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空肠弯曲杆菌是一种人畜共患病致病菌,作为一种食物源性病原菌,空肠弯曲杆菌能引起人和动物发生多种疾病,其治病机理正在被广泛的研究,本文主要介绍了目前空肠弯曲杆菌相关疾病的研究进展,以及通过实验介绍空肠弯曲杆菌的实验室分离及鉴定的一般方法。 相似文献
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空肠弯曲杆菌是弯曲杆菌属的一种，是几十年来倍受国内外广泛重视的人畜共患病原菌之一。近几年，其感染率在全世界呈上升趋势。为阐明空肠弯曲杆菌感染的致病作用以及如何进行防治，本文从其病原学、传染源、传播途径、临床表现以及预防与控制方面对空肠弯曲菌及该菌引起疾病的相关情况作一阐述。 相似文献
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牛弯曲杆菌病是由弯曲杆菌属细菌所引起的牛及其他动物的不同疾病的总称。与人畜有关的有2种病型，由胎儿弯曲杆菌引起的牛只不育与流产和主要由空肠弯曲杆菌引起牛及其他动物的急性肠炎。空肠弯曲杆菌目前有2个亚种，即空肠亚种和多伊尔亚种。空肠亚种与兽医学有关的是人畜共患病的重要病原菌。现介绍牛弯曲杆菌性腹泻的诊治方法。 相似文献
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空肠弯曲杆菌是弯曲杆菌属的一种。弯曲杆菌在兽医学上被认为是人畜共患疾病的病原菌１。近年来我国陆续报道了空肠弯曲杆菌是人类肠炎的重要致病菌之后，引起了国内外的广泛关注。１空肠弯曲杆菌对动物的危害该菌在自然感染条件下，可引起多种动物腹泻、肝炎、流产、不育等疾病，同时也引起人的急性肠炎和食物中毒２。２０世纪８０年代至今人们利用该菌实验性感染动物如口服感染犊牛、羔羊、狗、仔猪、猿猴、雏鸡等，均可引起腹泻。临床诊断中这些动物粪便带有血液和粘液，能够在消化系统中检出细菌；病理变化表现为肠粘膜充血、水肿、细胞… 相似文献
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空肠弯曲杆菌是一种人畜共患的食物源性病原菌，可引起人和动物细菌性腹泻，且该菌的感染率逐年递增。鞭毛是细菌菌体的一种特殊结构，与菌体的运动性密切相关，有助于其躲避有害环境，同时鞭毛在细菌的致病性等方面也起着重要作用。研究发现，空肠弯曲杆菌的发病机制与鞭毛在宿主上皮细胞的定植力、黏附、侵袭力及毒素的产生密切相关。文章概述了空肠弯曲杆菌鞭毛结构、功能、调控机制及相关基因等方面的研究进展，通过归纳总结已知基因缺失突变对鞭毛的影响，从分子水平了解鞭毛的调控机制，从而探讨空肠弯曲杆菌的致病机理，以期为降低其感染率提供理论依据。 相似文献
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Campylobacter jejuni is associated with, but not sufficient to cause vibrionic hepatitis in chickens
Jennings JL Sait LC Perrett CA Foster C Williams LK Humphrey TJ Cogan TA 《Veterinary microbiology》2011,149(1-2):193-199
Vibrionic hepatitis is a disease of poultry which is characterised by the presence of focal lesions in the liver, usually 1-2mm in size and greyish-white in colour. The cause of the disease remains unclear, as do the reasons for its recent re-emergence. We examined the livers of commercial broiler chickens taken during processing and found Campylobacter spp. in both normal livers and those displaying signs indicative of focal hepatitis. Livers with signs of hepatitis had significantly more Campylobacter spp. present than those without and other bacterial genera were infrequently present. We were unable to replicate the disease in a healthy host following experimental infection with a Campylobacter jejuni strain isolated from a liver showing signs of focal hepatitis. However, a significant T cell response to C. jejuni was seen in the liver of Campylobacter infected birds. We conclude that the presence of Campylobacter spp. in the liver alone is not sufficient to cause vibrionic hepatitis, but that a predisposing factor, possibly within the host is required. We also provide evidence that chickens mount an adaptive T cell response to systemic C. jejuni. 相似文献
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Campylobacter (C.) jejuni and C. coli can cause gastrointestinal disorders in humans characterized by acute inflammation. Inflammatory signals are initiated during interaction between these pathogens and human intestinal cells, but nothing is known about the stimulation of avian intestinal cells by Campylobacter. Interleukin-8 (IL-8) as a proinflammatory chemokine plays an important role in mobilizing cellular defence mechanism. IL-8 mRNA expression in both human intestinal cells (INT 407) and primary intestinal chick cells (PIC) was determined by quantitative real-time RT-PCR. The secretion of IL-8 protein by INT407 was measured using ELISA. Although C. jejuni and C. coli are considered to be harmless commensals in the gut of birds, the avian Campylobacter isolates investigated were able to induce the proinflammatory IL-8 in PIC as well as in INT407. In an in vitro system, C. jejuni as well as C. coli were able to induce IL-8 mRNA in PIC. Relation between the virulence properties like toxin production, the ability to invade and to survive in Caco-2 cells and the level of IL-8 mRNA produced by INT 407 and PIC after infection with Campylobacter strains was also investigated. 相似文献
