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1.
Clinical signs, haematological and biochemical abnormalities as well as the pathomorphological and electronmicroscopic findings observed in a 7 1/2 year old spayed female Dobermann suffering from chronic active hepatitis and cirrhosis are described. During almost the whole period of observation the clinical signs were nonspecific. The laboratory findings indicated a progressive liver disease. Gross findings revealed an atrophic cirrhosis. Histopathologically characteristic features of chronic active hepatitis were also seen together with a moderate copper accumulation localized in the periphery of the hepatic lobules. There was no evidence of cholestasis. 相似文献
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The authors present a case of benign idiopathic pericarditis in dog, describing a clinical case. The most important reasons for pericardial effusion are analyzed. Clinical signs of cardiac tamponade and aspects of electrocardiographic examination are demonstrated. Inconsistent long-term results achieved using corticosteroid therapy induced the authors to perform partial pericardiectomy (pericardial fenestration). The surgical approach was curative and, one year later, the dog doesn't show any signs of clinical disease. 相似文献
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Abstract. A histological study of 0+ rainbow trout, exposed to proliferative kidney disease (PKD) on an infected farm, showed evidence of infection from the beginning of June, gross pathological changes from the beginning of July, and clinical signs from mid-July. Evidence of healing was present in some samples from the second week of August. Kidney samples were divided into five grades (0–4) representing increasing severity of pathology. A sixth grade (H) was applied to kidneys showing signs of healing. The most frequent clinical signs were abdominal distension and exophthalmos. Melanosis, corneal cloudiness and ecchymoses were observed occasionally. Apart from renal enlargement, other internal gross pathological changes included ascites, gill and liver pallor, oedema, petechiation, and splenic enlargement. The majority of clinical signs and internal changes were only seen in fish with advanced renal swelling (grades 3 and 4). Histopathology was most marked in the kidney and was of three types: haemopoietic hyperplasia, vascular pathology and diffuse inflammatory change. Vascular changes, including occlusion of blood vessels in several organs and apparent haemoglobin crystallization, and destruction of renal excretory structures within areas of chronic diffuse inflammation were marked features of the histopathology in fish with clinical signs. The pathogenesis of PKD is discussed with reference to the histopathological changes. 相似文献
4.
为探讨鲁氏耶尔森菌侵染虹鳟的致病机制,本实验建立了鲁氏耶尔森菌感染虹鳟引起的肠炎红嘴病的病理模型,制定相应的临床症状及组织病理学评分系统,并对该模型进行研究。将43尾平均体质量约为12 g的健康虹鳟随机分成5组:3个实验组(n=30)、对照组(n=10)和哨兵组(n=3)。3个实验组分别采用2.0×106、2.0×107和2.0×108 CFU/m L的鲁氏耶尔森菌感染浓度,通过腹腔注射方式进行人工感染试验。对感染鲁氏耶尔森菌的虹鳟肠、肝脏、脾脏和肾脏组织进行镜检及临床症状、剖检病变判断,结合细菌学检测,按制定的评分系统评价各组肠炎红嘴病造模效果,确定最佳造模方案。结果显示,各攻毒组虹鳟感染后72 h均出现不同程度死亡,临床症状表现为红嘴、肛门红肿、鳍(胸鳍、腹鳍、臀鳍)等出现不同程度充血,下颌部、腹部出现出血点等。组织病理学可见肝脏、脾脏、肾脏及肠组织均有炎性细胞浸润现象出现,肝细胞、肠上皮细胞和肾小管上皮细胞等实质细胞变性、坏死,脾脏部位淋巴细胞减少、红细胞死亡堆积。综合各组得分发现,2.0×107 CFU/m L组的鲁氏耶尔森菌感染虹鳟造模效果最佳,患病虹鳟的临床症状显著且组内差异较小,病程迁延较长,便于研究。研究表明,对体质量约12 g的虹鳟幼鱼腹腔注射0.1 m L浓度为2.0×107 CFU/m L的鲁氏耶尔森菌可成功构建肠炎红嘴病病理模型。 相似文献
5.
