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不同锌源对断奶仔猪免疫和抗氧化作用的影响 总被引：11，自引：1，他引：11
选用 1 4 4头断奶仔猪 ,随机分成 4组 :一组为对照 ,饲喂添加氧化锌 1 0 0 mg/kg的日粮 ,另 3组分别饲喂添加氧化锌 30 0 0 m g/kg、蛋氨酸锌 1 0 0 m g/kg和纳米氧化锌 30 0 m g/kg的日粮 ,进行为期 5 2 d的饲养试验 ,以研究不同锌源对断奶仔猪消化和免疫功能的影响。结果表明 :高剂量氧化锌可提高血清中 Ig A的含量 5 .0 7%(P<0 .0 5 ) ,高剂量氧化锌和纳米氧化锌可使血清中免疫球蛋白 Ig M含量分别提高 2 .97%(P<0 .0 5 )和 5 .6 7%(P<0 .0 1 ) ;蛋氨酸锌可使血清中SOD活性比对照组提高 1 .36倍 (P<0 .0 1 ) ,高剂量氧化锌和蛋氨酸锌可分别使肝脏中 SOD活性提高 2 8.2 0 %(P<0 .0 5 )和 2 9.33%(P<0 .0 5 ) ;高剂量氧化锌、蛋氨酸锌和纳米氧化锌均可提高肝脏组织中金属硫蛋白 (MT)含量 相似文献
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试验旨在研究日粮中不同硫酸锌和蛋氨酸锌水平对断奶-2月龄生长肉兔各组织锌浓度的影响。选用断奶新西兰肉兔140只,随机分为7个处理,每个处理20个重复。在基础日粮中分别以硫酸锌和蛋氨酸锌形式添加40、80、120mg/kg锌,预试期7d,正试期18d。结果表明:不同来源的锌,均能有效提高肝脏、脾脏、肾脏、胰脏、血清、胫骨中锌含量;日粮锌极显著影响血清碱性磷酸酶(AKP)活性。在添加120mg/kg锌范围内,肝脏、血清、胰脏、脾脏锌浓度和AKP活性与日粮锌含量有较强的相关性。蛋氨酸锌使锌离子得到有效保护,锌的吸收利用率高于ZnSO4。 相似文献
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不同锌源对蓝狐生长及肝脏中锌铁含量的影响 总被引：1，自引：0，他引：1
为了考察在日粮中添加有机锌和无机锌对于蓝狐生长及肝脏中锌铁含量的影响。选取60日龄断乳蓝狐90只,于2007年8月2日~12月27日进行饲养试验。结果表明:在日粮中添加不同锌源的添加剂对于蓝狐生长及肝脏中锌铁含量的影响是不同的。与无机锌组比较,有机锌低剂量组和有机锌高剂量组在整个试验期的平均日增重分别提高了9.62%和12.67%,而且均差异显著(P<0.05);有机锌低剂量组与有机锌高剂量组之间的差异不显著(P>0.05)。有机锌低剂量组和有机锌高剂量组的肝脏中的锌含量比无机锌组分别提高了4.23%、15.15%,其中有机锌高剂量组极显著高于其他试验组(P<0.01),无机锌组与有机锌低剂量组的差异不显著(P>0.05)。有机锌低剂量组和有机锌高剂量组肝脏中铁的含量虽都比无机锌组略有提高,但差异均不显著(P>0.05)。 相似文献
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日粮锌源和锌水平对断奶仔猪血清及组织铜、铁、锌沉积的影响 总被引：4，自引：0，他引：4
选用临床检查健康的(26±2)日龄"杜×长×大"三元杂交断奶仔猪100头,按体质量和性别随机分为5组,每组20头,分别饲喂基础日粮、基础日粮+2000mg/kg氧化锌、基础日粮+3000mg/kg氧化锌、基础日粮+250mg/kg蛋氨酸锌、基础日粮+500mg/kg蛋氨酸锌。试验期14d。于断奶后0,7,14d,经前腔静脉采血,用原子吸收光谱仪检测血清中铜、铁、锌水平。试验结束时,每组选5头仔猪放血致死,取心、肝、肾、脑、脾、胸腺组织,测定铜、铁、锌含量。结果显示,仔猪断奶后,血清中铜、锌水平显著或极显著下降(P0.05或P0.01);添加不同锌源和锌水平的高锌日粮能提高断奶仔猪肝、肾、脑、血清锌的含量,显著或极显著降低仔猪血清铜和心、胸腺铜以及脾铁水平(P0.05或P0.01),对血清铁及其他组织铁含量无明显影响。这表明高锌日粮能增加断奶应激仔猪体内锌水平,降低部分组织中铜、铁含量。 相似文献
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试验选用234尾军曹鱼随机分为6个处理,每处理设3个重复,每重复13尾鱼,采用单因素浓度梯度法研究军曹鱼幼鱼商品饲料中锌的最适添加量。在基础日粮(锌含量为75.47mg/kg)中分别添加锌0、30、70、110、150和190mg/kg,制成6种试验日粮,分别投喂军曹鱼幼鱼6周。试验结果表明,基础日粮组鱼成活率、饲料系数、特定生长率、血清碱性磷酸酶(AKP)活性、肌肉和血清锌含量与添加锌组无显著差异(P>0.05)。添加锌组骨骼和肝脏锌含量与基础日粮组差异显著(P<0.05),表现为随锌添加的增加而上升的趋势。以成活率和特定生长率为评价指标,军曹鱼商品日粮中的锌含量可以满足其正常生长需求,不需要额外添加锌。 相似文献
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日粮高锌对仔猪养分消化率血液生理生化指标及粪中锌含量的影响研究 总被引：6，自引：0，他引：6
选用20kg左右长荣仔猪12头,考察日粮中分别添加0、3000mg/kg锌(氧化锌形式)对仔猪养分消化率、部分血液生理生化指标及粪中锌残留的影响。试验结果显示,相对于基础日粮,饲喂高锌日粮(3000mg/kg)可显著(P<0.05)提高仔猪采食量。但高锌日粮显著降低(P<0.05)粗纤维表观消化率,对粗蛋白、干物质、粗脂肪、钙和磷的表观消化率没有显著影响(P>0.05)。日粮添加3000mg/kg锌还可显著降低血红蛋白含量,而对红细胞数目没有影响。高锌对碱性磷酸酶活性升高有显著影响(P<0.05),而对谷-草转氨酶和乳酸脱氢酶没有显著影响(P>0.05)。而饲喂高锌日粮每日粪锌排泄量可达基础日粮组的33倍之多。结果表明,锌通过提高仔猪采食量,提高酶活性来改善猪的生长,但日粮添加超过需要量的锌水平,粪锌的残留及对环境的污染就不可忽略。 相似文献
