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肥厚型心肌病是猫常见的心脏疾病,目前其临床诊断和治疗管理均存在一定的挑战。生物标志物是近年来新兴的心脏病临床诊断工具,通常操作简便快捷,与心脏病常规诊断技术联合使用,可为疾病的诊断、监测和预后提供更多信息。本文归纳了心脏生物标志物在猫肥厚型心肌病诊疗中的应用现状和研究进展,旨在为生物标志物在猫肥厚型心肌病中的临床应用提供循证医学依据,为猫心肌病相关的新型心脏生物标志物的开发提供理论参考。 相似文献
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猫肥厚性心肌病(HCM)是临床上最常见的猫心脏疾病,该病主要以心室壁异常增厚为特征,与基因遗传有关。本文报告了一例美国短毛猫因去势手术诱发猫肥厚性心肌病。临床表现为呼吸急促,张口呼吸窘迫症状;X光检查肺部水肿,心脏轮廓增大,呈典型"爱心型"心脏影像;猫利钠肽前体快速检测试剂(SNAP Feline Pro BNP Test)检查呈阳性;超声波检查心肌肥厚,确诊为肥厚性心肌病。随对该患猫进行积极治疗。治疗一周后病情得到缓解,出院后长期服用心脏病药物来维持其心脏功能,回访,未出现异常。 相似文献
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肥厚性心肌病（Hypertrophic cardiomyopathy,HCM）是猫最常见的心脏病，特征是心室壁向心性增厚并发乳头肌肥厚。猫HCM继发动脉血栓栓塞（Arterial thromboembolism,ATE）检出率逐年升高，此病总体存活率低至35%，越来越受到重视。该文综述了猫HCM继发ATE的诊断与治疗进展，并特别介绍了目前主要治疗药物及其疗效。提出针对好发品种尽早建档，定期体检筛查，发病后及时送医；选育新品种；提高手术治疗和中西医结合治疗的技术；谨慎使用治疗血栓药物，尝试使用新型抗栓溶栓药物等综合措施以期提高此病治愈率。 相似文献
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猫肺高压(PH)相对少见,发病隐蔽,诊断难度高,缺乏相关治疗经验。2019年5月,笔者接诊了1例因呼吸困难、腹围增大前来就诊的患猫,通过详细的病史调查和体格检查初步怀疑患猫存在左心和右心充血的问题。超声心动检查结果显示,患猫存在严重的左心室局灶性增厚,针对右心的进一步检查确认了严重PH。结合血压检查结果和患猫的整体发病特点,患猫最终确诊为肥厚型心肌病(HCM)并发严重PH,且已出现全心充血性心衰。笔者在治疗患猫心衰方案的基础上添加了枸橼酸西地那非。患猫自确诊并治疗后存活了8个月。笔者希望通过本文向广大兽医师阐述猫PH的诊断要点,尤其是超声心动检查时需要注意的影像学表现,同时分享枸橼酸西地那非治疗猫PH的一些经验。 相似文献
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猫肥厚性心肌病(HCM)是宠物临床上最常见的一种心脏病,患猫发病前几乎没有任何症状,一旦发病则可能出现心力衰竭和血栓性栓塞等症状,甚至突然死亡。本文报道了一只9月龄中华田园猫,通过临床症状、SNAP检查、实验室检查以及心动超声检查等进行综合诊断,确诊该猫患有肥厚性心肌病。对其进行保守的药物疗法,患猫预后不良。 相似文献
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Hypertropic cardiomyopathy and hyperthyroidism in the cat 总被引：2，自引：0，他引：2
S K Liu M E Peterson P R Fox 《Journal of the American Veterinary Medical Association》1984,185(1):52-57
In a 21/2-year period, hypertrophic cardiomyopathy was found at necropsy of 23 cats that died (13 cats) or were euthanatized (10) because of problems associated with hyperthyroidism. Of these, 4 (17%) also had evidence of cardiac failure (pulmonary edema or pleural effusion). The mean body weight of the cats with hyperthyroidism and hypertrophic cardiomyopathy was significantly less (P less than 0.001) than that of clinically normal cats and cats with primary cardiomyopathy (congestive or restrictive) or excessive moderator band cardiomyopathy. In addition, the ratio of heart weight to body weight was significantly greater (P less than 0.001) in the 23 hyperthyroid cats than in the normal cats and cats with primary cardiomyopathy. Twenty (87%) of the cats had symmetric hypertrophy of the ventricular septum and left ventricular free wall, whereas the remaining 3 cats had disproportionate thickening of the ventricular septum, compared with the free wall, similar to what is found in cats with asymmetric hypertrophic cardiomyopathy. Histologic cardiac abnormalities included large, hyperchromatic nuclei, interstitial fibrosis, endocardial fibroplasia, fibrosis of the atrioventricular node, and marked disorganization of cardiac muscle cells. The study showed that hypertrophic cardiomyopathy develops in most hyperthyroid cats, some of which also develop congestive heart failure. Although the signs of heart disease in primary myocardial disease and thyrotoxic disease are similar, the characteristic signalment and clinical signs of hyperthyroidism should lead one to suspect the association of hypertrophic cardiomyopathy with the hyperthyroidism. 相似文献
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A 7.5-year-old male Persian cat with a history of asymptomatic hypertrophic cardiomyopathy was examined for severe lethargy and dyspnoea. Physical examination revealed bradycardia (60 beats/ minute), and ECG investigation revealed persistent atrial standstill that was most likely caused by atrial fibrosis. Persistent atrial standstill is a very rare cardiac condition in cats and is characterized by a complete lack of mechanical, electrical, and possibly endocrine function of the atria. Several pathophysiological mechanisms can cause atrial standstill and include hyperkalaemia, intoxication, and atrialfibrosis. On the basis of the clinical findings, atrial fibrosis was the most likely cause of atrial standstill in this cat. Treatment depends on the underlying cause, but pacemaker implantation can be considered if there are structural abnormalities. The prognosis is guarded in such cases. In this particular case, the cat was euthanized at the owner's request. 相似文献