A disease outbreak occurred during the Spring of 2006 among rainbow trout, Oncorhynchus mykiss, kept in growout tanks. During the outbreak 35% of the rainbow trout died. Typical clinical signs were ulceration on the dorsal surface of the fish. Based on biochemical characteristics and sequence of 16S rRNA, the causative bacteria isolated from diseased fish were identified as Pseudomonas putida. Histologically, skin ulcer initially was characterized by sloughed off epithelia and epithelial necrosis. In the advanced form of the disease, almost all layers of the skin down to the epidermis were lost. Outside of Japan, this study reports the first P. putida infection in fish. 相似文献
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Myocardial fibrosis and degeneration of unknown etiology is described in two adult, female goats of the Saanen and Pfauen breeds. Both animals presented with clinical signs of cardiac failure with subcutaneous edema, hydrothorax and ascites. The pathological lesions were characterized by cardiomegaly with ventricular and auricular dilatation and hypertrophy, massive subcutaneous edema and body cavity edema. The first goat additionally showed chronic liver congestion due to cardiac failure. Histologically, the most prominent changes were focally extensive cardiomyocyte degeneration and cardiac fibrosis. The clinical history and pathologic lesions are comparable to those of dilatative cardiomyopathy in SixRH cattle. 相似文献
8.
Abstract. During the exceptionally good summer of 1984, severe losses occurred at a number of marine salmon farms in the west of Ireland. Clinical signs and associated histopathology of the disease are described together with relevant meteorological data gathered during the course of the mortalities. The clinical, histopathological and meteorological data observed strongly suggest that prolonged exposure to solar ultraviolet radiation played a major role in the losses which occurred. Other contributory factors involved in the mortalities are described and discussed. 相似文献
9.
Two growth types of Renibacterium salmoninarum were isolated from subclinically infected rainbow trout, one producing the smooth colonies typical of R. salmoninarum and the other forming a thin film on the surface of the agar with no separate colonies. The atypical growth was present on kidney disease medium agar in primary cultures of the kidney but not on selective kidney disease medium (SKDM). Fluorescent antibody staining of the fresh isolate and polymerase chain reaction amplification were the most reliable techniques to identify the atypical growth of R. salmoninarum. The condition was reversible, with growth reverting from atypical to the smooth colony form in experimentally infected rainbow trout and under laboratory conditions. There was no mortality, or any clinical signs of bacterial kidney disease (BKD) in the fish challenged with the atypical growth, although small numbers of smooth colonies of R. salmoninarum were isolated from 8% of these fish. The atypical growth reported here may explain some of the failures of culture, when SKDM agar alone is used for the detection of BKD in subclinically infected fish. 相似文献
10.
L. LEIBOVITZ 《Journal of fish diseases》1989,12(2):125-136
Abstract. Diseases of bivalve molluscs characterized by the presence of prokaryotic intra-cytoplasmic inclusion bodies in epithelial cells are reviewed. The paper reports the history, clinical and pathological findings during hatchery epizootics of chlamydiosis in larval and postmetamorphic bay scallops, Argopecten irradians (Lamarck), and enzootic infection in wild, captive and cultured adult and juvenile bay scallops during a 15-year period (1972–1987) of surveillance for scallop diseases in the northeastern Atlantic coastal region of the United States. The disease was found in 44·4% of adult bay scallop laboratory accessions as an endemic disease without overt clinical signs or mortalities, and as a highly fatal epizootic disease with a rapid course in 20% of hatchery-reared larval and postmetamorphic bay scallop accessions. The pathogenesis and development of the chlamydial agent during hatchery epizootics are described. The importance of the congenital 'childhood' diseases of larval bay scallops and other species of bivalve molluscs is discussed. 相似文献
11.