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本试验旨在通过研究聚天门冬氨酸锌（PASP）对生长猪的生长性能、营养物质表观消化率、血清指标、组织器官锌沉积及锌排放的影响，探讨聚天门冬氨酸锌对硫酸锌的替代效果。试验选用体重相近[（31.73±3.50） kg]的（杜×长×大）三元杂交猪90头，随机分为3组，每组6个重复，每个重复5头猪。对照组锌水平及锌源为80 mg·kg-1一水硫酸锌（ZnSO4·H2O），试验Ⅰ组与Ⅱ组锌水平及锌源分别为60与40 mg·kg-1聚天门冬氨酸锌；试验预试期7 d，正试期30 d。结果表明：1）试验组与对照组平均日增重、料重比及腹泻率均无显著差异（P>0.05）。2）试验Ⅰ组和Ⅱ组钙（Ca）消化率显著高于对照组（P<0.05），粗蛋白质（CP）、粗脂肪（EE）、粗纤维（CF）、粗灰分（Ash）及磷（P）表观消化率在各组间无显著差异（P>0.05），试验Ⅰ组锌表观消化率显著高于对照组和试验Ⅱ组（P<0.05）。3）试验Ⅰ组和Ⅱ组粪锌水平分别比对照组降低了21.65%和30.87%，差异显著（P<0.01）。4）对照组血清中谷丙转氨酶（ALT）活性显著高于试验Ⅰ组和Ⅱ组（P<0.05），试验Ⅰ组球蛋白（GLB）水平显著高于对照组和试验Ⅱ组（P<0.05），血糖（GLU）、总蛋白（TP）、白蛋白（ALB）、总胆固醇（TC）及碱性磷酸酶（AKP）等指标在各组间差异不显著（P>0.05）。5）各组间肝、肾、胰、脾、骨骼、毛发、背最长肌中锌的沉积量均无显著差异（P>0.05），试验Ⅰ组和Ⅱ组血清锌浓度显著高于对照组（P<0.05）。综上所述，本试验条件下，饲粮中添加40 mg·kg-1聚天门冬氨酸锌即可满足该阶段猪的生长需要，并显著降低粪中锌的含量，进而证明聚天门冬氨酸锌在生长猪饲粮中可替代高剂量硫酸锌且有一定的减排作用。 相似文献
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This experiment was conducted to study the effects of zinc polyaspartic acid (PASP) monohydrate on growth performance,nutrient apparent digestibility, serum indexes, tissue and organ zinc accumulations and zinc emission of growing pigs, and to determine the substitution effect of zinc polyaspartic acid for zinc sulfate. Ninety Duroc×Landrace×Large White growing pigs with the body weight of (31.73±3.50) kg were randomly assigned into 3 groups with 6 replicates per group and 5 pigs per replicate. The zinc level and source of the control group was 80 mg·kg-1 zinc sulfate, while group Ⅰ and group Ⅱ were 60 and 40 mg·kg-1 zinc polyaspartic acid monohydrate, respectively. Pre-trial period was 7 days, and formal experiment period was 30 days. The results showed as follows: 1) There was no significant difference in average daily gain, feed to weight ratio and diarrhea rate among control group and test groups (P>0.05). 2) The calcium (Ca) apparent digestibilities of test group I and test group Ⅱ were significantly higher than that of the control group (P<0.05); There was no significant difference among groups in apparent digestibility of crude protein (CP), crude fat (EE), crude fiber (CF), crude ash (Ash) and phosphorus (P) (P>0.05). The apparent digestibility of zinc in the test group Ⅰ was significantly higher than those of the control group and the test group Ⅱ (P<0.05). 3) Compared with the control group, the fecal zinc content in the test group Ⅰ and Ⅱ were decreased by 21.65% and 30.87%, respectively, and the difference was significant (P<0.01). 4)The glutamate transaminase (ALT) activity of control group was significantly higher than those of test group Ⅰ and Ⅱ(P<0.05), the globulin(GLB) level of test group Ⅰ was significantly higher than those of control group and test groupⅡ(P<0.05), the indexes of blood glucose (GLU), total protein (TP), albumin (ALB), total cholesterol (TC) and alkaline phosphatase (AKP) were not significantly different among groups (P>0.05). 