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本试验将小型猪特异性麻醉剂(XFM)、氯胺酮复合安定及速眠新Ⅱ联合戊巴比妥钠三组麻醉药,对小型猪麻醉效果进行比较,将18头中国试验用小型猪随机分成3组,第一组肌肉注射猪小型猪复合麻醉剂(XFM)0.15 mL/kg体重;第二组氯胺酮(8 mg/kg体重)复合安定(1 mg/kg体重),肌肉注射;第三组速眠新Ⅱ0.1 mL/kg体重、戊巴比妥钠10.5 mg/kg体重,联合肌肉注射.试验结果表明,XFM组和速眠新Ⅱ组与氯胺酮组相比对体温和呼吸影响小;XFM组与其他两组比较麻醉诱导时间短,麻醉时间长,苏醒期短;氯胺酮组和XFM组与速眠新Ⅱ组相比麻醉镇痛、镇静、肌松效果好.综合评价XFM组与其他两组比具有对小型猪体温(T)、心率(HR)、呼吸频率(RR)影响小,麻醉时间适中,麻醉效果确实,镇静、镇痛、肌松效果均衡等优点. 相似文献
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本试验旨在观察小型猪特异性麻醉颉颃剂对小型猪的氧化损伤程度,及对小型猪特异性麻醉剂(XFM)的特异性颉颃效果。选用中国试验用小型猪14头,体重50kg左右,随机分为试验组和对照组,每组7头,均使用XFM肌肉注射进行麻醉,试验组使用小型猪特异性麻醉颉颃剂进行催醒,对照组则注射等量生理盐水,观察催醒效果,并检测血清中一氧化氮(NO)、一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)、丙二醛(MDA)浓度。结果表明,小型猪特异性麻醉颉颃剂后缩短了各项生理反射(夹耳反射、眼睑反射、痛觉等)的恢复时间(P0.05);血清MDA及SOD呈现无规则变化,且变化趋势不明显(P0.05),血清NOS及NO在注射XFM 30min后极明显降低(P0.01),然后逐渐回升,60min后恢复正常,差异不显著(P0.05)。表明小型猪特异性麻醉颉颃剂能够很好的拮抗XFM麻醉效果,产生较快的苏醒效果,在催醒过程中对小型猪没有产生明显的过氧化损伤,临床安全性较好。 相似文献
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本试验旨在研究小型猪特异性麻醉颉颃剂对小型猪特异性麻醉剂(XFM)麻醉下大鼠海马脑区c-jun基因mRNA转录的影响,藉以探究其催醒机制.90只成年SD大鼠被随机分成XFM麻醉组、XFM麻醉+生理盐水组、XFM麻醉+小型猪特异性麻醉颉颃剂组,每组分为5个不同采样时间点的亚组.采用实时荧光定量PCR技术检测样品中c-jun基因mRNA转录量.结果显示,XFM麻醉诱导大鼠海马脑区c-jun基因mRNA转录,各时间点海马脑区c-jun基因mRNA转录与0 min比较显著升高(P＜0.01),XFM麻醉大鼠腹腔注射生理盐水后各时间点海马脑区c-jun基因mRNA转录与XFM对照组间无显著差异(P＞0.05),注射小型猪特异性麻醉颉颃剂后抑制了XFM诱导大鼠海马c-jun基因mRNA的转录,与XFM对照组比较差异显著(P＜0.01或P＜0.05).结果表明,小型猪特异性麻醉颉颃剂抑制了XFM麻醉诱导大鼠海马脑区c-jun基因mRNA的转录,这可能与小型猪特异性麻醉颉颃剂催醒机制相关. 相似文献
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小型猪特异性麻醉颉颃剂对小型猪肝肾功能的影响 总被引：1，自引：0，他引：1
为研究小型猪特异性麻醉颉颃剂对小型猪肝肾功能的影响,以复合麻醉剂(XFM)麻醉的中国试验用小型猪为试验模型,采用小型猪特异性麻醉颉颃剂进行催醒,检测催醒过程中血清谷草转氨酶(GOT)、谷丙转氨酶(GPT)、碱性磷酸酶(ALP)、尿素氮(BUN)、肌酐(CREA)的变化。结果发现:不同时间点小型猪血清中各项指标与麻醉前相比,差异不显著(P>0.05),均在生理范围内波动。表明临床剂量的XFM特异性麻醉颉颃剂对小型猪肝肾功能无明显影响。 相似文献
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通过对麻醉过程中的心电图进行监测来比较3种复合麻醉剂对小型猪心电图的影响.将中国实验用小型猪分成3组,每组6头,第一组肌肉注射小型猪复合麻醉剂(XFM);第二组氯胺酮和安定联合肌肉注射;第三组速眠新Ⅱ和戊巴比妥钠联合肌肉注射,在麻醉后对心电图进行动态监测.氯胺酮组和速眠新Ⅱ组中的动物心电图波形发生了明显变化,XFM组动物在整个监测过程中未出现波形异常.3种药物麻醉后小型猪的心电图都发生了改变,与氯胺酮复合麻醉剂和速眠新Ⅱ复合麻醉剂相比,XFM对小型猪心电图影响轻微,安全性较高. 相似文献
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为了比较3种常用复合麻醉剂对小型猪循环、呼吸影响,将中国实验用小型猪分成3组进行比较.第1组肌肉注射小型猪复合麻醉剂(XFM)0.15 mL/kg体重;第2组联合肌肉注射氯胺酮8 mg/kg体重、安定1 mg/kg体重;第3组联合肌肉注射速眠新Ⅱ0.1 mL/kg体重、戊巴比妥钠10.5 mg/kg体重.试验结果表明,氯胺酮和速眠新Ⅱ对小型猪麻醉后的循环、呼吸系统有一定的抑制作用,尤其使用速眠新Ⅱ进行麻醉的小型猪血氧饱和度(SpO2)下降明显.XFM麻醉后小型猪循环、呼吸系统无明显影响,SpO2、血压(BP)以及呼吸系统各指标均在生理正常范围内,比较之下更适合用于小型猪的麻醉. 相似文献
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《饲料工业》2019,(18):54-58
应用电感耦合等离子-质谱技术(ICP-MS),建立饲料中钠、镁、铬、锰、铁、铜、锌、砷、硒、镉和铅等元素的测定方法。对饲料样品的前处理方法、仪器工作参数和11种元素标准曲线进行优化;并以加标回收、分析方法比对和重复测试说明方法的准确性和精密性。方法在0～1 000 ng/ml范围内线性良好,仪器检出限为0.557 7～5.072 ng/ml,具有良好的精密度,其回收率在88.1%～104.4%之间,相对标准偏差小于5.0%。同时与原子吸收和原子荧光方法进行比对,测定结果相近。所建立的方法简单、快速,可替代原子吸收和原子荧光方法测定饲料中的11种金属元素,为饲料的质量控制提供理想的元素分析方法。 相似文献
