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1.
Herbal dietary supplements have attracted more and more attention owing to their relative effectiveness in obesity ‐related metabolic disorders and diseases. This study investigated the therapeutic effects and underlying mechanisms of Capsosiphon fulvescens (CF) extracts on obesity, their associated metabolic disorders and hepatic steatosis in high‐fat diet (HFD)‐induced obese mice. Male C57BL/6 mice were fed with normal, HFD/Vehicle and HFD/CF (orally 300 mg/kg/day for CF). After 12 weeks, CF blocked HFD‐induced body weight, food intake, liver weight, hepatic triglyceride (TG), fat mass (weight of abdominal subcutaneous fat and epididymal adipose tissue) and biochemical parameters (total cohlesterol, glucose, TG, creatinine, high‐density lipoproteins cholesterol and low‐density lipoprotein cholesterol) of serum. CF also had improved serum levels of adiponectin, leptin and insulin‐like growth factor‐1 in HFD/CF mice. Moreover, CF ameliorated the hepatic steatosis‐reducing size of white adipose tissue. These results indicate that CF have anti‐obesity effects and are effective for reducing metabolic risk and hepatic steatosis.  相似文献   

2.
Soy protein regulates adiponectin and peroxisome proliferator‐activated receptor α (PPARα) in some species, but the effect of dietary soy protein on adiponectin and PPARα in the pig has not been studied. Therefore, the objective of this study was to determine whether soya bean meal reduction or replacement influences serum adiponectin, adiponectin mRNA, serum metabolites and the expression of PPARα and other genes involved in lipid deposition. Thirty‐three pigs (11 pigs per treatment) were subjected to one of three dietary treatments: (i) reduced crude protein (CP) diet containing soya bean meal (RCP‐Soy), (ii) high CP diet containing soya bean meal (HCP‐Soy) or (iii) high CP diet with corn gluten meal replacing soya bean meal (HCP‐CGM) for 35 days. Dietary treatment had no effect on overall growth performance, feed intake or measures of body composition. There was no effect of dietary treatment on serum adiponectin or leptin. Dietary treatment did not affect the abundance of the mRNAs for adiponectin, PPARα, PPARγ2, lipoprotein lipase or fatty acid synthase in adipose tissue. The mRNA expression of PPARα, PPARγ2, lipoprotein lipase or fatty acid synthetase in loin muscle was not affected by dietary treatment. In liver tissue, the relative abundance of PPARα mRNA was greater (p < 0.05) in pigs fed the HCP‐Soy diets when compared to pigs fed RCP‐Soy or HCP‐CGM diets. Hepatic mRNA expression of acyl‐CoA oxidase or fatty acid synthase was not affected by dietary treatment. Western blot analysis indicated that hepatic PPARα protein levels were decreased (p < 0.05) in pigs fed the RCP‐Soy diets when compared to pigs fed the HCP‐Soy diets. These data suggest that increasing the soy protein content of swine diets increases hepatic expression of PPARα without associated changes in body composition.  相似文献   

3.
1. The effect of dietary chitosan on fat deposition and lipase activity in the small intestinal contents was investigated in broiler chickens fed an adequate or high metabolisable energy (ME) diet. 2. Male broiler chickens at 14 d old were fed on the adequate or high ME diet supplemented with 0 or 50 g/kg chitosan, which has a low viscosity, for 3 weeks. 3. Dietary chitosan did not affect food intake, body weight gain or food efficiency in either dietary ME groups. 4. Dietary chitosan reduced the excessive abdominal fat deposition induced by the high ME diet. 5. Dietary chitosan increased the weight of intestinal contents irrespective of dietary ME concentration. 6. Dietary chitosan decreased the lipase activity per g of small intestinal contents. 7. These results suggest that dietary chitosan with low viscosity decreases lipase activity and fat absorption in the small intestine, consequently resulting in a reduction of fat deposition in broiler chickens. 8. It was concluded that dietary chitosan with low viscosity can decrease body fat deposition without reducing food intake and body weight gain in broiler chickens.  相似文献   

