共查询到20条相似文献，搜索用时 27 毫秒
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C. Mackenzie E. Haggett S. Powell M. Swarbrick T. Leaman 《Equine Veterinary Education》2018,30(10):518-521
A Thoroughbred colt with a history of dystocia was referred for further management of suspected hypoxia. The foal showed signs of neonatal maladjustment syndrome and hindlimb paralysis. Radiography revealed the presence of a severe lumbosacral injury. The foal was subjected to euthanasia due to a hopeless prognosis. Computed tomography was performed post‐mortem and revealed a type I Salter Harris fracture of the cranial physis of the first sacral vertebra. 相似文献
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A 3-year-old, 4.0 kg, female, spayed Silver Marten cross rabbit (Oryctolagus cuniculus) was presented for evaluation of a suspected recurring spindle cell sarcoma following primary excision by the referring veterinarian. Physical examination revealed a large subcutaneous mass on the left metatarsus and a fine needle aspirate revealed suspected neoplastic spindle cells. Hematologic evaluation was unremarkable and a computed tomography scan revealed invasion of the mass into skeletal muscles but showed no evidence of metastatic disease. An amputation was performed, after which the patient recovered uneventfully. However, the rabbit was found suddenly dead at time of discharge from unknown cause. Gross, histologic, and immunohistochemical evaluation was performed, which diagnosed a peripheral nerve sheath tumor. To the authors’ knowledge, this is the first detailed case report of a lagomorph peripheral nerve sheath tumor specifically confirmed with immunohistochemistry. Wide surgical excision is considered the treatment of choice and may be combined with radiation therapy. Further research is required to determine risk factors, the role of adjunctive therapy, as well as long-term prognoses for peripheral nerve sheath tumors in rabbits. 相似文献
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Surgical resection of a dysgerminoma in a mare 总被引：1，自引：1，他引：0
A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal with no history of health problems. Ultrasonographic examination of the mass confirmed its presence, but the origin of the mass could not be accurately determined. Routine haematology and serum biochemistry results were within normal limits. The mare was initially treated conservatively with antibiotics, but the mass continued to increase in size, so it was surgically excised. The mass involved the left ovary. The mare showed transient abdominal pain after surgery, but developed no other complications and was in foal 7 months later. On histology, the mass was diagnosed as a dysgerminoma, a rare ovarian tumour of germ cell origin. 相似文献
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Mellor PJ Polton GA Brearley M Haugland S Smith KC Scase TJ McNeil PE Holloway A Archer J Powell RM Villiers EJ Herrtage ME Argyle DJ Day MJ 《Journal of Feline Medicine and Surgery》2007,9(1):72-77
This is the first report of feline solitary plasmacytoma of bone. We describe the clinical, clinico-pathological, radiographic and pathological findings of two successfully treated cats with long-term follow-up. The first case presented with spinal pain and neurological deficits. Radiographs demonstrated sclerosis of lumbar vertebra L6 and a myelogram confirmed interference to flow of contrast in the L4-7 region. A biopsy of L6 revealed neoplastic plasma cell infiltration. There was no evidence of paraproteinaemia on serum protein electrophoresis. The cat underwent hypofractionated megavoltage radiotherapy. Clinical signs resolved completely and 4 years after diagnosis the cat remains well and has no electrophoretically detectable paraproteinaemia. The second case presented with neurological deficits of the tail and spinal radiographs revealed extensive osteolysis of the sacrum. A biopsy of sacral bone demonstrated neoplastic plasma cell infiltration. The animal was normoglobulinaemic. The cat improved clinically with induction chemotherapy (melphalan and methylprednisolone). The same chemotherapeutics were continued at maintenance doses for 4.3 years, at which time there was recurrence of neurological deficits and a palpable sacral mass. Cytological examination of a fine needle aspirate confirmed recurrence of plasma cell neoplasia. A low concentration monoclonal paraproteinaemia was detected. Vincristine was administered resulting in resolution of neurological deficits and a palpably smaller sacral mass. Eighteen months into vincristine therapy, there was recurrence of clinical signs and the cat was euthanased, more than 6 years after the initial diagnosis. 相似文献
