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1.
The effect of weaning on small intestinal morphology and the activities of three intestinal peptidases was investigated from 3 days prior to weaning to 9 days post-weaning in 64 piglets. Villous height, crypt depth and mitotic counts were determined at three positions along the small intestine. The activities of aminopeptidase N, dipeptidylpeptidase IV and gamma-glutamyl transpeptidase were measured at five positions along the small intestine. The villous height was maximal on the day of weaning. Post-weaning, the villi shortened at the proximal positions of the small intestine and the minimal length was observed on day 3 after weaning. Villous height did not decrease distally in the small intestine. Increased crypt depth was observed from 3-7 days post-weaning at all positions examined. Mitotic counts showed increased proliferative activity in the crypts from the third day post-weaning. Weaning influenced the activity of aminopeptidase N and dipeptidylpeptidase IV. The activities declined until day 3 post-weaning. After that, the activities increased and they had reached pre-weaning values by day 9 post-weaning. Weaning had only minor effect on the activity of gamma-glutamyl transpeptidase. In summary, weaning induced changes in small intestinal morphology and enzyme activity. The changes were maximal on day 3 post-weaning and during the following days, a gradual recovery of the small intestine was observed.  相似文献   

2.
At weaning, low feed intake level is a major factor responsible for gut disorders. However, less is known on adaptation of the antibacterial activity of pancreatic juice in response to variations in feed intake level. Moreover bovine colostrum has been demonstrated to decrease coliform counts in duodenal digesta and to improve health status of weaned piglets. Aims of the present study were to evaluate effects of feed intake level and of a bovine colostrum-supplemented diet on the pancreatic secretion of antibacterial activity in piglets at weaning. At 33 days of age, twenty-eight piglets fitted with two permanent catheters (for pancreatic juice collection and reintroduction) were weaned and allocated to one of the following three dietary treatments for 5 days: low feed allocation with a starter diet (L), gradually increased feed allocation with a starter diet (Ctrl), or gradually increased feed allocation with a starter diet supplemented with bovine colostrum (Col). In Ctrl piglets, the post-weaning secretion of antibacterial activity did not significantly differed from pre-weaning values. The pancreatic secretion of antibacterial activity in L piglets was higher than that in Ctrl piglets at day 5 (+ 300%; P < 0.05). Moreover in Col piglets the secretion of the antibacterial activity tended to increase by 55% (P = 0.08) compared to Ctrl piglets. Variations in the pancreatic secretion of antibacterial activity could constitute an adaptive phenomenon to maintain bacterial homeostasis in the upper small intestine during the early post-weaning period.  相似文献   

3.
Background: The intestinal epithelium is an important barrier that depends on a complex mixture of proteins and these proteins comprise different intercellular junctions. The purpose of this study was to investigate the postnatal and developmental changes in morphology, intercellular junctions and voltage-gated potassium(Kv) channels in the intestine of piglets during the suckling and post-weaning periods.Results: Samples of the small intestine were obtained from 1-, 7-, 14-, and 21-d-old suckling piglets and piglets on d 1, 3, 5, and 7 after weaning at 14 d of age. The results showed that the percentage of proliferating cell nuclear antigen(PCNA)-positive cells and alkaline phosphatase(AKP) activity, as well as the abundances of E-cadherin,occludin, and Kv1.5 m RNA and claudin-1, claudin-3, and occludin protein in the jejunum were increased from d 1to d 21 during the suckling period(P 0.05). Weaning induced decreases in the percentage of PCNA-positive cells,AKP activity and the abundances of E-cadherin, occludin and zonula occludens(ZO)-1 m RNA or protein in the jejunum on d 1, 3 and 5 post-weaning(P 0.05). There were lower abundances of E-cadherin, occludin and ZO-1m RNA as well as claudin-1, claudin-3 and ZO-1 protein in the jejunum of weanling piglets than in 21-d-old suckling piglets(P 0.05). The abundances of E-cadherin, occludin, ZO-1 and integrin m RNA were positively related to the percentage of PCNA-positive cells.Conclusion: Weaning at 14 d of age induced damage to the intestinal morphology and barrier. While there was an adaptive restoration on d 7 post-weaning, the measured values did not return to the pre-weaning levels, which reflected the impairment of intercellular junctions and Kv channels.  相似文献   