4.
Lu L  Luo XG  Ji C  Liu B  Yu SX 《Journal of animal science》2007,85(3):812-822
An experiment was conducted using a total of 336 one-day-old, Arbor Acres commercial male broilers to investigate the effect of dietary Mn supplementation on carcass traits, meat quality, lipid oxidation, relative enzyme activities in abdominal fat and meat, and Mn-containing superoxide dismutase (MnSOD) mRNA level in meat. Broilers were randomly allotted by BW to 1 of 8 replicate cages (6 chicks per cage) for each of 7 treatments in a completely randomized design involving a 2 x 3 factorial + 1 arrangement of treatments. Dietary treatments included the corn-soybean meal-based diet (control) and the basal diet supplemented with 100 or 200 mg of Mn/kg as MnSO(4) x H(2)O, Mn AA A with a chelation strength of 26.3 formation quotient (8.34% Mn), or Mn AA B with a chelation strength of 45.3 formation quotient (6.48% Mn). Birds fed supplemental Mn had lower (P < 0.10) percentages of abdominal fat, lipoprotein lipase (LPL), and malate dehydrogenase activities and greater (P < 0.07) hormone-sensitive lipase activities in abdominal fat than birds fed a control diet. Birds fed supplemental Mn from Mn AA A or Mn AA B had lower (P < 0.05) LPL activities in abdominal fat than those fed supplemental MnSO(4) x H(2)O. Birds fed supplemental Mn had lower (P < 0.03) malondialdehyde content in leg muscle and greater (P < 0.02) MnSOD activities and MnSOD mRNA level in breast or leg muscle than those fed the control diet. Birds fed supplemental Mn from Mn AA A had a greater (P < 0.02) MnSOD mRNA level in leg muscle than those fed supplemental MnSO(4) x H(2)O. Results from this study indicated that organic Mn was more available than inorganic Mn for decreasing LPL activity in abdominal fat of broilers, and dietary Mn might reduce abdominal adipose deposition by decreasing LPL and malate dehydrogenase activities or increasing hormone-sensitive lipase activity in abdominal adipose tissue. The results also indicated that dietary Mn upregulated muscle MnSOD gene expression pretranslationally in association with increased MnSOD activity, which might explain the decrease of malondialdehyde content in leg muscle.  相似文献   

5.
本试验旨在研究丁酸梭菌对肉鸡腿肌脂肪代谢的影响。试验选用1日龄爱拔益加肉公鸡192只,随机分为2个组,每个组6个重复,每个重复16只鸡。对照组饲喂基础饲粮,试验组饲喂在基础饲粮中添加1×10~9CFU/kg丁酸梭菌的饲粮,试验期为42 d。结果表明,与对照组相比:1)饲粮中添加丁酸梭菌显著增加了21日龄肉鸡腿肌肌内脂肪含量(P0.05),但对42日龄肉鸡腿肌肌内脂肪含量无显著影响(P0.05)。2)饲粮中添加丁酸梭菌显著降低了21日龄肉鸡腿肌激素敏感脂肪酶活性(P0.05),显著提高了21日龄肉鸡腿肌脂蛋白脂酶活性(P0.05),且有增加42日龄肉鸡腿肌脂蛋白脂酶活性的趋势(0.05P0.10)。3)饲粮中添加丁酸梭菌显著降低了21日龄肉鸡血清中游离三碘甲状腺原氨酸含量(P0.05)。4)饲粮中添加丁酸梭菌显著降低了21日龄肉鸡腿肌脂肪甘油三酯脂肪酶mRNA表达量(P0.05)。由此可见,饲粮中添加丁酸梭菌可通过改变21日龄肉鸡腿肌脂肪代谢相关酶活性和基因表达来增加肉鸡腿肌肌内脂肪含量。  相似文献   

