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1.
通过刺激前应用盐酸羟考酮观察福尔马林致痛模型大鼠的镇痛效果和血液中NO及P物质浓度的变化,探讨盐酸羟考酮超前镇痛的作用机制。选取健康成年Wistar大鼠32只,雌雄各半,体质量250~300 g,随机分为4组(每组8只),正常空白对照组(A组)腹腔注射0.9%氯化钠溶液2 m L;福尔马林模型组(B组)用微量注射器抽取5%福尔马林100μL注入大鼠右侧后爪掌心皮下致痛;盐酸羟考酮致痛前给药组(C组),福尔马林致痛前30 min腹腔注射盐酸羟考酮0.2 mg·kg-1;盐酸羟考酮致痛后给药组(D组),福尔马林致痛后30 min腹腔注射盐酸羟考酮0.2 mg·kg-1。致痛后1,10,20,30,45,60,90 min观察动物疼痛行为改变,以累积疼痛评分评定疼痛行为。致痛后90 min用水合氯醛麻醉大鼠,心脏采血3 m L测定其NO及P物质浓度的变化。根据大鼠行为学改变及疼痛评分的结果显示,本试验造模成功。疼痛评分值:致痛后10 min,C组比B组明显减小(P0.05);60~90 min,C、D组与B组比较明显减小(P0.05)。血液标本中NO浓度C、D组与B组比较明显降低,差异有统计学意义(P0.01),C组和D组比较,差异也有统计学意义(P0.05);血液中P物质浓度C、D组与B组比较明显降低,差异也有统计学意义(P0.001),C组和D组比较,差异也有统计学意义(P0.05)。结果表明,大鼠福尔马林致痛模型致痛前和致痛后30 min腹腔注射盐酸羟考酮均有明显的镇痛作用,镇痛效果与降低血液中NO及P物质的浓度相关,二者比较,致痛前30min给药即超前镇痛作用更显著。 相似文献
2.
《科技视界》2016,(22)
目的 :探讨氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗皮肤基底细胞癌的临床效果。方法 :选择2013年1月至2016年3月来我院进行治疗的皮肤基底细胞癌患者150例为研究对象,采用随机数字表法,将所有患者随机分为对照组(给予单纯氨基酮戊酸光动力疗法治疗)与观察组(氨基酮戊酸光动力疗法、手术及咪喹莫特联合治疗),比较两组患者的临床治疗效果、一期愈合率、治疗次数及不良反应的发生情况。结果:观察组患者的治疗有效率、一期愈合率、治疗次数及不良反应的发生率与对照组差异明显,具有统计学意义(P<0.05)。结论:综合方法治疗皮肤基底细胞癌的临床效果十分明显,在提高患者治疗总有效率的同时,能够明显降低并发症的发生率并减少治疗次数,安全性较高,值得在临床进行广泛应用。 相似文献
3.
冠心病、心绞痛患者 1 0 7例给予中医蜂疗 ,并设复方丹参片治疗 32例对照观察。治疗组以蜂王浆、蜂花粉、蜂蜜、蜂胶酊 ,按病人个体体征差异做调配内服 ,剂量 30ｇ(± 1 0ｇ) /日 ;蜂针在皮试无过敏后 ,按针灸学穴位配伍 ,一天或隔日一次 ,蜂针数量掌握在 8-2 0只左右 /次 ;一个月为一疗程。对照组 :以复方丹参片 (主要成份丹参、三七参、冰片 )口服 ,每次 3粒 ,每日 3次。结果 :治疗组中临床治愈 3例 ,显效 5 2例 ,有效 4 5例 ,无效 7例 ,总有效率为 93.4 6 % ;对照组中显效 1 0例 ,有效 1 6例 ,无效 6例 ,总有效率 81 .2 5 %。经统计学处… 相似文献
4.