The paper describes anamnestic, macroscopic and microscopic findings in a female ostrich (Struthio camelus), euthanatized because of central nervous and locomotion disorders. Systemic arteriosclerotic lesions were combined with adiposis and signs of spongiform encephalopathy, localized in the brain stem and the medulla oblongata. Aetiopathogenesis of the disease remains unknown. Differential diagnosis is discussed and the disease compared to similar findings in mammals which suffered from BSE/scrapie. 相似文献
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The Federal Republic of Germany is at present free from Foot-and-Mouth Disease (FMD). In many countries of the world, however, FMD is still an enzootic disease. Therefore, countries free from FMD have to be constantly on guard against importing the disease. The plurality of the agent as well as ways of transfer of the disease are described. In particular, clinical signs and pathological injuries are described and illustrated by photographs. Methods of preparing specimens from infected animals for laboratory diagnosis are pointed out. 相似文献
13.
Karoline Waldner Thomas Bechter Stefan Auer Florian Borgwardt Mansour El-Matbouli Günther Unfer 《Ecology of Freshwater Fish》2020,29(3):465-476
Proliferative kidney disease (PKD) is an emerging parasitic disease that affects wild and farmed salmonid fishes worldwide. Currently, it is widespread in Europe with records in many countries. This study assessed the status of PKD in the river Wulka, a small Austrian river, which was known to host a vital brown trout population despite having high water temperatures. Contrary to the initial hypothesis that the river was free from PKD, we observed an overall PKD prevalence of 92%. Noninfected fish were restricted to the uppermost river section. Twenty-two out of 87 PKD-positive fish of all age classes showed clinical signs, while five individuals exhibited signs of recovering from PKD infection. The severity of clinical signs was significantly dependent on the fish length and age, with smaller or younger individuals being more severely affected. Comparison of data from the earlier fish sampling events with those results from 2017 and 2018, together with the analyses of the pattern of water temperature since 2010, indicates that Wulka's brown trout population might become extinct in the near future. 相似文献
14.
Experimental and spontaneous infections with Corynebacterium suis in sows were investigated. In early stages animals show no clinical disorders or only for a short time. However, there are already marked changes in urinary samples (hematuria, proteinuria, leukocyturia, gross alterations). Using an endoscope mucosal irritations can be seen mainly on the floor of the bladders. In chronic cases alterations in urine are more pronounced. If a pyelonephritis is present in addition to the cystitis, general signs of illness are evident including anorexia, emaciation, anemia, subnormal body temperature and abortions. Bladders demonstrate an erosive and ulcerative, hemorrhagic cystitis on the whole mucosal surface. Uremia appears only in late stages of the disease. 相似文献
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Case definition for clinical and subclinical bacterial kidney disease (BKD) in Atlantic Salmon (Salmo salar L.) in New Brunswick,Canada 
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下载免费PDF全文 Bacterial kidney disease (BKD) is considered an important cause of loss in salmon aquaculture in Atlantic Canada. Causative agent of BKD is the Gram‐positive bacteria Renibacterium salmoninarum. Infected salmon are often asymptomatic (subclinical infection), and the disease is considered chronic. One of the challenges in quantifying information from farm production and health records is the application of a standardized case definition. Case definitions for farm‐level and cage‐level clinical and subclinical BKD were developed using retrospective longitudinal data from aquaculture practices in New Brunswick, Canada, combining (i) industry records of weekly production data including mortalities, (ii) field observations for BKD using reports of veterinarians and/or fish health technicians, (iii) diagnostic submissions and test results and (iv) treatments used to control BKD. Case definitions were evaluated using veterinarians’ expert judgements as reference standard. Eighty‐nine and 66% of sites and fish groups, respectively, were associated with BKD at least once. For BKD present (subclinical or clinical), sensitivity and specificity of the case definition were 75–100% varying between event, fish group, site cycle and level (site pen). For clinical BKD, sensitivities were 29–64% and specificities 91–100%. Industry data can be used to develop sensitive case definitions. 相似文献
17.
