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1.
本研究为了探讨恶性黑色素瘤的临床诊断及鉴别诊断要点,通过组织病理学检查和免疫组织化学染色方法对两例犬恶性黑色素瘤进行诊断。组织病理学检查发现瘤细胞排列紊乱,细胞主要呈梭形和上皮样两种细胞形态,可见瘤巨细胞、核分裂相,肿瘤细胞胞质中可见色素颗粒,细胞异型性明显,核仁较大,有丝分裂活跃,属于恶性黑色素瘤典型的组织学表现。免疫组织化学染色发现六种肿瘤标记物结果显示为CK（-）、Vimentin（+）、S-100（+）、CD34（-）、SMA-α（-）、KI-67（+）。通过组织病理学检查和免疫组化染色结果可以诊断为恶性黑色素瘤。 相似文献
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血管周细胞瘤是一种软组织肉瘤,起源于毛细血管壁的周细胞。在本报道中,描述了一只11岁中华田园犬的左腿腕关节肿块。为确定肿块性质,采用影像学、细胞学和病理学检查加以诊断。X光检查显示肿瘤始于软组织,肿物界限清晰;细胞学检查显示细胞呈梭形,核仁明显,细胞核大小不一;病理组织学结果显示存在围绕血管的梭形细胞;免疫组织化学结果显示波形蛋白和α-SMA阳性表达,desmin和S-100阴性表达,肿瘤组织中PCNA阳性肿瘤细胞的数量大于25%,Masson trichrome染色显示肿瘤组织中胶原纤维的含量少。结合病理学及免疫组化确诊为血管周细胞瘤。 相似文献
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脾脏血肿通常是由脾脏组织或脾脏内血管破裂,导致血液进入脾脏包膜下引起。该病临床上多因强烈外力造成,发病率低、不易诊断和治疗。外伤引发的脾破裂,如果大出血,会危及生命。笔者对1只13岁的老年雌性金毛犬进行诊治。血常规检查结果显示为贫血;犬-反应蛋白（cCRP）结果显示重度感染。通过DR检查腹腔内见高密度团块阴影与脾脏黏连,初步怀疑为脾脏肿瘤。CT扫描腹腔,腹部有大型混杂软组织肿物,超声可见肿物内部血供源自脾脏。对其进行剖腹检查,对脾脏肿瘤切除并进行病理组织学观察。脾脏病理组织学显示脾脏组织坏死及严重出血,未发现脾脏肿瘤细胞。结合DR、CT影像及病理组织学检查结果,诊断为脾脏血肿。通过手术摘除脾脏,术后连续使用1周抗生素和止血药,同时调节肝肾功能。术后根据伤口愈合的实际情况调整药物。病犬于术后第7天痊愈出院,预后良好。 相似文献
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肝胆管细胞癌是来源于肝胆管上皮细胞的恶性肿瘤,在多物种中都有发生。笔者运用组织病理学和免疫组织化学的方法,对2例犬肝肿瘤进行了诊断。结果显示：肝肿瘤眼观均为圆球形白色肿块,组织病理学检查肿瘤组织由呈腺管状排列的瘤细胞构成,有的腺管中央有坏死脱落的细胞,有的有黏液样物质,腺管间以薄的纤维结缔组织分隔,瘤组织有大片的坏死。瘤细胞多呈卵圆形,细胞核大、卵圆形,核分裂象多见,瘤细胞的CK19阳性表达,而CK18和AFP呈阴性表达。根据组织病理学和免疫组织化学检查结果判断,2例犬肝肿瘤为肝胆管细胞癌,本研究为犬肝肿瘤诊断积累了病理学资料。 相似文献
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通过对一例患乳腺上皮细胞癌的金毛犬诊断与治疗,根据肿瘤的局部、全身症状,对肿瘤进行早期诊断,结合影像学检查、病理学诊断、病史调查和体格检查等作出确切诊断,并制定出相应的治疗方案.采取手术摘除肿瘤,对切下的肿块进行组织病理学检查,为以后类似病例提供诊疗经验. 相似文献
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青海省格尔木市某猪场和互助县某猪场发生以仔猪咳嗽、气喘为主要症状的呼吸系统疾病 ,天气恶劣时症状加剧。根据发病情况、临床症状和病理学检查 ,确诊为猪喘气病。现将诊治情况报道如下。1 材料与方法1.1 病料来源两猪场送检仔猪共 4头 ,放血屠宰 ,进行病理学剖检及病理组织学检查。1.2 病理诊断方法眼观检查法 :通过病理剖检 ,眼观检查仔猪肺、淋巴结、肝脏、肾脏、脾等器官的变化。组织学检查法 :取病猪的肺、淋巴结、肝脏、肾脏、脾等组织 ,用 10 %福尔马林固定 ,常规石蜡切片 ,Ｈ .Ｅ染色后进行病理组织学检查。2 病理变化2 .1 … 相似文献
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《黑龙江畜牧兽医》2020,(4)
10岁加菲猫1只,就诊前2 d该猫出现打喷嚏、流鼻涕、眼睛分泌物增多、食欲减退、迅速消瘦、嗜睡少动、毛发无光泽、饮水次数增多、尿量增多的症状,为了对其所患疾病进行诊断,试验采用临床症状观察、临床检查、实验室检查、影像学检查、开腹探查和病理组织学、细胞学及PCR和细菌的分离培养等方法进行诊断。结果表明:临床检查该猫体况差、消瘦,体温38.3℃,心率160次/min,呼吸频率28次/min,微循环灌注(CRT)正常;血常规指标检查未见明显异常;血液生化指标检查血氨、乳酸、球蛋白含量等增高;X射线和B型超声波检查,怀疑肝脏肿瘤和肠穿孔;开腹探诊肝脏隔面有多个凸出于组织表面的暗红色、颗粒状、大小不等的结节,经肝组织细胞学和病理组织学检查最后确诊该猫患有恶性肝细胞癌,同时并发传染性腹膜炎。 相似文献
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报道猫输卵管异位妊娠1例,兽医临床罕见,在猫科动物未见报道。1例2岁英国短毛猫,腹部触诊有一实质性硬物,临床检查无其他异常。X射线显示腹内有一边缘清晰的椭圆形肿物。对患猫进行腹腔探查并行子宫、卵巢摘除手术,并对摘除组织进行组织病理学检查,其诊断结果为输卵管异位妊娠,可见输卵管内有孕囊,囊壁透明变性,输卵管管壁、孕囊囊壁与胎儿组织均有钙化。子宫内膜出现Arias-Stell样反应。1年后回访,该猫无任何异常,各项生理功能均正常。猫输卵管异位妊娠临床罕见,对于临床相关疾病诊疗有一定的参考价值和借鉴意义。 相似文献
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Two 12-year-old cats were diagnosed with chronic kidney disease (CKD) based on physical examination, clinicopathologic data and, in one case, abdominal ultrasound findings. Approximately 1 year after the initial diagnosis of CKD both cats developed renal transitional cell carcinoma (TCC)--bilateral in one cat. Based on post-mortem examination, one cat had no evidence of metastasis and the other had metastasis to the large intestine, heart and lungs. This is the first report of de novo bilateral renal TCC in a cat, as well as the first report of renal TCC developing in cats with previous history of confirmed CKD. 相似文献