面神经炎是一种较常见的神经系统疾病，蜂针疗法为其治疗提供了新思路。评价了蜂针疗法对面神经炎的疗效。使用Meta分析方法，纳入7篇RCT研究，共计506例。用R 4.1.1软件对总有效率进行汇总，蜂针疗法总有效率高于常规针灸（P <0.01），也高于药物治疗（P <0.05）。最终得出结论：蜂针疗法及其联合疗法可以提高周围性面瘫的疗效。 相似文献
5.
蜂针疗法配合热敷治疗类风湿性关节炎 总被引：1，自引：0，他引：1
目的：观察蜂针疗法配合热敷治疗类风湿性关节炎。方法：按疼痛部位,以阿是穴为主,采用蜂针疗法为主,配合青盐热敷。结果：近期控制4例,占11％,显效24例。占66．6％,有效7例,占19．4％,无效1例,占3％,总有效率97％。结论：以蜂针疗法为主,配合热敷,能短时间控制症状,临床疗效尚属满意。 相似文献
6.
《中国蜂业》2019,(2):16-19
[目的]观察中药联合蜂疗治疗胆结石的临床疗效、方法,将850例胆结石患者随机分为2组。对照组420例:以疏肝利胆消导散结中药汤剂治疗;治疗组430例:在对照组治疗方法基础上排石当天加蜂疗。2组治疗9天后观察临床疗效,并观察2组治疗前后影像学(肝胆彩超)变化,血清学指标,丙氨酸氨基转移酶(ALT),天冬氨酸氨基转移酶(AST),直接胆红素(DBIL)指标变化,临床症状变化。[结果]治疗组总有效率93.72%,对照组总有效率60.73%。2组治疗前后对比肝功指数及临床症状均降低,且治疗组降低明显优于对照组(P﹤0.05)。腹部肝胆彩超比较,治疗组结石体积减小的占35.0%,结石排空的占58%,胆结石体积发生总变化率占93%,而对照组均无明显变化。结石体积变化治疗组明显优于对照组(P﹤0.05)。[结论]蜂疗联合中药治疗胆结石疗效确切,可提高患者生活质量。 相似文献
7.
8.
目的探讨初期蜂针患者肿胀反应规律,为蜂针治疗避免不良反应发生提供参考和依据。方法将118例初次接受蜂针治疗的患者采用蜂针直刺法进行治疗,留针10分钟后,隔日1次,每月15次,治疗后30分钟观察患者肿胀反应及其他反应情况,共观察两个疗程。结果经观察,蜂针治疗后肿胀发生率为98.83%,其发生与服药、抓痒及发热与否有关。结论蜂针治疗后肿胀的发生是常见的,但一般不必给与特殊治疗将自动缓解,仍是一种较安全的治疗方法;临床进行蜂针治疗时对未服用激素治疗者及容易瘙痒、发热患者严密观察,防止严重肿胀等过敏反应的发生,尽量减少不必要的不良反应。 相似文献
9.
蜂针前后肢体血流图变化观察 总被引：4，自引：1，他引：3
蜂针治疗疾病已有很多临床报道，实践证明，蜂针对治疗类风湿、痛证等有良好的疗效〔１，２〕。我们选择门诊类风湿病人，进行蜂针前后的肢体血流图观察，并且进行自身左右对照。以观察病人对蜂针治疗前后的血流供应情况。１材料与方法本实验选择门诊接受蜂针治疗的类风湿... 相似文献
10.
目的:分析中西兽医结合治疗牛瘤胃臌气的疗效。方法:选取2018年5月~2019年5月期间于甘肃某农业服务中心收治的14头牛瘤胃臌气病牛进行分析研究,随机分为实验组与对照组,各7头,对照组进行常规西医治疗,实验组进行中西结合治疗,对比两组治疗效果。结果:在治疗效果上对比,实验组均达到有效及以上标准,总有效率为100.00%,对照组中有1头未达到有效标准,总有效率为85.71%,组间对比差异显著(P<0.05).在不良反应上对比,实验组有1头病牛发生全身出汗症状,不良反应发生率为14.28%,对照组有1头病牛发生呼吸困难,2头出现发热症状,不良反应发生率为42.85%,组间对比差异显著(P<0.05).结论:中西兽医结合治疗牛瘤胃臌气可以显著提升治疗与降低不良反应发生,进而可以减少养殖户的经济损失。 相似文献
11.