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Sahin O Morishita TY Zhang Q 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2002,3(2):95-105
Since its recognition as a human pathogen in the early 1970s, Campylobacter jejuni has now emerged as the leading bacterial cause of food-borne gastroenteritis in developed countries. Poultry, particularly chickens, account for the majority of human infections caused by Campylobacter. Reduction or elimination of this pathogen in the poultry reservoir is an essential step in minimizing the public health problem; however, farm-based intervention measures are still not available because of the lack of understanding of the ecological aspects of C. jejuni on poultry farms. Although Campylobacter is highly prevalent in poultry production systems, how poultry flocks become infected with this organism is still unknown. Many investigations indicate that horizontal transmission from environmental sources is the primary route of flock infections by Campylobacter. However, some recent studies also suggest the possibility of vertical transmission from breeder to progeny flocks. The transmission of the organism is not well understood, but it is likely to be through both vertical and horizontal transmission and may be affected by the immune status of the poultry host and the environmental conditions in the production system. Intervention strategies for Campylobacter infection in poultry should consider the complex nature of its transmission and may require the use of multiple approaches that target different segments of the poultry production system. 相似文献
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G Glünder S Petermann 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1989,36(2):123-130
Altogether 16 Campylobacter (C.) isolates could be recovered from 65 Herring gulls: 5 x C. laridis, 2 x C. jejuni biovar 1, 4 x C. jejuni biovar 2 and 5 x C. coli. Campylobacter spp. were isolated from 15 out of 51 samples from Kittiwakes: 2 x C. jejuni biovar 1 and 13 x C. laridis. All C. coli isolates grew on agar containing 1.5% NaCl. Two Campylobacter isolates from 50 House sparrows differed from all other isolates by a distinct beta-hemolysis and other phenotypic characteristics and could not be associated with a certain Campylobacter species. Epidemiological aspects and the possible role of the examined birds as a source of infection for man and domestic animals are discussed. 相似文献
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Mannering SA West DM Fenwick SG Marchant RM O'Connell K 《Veterinary microbiology》2006,115(1-3):237-242
Campylobacter species are a significant cause of sheep abortion in most sheep-raising countries. In New Zealand, Campylobacter fetus subsp. fetus is the leading cause of diagnosed sheep abortion and the species C. jejuni and C. coli have also been implicated. To date, strain typing information of C. jejuni sheep abortion isolates is limited. The objective of the present study was to genotype C. jejuni isolates cultured from sheep abortions submitted to diagnostic laboratories in New Zealand during the 2000 breeding season, using pulsed-field gel electrophoresis (PFGE). In this study, C. jejuni isolates were cultured from approximately 10% of farms from which Campylobacter species were isolated from sheep abortions in the year 2000. This equated to 25 C. jejuni isolates from 21 farms. These isolates were obtained from the veterinary diagnostic laboratories and strain typed using the molecular typing technique PFGE. Ten distinct PFGE types were identified amongst the isolates. No particular PFGE type was found most frequently amongst these C. jejuni sheep abortion isolates. However, indistinguishable or similar C. jejuni PFGE types were identified from different aborted foetuses from the same flock, consistent with the role of C. jejuni as an infectious cause of abortion in sheep. These strain types were similar or indistinguishable from C. jejuni sheep abortion isolates obtained in 1999 in a smaller study (Mannering, S.A., Marchant, R.M., Middelberg, A., Perkins, N.R., West, D.M., Fenwick, S.G., 2003. Pulsed-field gel electrophoresis typing of C. fetus subsp. fetus from sheep abortions in the Hawke's Bay region of New Zealand. NZ Vet. J. 51, 33-37). 