6.
本试验旨在探讨玉米RNA对小鼠脂肪沉积的影响。将20只28日龄C57BL/6J小鼠随机分为2组,每组10个重复,每个重复1只小鼠。对照组灌服生理盐水,试验组灌服玉米RNA(100μg/d),试验期4周。试验结束时检测小鼠的生长性能、血清生化指标、体组成、体成像、器官指数及脂肪相关基因的表达。结果显示:试验组小鼠体重和附睾脂肪组织指数显著低于对照组(P<0.05),且整体脂肪含量明显减少,表明小鼠脂肪沉积减少。血脂检测结果显示,与对照组相比,试验组血清球蛋白(GLB)含量显著增加(P<0.05),高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和总胆固醇(TC)含量极显著增加(P<0.01);脂肪相关基因检测结果显示,与对照组相比,试验组脂肪合成相关基因脂肪酸合成酶(FAS)和CCAAT增强子结合蛋白α(C/EBP-α)mRNA相对表达量极显著上调(P<0.01),过氧化物酶体增殖剂激活受体-γ(PPAR-γ)及脂肪分解基因脂肪甘油三酯脂肪酶(ATGL)和激素敏感脂酶(HSL)mRNA相对表达量显著上调(P<0.05),表明小鼠脂肪合成和脂肪分解增加。综上所述,玉米RNA能同时促进小鼠脂肪合成代谢和脂肪分解代谢,最终抑制脂肪沉积,为植物源核酸调控动物脂肪沉积影响因素的探索提供新证据。  相似文献   

7.
This study was conducted to estimate the effect of dietary energy level on lipid metabolism‐related gene expression of subcutaneous adipose tissue in Yellow breed × Simmental cattle. The experiment was conducted for 60 days. The results showed that final weight, average daily gain, average backfat thickness, (testicles + kidney + pelvic) fat percentage and subcutaneous fat percentage in the high and medium energy groups were significantly higher than in the low‐energy group but that the feed conversion ratio was significantly lower. The glucose, triglycerides, cholesterol, high‐density lipoprotein and low‐density lipoprotein in the high‐energy group were significantly higher than in the low‐energy group. With dietary energy increasing the activities of lipoprotein lipase (LPL), fatty acid synthase (FAS) and acetyl‐CoA carboxylase (ACC) significantly increased, whereas hormone‐sensitive lipase (HSL) and carnitine palmitoyltransferase‐1 (CPT‐1) significantly diminished. Peroxisome proliferator‐activated receptor γ (PPARγ), LPL, FAS, sterol regulatory element binding protein 1 (SREBP‐1), ACC, stearoyl‐CoA desaturase (SCD) and adipocyte‐fatty acid binding proteins (A‐FABP) gene expression were significantly increased by dietary energy increasing, and HSL and CPT‐1 gene expression were significantly decreased. These results indicated that with dietary energy increasing, the subcutaneous fat accumulation mainly increased due to adipose tissue lipogenic gene expression and decreased lipolytic gene expression.  相似文献   

8.
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9.
We have previously shown that anacardic acid has an uncoupling effect on oxidative phosphorylation in rat liver mitochondria using succinate as a substrate (Toyomizu et al. 2000). In the present study, in order to clarify whether or not anacardic acid could be used advantageously as a special feed/food supplement to reduce fat deposition through the uncoupling action, two sets of experiments were conducted to determine quantitatively the effect of dietary anacardic acid (0.1% w/w) supplementation. More specifically, effects on growth, feed efficiency, fattening, and levels of several constituents of blood serum in rats fed normal and low protein–high carbohydrate (CHO) diets were examined. There were no significant differences in bodyweight gain, feed consumption and feed efficiency among the experimental groups. For the total fat pad content, including inguinal and epididymal fat, significant interaction was shown between both treatments: dietary anacardic acid at 0.1% w/w significantly decreased the total fat pad content in rats fed the CHO diet, but not in rats fed the normal diet. Weights of heart, spleen and brown adipose tissue were not affected by either the dietary treatment or anacardic acid, while both liver and kidney weights decreased with feeding of anacardic acid at 0.1% w/w, but were not affected by the CHO diet. Anacardic acid supplementation in the diet had no effect on serum glutamic oxaloacetic transaminase, alkaline phosphatase or lactate dehydrogenase levels, suggesting that the dysfunction of liver or kidney may not be induced by dietary anacardic acid. The results of the present study reveal a unique function of anacardic acid in that, for dietary conditions enhancing body fat deposition, that is consumption of a diet high in carbohydrates, dietary anacardic acid has the potential to decrease body fat deposition. A possible mechanism for differences observed in anacardic acid‐induced regulation of body fat pad content between rats fed the normal and CHO diets, based on uncoupling action of anacardic acid on the mitochondrial oxidative phosphorylation, is discussed.  相似文献   