为探讨丹参注射液联合奥曲肽对犬急性胰腺炎的临床疗效,选取浙江大学附属动物医院2014年7月至2016年7月门诊诊断为犬急性胰腺炎的70例病例,将其分为治疗组和对照组,每组35例。对照组采用奥曲肽进行治疗;治疗组采用奥曲肽联合丹参注射液进行治疗,分析2组治疗后犬特异性胰脂肪酶水平、腹痛缓解时间、治疗时间以及临床综合效果。结果显示,治疗组和对照组的治疗有效率分别为80%和65.7%,两组之间具有显著性差异(P0.05),即治疗组能显著缓解腹痛时间和缩短治疗时间。因此,丹参联合奥曲肽治疗犬急性胰腺炎的临床效果显著优于单独使用奥曲肽,为犬急性胰腺炎的治疗提供一种新的临床方案。 相似文献
12.
* The working group was set up by the Veterinary Products Committee in response to current concern in both the public domain and in the scientific community about possible health risks related to the routine vaccination of cats and dogs. The working group concluded that vaccination plays a very valuable role in the prevention and control of the major infectious diseases in cats and dogs. Although adverse reactions to vaccination, including lack of efficacy, occasionally occur, the working group concluded that the overall risk/benefit analysis strongly supports their continued use. * Although for some diseases there is evidence of a longer duration of immunity following vaccination than the one year which is typically recommended on the product literature, there is currently insufficient information to propose revaccination intervals other than those proposed by the manufacturer and approved by the regulatory process. * Notwithstanding this, in view of the occasional occurrence of adverse reactions, the working group recommends that the product literature indicates that the regime for booster vaccinations is based on a minimum duration of immunity rather than a maximum. The working group further recommends that the product literature should state that a risk/benefit assessment should be made for each individual animal by the veterinary surgeon in consultation with the owner with respect to the necessity for each vaccine and the frequency of its use. * The evidence suggests that cats appear to be susceptible to the occasional development of sarcomas at sites of injection and there is some further evidence to suggest that, although other products may be involved, this may be more associated with the use of vaccines containing aluminium-based adjuvants. The working group therefore recommends that a generic warning to this effect should appear on the product literature for all feline vaccines administered by injection. The working group also highlighted the need for professional and educational bodies in the UK to bring to the attention of veterinary practitioners appropriate methods for prevention, diagnosis and treatment of this serious condition. * The working group considered in depth the monitoring of adverse reactions, including the advantages and disadvantages of surveillance schemes. A range of options for carrying out further epidemiological (analytical) studies was also considered. However, the working group emphasised that surveillance schemes, and the UK Veterinary Medicines Directorate (VMD) Suspected Adverse Reaction (SAR) Surveillance Scheme in particular, provided a very valuable resource. The large database within the VMD scheme (collected since 1985) was analysed as part of this report. Figures were derived in terms of incidence (reporting rate) of certain clinical signs per 10,000 doses, and risk factors as identified by statistical analysis. However, due to a number of constraints, the analysis was not fully comprehensive and the interaction of possible risk factors was not determined. * Product-related control charts were developed in order to detect changes in incidence rates of adverse reactions (per 10,000 doses sold) both within and between different vaccines. Such charts provide a powerful way to detect changing trends in incidence and, when used in conjunction with product characteristics, they may identify possible causes. In general, the data showed that the incidence of adverse reactions to cat and dog vaccines per 10,000 doses of product sold was relatively low. Although under-reporting is a feature of such surveillance schemes, it does appear that, overall, vaccination of cats and dogs should be considered safe and effective. * Finally, the working group was conscious, while preparing this report, of the extensive media coverage that has been given to the issue of the safety of human vaccines, in particular the mumps, measles and rubella (MMR) vaccine. The working group emphasises that the conclusions and recommendations included in this report relate only to the vaccines used in cats and dogs. The issues identified are specific to the diseases and species examined and no attempt should be made to draw analogous conclusions in relation to vaccines administered to humans. 相似文献
13.
