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1.
Ketzis JK Vercruysse J Stromberg BE Larsen M Athanasiadou S Houdijk JG 《Veterinary parasitology》2006,139(4):321-335
The interest in novel methods of controlling helminth infections in ruminants is driven primarily by the development of parasite resistance to currently available anthelmintics. While the purpose of anthelmintics is to achieve high efficacy, i.e. >90% reduction of adult and/or larval parasites in the target host animal, the purpose of novel parasite control methods is rather to assist in maintaining parasite infections below the economic threshold. The ability to maintain parasite levels below the economic threshold is related not only to the efficacy of the control method, but also to the epidemiology of the parasites, climatic conditions, the livestock management program, and integration in a sustainable parasite control program. Because of this fundamental difference, novel parasite control methods need to be evaluated using efficacy criteria different from that adopted for anthelmintics. Although the efficacy of novel parasite control methods may be demonstrated in classic dose-confirmation studies, the impact on livestock production parameters can only be evaluated when tested on-farm. In this paper, the rationale for evaluating novel methods differently from anthelmintics is reviewed, potential performance expectations are presented, and four novel parasite control methods (vaccines, nematophagous fungi, condensed tannins, and immunonutrition) are assessed based on the potential performance criteria. 相似文献
2.
Integrated and biological control of parasites in organic and conventional production systems. 总被引：5，自引：0，他引：5
Organic and other non-intensive animal production systems are of growing importance in several countries worldwide. In contrast to conventional farms, parasite control on organic farms is affected by several of the prescribed changes in management e.g. access to the outdoors in the summer and in most countries, a ban on preventive medication, including use of anti-parasiticides. Organic animal production relies heavily on grazing, and pasture or soil related parasites are thus of major importance. Several studies in northern temperate climate have indicated that outdoor production of pigs, primarily sows, and laying hens results in heavier and more prevalent helminth infections compared to conventional intensive production under indoor conditions. In organic dairy cattle, parasitic gastroenteritis in heifers may be more prevalent. In a short to medium term perspective, integrated control may combine grazing management with biological control using nematophagous micro-fungi, selected crops like tanniferous plants and on conventional farms, limited use of anti-parasiticides. At present, the non-chemotherapeutic control of pasture related infections is based mainly on grazing management strategies. Preventive strategies, where young, previously unexposed stock, are turned out on parasite-free pastures, can be used for grazing first season dairy heifers and in all-in-all-out poultry production. Evasive strategies aim at avoiding disease producing infections of a contaminated area by moving to a clean area and may be relevant for ruminants and pigs. In cattle, effective control of nematodes can be achieved by repeated moves of the herd or alternate grazing with other species. High stocking rates seem to be an important risk factor. In pig production, the effect of paddock rotation on parasite infections is largely unknown and studies are warranted. Control of nematodes by larvae-trapping fungi, or perhaps in the future by egg-destroying fungi, looks promising for ruminants and certain monogastric animals but delivery systems and practical dosing regimes integrated with grazing management have to be developed. In conclusion, good prospects are expected for acceptable parasite control without a heavy reliance on anti-parasiticides through integration of the above mentioned procedures but future studies are needed to confirm their efficacy under practical farming conditions. 相似文献
3.
Coles GC 《The Veterinary record》2002,151(6):165-169
It is suggested that the major factor in avoiding the development of anthelmintic resistance is the percentage of worms that do not encounter the anthelmintics (worms in refugia). This in turn is determined by the numbers of larvae on pasture, the percentage of animals treated and whether any stages in the host can avoid the action of anthelmintic. To maintain anthelmintic efficacy the percentage of worms in refugia must be sufficiently large. In cattle, this should involve treating only first-year animals and using a different pasture each year for calves. For sheep, only animals that have to be treated should be dosed with anthelmintic and clean grazing strategies that involve the use of anthelmintics should be avoided. For horses, reliance should be placed on the removal of faeces from pasture and only treating when the animals' condition requires it. Without a change in anthelmintic use there is the likelihood of increasing numbers of cases for which no anthelmintic is effective and animal welfare may be compromised. 相似文献
4.
