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1.
芬苯哒唑混悬液驱牛中华双腔吸虫试验徐德纯，张庆伟，宋奉列，敖恩（内蒙古兴安盟牧业科学研究所）内蒙古兴安盟中华双腔吸虫平均感染率为６４．８％，多年来威胁着养牛业的发展。为了尽快控制该寄生虫病的危害，寻找驱虫新药，１９９２年１１月我们应用芬苯哒唑混悬液在... 相似文献
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氟苯哒唑控释药丸对山羊线虫的驱除效果 总被引：1，自引：0，他引：1
通过给山羊投服氟苯哒唑控释药丸，观察药丸对山羊寄生线虫的驱除效果。I组为投服氟苯哒唑控释药丸组，投药后第5－105d线虫虫卵减少率为100％；II组为胃管一次给药组，给药后第5d线虫虫卵减少率为96．9％，30d后虫卵数回升。试验结束时，I组山羊平均增重比II组和不给药对照组（Ⅲ组）的平均增重分别多2．1kg和4．1kg。结果表明，控释药丸不仅比胃管一次给药的驱虫效果好，且药效时间明显延长。 相似文献
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丙硫苯咪唑控释装置及其在山羊体内的释药过程和药效研究 总被引：6，自引：1，他引：5
本试验对丙硫苯咪唑控释装置及其在山体内的释药过程和药效进行研究。筛选出丙硫苯咪唑释放率为１９±１ｍｇ／ｄａｙ的基质（Ｂ５７）。本控释装置适用于２０～３０ｋｇ山羊，在奶山羊体内能持续稳定释药６１±３ｄａｙｓ。类血浆中未能测出丙硫苯咪唑原药，只能测到其代谢产物丙硫苯咪唑亚砜和砜，其浓度分别为１３±３ｎｇ／ｍｌ和１２±６ｎｇ／ｍｌ。本装置对广东放牧的雷州山羊进行驱虫试验，结果试验组（剂量为０．７６ｍｇ／ 相似文献
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根据寄生虫预测预报模拟模型预测羊蠕虫在牧地上季节数量变化而制定防治计划，于１１月下旬每羊投服１０ｍｇ／ｋｇ芬苯哒唑片剂，于第二年４月初每羊投服该药长效控释丸一粒，于６月中旬考核结果，发现羊粪中虫卵量显著减少，羊各项生产指标均有所提高，显示了防治效果良好。 相似文献
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芬苯哒唑干粉混悬剂对绵羊肝片吸虫的驱除试验 总被引：1，自引：0，他引：1
芬苯哒唑是一种广谱驱虫药，对不同动物线虫的驱除效果已有大量报道，但对羊肝片吸虫的驱除效果却资料有限。为了验证芬苯哒唑干粉混悬剂对绵羊自然感染肝片吸虫的驱除效果，并确定适宜的使用剂量，笔者于2000年8月进行了本项试验。 相似文献
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阿苯哒唑(Albendazole)是目前广泛用于驱除人畜体内寄生蠕虫的广谱驱虫药,还具有杀灭虫卵和幼虫的功效。本试验在于检验阿苯哒唑对山羊肝片形吸虫的驱虫效果、反应及剂量选择。 1、试验动物与药物 (1)动物从农户选取经镜检粪卵阳性的山羊40只,体重22～31 kg,常规饲养。 (2)药物市售肠虫清片(商品名),白色,每片含阿苯哒唑200 mg,中美天津史克制药有限公司出品,批号:910916。选硫双二氯酚为对照药物,片剂,每片含有效成分0.5 g,江苏省江都县第二兽药厂生产,批号:910902。 2、试验分组试验山羊按每克粪卵数(EPG)随机分为5组,每组8只。1～4组为阿苯哒唑试验组,每kg体重用药剂量依次为: 相似文献
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1991年至1992年我在日本研修，其实习他为三重县阿山叶福岛养猪场。该场为锯木屑发酵猪舍，猪群寄生虫感染较严重，特别是猪鞭虫、猪蛔虫混合感染率高达81．3％。重感猪下痢，生长缓慢，且屠场白斑肝废弃率高，造成较大经济损失。我们采用苯硫哒唑进行了驱虫试验，取得满意的效果，现将试验经过和结果报道如下：试验材料药物：苯硫哒唑（明治制果株式会社生产的“每kg中含苯硫哒唑10g）。试验猪：福岛猪场各口龄LWD猪（经粪检确定为感染猪始虫、蛔虫阳性猪）。试验方法一、李辞哇哇驱虫用量用法比较试验设用量和用法为sins／ksXI日、3ms／… 相似文献
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阿苯哒唑(Albendazole)是一种新型的广谱驱虫药,目前广泛用于驱除人体内的线虫及绦虫的单纯或混合感染,还具有杀灭体内虫卵和幼虫的功效。本试验在于检验阿苯哒唑对猪寄生虫的驱虫效果、反应及剂量选择。现将 相似文献
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M. Eysker J. H. Boersema F. N. J. Kooyman T. J. G. M. Lam 《Veterinary parasitology》1995,60(3-4):339-348
A grazing study was performed with the main objective of examining the effect of fenbendazole (FBZ) in a ‘dose and move’ system on nematode infections in calves with special emphasis on Dictyocaulus viviparus.