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Aitor Gallastegui Emma Davies Allison L. Zwingenberger Stephanie Nykamp Mark Rishniw Philippa J. Johnson 《Veterinary radiology & ultrasound》2019,60(5):533-542
Complete assessment of vertebral trauma in dogs currently requires CT and MRI for evaluation of the osseous and soft tissue structures that contribute to vertebral stability. Some studies in people have suggested that MRI may be sensitive and specific at detecting vertebral fractures making this potentially a single modality that could be used in spinal trauma evaluation. This study aimed to assess the ability for observers to evaluate vertebral fractures using MRI when compared to CT, which was used as the reference standard. Twenty‐nine dogs with previously diagnosed acute vertebral fractures and four dogs with no vertebral fracture that had undergone sequential CT and MRI were included into the study. One hundred twenty‐eight vertebrae were evaluated for the presence of fractures. Imaging studies were read by two observers blinded to the history. While both observers had similarly high sensitivity and specificity for simple detection of any fractured vertebrae, interobserver agreement was only moderate (κ = 0.584). When evaluations were specifically limited to detection of structurally unstable fractured vertebrae both observers showed improved specificity and interobserver agreement became substantial (κ = 0.650). Complete agreement for exact fracture location between MRI and CT results was only achieved in 14.3‐32.6% of fractured vertebra with up to 79% of fractures being missed in some vertebral structures. This suggests that although MRI may be able to detect the presence of fractured vertebrae, it is not able to replace CT for the complete evaluation of the traumatized spine and documentation of fracture morphology. 相似文献
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eryl C. Jones DVM PhD Donald C. Sorjonen DVM MS Stephen T. Simpson DVM MS Joan R. Coates DVM MS Stephen D. Lenz DVM PhD John T. Hathcock DVM MS Michelle W. Agee MD PhD Jan E. Bartels DVM MS 《Veterinary radiology & ultrasound》1996,37(4):247-256
In a three-year prospective study, computed tomographic (CT) and surgical findings were compared for nine large breed dogs with lumbosacral stenosis. Surgically-excised tissue was examined histologically in seven dogs and additional necropsy evaluation was performed in one dog. The CT abnormalities observed at sites of confirmed cauda equina compression were: loss of epidural fat, increased soft tissue opacity, bulging of the intervertebral disc margin, spondylosis, thecal sac displacement, narrowed intervertebral foramen, narrowed vertebral canal, thickened articular process, articular process subluxation, articular process osteophyte, and telescoped sacral lamina. The CT characteristics of lumbosacral degenerative disease and discospondylitis were similar to those described in humans. In three dogs, CT findings at the site of cauda equina compression were consistent with congenital or developmental spinal stenosis, but the method of surgical exposure precluded confirmation. Epidural fibrosis (eight dogs) and multi-level CT abnormalities (six dogs) were identified but the cause(s) and significance were unknown. 相似文献
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A 10-year-old Rocky Mountain Saddle Horse mare was initially presented for erratic estrous cycles, infertility, and an enlarged ovary. The initial differential diagnosis list comprised neoplastic and nonneoplastic ovarian conditions. The primary differential diagnosis of granulosa cell tumor was deemed less likely because of clinical findings and laboratory results. Because of the chronic nature and apparent infertility resulting from the abnormal ovary, surgery was elected to remove the affected ovary. Exploratory laparotomy confirmed the presence of the enlarged ovary; however, a larger oviductal tumor was discovered. Both the ovary and tumor were removed and the mare recovered uneventfully. The mare cycled normally, conceived, delivered a healthy foal, and is currently in late gestation with her second pregnancy. 相似文献
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Nicola Scilimati Stefano Schiavo Eleonora Lauteri Francesca Beccati Giovanni Angeli Antonio Di Meo Marco Pepe 《Equine Veterinary Education》2023,35(2):82-86