5)There were no significant difference of the zinc accumulations in liver, kidney, spleen, pancreas, bone, hair, longgissimus dorsi among groups (P>0.05), the serum zinc concentrations of test group Ⅰ and Ⅱ were significantly higher than that of control group (P<0.05). In summary, under this experimental condition, 40 mg·kg-1zinc polyaspartic acid monohydrate could satisfy the needs of growing pigs at this stage, the fecal zinc content was significantly reduced, thus proving the feasibility of adding polyaspartic zinc instead of high dose zinc sulfate in growing pigs’ feed, and the emission reduction of zinc. 相似文献
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Alip Kumar Abdolreza Hosseindoust MinJu Kim KwangYeol Kim YoHan Choi SeokHee Lee SongYi Lee JunHyung Lee HyunJong Cho Wei Soo Kang ByungJo Chae 《The Journal of Poultry Science》2021,58(1):21
The effects of dietary supplementation of zinc (Zn) sources and concentrations were investigated on growth performance, absorption into tissues, fecal excretion, nutrient retention, and intestinal morphology in broilers fed a corn-soybean meal basal diet. A total of 525 one-day-old chicks (Ross 308) were assigned based on body weight to seven dietary treatments. There were five replicate pens for each treatment and 15 broilers per replicate pen. The dietary treatments included a basal diet (control, without supplementing Zn), and basal diet supplemented with Zn, as inorganic zinc sulfate (ZnS; 110 mg/kg); organic Zn-methionine (ZnM; 110 mg/kg); hot-melt extruded (HME) 25 zinc sulfate (27.5 mg/kg); HME50 zinc sulfate (55 mg/kg); HME75 zinc sulfate (82.5 mg/kg); or HME100 zinc sulfate (110 mg/kg) for 35 days in two phases (d 1–21, phase I and d 22–35, phase II). Bodyweight and feed efficiency of broiler chicks fed diets supplemented with increasing dietary concentrations of HME-Zn improved linearly during the study period (P<0.05). Compared to the control treatment, the ZnS, ZnM, and HME diets increased Zn concentrations in the serum and liver. Inorganic ZnS supply resulted in the highest Zn concentration in excreta. Increasing supplemented Zn content in diets as HME linearly increased Zn concentration in the excreta, serum, liver, and tibia. Broiler chicks fed diets supplemented with increasing concentrations of HME increased villus height (VH; linear and quadratic) of the jejunum and VH of the ileum (linear). Increasing concentrations of dietary Zn supplied as HME resulted in linearly enhanced dry matter, gross energy, and nitrogen retention of broilers on day 21. These results suggest that dietary HME-Zn at a lower level (55 ppm) shows the same growth performance as common ZnSO4 at 110 ppm. 相似文献
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2种锌源对体外培养胸腺细胞Bcl-2、Bax、Caspase-3 mRNA表达的影响 总被引：1，自引：0，他引：1