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Hepatobiliary neuroendocrine carcinoma was diagnosed in 17 cats in a period of 10 years. Seven tumors were of intrahepatic origin, one of which was a composite containing components of epithelial and neuroendocrine carcinoma. Nine tumors were of extrahepatic origin, and one tumor was located in the gall-bladder. The cats were adult and geriatric, and the male : female ratio varied according to tumor group. Hepatomegaly, anorexia, weight loss, and vomiting were the most common clinical signs observed in the cats with hepatic neuroendocrine carcinoma. The cats with extrahepatic neuroendocrine carcinoma showed these signs plus icterus (5/9) and high concentrations of hepatic enzymes. Histologically, the hepatic neuroendocrine carcinomas had two patterns, one with acinar structures separated by vascular stroma lined by cuboidal or columnar cells and the other solid with groups of anaplastic cells separated by vascular stroma. The composite tumor consisted of both bile duct carcinoma and neuroendocrine carcinoma. The extrahepatic neuroendocrine carcinomas and the gallbladder neuroendocrine carcinoma were characterized by solid sheets or groups of round to oval cells with vascular or fibrovascular stroma. Immunohistochemical examination of 10 of the neuroendocrine carcinomas revealed that all 10 stained with neuron-specific enolase; one bile duct carcinoma and the gallbladder carcinoma stained with chromogranin; four of five bile duct carcinomas and the gall bladder carcinoma stained with synaptophysin; and one bile duct carcinoma stained with gastrin. One cat with hepatic carcinoma had duodenal ulcer; in this cat, ultrastructural studies showed neurosecretory granules leading to the diagnosis of Zollinger-Ellison syndrome. In four cats in which necropsy was permitted, carcinomatosis (4/4), lymph nodes (4/4), lungs (2/4), and intestines (1/4) were the metastatic sites. Fourteen of the 17 cats were euthanatized during or immediately after surgery. 相似文献
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This case report describes a cat with metastasis of a bronchial adenocarcinoma to the abdominal skin. The cat had been treated with antibiotics and corticosteroids for several episodes of coughing when it acutely developed erythema, pustules and plaques on the abdominal skin. Diagnosis was based on cytological examination of fine-needle aspirates of cutaneous pustules, X-ray examination of the thorax and histological examination of skin biopsy samples. As the prognosis was poor, the cat was euthanased. Necropsy findings confirmed the diagnosis. Cutaneous metastases of lung carcinoma are rare in cats but have been reported in the digits with underlying bone involvement. To the authors' knowledge, this is the first report of metastasis of a feline bronchial carcinoma to the ventral skin. 相似文献
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Hyperadrenocorticism in cats: seven cases (1978-1987) 总被引：1，自引：0，他引：1
