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宠物犬猫皮肤癣菌病是一种常见的人兽共患病,是由皮肤癣菌引起皮肤出现界限明显的脱毛圆斑、渗出及结痂等症状。为了解上海市闵行区宠物犬猫皮肤癣菌病情况,我们在闵行区选取15家宠物医院,对临床疑似病例进行系统分析和病原学检查确诊、流行病学统计分析,制定有效的预防和治疗方案。该病的流行情况调查为后续防控犬猫皮肤癣菌病提供依据,进而有效保障闵行区市民身体健康和公共卫生安全。 相似文献
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犬、猫的皮肤真菌病是由皮肤丝状菌（或称为皮肤癣菌）引起的人兽共患真菌性皮肤传染病。主要对该病的病原、流行病学、临床症状、病理变化、诊断方法以及防治措施作一介绍,以期为有效防治该病提供参考。 相似文献
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犬、猫的皮肤真菌病是由皮肤丝状菌(或称为皮肤癣菌)引起的人兽共患真菌性皮肤传染病.主要对该病的病原、流行病学、临床症状、病理变化、诊断方法以及防治措施作一介绍,以期为有效防治该病提供参考. 相似文献
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犬皮肤癣菌病的临床诊断及防治措施 总被引：1，自引：0，他引：1
皮肤癣菌病是犬病临床最常见的真菌性皮肤传染病,本病在犬与人之间呈接触性传染,为人畜共患传染病。皮肤癣菌病是由皮肤癣菌对毛发、爪及皮肤等角质组织引起的感染,皮肤癣菌侵入这些组织并在其中寄生,引起皮肤出现界限明显的脱毛 相似文献
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犬和猫是自然界主要的弓形虫终末宿主,犬猫混养,以及隐性感染的猫科动物粪便污染周边环境,可导致健康犬只感染弓形体病,甚至危及人类健康。为了有效控制该病,经深入分析该病病原学特点、流行特点及临床症状特点,以利于准确鉴别诊断该病及制定完善的综合防治措施,达到理想的防治效果。 相似文献
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旨在建立重组酶聚合酶扩增技术(recombinase polymerase amplification, RPA)结合CRISPR/Cas12a技术的荧光检测方法，以快速、灵敏、可视化检测犬猫皮肤癣菌。以犬小孢子菌、石膏样小孢子菌及须毛癣菌为研究对象，针对真菌内转录间隔区，设计并合成特异性RPA引物和CRISPR RNA(crRNA),建立可同时或分别检测上述皮肤癣菌的荧光检测方法，并评价其检测灵敏度，通过检测临床样本评价本检测方法的敏感性和特异性。结果表明：RPA-CRISPR/Cas12a在37℃、总反应时间30 min的条件下，对三种皮肤癣菌的检测灵敏度可低至单拷贝。对24份临床样本进行检测，以真菌培养和菌落测序结果作为标准，使用可同时识别犬小孢子菌、石膏样小孢子菌及须毛癣菌的皮肤癣菌crRNA(dermatophyte crRNA,crRNA-DM)和可特异性识别犬小孢子菌的犬小孢子菌crRNA(Microsporum canis crRNA,crRNA-Mc)参与RPA-CRISPR/Cas12a反应时，敏感性和特异性均为100%。RPA-CRISPR/Cas12a技术可同时... 相似文献
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正犬猫皮肤病是能引起犬猫皮肤瘙痒、感染、结痂、脱毛及皮肤其他异常变化的疾病的统称,属于宠物犬猫临床上最常见的疾病之一。笔者于2016年1—10月份期间共接诊犬猫皮肤病病例587例,犬较常见的皮肤病是脓皮症,而猫较常见的是皮肤癣菌疾病。犬猫皮肤病不仅会对患病犬猫的外观造成很大的影响,而且还会对犬猫的训练、生活造成极大影响。另外,大部分犬猫皮肤病是一种人畜共患病。在临床诊断中由于皮肤病变的多样化和宠物在就诊时使用药物 相似文献
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Canine and feline dermatomycosis is the common skin disease in small animal,which not only affects the appearance of the canine and feline, but also leads to itching or pain, and even increases the risk of dog and cat owners suffering from dermatomycosis. Dermatomycosis is harmful to health of animals and human beings. The dermatomycosis is difficult to identify, has long treatment cycle and high recurrence, and affected by regional or/and environmental factors, lead to its prevalent and brought great difficulties to the clinical diagnosis and treatment. Canine and feline dermatomycosis could be diagnosed according to illness history survey, clinical symptoms, isolation and identification of pathogens and histopathological examination. In order to curing canine and feline dermatomycosis effectively, systemic therapy combined with topical administration, scientific and rational use of antibiotics, and improvement of animal feeding management should be carried. 相似文献
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Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2 
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下载免费PDF全文 R. S. Lewis J. Fidel S. Dassanayake M. H. Court N. S. Burke K. L. Mealey 《Veterinary and comparative oncology》2017,15(2):411-420
ABCG2 (ATP binding cassette subfamily G, member 2) mediates resistance to a variety of cytotoxic agents. Although human ABCG2 is well characterized, the function of canine ABCG2 has not been studied previously. Feline ABCG2 has an amino acid substitution in the adenosine triphosphate‐binding domain that decreases its transport capacity relative to human ABCG2. Our goal was to compare canine ABCG2‐mediated chemotherapeutic drug resistance to feline ABCG2‐mediated chemotherapeutic drug resistance. HEK‐293 cells stably transfected with plasmid containing canine ABCG2, feline ABCG2 or no ABCG2 were exposed to carboplatin, doxorubicin, mitoxantrone, toceranib or vincristine, and cell survival was subsequently determined. Canine ABCG2 conferred a greater degree of chemotherapy resistance than feline ABCG2 for mitoxantrone. Neither canine nor feline ABCG2 conferred resistance to doxorubicin, vincristine or toceranib. Canine, but not feline, ABCG2 conferred resistance to carboplatin, a drug that is not reported to be a substrate for ABCG2 in other species. 相似文献