采用地噻咪松作为诱导剂,建立小鼠胸腺细胞体外培养的凋亡模型,培养基中分别补加1 000μmol/L的硫酸锌或蛋氨酸锌,培养16 h.测定细胞的凋亡率、DNA片段化以及Bcl-2、Bax、Caspase-3 mRNA表达量.结果表明,地噻咪松显著提高体外培养腺细胞凋亡(P＜0.01),并上调Bcl-2、Bax、Caspase-3 3种基因的mRNA表达(P＜0.01).硫酸锌和蛋氨酸锌对地噻咪松诱导的凋亡均有显著的抑制作用(P＜0.01),并对上述3种基因表达的上调有抑制作用(P＜0.01).蛋氨酸锌处理的细胞凋亡率及Caspase-3 mRNA表达均高于硫酸锌处理,Caspase-3mRNA表达量差异达到了显著水平(P＜0.05).这表明,锌调控糖皮质激素诱导的细胞凋亡涉及到对基因转录水平的调节,2种锌源在一定程度上存在着差异. 相似文献
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C L Robinette 《Veterinary Clinics of North America: Small Animal Practice》1990,20(2):539-544
Zinc poisoning in small animals has been described in dogs, cats, birds, and ferrets, but the dog appears to be the species most often affected. Ingestion of zinc-containing metallic objects, including pennies, and zinc oxide ointments has been associated with the majority of the toxicoses. Clinical signs include anorexia, vomiting, diarrhea, hemolytic anemia, kidney dysfunction, and possible liver and pancreatic abnormalities. Treatments that have proven efficacious include fluid diuresis, blood transfusions as needed, general supportive care, and removal of the source of zinc. Further evaluation of the benefit of chelation therapy is urgently needed. 相似文献
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本试验旨在研究蛋氨酸螯合锌替代硫酸锌对肉鸡生产性能、肉品质及抗氧化指标的影响。试验选用1日龄体重接近的健康爱拔益加（AA）肉公鸡200只,随机分为2个处理,每个处理5个重复,每个重复20只鸡。各处理组肉鸡均饲喂基础日粮且将Zn的添加水平定为40 mg/kg,其中处理1组以硫酸锌形式添加锌,处理2组以蛋氨酸螯合锌形式添加锌。试验期为42 d。结果表明,①与硫酸锌相比,蛋氨酸螯合锌显著降低了22~42 d和1~42 d肉鸡的料重比（P < 0.05）,但对各阶段肉鸡平均日采食量、平均日增重以及21和42 d肉鸡体重均无显著影响（P > 0.05）。②蛋氨酸螯合锌替代硫酸锌对42 d肉鸡宰前体重、屠体重、全净膛重、腿肌重、屠宰率、胸肌率和腿肌率均无显著影响（P > 0.05）,但显著降低了42 d肉鸡全净膛率（P < 0.05）,增加了42 d肉鸡胸肌重、腹脂重和腹脂率（P < 0.05）。③蛋氨酸螯合锌替代硫酸锌对42 d肉鸡胸肌肉色、滴水损失和蒸煮损失均无显著影响（P > 0.05）。④与硫酸锌相比,蛋氨酸螯合锌显著提高了21和42 d肉鸡血清铜锌—超氧化物歧化酶（CuZn-SOD）活力以及42 d肉鸡血清总抗氧化能力（T-AOC）（P < 0.05）,降低了21 d肉鸡血清丙二醛（MDA）含量（P < 0.05）,但对21和42 d肉鸡血清谷胱甘肽过氧化物酶（GSH-Px）活力无显著影响。由此可见,蛋氨酸螯合锌替代硫酸锌具有提高肉鸡生产性能和抗氧化功能的作用。 相似文献
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Zinc toxicity, copper deficiency and an associated anaemia among weaned swill-fed pigs is described. The source of zinc was flaking galvanising from the inside of bins used to store swill before processing. The disease condition readily responded to supplementation of the diet with copper sulphate. The interactions between dietary zinc, copper and calcium are discussed with reference to the swill-feeding industry. It is concluded that supplementary copper should be routinely included in the ration of swill-fed pigs and that the use of galvanised bins for storing swill should be avoided. 相似文献
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锌参与动物体内300余种酶和功能蛋白的组成,它不仅影响营养物质、遗传物质的代谢,同时与许多活性物质有关。锌指蛋白的发现使人们认识到锌以锌指蛋白的方式调控着机体的生命活动,锌指蛋白是基因调控蛋白中最重要的蛋白。本文综述了锌与锌指蛋白的关系以及锌指蛋白对机体贫血的影响,以深入了解机体贫血的机制。 相似文献