相似文献
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Campylobacter jejuni is the leading cause of food-borne bacterial gastroenteritis in humans in the United States. Infectious bursal disease virus (IBDV) causes an immunosuppressive disease in young chickens. To analyze a possible role of IBDV-induced immunosuppression in colonization and shedding of C. jejuni, two experiments were conducted. In both experiments, group 1 consisted of noninoculated control chickens, groups 2 and 3 were inoculated with varying doses of C. jejuni, and groups 4 and 5 were inoculated initially with IBDV followed by doses of C. jejuni similar to groups 2 and 3. Campylobacter jejuni was recovered from the cloaca and cecum, but not the small intestines, from all chickens in groups 2 and 3. In groups 4 and 5, C. jejuni was recovered from the small intestines, cecum, and cloaca from all chickens. The amount (colony-forming units/sample) of C. jejuni recovered from chickens in groups 4 and 5 was significantly greater (P < 0.05) than the amount recovered from chickens in groups 2 and 3; and C. jejuni was also present sooner in these groups than in groups 2 and 3. Bursa samples from chickens in groups 4 and 5 were significantly smaller (P < 0.05) than in the other groups. Additionally, real-time polymerase chain reaction results for IBDV were positive in groups 4 and 5 and negative in all other groups. This study indicated that IBDV infection exacerbated colonization and shedding of C. jejuni, presumably through the immune suppression this virus causes in chickens. It highlights the need for further investigation into the role of immunosuppression in preharvest control strategies for food-borne disease-causing agents. 相似文献
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The absence of cecal colonization of chicks by a mutant of Campylobacter jejuni not expressing bacterial fibronectin-binding protein. 总被引：5，自引：0，他引：5
Campylobacter jejuni is a common cause of human gastrointestinal illness throughout the world. Infections with C. jejuni and Campylobacter coli are frequently acquired by eating undercooked chicken. The ability of C. jejuni to become established in the gastrointestinal tract of chickens is believed to involve binding of the bacterium to the gastrointestinal surface. A 37-kD outer membrane protein, termed CadF, has been described that facilitates the binding of Campylobacter to fibronectin. This study was conducted to determine whether the CadF protein is required for C. jejuni to colonize the cecum of newly hatched chicks. Day-of-hatch chicks were orally challenged with C. jejuni F38011, a human clinical isolate, or challenged with a mutant in which the cadF gene was disrupted via homologous recombination with a suicide vector. This method of mutagenesis targets a predetermined DNA sequence and does not produce random mutations in unrelated genes. The parental C. jejuni F38011 readily colonized the cecum of newly hatched chicks. In contrast, the cadF mutant was not recovered from any of 60 chicks challenged, indicating that disruption of the cadF gene renders C. jejuni incapable of colonizing the cecum. CadF protein appears to be required for the colonization of newly hatched leghorn chickens. 相似文献