Protecting sheep against early season myiasis (strike) is a significant problem in northern temperate farming systems, where fully-fleeced ewes and early-season lambs approaching market weight, are at high initial risk. Here, the prevention of early-season blowfly strike in ewes was examined on matched commercial sheep farms in south west England, using a new formulation of dicyclanil (CLiKZiN(?) pour on) with a short withdrawal period of 7 days. The ewes on seven farms received a prophylactic treatment with dicyclanil (CLiKZiN 1.25% pour-on suspension) in April 2011; ewes on three control farms received no treatment. The lambs at all farms remained untreated. No adverse reactions to treatment were recorded. On the treatment farms no ewe strikes were recorded between April and June (10 weeks). On control farms, there were 16 strike cases in ewes over the same period, giving a cumulative incidence of 31 cases per 1000 ewes. On the treatment farms only one lamb was struck whereas at the control farms 10 lamb strikes were recorded. The data demonstrate that CLiKZiN was highly effective at protecting ewes against early season strike-challenge. 相似文献
14.
Evaluation of Polysulfated Glycosaminoglycan for the Treatment of Hip Dysplasia in Dogs 总被引：1，自引：0，他引：1
JACEK J. DE HAAN DVM ROBERT L. GORING DVM Diplomate ACVS BRIAN S. BEALE DVM Diplomate ACVS 《Veterinary surgery : VS》1994,23(3):177-178
A double-blinded, controlled clinical study was performed to compare the response of adult dogs affected with hip dysplasia to a placebo and three different dosages of polysulfated glycosaminoglycan (PSGAG): 2.2 mg/kg, 4.4 mg/kg, and 8.8 mg/kg. Dogs were randomly assigned to treatment groups. The drug was administered intramuscularly every 3 to 5 days for a total of eight injections. Response to treatment was analyzed based on changes in lameness, range of motion (ROM), and pain on manipulation of the hip joints. Evaluation for adverse reactions included complete blood cell (CBC) count, blood urea nitrogen (BUN), creatinine, and physical examination. Data were collected on a total of 111 dogs. Eighty-four met all criteria for inclusion in the study. Dogs that were given 4.4 mg/kg of PSGAG showed the greatest improvement in orthopedic scores, whereas dogs in the placebo group showed the smallest improvement; however, the differences in clinical improvement between the four treatment groups were not statistically significant. No local or systemic adverse reactions related to the drug were observed. 相似文献
15.
The efficacy of ivermectin (0.08 per cent w/v oral solution) at different dose levels was evaluated against induced infections of adult Haemonchus contortus (21 days old) and Trichostrongylus colubriformis (21 days old) and fourth stage larvae of Oesophagostomum columbianum (17 days old), Ostertagia circumcincta (five days old) and Strongyloides papillosus (five days old). Twenty-five Boergoats (mutton goats) were randomly allocated by bodyweight within each sex to an untreated control group and four ivermectin treatment groups; ivermectin was administered at either 25, 50, 100 or 200 micrograms/kg orally, once. The goats were killed and processed for worm recovery 25 to 27 days after treatment. At 25 micrograms/kg the efficacy of ivermectin varied from 43 per cent for adult T colubriformis to more than 99 per cent for fourth larval stage O columbianum. Ivermectin at 50 micrograms/kg or higher was 99 per cent or more effective against all induced parasite infections with the exception of ivermectin at 50 micrograms/kg against S papillosus (97 per cent). For all parasites there was a statistically significant (P less than 0.05) difference between the control group and the pooled treated groups. No adverse reactions to ivermectin treatment were observed in the goats. 相似文献
16.