10.
The purpose of this article was to investigate the effects of dietary resveratrol supplementation during gestation and lactation of sows on the milk composition of sows and the fat metabolism of sucking piglets. Forty sows were allotted to two experimental treatment groups that included the following: (a) control sows (CON treatment, n = 20) fed with a corn–soybean meal control diet and (b) treatment sows (RES treatment, n = 20) fed with a control diet with addition of 300 mg/kg resveratrol. The results showed that the content of lactose in the colostrum was increased (p < 0.05) and the content of fat in 21‐day milk was increased (p < 0.05) by dietary resveratrol supplementation. In the RES treatment group, the concentrations of high‐density lipoprotein‐cholesterol (HDL‐C), low‐density lipoprotein‐cholesterol (LDL‐C), lipase activity and insulin (INS) in plasma of sucking piglets were increased (p < 0.05). In the adipose tissue, the enzyme activities of hormone‐sensitive lipase (HSL), acetyl‐CoA carboxylase (ACC) and lipoprotein lipase (LPL) increased significantly by RES treatment (p < 0.05), and the mRNA levels of acetyl coenzyme A‐alpha (ACCα), LPL, fatty acid transport protein (FATP1) and CCAAT–enhancer‐binding protein gene (C/EBPα) were higher in the RES treatment group (p < 0.05). In conclusion, resveratrol supplementation on gestational and lactating sows improved the content of lactose in the colostrum and the content of fat in milk at day 21 of lactation. In addition, resveratrol supplementation on sows increased HDL and LDL in the plasma of piglets. In piglet adipose tissue, the enzyme activity and mRNA level related to lipolysis, fatty acid uptake from circulating triacylglycerols and lipogenesis are partially improved by resveratrol supplementation on sows. These aspects affect fat metabolism in piglets.  相似文献   

11.
日粮代谢能水平对北京油鸡脂肪沉积和LPL基因表达的影响   总被引：3，自引：0，他引：3  
试验旨在研究不同日粮代谢能水平对北京油鸡脂肪沉积及脂蛋白酯酶（LPL）基因mRNA表达影响。试验以3周龄北京油鸡公鸡为研究对象,将480只公鸡随机分为4组,分别饲喂4个代谢能水平的日粮（12.122、12.540、12.958和13.376 MJ/kg）,每个处理组5个重复,每个重复24只鸡。试验期为10周。采用荧光定量PCR方法检测LPL基因mRNA表达水平。结果表明,日粮代谢能水平对鸡体脂沉积各项指标和LPL基因mRNA表达水平影响极显著,随日粮代谢能水平提高,各项体脂沉积指标极显著上升,胸肌和腿肌IMF、皮脂重和皮脂率在ME3达到峰值,LPL基因mRNA表达水平在ME2组达到峰值（P＜0.01）。LPL基因mRNA表达水平与腹脂率、皮脂重和皮脂率呈显著正相关（P＜0.05）。研究结果提示,日粮代谢能水平显著影响北京油鸡体脂沉积和LPL基因mRNA表达;LPL基因表达影响北京油鸡体脂沉积状况。  相似文献   

12.
This study was designed to estimate dietary energy level on intramuscular fat (IMF) deposition in Simmental × Yellow breed cattle. Results showed that ultimate weight and average daily gain in high and medium energy groups were significantly higher than low‐energy group, yet feed conversion ratio was significantly lower. IMF content was significantly increased by dietary energy increasing, whereas longissimus muscle shear force significantly decreased. Serum‐free fatty acids, triglycerides and glucose significantly increased by dietary energy increasing, whereas growth hormone (GH) significantly decreased. Enzyme activities of lipoprotein lipase (LPL), fatty acid synthase (FAS), and acetyl‐CoA carboxylase (ACC) significantly increased by dietary energy increasing, whereas hormone‐sensitive lipase (HSL) and carnitine palmitoyltransferase‐1 (CPT‐1) significantly diminished. Peroxisome proliferator‐activated receptor γ, sterol regulatory element‐binding protein 1, stearoyl‐CoA desaturase, adipocyte‐fatty acid‐binding proteins, ACC, LPL, and FAS gene or protein expression significantly increased by dietary energy increasing, whereas HSL, CPT‐1, and GH gene or protein expression significantly decreased. These results indicated that high dietary energy promoting IMF deposition is mainly by downregulating pituitary GH gene expression, decreasing serum GH concentration, increasing lipogenic genes levels of mRNA, enzyme activities and protein expression, and decreasing lipolytic genes levels of mRNA, enzyme activities, and protein expression.  相似文献   