4.
The aim of the study was to measure the effect of creep feeding during lactation on net absorption in the small intestine at 4 days after weaning. Intermittent suckling was used to increase creep feed intake during lactation. Creep feed containing chromic oxide was provided. Based on the colour of the faeces, piglets were classified as ‘eaters’ or ‘non-eaters’, respectively. At day 4 after weaning, an in vivo small intestine segment perfusion test was performed at 5 sites along the small intestine in 24 piglets (12 eaters and 12 non-eaters). At both sides of each intestinal segment a tube was fitted to perfuse and drain fluid in order to assess net absorption. Net absorption was higher in eaters than in non-eaters (P < 0.001). Net absorption varied greatly between and within piglets and was highest in the caudal segments of the small intestine (P < 0.001). These data suggest that creep feeding could be a useful tool in the prevention of post-weaning diarrhoea.  相似文献   

5.
This study comprised 48,931 litters in 89 sow herds. During the study (1976-82) weaning age decreased from approx. 42 days to approx. 30 days. The mean incidence of post-weaning diarrhoea was 6.0% of litters weaned, with little variation by year but with considerable variation among herds. Within the individual herd increased incidence occurred over limited periods, probably associated with specific infections. Litters with diarrhoea during the suckling period had increased risk of post-weaning diarrhoea. The incidence of post-weaning diarrhoea increased with litter size at weaning. Thus, a litter of 11-12 piglets at weaning had 1.2 times higher risk than litters with 8-10 piglets. In contrast to pre-weaning diarrhoea, there was no association between parity of the sow and diarrhoea in the litter after weaning. Litters weaned below 2 weeks of age had a 2-fold risk of developing diarrhoea after weaning and a 2.4-fold higher mortality rate than did litters weaned at 6-7 weeks. Similarly, litters weaned at an individual piglet weight below 3 kg bodyweight had a 3-fold higher risk of developing diarrhoea after weaning and a 5-fold higher mortality rate than did pigs from litters weaned at a bodyweight of 7-8 kg. The incidence of post-weaning diarrhoea decreased with increasing herd size. Piglets from litters with post-weaning diarrhoea had reduced weight gains after weaning and were 2.3 days older at 25 kg bodyweight than piglets from non-diarrhoeic litters. Likewise, diarrhoea after weaning was associated with an increased incidence of diseases of the skin and respiratory tract. Thus the risk of contracting respiratory disease was 4 times greater in diarrhoeic litters.  相似文献   

6.
The purpose of this study was to test whether dietary spray-dried porcine plasma (SDPP) in early-weaned piglets prevents small intestinal villus atrophy by trophic or protective activity. Fifty-four weaned, 18-day-old piglets were used to determine the effect of dietary SDPP on small intestinal villus length, crypt depth, enterocyt mitotic activity and brush border enzyme activities during the first week after weaning. The piglets were offered a diet containing either 8% SDPP or 8% casein. At 2 and 7 days after weaning, piglets were anaesthetized to provide samples of the small intestinal wall and killed immediately afterwards. There were no differences in daily gain and daily feed intake between the two dietary treatments. At day 2 after weaning, all piglets showed a marked reduction in villus height when compared with baseline values. In all piglets, small intestinal enterocyte mitotic activity had decreased by day 2 and was increased again on day 7. There were no significant effects of dietary SDPP on small intestinal villus length, crypt depth and enterocyt mitotic activity. This indicates that SDPP has no trophic effect on the small intestinal mucosa and that it does not protect against the damaging effect on the small intestinal villi that is associated with the process of weaning. There was no effect of SDPP on lactase-, sucrase- or maltase-specific activities that are a measure of the digestive function of the small intestine. It can be concluded that SDPP versus casein has no effect on small intestinal morphology and disaccharidase activities in early weaned piglets kept under low infection pressure.  相似文献   