Control of nematode parasites with reduced reliance on the use of anthelmintics was studied in 16 ewes with suckling twin lambs on contaminated pasture in Denmark. Ewes and lambs were treated with albendazole at turn-out 3 May. Ewes were removed from the groups on 26 July, and lambs were slaughtered on 11 October. The animals were allocated to 4 groups of 8 lambs and their 4 ewes. Group TS was treated with albendazole at weeks 3, 6 and 8 after turnout and set-stocked; group TM was similarly treated but moved to clean pasture in conjunction with the last drenching; group US was untreated and set-stocked, and group UM was left untreated but moved to clean pasture week 8 after turn-out. Supplementary feed was offered in June and August due to scarcity of pasture. Strategic treatments of ewes and lambs weeks 3, 6 and 8 after turn-out, with or without a move to clean pasture, were highly effective in controlling nematode infections for most of the season. This was reflected in better weight gains and carcass characteristics in the treated compared to untreated lambs, resulting in an average increase in the value of the product by 36%. The effect of moving without treatment (UM) on faecal egg counts was limited but peak pasture infectivity was reduced to less than 10% compared to the set-stocked group and weight gains of lambs were significantly better despite poor feed availability in late season. The study showed that under set-stocked conditions repeated anthelmintic treatments of both ewes and lambs in early season may ensure sufficient nematode control whereas moving animals to clean pasture without dosing was less efficient. The latter may, however, still be a viable option in organic and other production systems where routine use of anthelmintics is banned, particularly if weaning and moving are combined or a second move is performed. 相似文献
5.
Modeling of host genetics and resistance to infectious diseases: understanding and controlling nematode infections 总被引：1，自引：0，他引：1
This paper considers approaches to modeling the dynamics of infectious disease and the application of such models to nematode parasite infections in ruminants. Particularly, these models are developed to account for host genetics and may be used to assess the effects of using genetics to control nematode infections. Three main issues are critically examined: the infection transmission cycle from pasture to host to pasture, the expected genetic relationships between resistance and performance, and the risks of parasite evolution in response to genetic changes in the host. To obtain answers that are realistic and of practical use, the modeling approaches require a solid grounding in biology. This biology is formalized and described using mathematical techniques, with the models parameterized using experimental or field data. Transmission dynamics have been quantified by modeling and are backed by strong experimental data. Selection for resistance will be successful in reducing egg output, pasture larval contamination and hence subsequent larval challenge. Modeling frameworks have been developed to predict genetic relationships between resistance to infectious disease and performance in general, and genetic correlations predicted for nematode resistance are close to mean published values. These predicted correlations strengthen as the larval challenge increases and the dietary (protein) adequacy decreases, however modeling challenges remain. Lastly, although convincing experimental data is not yet available, arguments based on modeling suggest that the risks of parasite evolution in response to genetic changes in the host should be less than the risks arising from other control strategies, such as anthelmintics. Thus, modeling techniques predict that selective breeding for resistance should be an effective and sustainable complementary control measure. 相似文献
6.
Nematode parasites have been a major factor limiting sheep production in New Zealand for more than 100 years. Twenty-nine species of nematodes were unintentionally introduced with sheep into New Zealand, but it is principally species of Haemonchus, Ostertagia, Trichostrongylus, Nematodirus and Cooperia that are associated with production losses and clinical disease. The seasonal dynamics of nematode infection are the consequence of complex inter-relationships between the sheep, their husbandry and the prevailing climate. The patterns of pasture contamination by nematode eggs and then larvae and the subsequent levels of infection in ewes and lambs are broadly similar throughout New Zealand. Numbers of infective larvae on pasture build up over summer to a peak in autumn/early winter with, in some years, a spring peak derived from the parturient rise in faecal nematode egg counts (FEC), expressed in eggs per gram of faeces (epg), in lactating ewes. The immune capability of lambs is initially low but increases with the magnitude and duration of exposure to infection. Once significant immunity has developed (usually by 10-12 months of age), sheep are capable of markedly restricting parasite infection, except during times of disease, malnutrition or stress. For the effective control of nematode parasites, farmers have come to rely almost exclusively on broad-spectrum anthelmintics. However, issues relating to resistance, residues and eco-toxicity increasingly threaten the sustainability of chemotherapy. In order to maintain present levels of parasite control and productivity in the long term, farmers need to integrate management practices aimed at minimising animal exposure to parasites with reduced reliance on anthelmintics. 相似文献
7.