R W Nelson E C Feldman M C Smith 《Journal of the American Veterinary Medical Association》1988,193(2):245-250
Hyperadrenocorticism was diagnosed in 7 cats with concurrent diabetes mellitus. Four cats had pituitary adenoma with bilateral adrenocortical hyperplasia, 1 cat had pituitary carcinoma with bilateral adrenocortical hyperplasia, 1 cat had adrenocortical carcinoma, and 1 cat had adrenocortical adenoma of the left adrenal gland. One year later, adrenocortical adenoma involving the right adrenal gland also was diagnosed in this cat. Clinical signs included polyuria and polydipsia (n = 7), development of pot-bellied appearance (n = 5), dermatologic alterations (n = 5), lethargy (n = 3), weight loss (n = 3), dyspnea/panting (n = 2), and recurrent bacterial infections (n = 2). In 6 cats, the diagnosis of hyperadrenocorticism was established before death on the basis of results of the ACTH stimulation test (n = 3) and the dexamethasone screening test (n = 5). Pituitary-dependent hyperadrenocorticism was differentiated from adrenocortical neoplasia on the basis of results of the dexamethasone suppression test (n = 4), endogenous ACTH concentration (n = 3), results of abdominal radiography and ultrasonography (n = 3), and exploratory celiotomy (n = 1). Four cats died or were euthanatized without treatment attempts. Treatment with mitotane followed by 60Co teletherapy was ineffective in one cat with pituitary adenoma. One cat with pituitary carcinoma died one week after bilateral adrenalectomy. Bilateral adrenocortical adenomas were removed surgically in the affected cat. 相似文献
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W F Immink A J van Toor J H Vos J S van der Linde-Sipman A A Lubberink 《The Veterinary quarterly》1992,14(3):81-85
This paper describes four cats with hyperadrenocorticism. Cat 1 showed polydipsia and polyphagia. Diabetes mellitus was initially diagnosed. As the animal appeared to be insulin resistant, pituitary and adrenocortical function tests were performed and the diagnosis of hyperadrenocorticism was made. Resistance to the high-dose dexamethasone suppression test was noticed in this cat. Pathological examination revealed a pituitary chromophobe adenoma. Cat 2 presented with diabetes mellitus, which was treated with insulin. The animal had a pendulous abdomen and its coat was in a poor condition. The low-dose dexamethasone suppression test demonstrated hyperadrenocorticism. Necropsy findings of pituitary tumour and hyperplasia of the adrenal cortex confirmed the diagnosis. Cat 3 showed clinical abnormalities indicative of hyperadrenocorticism, for instance, muscle weakness, alopecia, multiple abscesses. The diagnosis of hyperadrenocorticism was confirmed by the results of the lowe-dose dexamethasone suppression test. Pathological examination revealed an adrenocortical carcinoma. Cat 4 presented with polydipsia. The cause of this symptom was not found initially. One and a half years later additional symptoms, such as nephritis and polyphagia developed. Hyperadrenocorticism was diagnosed because of a palpable mass cranial to the left kidney. The diagnosis was confirmed by the results of the lowe-dose dexamethasone suppression test and the necropsy findings. 相似文献