7.
Two experiments were performed in order to study how weaning and post-weaning dietary zinc level affect serum IGF-I. Further, whether the growth-enhancing effect of 2500 ppm of dietary zinc (Zn2500) and/or 175 ppm of dietary copper (Cu175) in post-weaning diets is associated with elevated serum IGF-I levels in piglets was studied. Experiment 1 included 54 piglets (six litters of nine piglets). One piglet from every litter was assigned to a control group (blood sampled 1 day before weaning). At weaning the remaining eight piglets from every litter were allocated randomly to four dietary treatments with increasing zinc inclusions (Zn100, Zn250, Zn1000, Zn2500). In exp. 2, 48 piglets (six litters of eight piglets) were allocated to four dietary treatments (Zn100, Zn100Cu175, Zn2500, Zn2500Cu175). All piglets in exp. 1 were blood sampled at -1, 1-2, 5-6 or 14-15 days after weaning and in exp. 2 blood samples were taken from all pigs 5-7 days after weaning. Feed intake was recorded per pen (two piglets) and weight gain was recorded for every piglet. Just after weaning feed intake was very low, piglets lost weight and serum IGF-I decreased in exp. 1. However, the piglets fed 2500 ppm of zinc reached pre-weaning levels of serum IGF-I at 14-15 days post-weaning, whereas piglets receiving lower zinc levels showed no changes in serum IGF-I. In exp. 2, additional dietary zinc in weaning diets for piglets was found to be associated with increased feed intake, improved growth rate and increased serum IGF-I. High levels of dietary copper did not affect any of these measurements. Zinc-induced rise in serum IGF-I was partly due to increased feed intake. After correcting for differences in feed intake, zinc significantly increased serum IGF-I. However, to completely separate effects of feed intake from effects of zinc status, pair-feeding should be considered in future studies.  相似文献   

8.
Body weight gain after weaning is correlated with villous height and disaccharidase activity. This evidence suggests that the maintenance of the small intestinal structure and function after weaning is important for the growth of piglets. We demonstrated that the influence of weaning age was obtained by disaccharidase activities and villous height in eight sections of the porcine small intestine. Therefore, we designed three weaning ages (weaned at the ages of 14, 21 or 28 days) and the piglets were slaughtered after 7 or 14 days post‐weaning. The remaining suckling piglets were slaughtered at the age of 1, 7, 14, 21 and 28 days. Four piglets were slaughtered at each event; therefore, 44 piglets were used in this study. Villous height and disaccharidase activities were measured in each section of the small intestine. Early weaning such as that at 14 days had severe influence on villous and disaccharidase activities. In particular, weaning of 14‐day‐olds did not result in maltase activity at least 2 weeks post‐weaning. Accordingly, the weaning age of crossbred piglets is recommended to be at least 21 days or more on the basis of villous height and disaccharidase activity analyses.  相似文献   

9.
Alterations in piglet small intestinal structure at weaning   总被引：29，自引：1，他引：28  
The small intestinal mucosa of 112 piglets aged between 21 and 32 days was examined to identify the effects on its structure of weaning and of consumption of creep food. In unweaned control pigs a gradual increase in crypt depth occurred with age, while villus height altered little. In contrast, weaned pigs showed a highly significant increase in crypt depth and an increase in the complexity of villus morphology with a dramatic reduction in villus height. Crypts elongated most in the distal small intestine, while the loss of villus height was greatest proximally. No inflammatory reaction was seen and the alterations were not influenced by consumption of creep food before weaning. This failed to support the hypothesis that hypersensitivity to dietary antigens is involved in the aetiology of such intestinal changes. The reduction in small intestinal absorptive area and the appearance of a less mature enterocyte population help to explain the increased susceptibility of the pig to diarrhoea and growth checks in the post-weaning period.  相似文献   

10.
Early weaning induces villous atrophy in the small intestine. Reduction in villous height in the small intestine after weaning is associated with reductions in brush‐border enzyme activity. Body weight gain after weaning is, therefore, correlated with villous height. This evidence suggested that the maintenance of small intestinal structure and function after weaning is important for the growth of young pigs. On the other hand, the relationship between villous height and the activity of the digestive enzymes in the small intestine has not been studied with piglets from the suckling to the growing period. Five suckling piglets, four piglets in the proximal stage of weaning, four pigs in the distal stage of weaning and four growing pigs were used. The activities of lactase (LA), sucrase (SA) and maltase (MA) were determined. LA showed a positive correlation with villous height in weaning. SA and MA were positively correlated with villous height from suckling to growing. In a previous study, non‐infectious dyspeptic diarrhea was frequently observed in growing piglets on Japanese swine farms. The maintenance of villous height to retain disaccharidase activity may prevent dyspepsic diarrhea in this stage.  相似文献   