Nematode parasites have been a major factor limiting sheep production in New Zealand for more than 100 years. Twenty-nine species of nematodes were unintentionally introduced with sheep into New Zealand, but it is principally species of Haemonchus, Ostertagia, Trichostrongylus, Nematodirus and Cooperia that are associated with production losses and clinical disease. The seasonal dynamics of nematode infection are the consequence of complex inter-relationships between the sheep, their husbandry and the prevailing climate. The patterns of pasture contamination by nematode eggs and then larvae, and the subsequent levels of infection in ewes and lambs are broadly similar throughout New Zealand. Numbers of infective larvae on pasture build up over summer to a peak in autumn/early winter with, in some years, a spring peak derived from the parturient rise in faecal nematode egg counts (FEC), expressed in eggs per gram of faeces (epg), in lactating ewes. The immune capability of lambs is initially low but increases with the magnitude and duration of exposure to infection. Once significant immunity has developed (usually by 10–12 months of age), sheep are capable of markedly restricting parasite infection, except during times of disease, malnutrition or stress. For the effective control of nematode parasites, farmers have come to rely almost exclusively on broad-spectrum anthelmintics. However, issues relating to resistance, residues and eco-toxicity increasingly threaten the sustainability of chemotherapy. In order to maintain present levels of parasite control and productivity in the long term, farmers need to integrate management practices aimed at minimising animal exposure to parasites with reduced reliance on anthelmintics. 相似文献
8.
The Australian ruminant livestock industries are faced with the need to control parasitic infectious diseases that can seriously impact the health of animals. However, increasing levels of resistance to insecticides, anthelmintics and acaricides are substantially reducing the ability to control some of these parasites. Here we review the current situation with regard to chemical resistances in parasites across the various sectors of the Australian ruminant livestock industries and assess the level of threat that these resistances pose to the sustainability of these sectors in the short to long terms. We also look at the extent to which testing for resistance occurs across the various industry sectors, and hence how well-informed these sectors are of the extent of chemical resistance. We examine on-farm management practices, breeding of parasite-resistant animals, and non-chemical therapeutics that may act as short to long term means to reduce the current reliance on chemicals for parasite control. Finally, we look at the balance between the prevalence and magnitude of current resistances and the availability and adoption rates of management, breeding and therapeutic alternatives in order to assess the parasite control outlook for the various industry sectors. 相似文献
9.
Thomas M Craig 《Veterinary Clinics of North America: Food Animal Practice》2006,22(3):567-581
Anthelmintic resistance has been a problem almost from the first use of the drugs introduced during the past 50 years. Evaluation of anthelmintics on a specific farm is essential to determine which drugs may be used in controlling parasite numbers. Treatment of livestock during the season in which parasite transmission is unfavorable lessens pasture contamination. Targeting treatment places less pressure on susceptible worms, diluting the resistant parasite population. Pasture management and using safe pastures for animals at highest risk lower pasture exposure. Selection for individual animals resistant to the effects of parasites lessens the need for use of anthelmintics. Alternatives to anthelmintics include cryptic antigen vaccines, copper wires, and biologic compounds. 相似文献
10.
Gastrointestinal (GI) nematode infection is a major constraint for grazing livestock production. The increasing prevalence and severity of anthelmintic-resistant nematodes in many parts of the world has led to a search for non-chemical control options. Under experimental conditions, the nematophagous fungus Duddingtonia flagrans is emerging as an alternative to chemotherapy for the control of GI nematode infection in biological production systems. Also, recent information points to the role of energy nutrition to increase the immune response against GI nematode infection. In this study the effect of D. flagrans and energy supplementation on the epidemiology of GI nematode infections is explored on grazing kids. Four groups of 10, 4-month old goats were turned out on infected pasture in the early spring and allocated to four separate paddocks where they were rotationally grazed for 16 weeks. One of these groups (F) received 0.5 x 10(6) D. flagrans spores/kg BW/d. Another group (S) was supplemented with 100 g barley grain per day. A third group (F+S) received both nematophagous fungi and barley supplement treatments simultaneously while the fourth group (C) was used as a non-treated control. Both nematophagous fungi and barley supplement had a significant effect (P<0.01) on reducing pasture infectivity, faecal egg excretion and worm burdens at slaughter that was particularly evident for Trichostrongylus colubriformis. The combination of both treatments showed a synergistic effect on the control of gastrointestinal nematode infections. At slaughter, the average total post-mortem worm count of the F+S group was reduced by 65% compared with the non-treated control. The results herein show that D. flagrans can act as an efficient biological control agent against kid GI nematode infections on pasture, which could further improve carcass characteristics. While small amounts of energy supplement can also reduce kid infection, the effect of D. flagrans as a biological control agent appeared clearly enhanced both in magnitude and duration by energy supplementation. This has clear implications for grazing animals and provides an efficient method for the practical control of parasitic nematodes in biological production systems. 相似文献
11.
