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1.
为探究蝌蚪变态前后形态表型、内脏器官大小和免疫功能与特定生活史阶段的关系，测定了泽陆蛙（Fejervarya multistriata）从37期蝌蚪发育至46期幼蛙，多个关键生活史阶段身体大小、内脏器官系数及对植物血凝素（phytohemagglutinin，PHA-P）的反应的变化。结果显示：（1）泽陆蛙的体重、体宽、尾长和体全长都从37期至40～41期升高，之后下降，至46期降至最低值（P < 0.05）；体长42～43期最高，显著高于37期和46期（P < 0.05）。（2）肝、脂肪体和肾湿重系数都在44～45期最高，38～39期最低（P < 0.05），而鳃或肺湿重系数37期显著高于其他发育阶段（P < 0.05），消化道长度系数37期、38～39期和40～41期都显著高于42～43期、44～45期和46期（P < 0.05），心和脾湿重系数均不随发育阶段而变化（P > 0.05）。（3）对PHA-P的反应的最大反应值37期蝌蚪出现于注射后2 h，38～39和42～43期见于3 h，其他发育阶段见于4 h，42～43期蝌蚪显著高于38～39期蝌蚪和46期幼蛙（P < 0.05）。从水生到陆生，泽陆蛙的形态表型变化先于内脏器官大小，以被延迟和下降的免疫功能为代价，影响其成功登陆。 相似文献
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R Q Blackwell B N Blackwell J T Huang L C Chien A Samaharn C Thephusdin C Borvornsin 《Science (New York, N.Y.)》1965,150(703):1614-1615
Hemoglobin J(Korat), a "fast" hemoglobin with an anomaly in its beta chain different from the anomalies previously reported, was the major hemoglobin component in the blood of nine subjects among 1923 Thais from northeastern Thailand. After hemoglobin E, J(Korat) is the second most frequent of the anomalous hemoglobins among Thais. 相似文献
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As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation. 相似文献
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Hemoglobins A and A2 in New World primates: comparative variation and its evolutionary implications 总被引：3，自引：0，他引：3
S H Boyer E F Crosby T F Thurmon A N Noyes G F Fuller S E Leslie M K Shepard C N Herndon 《Science (New York, N.Y.)》1969,166(911):1428-1431
Hemoglobin A(2) (alpha(2)delta(2)) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A(2) exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (alpha(2)beta(2)), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in delta than in beta Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly netutral gene. 相似文献
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本文报道鸭瘟鸭病毒性肝炎二联弱毒疫苗对雏鸭进行早期免疫的试验结果。试验采用不含鸭瘟和鸭病毒性肝炎母源抗体和含不同滴度母源抗体水平的１日龄的四川麻鸭雏鸭，用鸭瘟鸭病毒性肝炎二联弱毒疫苗经皮下注射、饮水、滴鼻和喷雾进行免疫，探索不同免疫途径对鸭瘟和鸭病毒性肝炎的免疫效果及免疫持续期，选出最佳免疫途径。试验结果表明：１．对于没有母源抗体的１日龄雏鸭，用鸭瘟鸭病毒性肝炎二联弱毒疫苗进行免疫的最佳途经是皮下注射和饮水免疫，其中皮下注射效果比饮水稍好：①到３日龄产生对鸭病毒性肝炎部分免疫力，４日龄产生坚强免疫力；②皮下注射到３日龄、饮水免疫到４日龄均产生对鸭瘟的坚强免疫力，保护期持续２个月以上。２．对有母源抗体的雏鸭进行免疫的最佳途经是饮水免疫：①到３４日龄产生对鸭病毒性肝炎部分免疫力，５日龄产生坚强免疫力；②３４日龄产生对鸭瘟部分免疫力，５日龄产生对鸭瘟的坚强免疫力，其免疫持续期２个月以上。 相似文献
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Phenylhydrazine-induced anemia in the domestic cat results in an increase in minor, high oxygen affinity hemoglobin B components and an accompanying decrease in the major, low affinity B component. This change is accompanied by an unusually large increase in erythrocytic adenosine triphosphate and 2,3-diphosphoglycerate, a slight decrease in the oxygen affinity of whole blood, and a large decrease in the Hill constant. 相似文献
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卵黄免疫球蛋白(Immunoglobulin of yolk,IgY)是鸟类、爬行动物和两栖类动物体内的主要抗体,与哺乳动物IgG功能类似,一般从被抗原免疫的母鸡卵黄中提取。与IgG相比,IgY具有许多突出的优点,在制备针对多种抗原的多克隆抗体、免疫检测、人类和动物疾病的预防治疗等方面均得到广泛应用。对IgY在免疫检测方面的应用进展进行了综述。 相似文献
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Antibodies to rabbit cytochrome c arising in rabbits 总被引：3，自引：0，他引：3
Antibodies reactive with rabbit cytochrome c have been observed in rabbits immunized with several heterologous cytochromes. Such antibodies have also been observed in rabbits immunized with rabbit cytochrome c conjugated to bovine gamma globulin. The serum of a rabbit immunized with human cyto chrome c reacted with the cytochrome c of the same rabbit. 相似文献
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鸭病毒性肝炎高免卵黄抗体的研制 总被引：5，自引：0，他引：5
用DVH弱毒疫苗和DVH油乳剂苗免疫健康高产蛋鸡制备高免卵黄抗体,研究了高免卵黄抗体治疗雏鸭DVH的疗效。结果表明,高免卵黄抗体治疗DVH的疗效取决于卵黄抗体的中和效价、治疗时间和免疫途径。卵黄抗体的中和效价应达28.5以上,并且在感染DVH 24 h以内对雏鸭进行肌肉注射,免疫效果最好。 相似文献
11.