C J Proudman 《Equine veterinary journal》1992,24(2):90-93
The records of 200 colic episodes, collected prospectively, over a two year period, from first opinion cases, were analysed and compared with a control sample selected at random from the same population. Analysis by colic type revealed 72% spasmodic/undiagnosed; 7% surgical; 5.5% flatulent; 5% pelvic flexure impactions; 9.5% other implications and 1% colitis. A possible predisposing cause was identified in 43% of the spasmodic/undiagnosed cases. The total incidence of colic in each age group showed no statistically significant differences from the control population. Stallions were significantly under represented in the colic population. When compared with the control sample the number of spasmodic/undiagnosed colic cases in the 5-10-year-old group and the number of surgical colics in the over 15-year-old group were significantly greater than expected. No statistically significant correlation was found when the seasonal incidence of colic was compared with monthly temperature, change in monthly temperature, monthly rainfall, and rainfall weighted for temperature. 相似文献
17.
Objective To compare the effects of two oil emulsion adjuvants (incomplete Freunds adjuvant and a proprietary oil adjuvant), DEAE-dextran, L-tyrosine particles and Quil A on the humoral immune responses of sheep immunised with recombinant pili of Dichelobacter nodosus (strain A).
Procedure Antibody titres were studied for up to 32 weeks and were measured by bacterial agglutination and ELISA. The relative avidity of antibodies for pili was determined and the incidence and severity of adverse reactions at the site of injection of vaccines were recorded.
Results The oil emulsion adjuvants and Quil A were more effective than either DEAE-dextran or L-tyrosine at stimulating antibodies in sheep. The incidence and severity of adverse reactions was lower in sheep which received vaccines containing either Quil A or DEAE-dextran than in sheep which received vaccines containing oil emulsion adjuvants. L-tyrosine had no adverse effects.
Conclusion Quil A was as effective as oil adjuvants at stimulating high levels of antibodies against recombinant pili in sheep and had the significant advantage of being less irritant after subcutaneous injection. 相似文献
Procedure Antibody titres were studied for up to 32 weeks and were measured by bacterial agglutination and ELISA. The relative avidity of antibodies for pili was determined and the incidence and severity of adverse reactions at the site of injection of vaccines were recorded.
Results The oil emulsion adjuvants and Quil A were more effective than either DEAE-dextran or L-tyrosine at stimulating antibodies in sheep. The incidence and severity of adverse reactions was lower in sheep which received vaccines containing either Quil A or DEAE-dextran than in sheep which received vaccines containing oil emulsion adjuvants. L-tyrosine had no adverse effects.
Conclusion Quil A was as effective as oil adjuvants at stimulating high levels of antibodies against recombinant pili in sheep and had the significant advantage of being less irritant after subcutaneous injection. 相似文献
18.
OBJECTIVE: To determine the incidence and nature of adverse reactions of dogs and cats to tick antitoxin serum and to re-evaluate the role of atropine in the treatment of tick paralysis. DESIGN: A retrospective questionnaire of veterinarians. PROCEDURE: Questionnaires were posted to 320 veterinarians in tick-endemic regions of Australia. Questions referred to dogs and cats treated for tick paralysis over a period of three years: the number treated, treatment protocols and adverse systemic reactions to tick antitoxin serum. Ninety completed questionnaires were returned and responses analysed. RESULTS: Veterinarians reported that approximately 3% of dogs exhibited adverse reactions immediately following treatment with tick antitoxin serum. Eighteen percent of these reactions were described as anaphylaxis, with the remaining 82% attributed to the Bezold-Jarisch reflex. Six percent of cats treated with tick antitoxin serum reacted adversely and the majority of reactions (63%) were ascribed to the Bezold-Jarisch reflex. Atropine was used routinely by 10% of responding veterinarians in the treatment of dogs and cats with tick paralysis. A similar number of veterinarians used atropine only in selected cases. Most veterinarians (76%) reported that they never used atropine in the treatment of tick paralysis in either dogs or cats. Within the survey population, premedication with atropine reduced the number of Bezold-Jarisch reactions following tick antitoxin administration approximately five-fold in dogs and four-fold in cats. CONCLUSIONS: Data from this pilot survey indicate that more cats than dogs have adverse systemic reactions to tick antitoxin serum and that the majority of these reactions in both dogs and cats could be related to the Bezold-Jarisch reflex. The number of reactions to tick antitoxin serum in dogs and cats could be significantly reduced by the routine use of atropine prior to administration of tick antitoxin serum. 相似文献
19.