Periparturient Merino ewes obtained from lines of sheep that had been selected either for increased resistance to Haemonchus contortus (R) or at random (C) were supplemented, while grazing at pasture, with either nil or 250 g/day cottonseed meal (CSM) for the 6 weeks prior to or the 6 weeks after the start of parturition. Ewes from both supplement groups had lower (mean 66% reduction) faecal egg counts (FECs) during the postpartum period and this coincided with a period of maternal body weight loss. Factors which increased the rate of maternal body weight loss, such as pregnancy and lactation status, also increased FEC. Evidence is presented that the magnitude of the periparturient rise (PPR) in FEC in grazing ewes will be greatest during periods of maternal weight loss and at these times supplementation to increase metabolisable protein (MP) supply will be most effective in increasing resistance to nematode parasites. The resistance of R ewes to nematode parasites was greater than that of C ewes throughout the experiment and was sufficiently low such that anthelmintic treatment in a commercial environment may not have been required. Irrespective of actual FEC, ewes from all treatment combinations exhibited a PPR in FEC. Reduced FEC of R ewes resulted in reduced apparent pasture larval contamination after 18 weeks of continuous grazing but supplementation was ineffective in this regard. It is suggested that integrated parasite management (IPM) programs for periparturient ewes should make use of both protein supplementation and genetic selection to increase worm resistance and reduce dependency on anthelmintics for worm control. 相似文献
12.
H C Gibbs 《Veterinary Clinics of North America: Food Animal Practice》1986,2(2):345-353
From a parasite viewpoint, therefore, hypobiosis is a most useful life cycle adaptation to ensure persistence and has been reported in most of the important nematode species parasitizing sheep in North America. It facilitates the synchronization of the nematode life cycle to changing host and environmental conditions. It also enables the parasite to have available large numbers of infective forms at points in the host life cycle that coincide with the presence of susceptible neonates, thus ensuring transmission. The accompanying periparturient rise seen with many of these species following development of hypobiotic larvae has very important implications for the planning of control procedures. Because it appears to be the major source of pasture contamination early in the grazing season, it is the prime source of infection for the lambs. These lambs can in turn serve to augment pasture contamination, leading to very heavy levels of pasture infectivity in late summer and fall. By scheduling anthelmintic treatments so as to suppress this rise in egg counts, pasture contamination can be kept to a minimum. More effective, less frequent dosing with anthelmintics is needed. 相似文献
13.
Biological control of parasitic nematodes of livestock is currently under development and represents another tool that may be integrated into helminth parasite control strategies. This paper presents a brief introduction to commercial sheep farming in South Africa and currently available nematode parasite control methods. These include the FAMACHA clinical assay, strategies of pasture management, dilution of resistant worm species by introduction of susceptible worms, breed resistant sheep and nutritional supplementation. The purpose of this paper is to outline the principles of biological control using nematophagous fungi and how it may be applied on sheep farms in South Africa. 相似文献
14.
The free-living stages of gastrointestinal nematode parasites of sheep are strongly affected by climate. Thus, extreme heat and cold are detrimental to development and survival, while, within tolerable limits, increasing temperatures generally accelerate development but increase mortality. Moisture is needed for development and translation of larvae from faeces to pasture, and so rainfall is a limiting factor for transmission. Together, these factors underpin seasonal patterns of infection in sheep, as well as geographic variation in the epidemiology and relative importance of different species within Europe. Local knowledge and experience enable treatment to be targeted appropriately to prevent dangerous levels of infection. This traditional know-how can be supplemented by predictive epidemiological models, built on thorough understanding of the influence of climate on larval availability. However, management also has a dominant role in determining patterns of infection, and is itself influenced by climate. Current geographic variation in nematode epidemiology across Europe, and knowledge of systems from outside Europe, can provide only limited perspectives on the likely effects of climate change on disease in future. This is because disease arises from complex interaction between host and parasite factors, and the implementation of optimal control strategies to meet new challenges will be slowed by the inertia of current systems. Approaches to nematode control must therefore take account not only of parasite biology, but also the forces that shape sheep farming systems and management decisions. 相似文献
15.