This case report describes the clinical and diagnostic imaging findings, treatment and outcomes of a 15-day-old Thoroughbred foal referred for the evaluation of severe left hindlimb lameness of 8 days' duration. Radiographic examination of the left hindlimb and transcutaneous ultrasonographic examination of the pelvis were unremarkable. A computed tomographic (CT) examination was performed to investigate the proximal aspect of the limb and the pelvis; CT scans of the thorax were also acquired. In this case, CT images allowed detection of a closed, slightly displaced, oblique wedge-like fracture of the left caudal ramus of the pubis and medial ramus of the ischium, allowing an accurate diagnosis to guide appropriate treatment and prognostication. The foal was treated with anti-inflammatory drugs and box-rest. A follow-up by telephone interview with the trainer 3 years later revealed that the horse is in full athletic activity without any residual gait alteration related to the pelvic fracture. 相似文献
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Hemoperitoneum caused by rupture of a juvenile granulosa cell tumor in an equine neonate 总被引：1，自引：0，他引：1
S L Green T E Specht S C Dowling A J Nixon J H Wilson J B Carrick 《Journal of the American Veterinary Medical Association》1988,193(11):1417-1419
A neonatal foal was examined because of apparent abdominal pain and distention, anemia, and hemoperitoneum. Exploratory laparotomy was performed, and a large spherical mass, which had ruptured, was found in the area of the left ovary. Left salpingo-oophorectomy was performed. The mass was determined to be a juvenile granulosa cell tumor. 相似文献
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Artashes R. Khachatryan Tamara B. Wills Kathleen A. Potter 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2009,38(2):257-260
Abstract: A 1‐year‐old, castrated male, mixed‐breed dog was presented for sporadic episodes of kyphosis, tremors, and vocalizing. On neurologic examination, the lesion was localized to spinal cord segments T3–L3. Magnetic resonance imaging of the spine showed an expansile mass occupying most of the ventral aspect of the spinous process of T6. Fine‐needle aspirates of the mass were examined cytologically. A moderately cellular population of pleomorphic spindle cells and abundant mucinous matrix were observed. The cytologic diagnosis was spindle cell neoplasia, with myxosarcoma and fibrosarcoma as the primary differential diagnoses. The dog was euthanized. Histopathologic evaluation of the mass and surrounding tissue confirmed a low‐grade spindle cell sarcoma, with severe compressive myelopathy and mild neutrophilic inflammation. The neoplastic cells stained positive for mucopolysaccharides with Alcian blue, resulting in a final diagnosis of low‐grade (grade 1) myxosarcoma. Fine‐needle aspiration was useful in making a preliminary diagnosis of myxosarcoma in this case. Myxosarcoma should be included in the differential diagnosis for a vertebral mass in a young dog. 相似文献
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A 36-day-old, 100-kg Thoroughbred colt was presented with a sudden onset of abnormal head carriage and pyrexia. Radiography revealed an osteomyelitis of the vertebral body of the second cervical vertebra. Ultrasonography revealed abscessation in the region of the atlantoaxial articulation on the left side, and fluid aspirated from the abscess confirmed suppurative inflammation. Surgical management was not feasible on economic grounds, and therefore this case was managed with aggressive medical therapy based on the most likely pathogens involved. To provide prolonged antibiotic therapy within the client’s budget, the antibiotic flucloxacillin (Staphlex, 500 mg) was used at a dose of 10 mg/kg by mouth, three times daily. Thirty-eight days after first presentation, the foal was euthanized because of chronic pain and deterioration in neurologic signs. A diagnosis of chronic osteomyelitis of the body of the second cervical vertebra (axis) was made with concurrent septic arthritis of the atlantoaxial joint involving the articular surface of the first cervical vertebra (atlas) and cervical myelopathy of the spinal cord within the first two vertebrae. No pathogens were isolated post mortem. This is the first report to describe the use of flucloxacillin in a foal. Although the outcome was fatal, the medical therapy provided could be considered successful at sterilizing the bony lesion. 相似文献
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William G Van Alstine William R Widmer 《Journal of veterinary diagnostic investigation》2003,15(3):289-291