11.
断奶应激对仔猪肠黏膜形态的影响   总被引：3，自引：0，他引：3  
在仔猪断奶过渡期，胃肠结构受损是很普遍的，断奶后一段时间内，胃肠结构受损程度不同，本文研究了断奶后7d内（断奶后0-6d)，仔猪小肠黏膜形态的变化，试验仔猪28日龄断奶。试验分7组，每组6头仔猪。从断奶当天开始，每1d定时定点剖杀取小肠前段，小肠中部，小肠后段作组织切片，观察其绒毛高度，隐窝深度。结果表明，断奶后前4d，绒毛高度缩短，隐窝加深，断奶后第4d绒毛高度最短，断奶后第5d开始恢复。  相似文献   

12.
The effect of enteritis on the development of the small intestine was examined in newborn, colostrum-deprived piglets infected with a human isolate of Y. enterocolitica (serotype 0:3, biotype 4) soon after birth. The piglets were killed 3 days (n = 6) or 5 days (n = 8) after infection, or antibiotic therapy was commenced on day 5 and the animals killed on day 14 (n = 5). Compared with the non-infected controls, infected animals had reduced mucosal lactase and sucrase, but not maltase activity, while after antibiotic therapy, previously infected piglets had a lower lactase and a higher maltase and sucrase activity. Lactase activity was significantly reduced in the duodenum and jejunum, and mean values were lower in the ileum, but the difference did not reach significance; maltase activity was greater at all ages from the distal jejunum to the mid-ileum; sucrase activity was reduced in all segments up to day 5 but after antibiotic therapy was increased in the jejunum and appeared early in the ileum. Enzyme profiles were more mature along the crypt-villus axis in some segments of the intestine in previously infected piglets. Sodium-potassium-ATPase activity was unchanged. There was a reduced villus height:crypt depth ratio, crypt hyperplasia and increased crypt cell proliferation. Morphological maturation, indicated by loss of vacuoles and location of the nucleus at the base of the enterocyte, proceeded distally from the duodenum to ileum from 3 to 14 days of age when only the ileum remained immature. In infected piglets, there was reduced vacuolation and earlier location of the nucleus at the base of the cell in the distal intestine. Accelerated maturity of specific disaccharidases and enterocyte morphology in infected piglets appears to be due to physical damage to the mucosa resulting in faster proliferation of crypt cells and migration of enterocytes. It is suggested that this may reduce macromolecular internalisation and impair the ability to utilise dietary carbohydrate and may have long-term effects on growth and immunological responses of the gut.  相似文献   

13.
The present study was undertaken to characterise the carbohydrate profile of the porcine small intestine using lectin histochemistry during the period from 3 days prior to weaning to 9 days post-weaning. A total of 56 piglets weaned at 4 weeks of age were included in the experiment. The most prominent changes in the glycosylation pattern were observed in the goblet cells. The highest lectin reactivity of the goblet cells in the crypts was observed 7 days post-weaning which suggests that the protective effect of the mucus layer against pathogenic bacteria is increasing during the postweaning period. The staining pattern of the apical membrane remained unchanged during the experimental period. This indicates that the glycosylation process in the goblet cells is rapidly inducible whereas changes in the glycosylation pattern of the apical membrane requires more time. The glycosylation pattern of both goblet cells and apical membrane differed between the positions of the small intestine. As glycoconjugates can act as attachment sites for microorganisms, these differences in the distribution of sugar residues may be one explanation for the site-specificity of certain pathogens.  相似文献   

14.
Effects of adding fermented wheat to liquid diets on gastrointestinal characteristics in weanling piglets were studied. Gastrointestinal characteristics of 40 28-d-old weanling piglets were measured at the day of weaning (d 0) and at d 4 and 8 after weaning. Piglets were group-housed and fed twice daily. Feeding level was based on the average metabolic BW of piglets per group. Groups were fed a liquid diet with either 45% unfermented wheat (FERM_0) or 45% fermented wheat (FERM_45). The other 55% of the diet was identical. To ferment wheat, water at 30 degrees C was added to milled wheat in a 1:2.2 ratio. The pH and contents of lactic acid, acetic acid, propionic acid, and butyric acid were measured in the digesta of the stomach, three parts of the small intestine, cecum, and large intestine. In addition, changes in microbial populations in the digesta were studied during the period after weaning. Moreover, villus height, crypt depth, and villus shape were studied in the small intestine. Piglets fed FERM_45 showed lower gastric pH (P < 0.05) at d 4 and higher gastric lactic acid content (P < 0.001) at both d 4 and 8. Piglets fed FERM_45 showed in the first part of the small intestine higher villus height (P < 0.01) at d 8 and higher villus:crypt ratio (P < 0.001) at both d 4 and 8. Villus shape tended (P < 0.10) to be favorable for piglets fed FERM_45. The present study indicates that feeding a partly fermented liquid diet to weanling piglets may be a concept to prevent undesirable changes in mucosal architecture after weaning.  相似文献   