A benefit to cost analysis of the effect of premilking teat hygiene on somatic cell count and intramammary infections in a commercial dairy herd. 
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下载免费PDF全文 P L Ruegg I R Dohoo 《The Canadian veterinary journal. La revue veterinaire canadienne》1997,38(10):632-636
A field trial was conducted to determine the effect of premilking teat disinfection (predipping) on several measures of mastitis in a commercial dairy farm where the predominant organisms isolated from intramammary infections were coagulase negative Staphylococcus spp. Cows were randomly assigned to a treated (predipped with 0.5% iodine germicide plus "good udder preparation") or a control group ("good udder preparation" alone). Sterile composite milk samples were collected at the initiation of the trial and on an approximately bimonthly basis throughout the duration of the trial. There was no difference in the prevalence of isolation of coagulase-negative Staphylococcus spp. from composite milk samples obtained during the 6 herd cultures. The incidence rate for clinical mastitis in the control group was 1.38 cases per 1000 cow days. The incidence rate for clinical mastitis in the treatment group was 1.06 cases per 1000 cow days. The ratio of these 2 was 1.3, suggesting a higher rate in the control group, but the ratio was not statistically significant (P = 0.34). Logistic regression analysis indicated that the effect of treatment group was not significant, although the coefficient suggested that predipping reduced the risk of clinical mastitis. The benefit to cost ratio of 0.37 indicated that the benefit of reduced incidence of clinical cases of mastitis would not have justified the added expense required to predip the herd. 相似文献
20.
Slingsby LS Murison PJ Goossens L Engelen M Waterman-Pearson AE 《Veterinary anaesthesia and analgesia》2006,33(5):313-327
OBJECTIVE: To assess the analgesic efficacy and adverse effects of a novel, long-acting sufentanil preparation in dogs undergoing ovariohysterectomy (OHE). STUDY DESIGN: Blinded, positively controlled, randomized field trial with four parallel treatment groups. ANIMALS: Eighty client owned dogs undergoing elective OHE randomly allocated into four treatment groups (each n = 20). MATERIALS AND METHODS: Three groups received intramuscular (IM) sufentanil (at 10, 15 and 25 microg kg(-1), respectively) and the control group received subcutaneous (SC) carprofen 4 mg kg(-1) SC plus acepromazine 0.05 mg kg(-1) IM as pre-anaesthetic medication. OHE was performed under thiopental/halothane anaesthesia. Visual Analogue Scale (VAS) scores for pain and sedation were awarded and mechanical nociceptive thresholds were measured at the wound and hock before surgery and up to 24 hours after tracheal extubation. Serum cortisol was measured before surgery, during surgery and up to 24 hours after tracheal extubation. Animals with inadequate post-operative analgesia were given rescue medication. RESULTS: In the carprofen group, VAS pain scores were significantly higher, wound tenderness was greater and requirement for rescue analgesia was more than in the sufentanil-treated groups. Sufentanil produced dose dependent analgesia and sedation. All treatment groups showed similar patterns of change for cortisol concentrations. Use of the sufentanil preparation was associated with a relatively high incidence of adverse events. CONCLUSIONS: The long-acting preparation of sufentanil provided excellent post-operative analgesia that was significantly better than that provided by carprofen. However, use of this formulation, in the anaesthetic technique used in the study, resulted in a relatively high incidence of adverse effects. CLINICAL RELEVANCE: Full mu (MOP) opioid agonists provide significantly better post-operative analgesia than nonsteroidal anti-inflammatory drugs after moderately painful surgery. However, the widely recognized adverse effects of opioids may preclude the use of these agents. 相似文献