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OBJECTIVE: To determine and compare substrate specificity and kinetic rate constants of feline and canine alcohol dehydrogenase (ADH) with ethanol (EtOH) and ethylene glycol (EG) as substrates in vitro, with and without fomepizole. SAMPLE POPULATION: Livers from 3 dogs and 3 cats. PROCEDURE: Canine and feline ADH activity, in cytosolic fractions of homogenized liver, was determined by use of various concentrations of nicotinamide adenine dinucleotide (NAD), EtOH, or EG as substrates. Initial reaction velocities were calculated, and kinetic inhibition rate constants (Ki) for fomepizole were determined. RESULTS: Substrate specificity of canine and feline ADH for EtOH or EG was not significantly different. A 2-fold difference was detected in the maximal velocity of canine, compared with feline, ADH, using either substrate. Fomepizole Ki in feline hepatic homogenates was significantly greater than Ki in canine hepatic homogenates when either EtOH or EG was used as substrate (10- and 30-fold, respectively). A 6-fold increase in the concentration of fomepizole was required to achieve ADH inhibition, with feline homogenates equivalent to those of canine homogenates. CONCLUSIONS AND CLINICAL RELEVANCE: Feline ADH has lower enzymatic capacity for turnover or is less concentrated in liver than canine ADH with regard to EtOH and EG catalysis. Canine ADH was more effectively inhibited by fomepizole than feline ADH. Results suggest that higher dosages of fomepizole may be more effective to treat cats with EG intoxication than dosages reported to treat dogs. 相似文献
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The treatment of inflammatory bowel disease (IBD) possesses numerous difficulties owing to the unclear etiology of the disease. This article overviews the drugs used in the treatment of IBD depending on the intensity of clinical symptoms (Canine Inflammatory Bowel Disease Activity Index and Canine Chronic Enterophaty Clinical Activity Index). Patients demonstrating mild symptoms of the disease are usually placed on an appropriate diet which may be combined with immunomodulative or probiotic treatment. In moderate progression of IBD, 5-aminosalicylic acid (mesalazine or olsalazine) derivatives may be administered. Patients showing severe symptoms of the disease are usually treated with immunosuppressive drugs, antibiotics and elimination diet. Since the immune system plays an important role in the pathogenesis of the disease, the advancements in biological therapy research will contribute to the progress in the treatment of canine and feline IBD in the coming years. 相似文献
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Identification of plaque spirochetes from dogs is rare and no studies to date report cultivation of canine or feline plaque spirochetes. Plaque samples obtained from canine and feline patients were cultured in broth media. Spirochetes cultured were subjected to microscopic evaluation and were cloned on a solid medium. The clones were provisionally identified using species-specific PCR for treponema isolated from human plaque. Canine spirochete clones included Treponema denticola, T. socranskii ssp., T. vincentii, T. maltophilum, T. medium, and T. pectinovorum. Feline clones included T. maltophilum and T. socranskii. Non-amplified clones may represent novel treponemes. Future studies will be aimed at comparison of the spirochetes present in dogs and cats with or without periodontal disease. 相似文献
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Canine and feline C3 have been found by immune precipitation to have a molecular weight of 198K and 197K respectively. Each comprises two polypeptide chains α and β (canine α - 126K β - 72K; feline α - 125K β - 72K). The α chain is subsequently cleaved by C3b ina to produce two fragments αedc (canine 65K; feline 64K) and αfb (canine 40K; feline 46K). The findings are compared to the documented molecular structure of human C3. 相似文献
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The following viruses as well as bacteria and mycoplasma have been isolated from dogs with contagious respiratory disease: canine distemper virus; Canine adenoviruses (type 1 and 2); Parainfluenza type 2 (SV5); Reovirus type 1; Canine Herpesvirus; Bordetella bronchiseptica, Streptococcus, Pasteurella, Staphylococcus and Mycoplasma. The occurrence of these agents can be in direct relationship with: the evolution of a systemic disease; respiratory disorders being a regular or inconsistant symptom of this disease; the evolution of a disease restricted to the respiratory tract; the tropism of the bacterial or viral agent is exclusively respiratory; secondary bacterial complications to a primary viral infection; saprophyte state or latency without pathologic significance. These various infectious agents are implicated alone or in mixed infections and the wide variety of clinical symptoms don't allow to precise a clinical diagnosis. We will try to bring some bases allowing, by the help of laboratory an etiologic diagnosis. This diagnosis is essential for providing an efficient prevention. We will approach some parameters which we have been confronted with as regards Canine Distemper and Canine Adenovirosis. Our purpose is, through these examples of the canine pathology, to confirm and complete some other similar situations which can appear in other animal species. 相似文献