13.
Use of carbohydrate and fat as energy source by obese and lean swine   总被引：5，自引：0，他引：5  
Genetically obese and lean pigs were fed isonitrogenous-isoenergetic (digestible energy) amounts of a high or low fat diet from 25 kg body weight. Obese pigs gained less and required more feed per unit gain than lean pigs. Lean pigs were more muscular with less fat than obese pigs. Obese pigs utilized more dietary amino acids for energy (greater plasma urea N) than did lean pigs. Weight gain was similar at all intermediate periods in obese pigs fed the two diets. However, gain tended (P less than or equal to .10) to be greater and the ratio of dietary energy intake to gain tended (P less than or equal to .10) to be less in obese pigs fed high compared with low fat diets. Similar results were observed in lean pigs fed the two diets. The high fat diet produced more carcass adipose tissue deposition in both strains after 20 wk of feeding (detectable by ultrasound at 14, but not at 7 wk). Adipose tissue lipogenic rate (glucose incorporation) was similarly depressed by fat feeding in both obese and lean pigs. Obese and lean pigs both utilized dietary carbohydrate and fat differentially but there was no indication of genetic divergence regarding this utilization. In both strains of pigs, energy from the fat-enriched diet was preferentially partitioned into carcass adipose tissue.  相似文献   

14.
Antibiotics stimulate the growth of animals but result in drug residues and bacterial resistance. In this study, the negative effect of antibiotics on abdominal fat deposition was evaluated in broilers. The results showed that adding both chlortetracycline (50 g/1,000 kg) and tylosin (50 g/1,000 kg) significantly increased abdominal fat weight, abdominal fat percentage (p < .05), and triglyceride and cholesterol levels (p < .05) in blood. Also, both products synchronously stimulated intestinal absorption and synthesis of liver fat. The expression levels of the peroxisome proliferator‐activated receptor γ (PPARγ), diacylgycerol acyltransferase 2 (DGAT2), lipoprotein lipase (LPL), and fatty acid‐binding protein (FABP4) genes in abdominal fat tissue significantly increased (p < .05 or 0.01) when antibiotics were added to the feed. However, no significant difference was found in expression of the fatty acid synthesis (FAS) or acetyl CoA carboxylase (ACC) genes. Further in vitro study results revealed that antibiotics had no effect on fat content or the related gene expression levels in preadipocytes. In summary, the antibiotics induced fat deposition in adipose tissues by activating extracellular absorption of fatty acids from intestinal absorption and synthesis of liver fat. However, it shows no direct regulation by adipose tissue.  相似文献   

15.
1. Fat deposition in abdominal, mesenterial, sartorial and gizzard adipose tissues (AT), liver, breast muscle, skin and carcase was studied in male broilers, selected for high (HF) and low (LF) abdominal fat and fed on diets differing in energy density and total fat content. 2. There were no significant differences in body weight in the experimental groups. The relative weight (g/kg body weight) of the dissected adipose tissues was higher in HF than in LF birds. Fat concentration in the AT (sartorial excepted), skin and body was higher in the HF compared with the LF birds. The lines did not differ significantly in liver and breast muscle fat content. 3. Abdominal AT was affected by selection or dietary fat more than other AT and total body fat. 4. In the HF birds increasing energy density from 12.3 to 13.4 MJ/kg (dietary fat kept constant: 5.46 g/MJ) significantly increased the weight of the abdominal, mesenterial and sartorial AT. Increasing dietary fat (at both energy densities) decreased the weight of the AT, whereas increasing both energy and fat did not affect it. In the LF birds, similar but milder and insignificant trends were observed. It is suggested that this interaction has biological significance.  相似文献   

16.
To study effects of isoprothiolane and phytosterol on dietary fat necrosis, 3 groups of rats were fed hardened-tallow (HT) diet. Two groups of rats received either isoprothiolane (50 mg/kg) or phytosterol (20 mg/kg) orally once a day consecutively for 10 weeks. One group of rats received standard diet (CE-2) as a control. Fat necrotic lesions were observed in epididymal and perirenal adipose tissues from all rats in the 3 groups fed HT diet. Rats with fat necrosis were characterized by visceral type obesity and saturation in fatty acid composition of triglyceride in adipose tissue. The highest glucose conversion to total lipids was seen in adipocytes from the rats given phytosterol. There was no lipolytic response to epinephrine stimulation (1-100 microM) in adipocytes from the rats given only HT diet, while similar response of adipocytes from the 2 groups treated with either drug to those from the rats fed standard diet was observed. The levels of total saturated fatty acids of phospholipid in adipose tissue from the rats given either drug were lower than that of the rats given only HT diet. These data suggest that either drug alters fatty acid composition of phospholipid in fat cell membrane and enhances lipolysis of the cells.  相似文献   

