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《黑龙江畜牧兽医》2016,(14)
为了评价蜘蛛香胶囊对靶动物犬的安全性,试验选择24只试验犬,随机分为3组,分别为1倍推荐剂量(50 mg/kg)组、3倍推荐剂量(150 mg/kg)组和5倍推荐剂量(250 mg/kg)组,每天口服给药2次,连续给药3 d。分别在给药前1天、给药后第1天、第3天、第5天采集血液,对犬的血常规和血液生化指标进行分析比较,并观察给药前后犬的临床症状变化。结果表明:试验期间各剂量组犬临床症状正常,给药后的血常规和血液生化指标与给药前相比无显著差异(P0.05)。说明蜘蛛香胶囊在5倍推荐剂量(250 mg/kg)范围内连续给药3 d,对靶动物犬的临床体征和血液生理生化指标无明显影响,该药临床应用安全。 相似文献
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本试验收集重庆动物园人工饲养的4只北白颊长臂猿和1只黄颊长臂猿血液样本用以检测血常规和血液生化指标，共检测了24项血常规指标和26项血液生化指标。结果显示，亚成体北白颊长臂猿和成年黄颊长臂猿血常规和血液生化指标均有部分不在成年北白颊长臂猿血常规和血液生化指标“平均值±标准差”内，表明不同年龄、性别和物种可能影响长臂猿血常规和血液生化指标检测值。本试验是健康长臂猿血常规和血液生化指标的国内首次详细检测，为国内圈养长臂猿血液标准值的确定提供了基础数据，对长臂猿的饲养繁育、健康管理和疾病诊断等具有指导意义。 相似文献
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为了对临床一例外伤犬进行诊治,试验采用临床检查、X射线检查进行确诊,同时结合血常规、血液生化指标结果判定患犬是否适合手术,并对手术风险进行评估。结果表明:患犬为肩胛部软组织开放性损伤、肩胛部皮肤挫伤,血常规及血液生化指标结果均正常,可以手术但存在风险,一是患犬为老龄犬,有心脏病史;二是手术不符合术前禁食、禁水的要求。由于情况紧急,不得不进行麻醉处理,与犬主人沟通后进行麻醉手术,在手术将要结束时患犬发生气管塌陷症状,遂即采取紧急治疗措施,最后患犬恢复正常。说明在对犬外伤处理时一定要谨慎,避免继发其他疾病。 相似文献
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对１日龄雏鸡感染鸡贫血因子（ＣＡＡ）后血浆的凝血酶时间，凝血酶原时间，部分凝血活酶时间，纤维蛋白原含量及副凝试验等指标进行了检测。结果表明，感染ＣＡＡ雏鸡血浆凝血时间和部分凝血活酶时间分别于感染后７－２８日和１４－２１日明显延长；凝血酶原时间和纤维蛋白原含量于７－１４日虽吴现延长或减少，但无统计学意义；副凝试验于感染后７－１４日呈阳性反应。 相似文献
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《Veterinary anaesthesia and analgesia》2020,47(3):309-314
ObjectiveTo evaluate a veterinary-specific oscillometric noninvasive blood pressure (NIBP) system according to the guidelines of the American College of Veterinary Internal Medicine (ACVIM) Consensus Statement.Study designProspective clinical study.AnimalsA total of 33 client-owned cats (20 females and 13 males).MethodsCats were premedicated with methadone (0.3 mg kg−1) and alfaxalone (2 mg kg−1) intramuscularly. After 15 minutes anesthesia was induced with isoflurane (3%) in 100% oxygen by facemask while breathing spontaneously. A 22 gauge catheter was placed in the median caudal artery and systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures were measured. NIBP measurements were collected by placing the cuff (40% of limb circumference) on the right or left antebrachium. The agreement between the two methods was evaluated with the Bland–Altman methods, and the oscillometric NIBP device was evaluated using the ACVIM guidelines for validation of devices.ResultsData from 30 of the 33 cats were analyzed. Five paired measurements were taken from each cat, totaling 150 paired measurements. Mean bias (limits of agreements) for SAP, DAP and MAP were 2.7 (−22.7 to 28.1), 0.9 (−22.3 to 24.2) and 1.3 (−20.4 to 23.0). The oscillometric NIBP passed all validation criteria, except correlation which was <0.9 for SAP, DAP and MAP.Conclusions and clinical relevanceThe Vet20 did not meet all validation criteria by the ACVIM. However, all criteria except correlation were met. 相似文献
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对内地生活藏獒37只（雌性19只,雄性18只）断奶时（45日龄）的部分血液生理生化指标进行测定分析,比较了雌雄藏獒的血液生理和生化指标的差异;内地藏獒与西藏高原藏獒、一般犬的差异。结果表明：在测定的12项生理值和12项生化值中,仅单核细胞百分数雌雄之间有显著差异（P〈0．05）,其他指标均无显著差异。内地藏獒与一般犬相比,仅白细胞数、血糖等指标无显著差异,其他各指标均有显著差异（P〈0．05）。内地藏獒与高原藏獒相比,除了白细胞数和血小板数外,其他指标均有显著差异（P〈0．05）。此结果将为内地藏獒养殖及疾病的防治提供基础数据。 相似文献
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Anthony B. Zambelli BSc BVSc DiplSenMgmt MMedVet Andrew L. Leisewitz BVSc MMedVet DECVIM-CA PhD 《Journal of Veterinary Emergency and Critical Care》2009,19(1):102-112
Objective – To establish the efficacy of Oxyglobin (HB-200) in canine babesiosis and compare it to standard therapy, packed red blood cell transfusion (pRBCT) with respect to improvements in specific parameters of blood gas, acid-base, blood pressure, and subjective evaluations.