左旋咪唑对异育银鲫免疫促进作用的初步研究 总被引：14，自引：1，他引：13
对异育银鲫注射左旋咪唑（ＬＭＳ）、福尔马林灭活的嗜水气单胞菌（ＦＫＣ）和添加ＬＭＳ的ＦＫＣ（ＬＭＳ＋ＦＫＣ）后,通过测定鱼体血液中白细胞的吞噬活性和血清中凝集抗体效价,观察了ＬＭＳ对异育银鲫免疫应答的增强作用。结果表明：无论单独注射ＬＭＳ还是与ＦＫＣ结合注射,ＬＭＳ均能明显地促进供试鱼血液中白细胞的吞噬活性;而且ＦＫＣ＋ＬＭＳ免疫组的血清凝集抗体效价高于ＦＫＣ免疫组。 相似文献
12.
草鱼的体液免疫应答及抗体产生细胞 总被引：3，自引：1，他引：2
以草鱼出血病病毒和牛血清白蛋白（ＢＳＡ）为抗原妆种草鱼,比较了草鱼对两种抗原的体液免疫应答情况。结果显示,在接种了ＢＳＡ的草鱼中,１４ｄ后检测至抗体,其效价在２８ｄ达到峰值;而接种了出血病病毒的草鱼,在２１ｄ后检测到抗体,抗体效价在３５ｄ达到峰值。用ＦＴＴＣ－ＢＳＡ检测免疫ＢＳＡ草鱼的抗体产生细胞,探讨了抗体产生效价与抗体细胞数量的关系。 相似文献
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Hemoglobin of 30 Macaca mulatta monkeys and of 15 Macaca irus monkeys consisted of one electrophoretic component similar to human hemoglobin A. Twenty-one M. irus monkeys had two types of hemoglobin. In 20 animals the hemoglobin resembled human hemoglobin AJ, and in one animal it resembled human hemoglobin AI. 相似文献
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A striking similarity has been found between the composition of peptides obtained from tryptic digestion of normal adult hemoglobin (hemoglobin A) and fetal hemoglobin (hemoglobin F). 相似文献
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Intestinal uptake of macromolecules: effect of oral immunization 总被引：21，自引：0，他引：21
Animals were orally immunized with horseradish peroxidase and bovine serum albumin, and absorption of these antigens was studied. In comparison with controls, a consistent and significant decrease in peroxidase uptake was noted in both germ-free and conventional rats immunized with peroxidase; a similar decrease in serum albumin uptake was also noted in animals immunized with serum albumin. There was no difference in the uptake of an unrelated macromolecule. These observations suggest that local immunization interferes specifically with the intestinal uptake of macromolecular antigens. 相似文献
17.
Two populations of North Carolina have been analyzed for hemoglobin patterns by paper electrophoresis. Of 534 Cherokee Indians, both mixed and full bloods, all showed normal hemoglobin. Lumbee Indians of less certain ethnic status had 1.7 percent of hemoglobin S, an equal amount of hemoglobin C, and one possible hemoglobin D trait among 1332 bloods studied. 相似文献
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抑制素主动免疫对母牛卵泡发育的影响 总被引：10，自引：0，他引：10
本试验以猪精液抑制素粗提物主动免疫母牛,研究了对母牛卵泡发育和内分泌的影响。免疫,母牛的卵泡发育率为１４５．５％,排卵率为１１８．２％,分别比对照组提高４５．５％和１８．２％。通过放射免疫法对免疫牛血液中ＦＳＨ,ＬＨ,Ｅ２水平测定发现,发情时免疫组母牛ＦＳＨ水平高于对照组,免疫组中多卵发育牛ＦＳＨ水平高于单卵牛,免疫组与对照组中ＬＨ水平相差不大,多卵牛发情时Ｅ２水平较高。 相似文献
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抑制素基因免疫诱导单胎绵羊孪生的研究 总被引：14，自引：2，他引：14
应用抑制素基因免疫重组质粒 (PCIS)免疫绵羊 ,首次免疫后 ,绵羊能够产生抗抑制素抗体 ,加强免疫后抗体增加显著 (P <0 0 5 ) ,免疫羊的抗体阳性率可达 4 6 7%。免疫组与对照组促卵泡素 (folliclestimutatinghormone ,FSH)的含量在加强免疫第 4 5天时差异显著 (P <0 0 5 )。在首次免疫第 2 0天与加强免疫第 4 5天 ,抗体阳性羊的促卵泡素含量显著高于抗体阴性羊 (P <0 0 5 )。免疫羊的双羔率达 39 2 % ,显著高于对照组 (P <0 0 5 ) ,比对照组提高 2 9 2 %。 相似文献
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采用已构建的能表达致断奶仔猪腹泻（PWD）和仔猪水肿病（ED）大肠杆菌保护性抗原FedA-Stx 2e B-FaeG融合蛋白的重组菌BL21（pFSFaeG）和重组菌X4550（pFSFaeG）,经IPTG诱导后制成抗原,经口服及灭活后制成油乳剂苗免疫小鼠后,检测IgG抗体水平的变化。结果表明：重组菌经灭活后免疫小鼠能够诱导产生针对上述3种保护性抗原的特异性抗体IgG。免疫效力试验结果显示,两种重组菌的最佳免疫途径均为灭活后经腹腔免疫。 相似文献