15.
In production systems, piglets usually fast for a period after weaning, thereby increasing the risk of diarrhea and a reduction in growth. The low level of eating may relate to insufficient drinking activity, as solid feed intake must be accompanied by water intake. Mixing of newly weaned piglets is a well-known stressor and a common procedure in pig production. The effect of mixing on the temporal development of eating and drinking activity in newly weaned piglets has not been elucidated. High concentrations of zinc (Zn) in the feed improve the health and performance of piglets after weaning, but the underlying mechanisms are still obscure. One possibility is that Zn affects eating and drinking behavior. The effects of mixing 4 littermates from each of 2 litters and adding zinc oxide (ZnO; 2,500 ppm of Zn) to the feed were studied in a 2 x 2 factorial experiment using 123 piglets weaned at 27 d of age. Individual eating and drinking times during the initial 48 h after weaning were analyzed on 2 levels of aggregation, day and hour. The piglets spent less time eating on the first day after weaning compared with the second day (20 +/- 5 vs. 98 +/- 10 min, respectively; P < 0.001), whereas they spent more time drinking on the first day compared with the second day (13 +/- 1 vs. 9 +/- 0.5 min, respectively; P < 0.001). Eating and drinking times were positively associated (P < 0.001). Females ate for longer than males (61 +/- 8 vs. 44 +/- 7 min/24 h, respectively, P = 0.002), whereas sex did not affect drinking time. Drinking time increased (P = 0.003) and eating time decreased (P = 0.001) with increasing preweaning growth rate and weaning weight. Neither mixing nor addition of ZnO affected the daily eating time. However, nonmixed piglets given 2,500 ppm of Zn as ZnO in the feed spent more time drinking per day (12 +/- 1 min) than did nonmixed piglets offered 100 ppm of Zn as ZnO (10 +/- 1 min; P = 0.002). Mixing also affected the hourly distribution of the drinking activity (P < 0.05). In conclusion, the drinking behavior of newly weaned piglets was more affected by the external factors, mixing and addition of ZnO to the feed, than the eating behavior. As eating and drinking are strongly associated, more focus should be paid to the water intake and the interplay between eating and drinking behavior in future studies aiming to reduce weaning problems.  相似文献   

16.
This study aimed at investigating the effects of weaning kids abruptly at an average of 55 ± 13 days of age on intake, behavioral and serum parameters and, lasted for a total of six weeks; two weeks pre-weaning and four weeks post-weaning. Sixteen single kids with equal gender were used. Kids were only allowed to stay with their mothers for suckling (45 min/period) both in the morning and in the evening period during pre-weaning. Grower concentrate and hay were offered ad libitum . The duration of the study was divided into three periods for the sampling of behavioral and serum parameters; (i) pre-weaning period lasting for two weeks (P-BW) (ii) early post-weaning period lasting for one week (P-AW1) and (iii) late post-weaning period lasting for three weeks (P-AW2). Daily weight gain of kids gradually decreased as the observation period progressed ( P  = 0.001). However concentrate feed intake increased from 0.154 kg/day in P-BW to 0.479 kg/day in P-AW1 and 0.499 kg/day in P-AW2. Water intake, rumination and standing behaviors decreased in P-AW2 ( P  < 0.001), whereas activity towards concentrate feed (CF) ( P  < 0.001) and roughage ( P  = 0.012) increased as compared to P-BW and P-AW1. Abnormal oral activity was not affected by the periods ( P  = 0.906). CF was significantly higher in females ( P  = 0.003), whereas males displayed higher lying behavior ( P  = 0.007). Glucose, total protein, urea, cholesterol, HDL-cholesterol, LDL-cholesterol concentrations ( P  = 0.001) and ALP activity ( P  = 0.003) were significantly affected by the periods. The results of the present study suggest that behavioral and serum parameters across the periods describe changes in the nutritional conditions as a result of the transition from milk to solid feed in association with weaning.  相似文献   