Design – Prospective, randomized, clinical trial.
Setting – Onderstepoort Veterinary Academic Hospital.
Animals – Twelve dogs (8–25 kg) naturally infected with Babesia rossi and a hematocrit of 0.1–0.2 L/L (10–20%).
Interventions – Treatment groups were randomized to receive either 20 mL/kg of Oxyglobin or pRBCT over 4 hours via a central venous catheter. Transfusions were followed by lactated Ringer's solution infusion. Rectal temperature, femoral arterial and mixed venous blood sampling, oscillometric blood pressure, and subjective assessment of patient status (habitus), and appetite were performed at time points 0, 1, 4, 8, 24, 48, and 72 hours.
Main Results – Dogs presented with a hypoalbuminemic alkalosis; hyperchloremic, dilutional acidosis; normotensive tachycardia; pyrexia; depression; and anorexia. Both treatments produced similar results, with the exception of significant differences in pH (4 h); PCO2 (4 h); hemoglobin (8 h, 24 h); mean arterial pressure (48 h); albumin (4 h, 8 h); habitus (8 h, 48 h); and appetite (24 h). Arterial O2 content was higher for pRBCT than Oxyglobin at 72 hours, but central venous PO2 did not differ between groups or over time and was consistently subnormal.
Conclusions – Oxyglobin provides similar overall improvements to pRBCT in dogs with anemia from babesiosis, with respect to blood gas, acid-base and blood pressure, although patients receiving packed cells tended to have more rapid normalization of habitus and appetite. 相似文献
Design – Prospective, randomized, clinical trial.
Setting – Onderstepoort Veterinary Academic Hospital.
Animals – Twelve dogs (8–25 kg) naturally infected with Babesia rossi and a hematocrit of 0.1–0.2 L/L (10–20%).
Interventions – Treatment groups were randomized to receive either 20 mL/kg of Oxyglobin or pRBCT over 4 hours via a central venous catheter. Transfusions were followed by lactated Ringer's solution infusion. Rectal temperature, femoral arterial and mixed venous blood sampling, oscillometric blood pressure, and subjective assessment of patient status (habitus), and appetite were performed at time points 0, 1, 4, 8, 24, 48, and 72 hours.
Main Results – Dogs presented with a hypoalbuminemic alkalosis; hyperchloremic, dilutional acidosis; normotensive tachycardia; pyrexia; depression; and anorexia. Both treatments produced similar results, with the exception of significant differences in pH (4 h); PCO
Conclusions – Oxyglobin provides similar overall improvements to pRBCT in dogs with anemia from babesiosis, with respect to blood gas, acid-base and blood pressure, although patients receiving packed cells tended to have more rapid normalization of habitus and appetite. 相似文献
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为了研究黄芩苷对H6N6禽流感(avian influenza,AI)病毒感染小鼠的血液学指标的影响。选用6-8周龄小鼠108只,随机平均分为阴性对照组、病毒阳性组、低、中、高黄芩苷治疗组和西药对照组;攻毒:阴性对照组尾静脉注射灭菌生理盐水0.2mL/只,其余各组均尾静脉注射H6N6禽流感病毒(108EID50) 0.2mL/只;治疗:攻毒3 d后进行灌胃给药,黄芩苷治疗组(0.014,0.028,0.056 mg/只/d),西药对照组(0.39 mg/只/d),病毒阳性组、阴性对照组每天给予等体积灭菌生理盐水,分别于治疗后3、6、9 d采血进行血常规检测。通过对各组别患鼠血液中白细胞、红细胞和血小板数目变化的分析。结果表明:(1)治疗后3、6、9 d高剂量黄芩苷组白细胞总数、中性粒细胞数目均极显著低于病毒阳性组和低、中剂量黄芩苷组(P0.01);(2)在治疗3、6和9 d时淋巴细胞数目和淋巴细胞百分比均极显著或显著高于病毒阳性组、低剂量黄芩苷治疗组和中剂量黄芩苷治疗组(P0.01或P0.05),与西药对照组差异不显著(P0.05);(3)在治疗3、6和9 d时,所有黄芩苷治疗组红细胞数目、血红蛋白浓度和平均红细胞血红蛋白含量均极显著高于病毒阳性组(P0.01),与阴性对照组合西药对照组差异不显著(P0.05);(4)在治疗3、6和9 d时所有黄芩苷治疗组血小板数目均极显著低于病毒阳性组(P0.01)。小结:黄芩苷在较高浓度时,对H6N6禽流感引起的炎症反应,具有降低白细胞总数,抑制出血反应的作用。 相似文献
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圈养山魈血液生理生化指标测定 总被引：3，自引：1，他引：2
应用SysmexF820血球计数仪和OLympusAU400全自动生化分析仪对成都市动物园圈养的23只山魈的89个血液样本的45项生理生化指标进行测定和统计分析,结果表明,山魈血液常规值RBC、HGB、HCT及生化值BUN雄性高于雌性,生化值LDH、HBDH雄性低于雌性,其他项目山魈雌雄间差异不显著(P>0.05)。在成年与非成年山魈测定值比较中,血液常规值RBC、WBC、HGB、HCT、PLT、LYMPH%、LYMPH#及生化值ALB、A/G、Tb、Ib、ALP、Ck、LDH、HBDH、Ca、P、γGGT、K成体低于非成年山魈,而血液常规MO GR%及生化值GLB、Db、BUN、Cr、GLU成年高于非成体,其他项目差异不显著(P>0.05)。 相似文献