Mycobacteria are significant pathogens of laboratory zebrafish, Danio rerio (Hamilton). Stress is often implicated in clinical disease and morbidity associated with mycobacterial infections but has yet to be examined with zebrafish. The aim of this study was to examine the effects of husbandry stressors on zebrafish infected with mycobacteria. Adult zebrafish were exposed to Mycobacterium marinum or Mycobacterium chelonae , two species that have been associated with disease in zebrafish. Infected fish and controls were then subjected to chronic crowding and handling stressors and examined over an 8-week period. Whole-body cortisol was significantly elevated in stressed fish compared to non-stressed fish. Fish infected with M. marinum ATCC 927 and subjected to husbandry stressors had 14% cumulative mortality while no mortality occurred among infected fish not subjected to husbandry stressors. Stressed fish, infected with M. chelonae H1E2 from zebrafish, were 15-fold more likely to be infected than non-stressed fish at week 8 post-injection. Sub-acute, diffuse infections were more common among stressed fish infected with M. marinum or M. chelonae than non-stressed fish. This is the first study to demonstrate an effect of stress and elevated cortisol on the morbidity, prevalence, clinical disease and histological presentation associated with mycobacterial infections in zebrafish. Minimizing husbandry stress may be effective at reducing the severity of outbreaks of clinical mycobacteriosis in zebrafish facilities. 相似文献
18.
Investigation of outbreaks of a novel disease, 'Sleepy Grouper Disease', affecting the brown-spotted grouper, Epinephelus tauvina Forskal 总被引：2，自引：0，他引：2
Abstract. A novel disease affecting the brown-spotted grouper, Epinephelus tauvina Forskal, described here as Sleepy Grouper Disease1 (SGD), resulted in significant economic losses in some Singaporean marine net-cage farms from April to August 1992. Investigations suggested that the aetiological agent was a virus, probably introduced with imported groupers. The virus was provisionally identified as an iridovirus on morphological evidence. The disease caused extreme lethargy in affected fish with few visible external signs. Mortalities either occurred gradually over the week from onset of clinical signs, or over a shorter period and in large numbers if fish were stressed. Consistent tissue changes were seen by light microscopy in the spleen, heart and kidney of affected fish. Electron microscopy showed viral particles associated with damage to cell organelles. In an experimental infection, apparently healthy fish cohabiting with an infected fish developed similar lesions and died. The significance of SGD in grouper culture is discussed. 相似文献
19.
A rarely diagnosed case of urachal abscessation without any signs of inflammation of the extra-abdominal navel in a seven-month-old Braunvieh heifer is described. The symptoms of this disease, its diagnosis by the means of ultrasonographic examination and its therapy are explained. The technique of ultrasonographic examination is supposed to be a facilitation of presurgical diagnosis of umbilical disease. Nevertheless the value of this diagnostic procedure should be checked up on more patients. 相似文献
20.
Pseudotuberculosis is a bacterial septicaemia caused by Photobacterium damselae subsp. piscicida in several marine fish species. Yellowtail Seriola quinqueradiata is the most sensitive fish species to this disease. The internal organs of naturally infected yellowtail exhibit whitish
spots, tubercle-like tissue structures, consisting of bacterial accumulations. There have been many trials for experimental
infection, however adequate method of infection that reproduces moderate mortality and primary clinical signs has not yet
established. Present investigation evaluated an immersion infection method by using logarithmic culture-phase bacteria resulting
in higher mortality than that using stationary culture-phase bacteria. Typical white spots on the spleen and kidney were also
observed constantly in dead fish. Transmission electron microscopy and fluorescent antibody microscopy showed bacterial clusters
not only in the spleen and kidney but also in the blood channels in the secondary gill filaments. These results were confirmed
repeatedly by plural experiments. The use of logarithmic-phase bacteria in immersion infection is an appropriate technique
to reproduce moderate mortality and primary clinical signs, which will be a reliable infection method also for the challenge
test of pseudotuberculosis vaccine. 相似文献