R P Herd C F Parker K E McClure 《Journal of the American Veterinary Medical Association》1984,184(6):680-687
Epidemiologic approaches to parasite control, with reduced reliance on the use of anthelmintics, were studied in 6 groups of weaned lambs and 4 groups of suckling lambs grazing fertilized pastures. Strategies tested included prophylactic treatments in the spring, provision of safe pastures, treat-and-move strategies, and winter (prelambing) treatment of ewes. Suppressive treatment with a non-benzimidazole drug was used as a production yardstick against which the epidemiologic approaches were judged. Suppressive treatment with a benzimidazole drug was used to determine the drug resistance status of the flock. The success of each strategy was evaluated by measurements of body weight, wool growth, fecal egg counts, pasture larval counts, and total worm burdens. Prophylactic treatments in the spring were just as effective as suppressive treatments throughout the entire grazing season and resulted in significant (P less than 0.001) increases in weight gain. Effective parasite control also was obtained by moving ewes and lambs to safe pastures (low infectivity) in May, and resulted in significant (P less than 0.001) increases in weight gain. A treat-and-move strategy led to significant (P less than 0.001) increases in weight gain until September, but then a loss of weight in October, suggesting the need for a double treat-and-move strategy in the case of late-marketed lambs. The value of winter (prelambing) treatments for ewes also was demonstrated. Suppressive treatments with a benzimidazole drug confirmed the presence of benzimidazole-resistant nematodes. 相似文献
16.
Innes EA Bartley PM Rocchi M Benavidas-Silvan J Burrells A Hotchkiss E Chianini F Canton G Katzer F 《Veterinary parasitology》2011,180(1-2):155-163
Protozoan parasites are among some of the most successful organisms worldwide, being able to live and multiply within a very wide range of hosts. The diseases caused by these parasites cause significant production losses in the livestock sector involving reproductive failure, impaired weight gain, contaminated meat, reduced milk yields and in severe cases, loss of the animal. In addition, some protozoan parasites affecting livestock such as Toxoplasma gondii and Cryptosporidium parvum may also be transmitted to humans where they can cause serious disease. Data derived from experimental models of infection in ruminant species enables the study of the interactions between parasite and host. How the parasite initiates infection, becomes established and multiplies within the host and the critical pathways that may lead to a disease outcome are all important to enable the rational design of appropriate intervention strategies. Once the parasites invade the hosts they induce both innate and adaptive immune responses and the induction and function of these immune responses are critical in determining the outcome of the infection. Vaccines offer green solutions to control disease as they are sustainable, reducing reliance on pharmacological drugs and pesticides. The use of vaccines has multiple benefits such as improving animal health and welfare by controlling animal infections and infestations; improving public health by controlling zoonoses and food borne pathogens in animals; solving problems associated with resistance to acaricides, antibiotics and anthelmintics; keeping animals and the environment free of chemical residues and maintaining biodiversity. All of these attributes should lead to improved sustainability of animal production and economic benefit. Using different protozoan parasitic diseases as examples this paper will discuss various approaches used to develop vaccines to protect against disease in livestock and discuss the relative merits of using live versus killed vaccine preparations. A range of different vaccination targets and strategies will be discussed to help protect against: acute disease, congenital infection and abortion, persistence of zoonotic pathogens in tissues of food animals and passive transfer of immunity to neonates. 相似文献
17.