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The objective of the research was to characterize the clinical, fluorescein angiographic, pathologic and microscopic features of feline pulmonary carcinoma with ocular metastasis that resulted in ischemic chorioretinopathy. Four cats with confirmed or presumed primary pulmonary neoplasia with posterior segment metastasis were studied. The medical records from four cats with a diagnosis of bronchogenic carcinoma and intraocular metastasis were reviewed. Physical and ophthalmic examinations and thoracic radiographs were performed in all cases, and fluorescein angiography was performed in two cases. Classification of the neoplasms was determined by fine-needle aspiration and biopsies of peripheral metastatic lesions, and/or complete necropsies. All four cases had unilateral or bilateral blindness and ophthalmoscopic lesions characterized by a wedge-shaped, tan discoloration in the tapetal fundus, variable but mild serous exudation under the retina, and profoundly attenuated retinal vasculature. Painful swelling and necrosis of the distal extremities and/or mass lesions in the appendicular musculature were also present. Clinical findings, along with microscopic findings from biopsy specimens or complete postmortem examination, documented widespread metastasis of variably differentiated, neoplastic, columnar epithelial cells presumed to be of bronchial origin. Tumor cells were predominately located within the systemic vasculature, consistent with classification of angioinvasive pulmonary carcinoma. Fluorescein angiographic and histopathologic findings in the affected globes suggested that the posterior segment lesions resulted from invasion and growth of neoplastic cells within the chorioretinal vasculature, resulting in secondary ischemic necrosis of the retina and choroid. Ischemic chorioretinopathy and necrosis of the distal extremities, associated with primary bronchogenic carcinoma, appear to be a unique neoplastic syndrome in the domestic cat. 相似文献
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Suzanne M. Cook DVM Gregory B. Daniel DVM MS Michael A. Walker DVM MS Jeanne M. Maddux DVM PhD Christine C. Jenkins DVM Edward R. Klebanow DVM Donna M. Bouley DVM David F. Dean DVM Mark G. Petersen DVM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1993,7(5):303-308
Three cats were diagnosed as hyperthyroid based on clinical signs, historical findings, laboratory abnormalities, and basal serum thyroxine (T4 ) concentrations, and/or nuclear thyroid scans. Additionally, a presumptive diagnosis of thyroid carcinoma with pulmonary metastasis was made in each cat based on radiographic or scintigraphic evaluation. All three cats had solitary pulmonary nodules 1.5 to 2 cm in diameter on survey thoracic radiographs; one cat also had chylous pleural effusion and pulmonary lobar consolidation. Focal pulmonary accumulation of sodium pertechnetate (99m TcO4 -) and/or radioiodine (131 I) corresponding to radiographic lesions were seen in all cats. Two cats were treated with single ablative doses (1111 to 1480 MBq) of131 I; the remaining cat was euthanatized.