Three pigs, weighing 63 kg-70 kg each, from a group of 8 pigs in an outdoor pen that was struck by lightning were necropsied. All 3 pigs presented with hind limb paralysis. The only lesions identified were multiple fractures of the last (seventh) lumbar vertebral body and first sacral vertebral segment, with dorsal displacement of the sacrum and transection of the distal spinal cord and spinal nerves. Hemorrhages extended from the fracture sites into muscles immediately surrounding the lumbosacral junction and retroperitoneally into the pelvic cavity. These hemorrhages were not clearly visible until the pelvic region was dissected. Lesions commonly found in human lightning-strike victims were not present in these pigs. Because vertebral fractures may be the only lesions and may be grossly subtle in heavily muscled pigs, careful pelvic and vertebral dissection is recommended in cases of suspected lightning strike and electrocution. 相似文献
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Jonathan R Hughes Balazs Szladovits Randi Drees 《Veterinary radiology & ultrasound》2019,60(3):306-315
Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine‐needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body imaging in staging mast cell tumors in the authors’ institution enabling evaluation of multiple body areas in one examination. The aim of this study was to compare the CT examinations acquired for staging of mast cell disease to their subsequent liver and spleen cytology findings. Medical records of dogs with primary mast cell tumors that underwent abdominal CT and concurrent liver and spleen aspirates were reviewed. The CT examinations were evaluated for attenuation, size, and margination of the liver and spleen. The relationship between CT findings and cytology results was analyzed. Forty‐nine dogs matched the inclusion criteria: five of forty‐nine dogs with cutaneous mast cell tumors were positive for metastasis from liver and/or spleen aspirates. Of the five dogs with cytological evidence of liver or spleen metastasis, four had normal CT liver attenuation and size, one dog had concurrent primary hepatocellular neoplasia, four dogs had abnormal splenic parenchyma (two nodular and two diffuse heterogeneity), and one dog had a normal attenuation of the spleen. In four dogs, the spleen was subjectively enlarged. Computed tomographic evaluation of the liver showed no consistent pattern associated with mast cell metastasis and did not predict cytology results. Multifocal splenic hypoattenuating lesions more commonly coincided with mast cell metastasis. Sampling of the liver and spleen remains to be considered in the absence of abnormal CT findings for full staging. 相似文献
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Richard J. McMullen Alison B. Clode Arun Kumar R. Pandiri† David E. Malarkey‡ Tammy Miller Michau Brian C. Gilger 《Veterinary ophthalmology》2008,11(S1):44-50
A case of epibulbar melanoma in a 6-month-old, gelded, chestnut Hanoverian foal is reported. The location and clinical appearance upon initial presentation led to the tentative diagnosis of staphyloma or a congenital mass of unknown origin. An attempt was made to surgically excise the mass under general anesthesia, but due to its infiltrative nature and intraoperative appearance, most, but not all was removed without compromising the integrity of the globe. Histopathological evaluation revealed a multinodular to packeted, poorly demarcated, unencapsulated, infiltrative exophytic melanocytic neoplasm composed of bundles and nests of plump spindloid to polygonal heavily pigmented epithelioid neoplastic cells interspersed with pigment-laden macrophages within a fine fibrovascular stroma. Upon examination after enucleation, neoplastic cells were found to infiltrate into the lateral cornea, sclera and the choroid. This is a unique case of an epibulbar melanoma with choroidal invasion in a foal. Based on the sudden onset and rapid growth as well as the histological evidence of invasion, well-differentiated features, heavy pigmentation, and no apparent mitoses, this neoplasm was considered to be a low-grade malignant melanoma. At 14 months after excision there is no evidence of recurrence. 相似文献
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J C Patterson-Kane F Y Schulman N Santiago L McKinney C J Davis 《Veterinary pathology》2001,38(6):712-714