Dairy production in the tropics represents a major challenge, especially when reliant on grazed forages, because of the conflicting factors of a high nutritional demand to sustain lactation on the one hand, and the relatively low quality of tropical grasses and a stressful environment, on the other. This paper focuses primarily on those tropical situations where grazed pasture is the cheapest feed resource. Effective management of the pasture as well as the animals that graze it is required in order to maximize economic viability of the farming enterprise. Feed planning helps to ensure that pasture use is maximized, either directly by grazing or, where profitable, indirectly by cutting for conservation. High rates of pasture utilization at each grazing minimize pasture senescence and decay and ensure that pasture remains in a vegetative state of the highest possible nutritional quality. Total annual feed requirements of the grazing herd must therefore be matched as closely as possible to the total annual pasture production on the farm. Stocking rate is critical in this regard, and is the single most important determinant of productivity in pastoral farming. Periods of pasture surplus or deficit will inevitably arise, but can be minimized by matching the monthly feed requirements of the herd as closely as possible to the monthly feed production on the farm. Herd requirements can be influenced, for example, through altering calving patterns and drying off dates. Even with good pasture management practices, it is highly likely that tropical pasture quality will be low for part of the year. Utilization of low-quality forages can be improved through the appropriate use of feed supplements, and the key principles are discussed. Firstly, conditions for optimum fermentative digestion in the rumen must be promoted through adequate provision of fermentable energy and nitrogen as well as essential minerals, such as phosphorus and sulfur. Further supplementation with metabolizable energy or protein, depending on what limits animal production, may be profitable. Various practical supplementation strategies for tropical forages are discussed. Finally, some suggestions for future research and development for enhancing the profitability of pasture-based dairy production in the humid tropics are made. 相似文献
18.
RJ DOBSON RB BESIER EH BARNES SCJ LOVE A VIZARD K BELL LF Le JAMBRE 《Australian veterinary journal》2001,79(11):756-761
OBJECTIVE: To provide principles for the appropriate use of avermectin/milbemycin or macrocyclic lactone (ML) anthelmintics in sheep, to ensure effective worm control and to minimise selection for ML resistance. STRATEGY: The principles were based on an assessment of the information currently available. The MLs were categorised into three groups (ivermectin [IVM], abamectin [ABA] and moxidectin [MOX]) based on structural differences, persistence and efficacy against ML resistant strains. The reported order of activity or efficacy against ML resistant worm strains was IVM相似文献
19.
Knox MR Besier RB Le Jambre LF Kaplan RM Torres-Acosta JF Miller J Sutherland I 《Veterinary parasitology》2012,186(1-2):143-149
Gastrointestinal helminth parasites impact on livestock production systems throughout the world, and the use of anthelmintics to control this problem has lead to the inevitable development of populations of helminths resistant to these treatments. This, coupled with consumer desires for minimal chemical inputs into food and fibre production, has prompted research into non-chemical approaches to helminth control. Scientists of the "Novel Approaches to the Control of Helminth Parasites of Livestock" group met for the 6th time in August 2010 and this paper summarises that meeting. Six scientific sessions addressed current approaches and topics of interest through formal presentations and discussion of issues raised by the contributing authors. Close interaction between researchers and extension specialists during the meeting has contributed to enhanced prospects for field application of research outcomes in the future. 相似文献
20.
J. B. Matthews 《Equine Veterinary Education》2008,20(10):552-560
Intestinal nematodes are an important cause of equine disease. Of these parasites, the Cyathostominae are the most important group, both in terms of their prevalence and their pathogenicity. Cyathostomin infections are complex and control is further complicated by ever‐increasing levels of resistance to some of the commonly used anthelmintics. There are no new equine anthelmintics under development, so it is imperative that the efficacy of any currently‐effective drug classes be maintained for as long as possible. It is believed that the proportion of refugia (i.e. the percentage of parasites not exposed to a drug at each treatment) is one of the most crucial factors in determining the rate at which anthelmintic resistance develops. It is important, therefore, that levels of refugia be taken into account when designing nematode control programmes for horses. This can be assisted by knowledge of the local epidemiology of the infection, supplemented by faecal egg count analysis to identify those animals that are making the major contribution to pasture contamination. This type of rational nematode control requires equine veterinary surgeons to get involved in designing and implementing deworming programmes. The advice given must be based on a combination of knowledge of cyathostomin biology and epidemiology as well as an awareness of the parasite population's current drug sensitivity and a sound history of husbandry at the establishment. As anthelmintic resistance will be the major constraint on the future control of cyathostomins, researchers are now actively investigating this area. Studies are underway to develop tests that will enable earlier detection of anthelmintic resistance and an assay that will help identify those horses that require anthelmintic treatments targeted at intestinal wall larvae. 相似文献