17.
Decreasing traits of fecal immunoglobulin A in neonatal and weaning piglets   总被引：2，自引：0，他引：2  
The concentration of fecal secretory immunoglobulin A (sIgA) in neonate and weaning piglets was measured daily from 1 day after birth to 50 days of age. The concentration of fecal sIgA started from the level of 10(4) microg/g wet feces 1 day after birth and then increased to a maximal value of up to 10(5) microg/g within a few days of birth. The values constantly declined to between 10(1) and 10(2) microg/g for the next 10 days and were relatively constant until weaning. The level of sIgA in the feces remained very low until at least 50 days of age. The vulnerability of pre- or post-weaning piglets can be explained, at least in part, by this low level of sIgA in the intestine.  相似文献   

18.
缓释复合酸化剂对断奶仔猪消化道酸度及肠道功能的影响   总被引：7，自引：0，他引：7  
本试验选用28 R龄断奶、平均体质量(7.00±0.10)kg的长白猪(♂)×大白猪(♂)二元杂交仔猪64头,按单因索试验设计原则,研究在玉米一豆粕一膨化大豆型基础日粮中添加不同类型(包被未包被)复合酸化剂对断奶仔猪胃肠道酸度、生产性能、肠组织形态、消化酶活性、肠道微生物菌群及肠黏膜抗体SIgA的影响.试验设4个处理,每个处理4个重复,每个重复4头猪(公母各半),饲养试验时间为35 d.结果表明,微胶囊型缓释复合酸化剂可以极显著降低断奶仔猪胃和小肠pH(P＜0.01);极显著提高空肠绒毛高度和隐窝深度的比值(P＜0.01);断奶前期,显著提高小肠蔗糖酶和乳糖酶活性(P＜0.05);断奶后期,极显著提高仔猪盲肠和结肠中乳酸杆菌数量,降低大肠杆菌数量(P＜0.01);微胶囊型缓释复合酸化剂还有增加仔猪肠黏膜抗体SIgA分泌量的趋势(P＞0.05).结果提示,在断奶仔猪日粮中添加微胶囊型缓释复合酸化剂,可以通过降低肠道pH,优化肠道微生物区系,改善肠组织形态和功能,从而提高断奶仔猪肠道的消化力和适应性,并促进仔猪生长.  相似文献   

19.
74头28日龄健康二元杂交断奶仔猪分成3组，用于研究外源性谷氨酰胺（glutamine,Gln)和谷氨酰（glutamate, Glu)对断奶仔猪小肠粘膜形态，结构和功能及骨骼肌中DNA，RNA合成的影响。结果表明：与对照组相比，添加1%谷氨酰胺或1%谷氨酸可防止断奶后1周内空肠绒毛萎缩，减少断奶后2周内空肠固有膜内未成熟细胞数；显著改善断奶后1周内小肠吸收功能，并促进肌肉中RNA合成。这些结果为利用Gln、Glu缓解仔猪断奶应激，改善生产性能提供了实验基础。  相似文献   

20.
Weaning process widely affects the small intestinal structure and function in piglets, while the responses of large intestine to weaning stress are still obscure. The purpose of this study was to determine the developmental changes (i.e., short chain fatty acids (SCFAs) concentrations, growth parameters, crypt‐related indices and antioxidant capacity) in colon of piglet during weaning. Forty piglets were weaned at day 21 and euthanized to collect colonic tissues and digesta samples on day 0, 1, 3, 7 and 14 post‐weaning (n = 8). Piglet growth performance was improved (p < .001) on day 7 and 14 post‐weaning. The concentrations of acetate, propionate, butyrate, valerate, isobutyrate, isovalerate and total SCFAs were higher (p < .001) during the late post‐weaning period. The mRNA abundances of SCFAs transporters were greater (p < .001) on day 7 and 14. The absolute and relative weights, absolute length and perimeter of colon were greater (p < .001) on day 7 and 14. Similarly, post‐weaning increases (p < .001) in colonic crypt depth and Ki67 positive cells numbers per crypt were observed during the same period. Colonic crypt fission indices decreased (p < .01), while total crypt numbers increased (p < .001) on day 14 after weaning. Moreover, total SCFAs concentration was significantly associated with colonic growth parameters and Ki67 cells/crypt (p < .001). In addition, catalase content was decreased on day 3, 7, and 14, whereas, the concentrations of total superoxide dismutase (T‐SOD) and manganese‐containing superoxide dismutase (MnSOD) were higher (p < .05) on day 1 and 3 post‐weaning. These results showed that weaning process has a significant effect on colonic growth and development, which might be associated with the change of SCFAs concentrations in colon.  相似文献   

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