量,分析了发酵时间与酸奶硬度及羰基化合物含量的关系。结果表明:不同酸奶发酵剂在豆浆体系中的发酵速率有明显的差异,5种酸奶发酵剂在豆浆中的发酵速率排序为DECBA。同时,不同发酵剂制备的酸奶在硬度上差异显著(P0.05)且酸奶硬度与发酵时间呈高度正相关的关系。在风味方面,体系到达p H5.5的时间越长,大豆酸奶中羰基化合物的含量越高。研究表明,A与B酸奶发酵剂的发酵特性及发酵产物的质构接近,但是风味成分差别较大;D与E发酵剂的特点是发酵速率较快;C发酵剂能产生较多的2,3-丁二酮。综合分析,A发酵剂最适合用来制备质构良好、风味清淡醇香的大豆酸奶。  相似文献   

20.
Although the intramedullary nailing is thought to be the method of choice for treatment of closed tibial shaft, there is ongoing debate on the optimal surgical approach in patients with open types of these fractures. In addition, choosing between the reamed and unreamed intramedullary nailing is still an issue for the orthopedic surgeons. In present study, we aimed to compare the outcome and consequences of OA tubular external fixation vs. unreamed intramedullary nailing in open grade IIIA-IIIB tibial shaft fractures. In a randomized clinical trial, 50 patients with open tibial shaft fractures (grades IIIA-IIIB) were recruited in Tabriz Shohada teaching centre in a 2-year period of time. They randomized in two equal groups underwent either AO tubular external fixation or unreamed intramedullary nailing. These 2 groups were matched for sex, age and fracture-grade. The follow-up time was one year. Union time, surgical outcome, postoperative complications and the ambulation time were compared between the two groups. Twenty five patients, 20 males and 5 females with a mean age of 30.80 +/- 5.24 years were allocated in unreamed intramedullary group and 25 other patients, 22 males and 3 females with a mean age of 28.92 +/- 8.88 years were studied in the external fixation group (p = 0.70 and 0.37, respectively). The two groups were matched for sex (p = 0.70) and age (p = 0.37). The time of union was 3, 4, 5 and 6 < or = weeks after operation in 28, 12, 32 and 28% of the cases in unreamed intramedullary group vs. 4, 12, 48 and 36% of the cases in external fixation group, respectively (p = 0.14). Post-operative infection, soft tissue injury, malunion and nonunion were documented in 16, 8, 0 and 4% of the cases in unreamed intramedullary group vs. 32, 12, 24 and 8% of the cases in external fixation group, respectively (p = 0.19, 0.50, 0.02 and 0.50, respectively). The mean ambulation time after operation was 2.92 +/- 2.43 weeks in the unreamed intramedullary nailing group vs. 2.68 +/- 2.14 weeks in the external fixation group (p = 0.71). Our results are in favor of unreamed intramedullary nailing against external fixation in treatment of open tibial shaft fractures.  相似文献   

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