A 3-year-old female neutered Staffordshire Bull Terrier presented with a mixed germ cell tumor involving the base of the iris and the ciliary body of the right eye. The tumor mass was composed primarily of packeted vacuolated, polygonal (hepatoid) cells and small round cells; epithelial cells lining tubuloacinar structures were a less prominent component. The hepatoid and round cells stained positively for alpha-fetoprotein and cytokeratin. The epithelial cells stained positively for cytokeratin only, and some contained cytoplasmic mucin droplets. The polygonal cells were interpreted as a hepatoid variant of yolk sac tumor, and the epithelial cells were considered a teratomatous component. Trabeculae of bone were observed within the mass and may have been metaplastic or a teratomatous element. Extragonadal germ cell tumors are rare in dogs and have previously been reported only in the suprasellar region. This is the first report of this tumor type in the eye of a nonhuman species. 相似文献
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Wills TB Bohn AA Finch NP Harris SP Caplazi P 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2005,34(4):405-408
A 5-year-old male castrated ferret was presented to the Washington State University College of Veterinary Medicine for evaluation of progressive hair loss and a large, rapidly growing ventral neck mass. The patient had been diagnosed previously with an insulinoma, which was managed medically. Fine-needle aspirates of the neck mass were performed. The cytologic results were most consistent with epithelial neoplasia, likely a carcinoma; thyroid origin was considered likely based on tumor location and cell morphology. The tumor grew rapidly, and the owners elected euthanasia 1 week after examination. At necropsy, a circumscribed, ovoid mass disrupted the right cervical musculature next to the right lobe of the thyroid gland. Histopathologic evaluation revealed an infiltrative mass consisting of cuboidal cells arranged in solid sheets and irregular follicles enclosing colloid. The cells were large, with prominent nucleoli, and had a high mitotic rate. The histopathologic diagnosis was consistent with thyroid follicular adenocarcinoma. Immunochemical findings confirmed thyroglobulin production by neoplastic cells, but to a lesser extent than in normal ferret thyroid tissue. To our knowledge, this is the first case of thyroid follicular adenocarcinoma to be reported in a ferret, with only 1 other case of thyroid carcinoma, a C-cell carcinoma, described previously. 相似文献
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Tissues from subcutaneous lymphosarcomas and regional lymph nodes were examined by light and electron microscopy and by lectin histochemistry. Tumors were composed of two major cell types: small lymphocytes with few organelles and pleomorphic histiocytic cells with undulant surfaces, large numbers of cytoplasmic vacuoles, and many mitochondria with large crystalline inclusions. A large gram-positive coryneform bacterium was isolated from tumor nodules but was not identified morphologically in tumor tissues. Evaluation of sections of tumors with lectins as histochemical probes revealed three staining patterns: 1) lectin labeling histiocytic cells only (wheat germ, succinylated-wheat germ, Phaseolus vulgaris and soybean agglutinins); 2) lectins labeling histiocytic, interstitial and some lymphoid cells (concanavalin A, and Pisum sativum, Lens culinaris, and Ricinus communis I agglutinins); and 3) lectins failing to label any cell (peanut, Sophora japonica, and Ulex europaeus I agglutinins). In the lymph node, macrophages were labeled by lectins of groups 1 and 2; interdigitating reticular cells were labeled by group 2 lectins. Lectin staining of histiocytic cells in tumor tissues suggested that these were reactive cells and that lymphoid cells were the primary neoplastic component. 相似文献
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Pratt SM Stacy BA Whitcomb MB Vidal JD De Cock HE Wilson WD 《Journal of the American Veterinary Medical Association》2003,222(4):486-90, 450
A 13-year-old Morgan gelding was evaluated because of a mass in the caudal region of the abdomen. The horse had been presumed to be a gelding, but necropsy findings revealed a retained testis in the right retroperitoneal space. Histologically, the retained testis contained neoplastic cells; metastases were identified in the liver, spleen, lungs, and sublumbar lymph nodes. Immunohistochemical examination of the testis and metastatic tissues confirmed the diagnosis of malignant Sertoli cell tumor. Testicular neoplasms are infrequently reported in stallions. Seminomas are most commonly reported, whereas Sertoli cell tumors are considered to be rare. Typical biological behavior of Sertoli cell tumors in horses is unknown. To the authors' knowledge, there have been 2 reports of Sertoli cell tumors in horses; the tumors developed in descended testes, and 1 tumor was malignant. 相似文献