共查询到20条相似文献，搜索用时 31 毫秒
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Antisense transcription in the mammalian transcriptome 总被引：2，自引：0，他引：2
Katayama S Tomaru Y Kasukawa T Waki K Nakanishi M Nakamura M Nishida H Yap CC Suzuki M Kawai J Suzuki H Carninci P Hayashizaki Y Wells C Frith M Ravasi T Pang KC Hallinan J Mattick J Hume DA Lipovich L Batalov S Engström PG Mizuno Y Faghihi MA Sandelin A Chalk AM Mottagui-Tabar S Liang Z Lenhard B Wahlestedt C;RIKEN Genome Exploration Research Group;Genome Science Group 《Science (New York, N.Y.)》2005,309(5740):1564-1566
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Nonhistone chromosomal proteins and gene regulation 总被引：33，自引：0，他引：33
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Genome-wide mapping of in vivo protein-DNA interactions 总被引：5，自引：0，他引：5
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modENCODE Consortium Roy S Ernst J Kharchenko PV Kheradpour P Negre N Eaton ML Landolin JM Bristow CA Ma L Lin MF Washietl S Arshinoff BI Ay F Meyer PE Robine N Washington NL Di Stefano L Berezikov E Brown CD Candeias R Carlson JW Carr A Jungreis I Marbach D Sealfon R Tolstorukov MY Will S Alekseyenko AA Artieri C Booth BW Brooks AN Dai Q Davis CA Duff MO Feng X Gorchakov AA Gu T Henikoff JG Kapranov P Li R MacAlpine HK Malone J Minoda A Nordman J Okamura K Perry M Powell SK Riddle NC Sakai A 《Science (New York, N.Y.)》2010,330(6012):1787-1797
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Ivens AC Peacock CS Worthey EA Murphy L Aggarwal G Berriman M Sisk E Rajandream MA Adlem E Aert R Anupama A Apostolou Z Attipoe P Bason N Bauser C Beck A Beverley SM Bianchettin G Borzym K Bothe G Bruschi CV Collins M Cadag E Ciarloni L Clayton C Coulson RM Cronin A Cruz AK Davies RM De Gaudenzi J Dobson DE Duesterhoeft A Fazelina G Fosker N Frasch AC Fraser A Fuchs M Gabel C Goble A Goffeau A Harris D Hertz-Fowler C Hilbert H Horn D Huang Y Klages S Knights A Kube M Larke N Litvin L Lord A 《Science (New York, N.Y.)》2005,309(5733):436-442
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本文描述了华山新麦草同纤毛鹅观草、鹅观草、普通小麦和节节麦属间杂种小孢子发生过程中，细胞间通过接合管或接合孔转移遗传物质的现象。遗传物质的转移引起多核细胞的出现和染色体数目的变化。这些变化为生物进化提供了重要的物质基础。初步证明细胞间遗传物质的转称是受基因系统控制的，华山新麦草的Ｎｂ染色体组上可能存在控制细胞间遗传物质转移的基因系统。并讨论了细胞间遗传物质转移后，在物种演化过程中的意义和作用。 相似文献
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Yamada K Lim J Dale JM Chen H Shinn P Palm CJ Southwick AM Wu HC Kim C Nguyen M Pham P Cheuk R Karlin-Newmann G Liu SX Lam B Sakano H Wu T Yu G Miranda M Quach HL Tripp M Chang CH Lee JM Toriumi M Chan MM Tang CC Onodera CS Deng JM Akiyama K Ansari Y Arakawa T Banh J Banno F Bowser L Brooks S Carninci P Chao Q Choy N Enju A Goldsmith AD Gurjal M Hansen NF Hayashizaki Y Johnson-Hopson C Hsuan VW Iida K Karnes M Khan S Koesema E Ishida J Jiang PX Jones T Kawai J Kamiya A Meyers C Nakajima M 《Science (New York, N.Y.)》2003,302(5646):842-846
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真核生物转录调控过程是大量的顺式调控元件与反式作用因子相互作用的结果.研究发现,这一调控过程与染色质核小体的动态定位相关,调控因子的结合需要裸露的无核小体的DNA区域,即开放的染色质位点.因此,高效精确地定位基因组上的开放染色质位点为成功地发掘基因组调控元件,乃至揭示基因表达调控机制提供了重要线索和有效手段.本文对开放染色质位点的定义、主要研究方法以及功能注释进行概述,希望对在基因组水平上调控元件的发掘,尤其是在植物中的应用提供借鉴. 相似文献
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Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes 总被引：1，自引：0，他引：1
Krishnakumar R Gamble MJ Frizzell KM Berrocal JG Kininis M Kraus WL 《Science (New York, N.Y.)》2008,319(5864):819-821
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Capturing chromosome conformation 总被引：4，自引：0，他引：4
We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae, we could confirm known qualitative features of chromosome organization within the nucleus and dynamic changes in that organization during meiosis. We also analyzed yeast chromosome III at the G1 stage of the cell cycle. We found that chromatin is highly flexible throughout. Furthermore, functionally distinct AT- and GC-rich domains were found to exhibit different conformations, and a population-average 3D model of chromosome III could be determined. Chromosome III emerges as a contorted ring. 相似文献
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A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allows direct comparison and integration of different classes of data. The resulting probabilistic gene network estimates the functional coupling between genes. Within this framework, we reconstructed an extensive, high-quality functional gene network for Saccharomyces cerevisiae, consisting of 4681 (approximately 81%) of the known yeast genes linked by approximately 34,000 probabilistic linkages comparable in accuracy to small-scale interaction assays. The integrated linkages distinguish true from false-positive interactions in earlier data sets; new interactions emerge from genes' network contexts, as shown for genes in chromatin modification and ribosome biogenesis. 相似文献