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The importance of cardiomyopathy as a cause of heart disease in the cat has been well-documented in the U.S.A., but has had little attention in the British literature. This paper records the pathological changes in 12 cats which were identified as cases of feline primary myocardial disease. The main lesions were dilatation of ventricles or atria, and degeneration and fibrosis in the myocardium. Of the 12 cats, three had been diagnosed as having iliac thromboembolism, shown on autopsy to be secondary to cardiomyopathy and atrial thrombosis. In the other cats signs were often vague, cardiac disease had not been suspected and varied clinical and symptomatic diagnoses had been considered. 相似文献
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Mark D. Kittleson DVM PhD Paul D. Pion DVM Laura A. DeLellis DVM Yousry Mekhamer BVSc Noel Dybdal DVM PhD Clinton D. Lothrop Jr. DVM PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1992,6(6):320-324
Serum growth hormone concentration was measured by radioimmunoassay in 31 cats with hypertrophic cardiomyopathy, 38 normal cats, and 35 cats with other cardiac disease. Cats with hypertrophic cardiomyopathy had a significantly increased serum growth hormone concentration when compared with normal cats and cats with other cardiac disease. The serum growth hormone concentration in cats with hypertrophic cardiomyopathy was less than that previously reported in cats with growth hormone secreting pituitary tumors. Pituitary tumors were not identified in eight of the cats with hypertrophic cardiomyopathy examined at necropsy. An increased serum growth hormone concentration may be measured in cats with hypertrophic cardiomyopathy but it is unclear if the increased serum growth hormone concentration is a cause or effect of hypertrophic cardiomyopathy. 相似文献
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Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. Hypertrophic cardiomyopathy is poorly described in the Sphynx. The objective of this study was to phenotypically characterize Sphynx hypertrophic cardiomyopathy and to evaluate for a familial etiology. Records of 18 affected cats (11 female, seven male) were evaluated. Age of affected cats ranged from 0.5 to 7 years (median, 2 years). Four affected cats were from a single family and included an affected cat in each of four generations (three females, one male). Further studies are warranted to evaluate for a causative mutation and better classify the phenotypic expression. 相似文献
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Tsujino K Hikasa Y Minami S Okamoto Y Morita T Shimada A 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(6):631-634
A 10-year-old cat with the paresis of hind limbs was initially diagnosed as a hypertrophic cardiomyopathy followed by acute thromboembolism of caudal abdominal aorta from the findings of the medical examinations. However, this case was proved to be an chronic myocardial infarction due to arteriosclerosis of coronary arteries by the pathologic diagnosis. In the left ventricular, the hypertrophy and the narrowing were slight, and a coagulative infarction was seen obviously. The intramural coronary arteriosclerosis showed thickening of the wall due to medial hyperplasia by fibrosis, and arterial stenosis. Myocardial infarction and arteriosclerosis are scarcely any reports of these lesions in cats. This case is valuable for an extremely rare case of myocardial infarction in the cat. 相似文献