17.
To clarify the details of the anti‐obesity effect of theanine, γ‐glutamylethylamide, female ICR mice were fed diets containing theanine at the concentrations of 0.01, 0.02, 0.04, 0.08 and 0.16% for 16 weeks. Bodyweight and food intake in the mice were measured every 4 weeks, and several organs and intraperitoneal adipose tissues (IPAT) were weighed after the feeding. In addition, lipid levels in the serum and liver were analyzed. As a result, the bodyweight increase and weight of IPAT were significantly reduced in mice fed 0.04% theanine compared with controls, but not in mice fed other diets. The levels of triglycerides (TG) and non‐esterified fatty acids in the serum and TG level in the liver in mice fed the 0.04% theanine diet were remarkably decreased. These results indicated that bodyweight increase and fat accumulation were suppressed by a limited concentration of 0.04% theanine in mice.  相似文献   

18.
Recent in vitro evidence suggests that the phytol‐derived fatty acids, phytanic acid (PA) and pristanic acid (PrA), are components of animal products with the potential to cause both beneficial and harmful effects on human health. In this study, we investigated the in vivo tissue accumulation of PA and PrA and the changes in tissue lipid profiles, using mice fed a phytol‐containing diet. After 4 weeks of treatment with a diet containing 1.0% phytol, plasma, adipose tissue, liver, and brain were collected and their lipid profiles were biochemically and gas‐chromatographically determined. Dietary phytol caused PA and PrA accumulation in the adipose tissue and liver but not in the brain, and reduced plasma and liver triacylglycerol levels. Phytol intake also decreased the fatty acid concentrations in the adipose tissue, especially polyunsaturated fatty acids such as linoleic acid, but increased the concentrations of these fatty acids in the liver. However, dietary phytol had a low impact on the brain lipid profile. This study suggests that dietary phytol intake caused accumulation of PA and PrA and modified lipid profiles in the adipose tissue and liver, but that the brain is an insusceptible tissue to dietary phytol‐induced changes.  相似文献   

19.
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20.
Melatonin (MT) influences lipid metabolism in animals; however, the mechanistic effect of melatonin on liver fat and abdominal adipose deposition requires further clarity. In order to study the effects of melatonin on lipid metabolism, and hepatic fat and abdominal adipose deposition in animals, twenty Sprague–Dawley (SD) rats of 6 weeks of age with similar bodyweight were randomly divided into two groups: control (CTL) and MT-treated (10 mg/kg/day). During a 60-day experiment, food intake and bodyweight were measured daily and weekly respectively. At the end of treatment, blood samples were collected to collect plasma to quantify hormones and metabolic indicators of lipid metabolism. In addition, organ and abdominal adipose depots including liver, and omental, perirenal, and epididymal fat were weighed. Liver tissue was sampled for sectioning, long-chain fatty acid (LCFA) quantification, and gene chip and Real-time quantitative PCR (qPCR) analyses. The results showed that liver weight and index (ratio of liver weight to body weight) in MT group reduced by 20.69% and 9.63% respectively; omentum weight and index reduced by 59.88% and 54.93% respectively, and epididymal fat weight reduced by 45.34% (p = 0.049), relative to CTL. Plasma lipid indices, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) with MT treatment decreased significantly compared with the control. Fat and 8 LCFA content in liver in MT group also decreased. Gene chip and qPCR demonstrated that there were 289 genes up-regulated and 293 genes down-regulated by MT. Further analysis found that the mRNA expression of lipolysis-related genes increased, while the mRNA expression of lipogenesis-related enzymes decreased (p < 0.05) with MT. This study concluded that melatonin greatly affected fat deposition, and hepatic LCFA supply and the expression of genes associated with lipogenesis and lipolysis.  相似文献   

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