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In experiment 1, 6 pregnant mares received a concentrate that contained a trace mineral premix that provided 14.3 mg Cu, 40 mg Zn, 28 mg Fe, 28 mg Mn, 0.08 mg Co, 0.16 mg I, and 0.16 mg Se/kg concentrate (group A). Seven mares received the same concentrate plus 502 mg Zn and 127 mg Cu once daily (group B). No differences (P > .05) in foal growth data, or Cu, Zn, and Fe concentrations of mare milk, mare serum, or foal serum were observed. In experiment 2, 6 pregnant mares received the same concentrate as group A (group C), and 8 mares received the same concentrate fortified with 4× the trace mineral premix (group D). Group C mares had higher serum Zn concentration at 1 day (P < 0.01) and 56 days (P < 0.04). Group C mares had higher milk Fe concentration at 28 days (P < .01), and group D mares had higher milk Cu concentration at 56 days (P < .01). Group C foals had higher serum Cu concentration at 14 days (P < .03). The results from this study provide no evidence to indicate that supplementing late gestating and lactating mares with higher dietary trace mineral levels than those recommended currently by NRC has any influence on foal growth and development, or on the Cu, Zn, and Fe concentrations of the mare milk, mare serum, or foal serum. 相似文献
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Breed differences for weight (CW), height (CH), and condition score (CS) were estimated from records (n = 12,188) of 2- to 6-yr-old cows (n = 744) from Cycle IV of the U.S. Meat Animal Research Center's Germplasm Evaluation (GPE) Program. Cows were produced from mating Angus and Hereford dams to Angus, Hereford, Charolais, Shorthorn, Galloway, Longhorn, Nellore, Piedmontese, and Salers sires. Samples of Angus and Hereford sires were 1) reference sires born from 1962 through 1970 and 2) 1980s sires born in 1980 through 1987. The mixed model included cow age, season of measurement and their interactions, year of birth, pregnancy-lactation code (PL), and breedgroup as fixed effects for CW and CS. Analyses of weight adjusted for condition score included CS as a linear covariate. The model for CH excluded PL. Random effects were additive genetic and permanent environmental effects associated with the cow. Differences among breed groups were significant (P < 0.05) for all traits and were maintained through maturity with few interchanges in ranking. The order of F1 cows for weight was as follows: Charolais (506 to 635 kg for different ages), Shorthorn and Salers, reciprocal Hereford-Angus (HA) with 1980s sires, Nellore, HA with reference sires, Galloway, Piedmontese, and Longhorn (412 to 525 kg for different ages). Order for height was as follows: Nellore (136 to 140 cm), Charolais, Shorthorn, Salers, HA with 1980s sires, Piedmontese, Longhorn, Galloway and HA with reference sires (126 to 128 cm). Hereford and Angus cows with reference sires were generally lighter than those with 1980s sires. In general, breed differences for height followed those for weight except that F1 Nellore cows were tallest, which may in part be due to Bos taurus-Bos indicus heterosis for size. 相似文献
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液相色谱-串联质谱法测定动物尿液中11种β-受体激动剂残留量的不确定度评估 总被引：1，自引：1，他引：0
采用液相色谱-串联质谱法测定动物尿液中11种β-受体激动剂残留量,对标准溶液、体积、质谱峰面积、浓缩过程及回收率等测定不确定度因素进行了分析,通过评定各不确定度分量及标准不确定度,得出11种β-受体激动剂的扩展不确定度在0.7 ～ 1.1 ng/mL范围内.由各因素对合成不确定度的贡献比分析可知,影响较大的因素为试验回收率及标准溶液浓度. 相似文献
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