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《Veterinary journal (London, England : 1997)》2015,203(1):18-26
Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD. 相似文献
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Taillefer M Di Fruscia R 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(5):437-445
Twenty-one cats with hypertrophic cardiomyopathy were enrolled in this study to determine if the administration of benazepril (0.5 mg/kg body weight [BW], PO, q24h) to cats with subclinical hypertrophic cardiomyopathy improves cardiac diastolic function and reverses left ventricular hypertrophy when compared with diltiazem controlled delivery (CD) (10 mg/kg BW, PO, q24h). Cats were evaluated at day 0 and after 3 and 6 months of therapy. In the benazepril group (n = 11), the diastolic transmitral flow of the E and A waves ratio (E/A ratio) increased significantly between 0 and 6 months (P = 0.009) and the thickness of the left ventricular free wall in systole (LVFWs) decreased significantly between 0 and 3 months (P = 0.04). In the diltiazem CD group (n = 5), none of the parameters varied significantly throughout the study. There was no difference between the benazepril and the diltiazem CD group throughout the study. Therefore, the variations observed for the E/A ratio and the LVFWs may have been incidental. Further studies will be needed to establish the role of benazepril in subclinical hypertrophic cardiomyopathy in cat. 相似文献
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During the last 3 years, a total of 144 cats underwent echocardiographic screening at two investigational clinics before being admitted for breeding. The number of cats presented for that purpose has constantly increased. 8.3% of cats were diagnosed as having hypertrophic cardiomyopathy and 6.9% were diagnosed as suspicious. Male cats were more affected than females (9.4% vs 7.7%). In 4.2 of all presented cats, a congenital cardiac malformation was recognised, most often tricuspid valve dysplasia. 相似文献
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Myocardial taurine concentrations in cats with cardiac disease and in healthy cats fed taurine-modified diets. 总被引：2，自引：0，他引：2
Myocardial taurine concentrations were measured in cats with cardiac disease and in healthy cats fed diets with various concentrations of taurine. Group 1 was composed of 26 cats with 3 categories of naturally developing cardiac disease: dilatative cardiomyopathy (group 1A), 10 cats; hypertrophic cardiomyopathy (group 1B), 9 cats; and volume overload (group 1C), 7 cats. These cats had been fed various commercial diets. Group 2 was composed of 40 healthy cats that had been fed diets varying in taurine concentration (0 to 1% taurine) for at least 2 years. Mean myocardial taurine concentrations did not differ significantly between group-1 cats with dilatative cardiomyopathy and those with hypertrophic cardiomyopathy or volume overload. Cats in group 1A had a mean myocardial taurine concentration 3 times higher than healthy cats fed a taurine-free diet (P less than 0.002). Mean myocardial taurine concentrations did not differ significantly between group-1A cats and healthy cats fed a diet containing 0.02% taurine; group-1A cats had significantly lower mean myocardial taurine concentrations than did healthy cats fed a synthetic diet containing 0.05 or 1.0% taurine (P less than 0.001). Acute oral administration of taurine in 5 group-1A cats appeared to increase mean myocardial taurine concentrations, compared with similar cats not given taurine during treatment for cardiac failure. In group-2 cats, mean myocardial taurine concentrations increased directly with percentage of dietary taurine. 相似文献