One of the treated cats died 8 days later; the other cat was euthanatized 22 weeks following treatment. Histopathologic examination of tissue obtained at necropsy confirmed metastatic thyroid carcinoma in one cat and bronchogenic adenocarcinoma in two cats. Our findings indicate that increased radionuclide uptake in focal pulmonary lesions and cytologic evaluation of tissue obtained by fine-needle aspiration are not specific for thyroid tissue. (Journal of Veterinary Internal Medicine 1993; 7:303–308. Copyright © 1993 by the American College of Veterinary Internal Medicine.) 相似文献
One of the treated cats died 8 days later; the other cat was euthanatized 22 weeks following treatment. Histopathologic examination of tissue obtained at necropsy confirmed metastatic thyroid carcinoma in one cat and bronchogenic adenocarcinoma in two cats. Our findings indicate that increased radionuclide uptake in focal pulmonary lesions and cytologic evaluation of tissue obtained by fine-needle aspiration are not specific for thyroid tissue. (Journal of Veterinary Internal Medicine 1993; 7:303–308. Copyright © 1993 by the American College of Veterinary Internal Medicine.) 相似文献
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Becker TJ Perry RL Watson GL 《Journal of the American Animal Hospital Association》1999,35(6):499-505
A 12-year-old, spayed, female domestic shorthair cat was diagnosed with severe and extensive hypertrophic osteopathy of the appendicular skeleton. Diagnostic ultrasound detected a mass lesion in the right adrenal gland. A right adrenalectomy was performed, and histopathological examination confirmed an adrenocortical carcinoma. No radiographic evidence of pulmonary metastasis was found on initial presentation or recheck thoracic radiographs taken 15 weeks later. Almost complete regression of periosteal new bone formation occurred 15 weeks following the successful surgical removal of the adrenal tumor. 相似文献
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A 14-year old domestic shorthair cat was presented because of vomiting, anorexia and an abdominal mass. A diagnosis could not be made preoperative and during surgery the mass was assigned to the gastric part of the pancreas. A partial pancreatectomy and splenectomy was performed using a Ligasure? vessel sealing device. No surgery related complications occurred. Histological examination revealed an anaplastic carcinoma of the pancreas. The cat was in a good clinical condition 14 days after surgery. After 2 months the cat was euthanized with the suspicion of a bone tumor. Findings of this case demonstrate that pancreatic carcinoma in cats has a poor prognosis but pancreatectomy can be performed using a bipolar vessel sealing device as a safe and fast alternative to standard surgical techniques. 相似文献
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Introduction: STI571 (Gleevec, imatinib mesylate) is a receptor tyrosine kinase inhibitor with selectivity for Bcr‐Abl, platelet‐derived growth factor (PDGF), stem cell factor (SCF), and c‐Kit. Side effects with use in humans include vomiting, diarrhea, nausea, myalgia, edema, and cutaneous reactions. Renal and hepatic toxicity have also been reported. In dogs, there is significant hepatic toxicity at sub‐clinical doses. The purpose of this prospective study was to determine the toxicity level and potential treatment protocol in tumor bearing cats. Methods: A phase I clinical trial was performed in client owned cats using an escalating dose of STI571 in tumor bearing cats. Cats included in the study had a histologic diagnosis of fibrosarcoma or other tumors and were staged with CBC, biochemical profile, thoracic radiographs, and abdominal ultrasound. None of the cats received concurrent chemotherapy, but those previously treated with surgery, radiation therapy, or chemotherapy, were not excluded. The initial starting dose was 5 mg/cat PO SID and was gradually increased to 10 and 20 mg/cat PO SID at a 2–6 week interval depending on laboratory work and disease progression. A repeat physical examination, CBC, and biochemical profile, were performed every 2 weeks for 2 rechecks, then every 4 weeks. Results: Six cats were enrolled in the study. Four cats had oral squamous cell carcinoma, and two cats had cutaneous fibrosarcoma. One cat demonstrated leukocytosis, increased liver enzymes, and signs of acute renal failure two weeks after initiating therapy (5 mg PO SID). No dose escalation was made in this cat. Five cats endured dose escalations of 10 mg PO SID in two cats and 20 mg PO SID in three cats and were treated for 2–4 months. None of these cats experienced any signs of toxicity as measured by CBC and biochemical profile. Conclusions: Only one cat experienced toxicity that may have been associated with low dose administration of STI571. As most cats tolerated the drug without an adverse effect, further evaluation of STI571 in a phase II clinical trial is warranted. 相似文献