Three groups of six calves were grazed from May to October 1993. One group (DM7) was treated with FBZ and moved to aftermath (pasture which had only been mown) 7 weeks after turnout. The second group (DM9) was similarly treated and moved 9 weeks after turnout and the third group served as untreated pasture control group (PC) and was moved to aftermath 9 weeks after turnout.
FBZ treatment removed adult lungworms from DM7 and DM9. Tracer calves grazed during the first 7 or the first 9 weeks after turnout acquired mean burdens of 18 and 125 lungworms, respectively. In PC faecal larval counts increased until the end of August. Most of the animals in this group were then suffering from lungworm disease and emergency treatment with ivermectin was given. In both FBZ-treated groups, larvae reappeared in the faeces of some of the calves 4–5 weeks after treatment. Subsequent reinfection resulted in higher mean faecal larval counts in both groups 2 months after treatment, although variation in faecal larval counts was high. In DM7 values tended to be higher than in DM9. These higher larval counts were associated with mild signs of parasitic bronchitis in some calves of DM7, whereas no signs were seen in DM9.
At the end of the experiment, all calves, and also a group of six permanently housed non-infected control calves (HC), were infected experimentally with 5000 D. viviparus larvae to evaluate development of immunity. The worm counts at necropsy showed that all calves on pasture had developed immunity. 相似文献
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芬苯达唑干混悬剂对绵羊裸头科绦虫的驱除效力试验 总被引：2，自引：0，他引：2
应用芬苯达唑干混悬剂,分别按5,10,20mg/kg体重剂量驱除绵羊裸头科绦虫,并设吡喹酮片剂20mg/kg体重剂量药物对照组和阳性对照组。粪检结果:芬苯达唑干混悬剂5,10,20mg/kg剂量对裸头科绦虫的粪便虫卵(节片)转阴率分别为70.0%、100.0%和100.0%。用药后14d剖检结果:芬苯达唑干混悬剂5mg/kg体重剂量对莫尼茨绦虫、无卵黄腺绦虫的驱虫率分别为70.7%、63.0%;10、20mg/kg体重剂量的驱虫率均达100.0%。结果表明10mg/kg和20mg/kg体重芬苯达唑干混悬剂试验剂量对绵羊裸头科2属绦虫均有效,其中10mg/kg以上剂量驱除绵羊裸头科绦虫高效安全。 相似文献
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Joe Luksovsky Thomas M. Craig Glenda M. Bingham Tracy Cyr David Forrest 《Journal of Equine Veterinary Science》2013
A study was undertaken at the Texas A&M Horse Center to evaluate and compare the effectiveness of three anthelmintics—ivermectin, fenbendazole, and a combination of ivermectin and pyrantel pamoate—on fecal egg count reductions of cyathostomes and Parascaris equorum in 30 naturally infected foals. The foals were randomized into three treatment groups, with individuals being rerandomized after each 8-week observation period. The treatments of ivermectin and fenbendazole were given at the manufacturer's recommended doses, and the pyrantel treatment was given at two times the manufacturer's recommended dose. Fecal egg counts were performed at the time of treatment and at 2-week intervals after treatment for a total of 8 weeks. Each foal received a total of three treatments during the course of the study. Fecal egg counts were performed by a modified McMaster's test, with a sensitivity of 25 eggs per gram of feces, and by the modified Wisconsin double centrifugal flotation technique, with a sensitivity of 0.2 eggs per gram of feces. Fecal egg reduction percentages were calculated. Analysis of the results showed that ivermectin, either used alone or with pyrantel, was a more effective anthelmintic for cyathostome (small strongyle) control than fenbendazole. Fenbendazole and pyrantel showed a higher initial reduction in Parascaris egg counts when compared with the ivermectin-only-treated group, but this difference lessened over time. The use of the combination treatment showed the best results for controlling both parasites, indicating that a combination of anthelmintics may be necessary to control parasites on some equine farms. 相似文献
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《Veterinary parasitology》2015,207(3-4):276-284
Anthelminthic resistance in nematodes of beef cattle is an emerging issue globally with implications for effective parasite control. The prevalence of resistance in beef cattle in the Mediterranean-style climatic zone of south-west Western Australia was assessed on 19 farms, using faecal egg count reduction tests. Pre-treatment faecal worm egg counts were compared with counts at 14 days after treatments with ivermectin (injectable), fenbendazole (oral), or levamisole (oral). A separately grazed group treated with topical ivermectin (pour-on) and sampled at 28 days was included as a comparison against injectable ivermectin. The results demonstrate that resistance is common, with failure of at least one anthelmintic (<95% reduction for each species, by arithmetic means) for either of the major species Cooperia oncophora or Ostertagia ostertagi on 17 of the 19 properties. Resistance to ivermectin (injectable) was demonstrated in C. oncophora in 59% of tests, but ivermectin was fully effective against O. ostertagi by this route. Conversely, O. ostertagi resistant to fenbendazole and levamisole were present on 50% and 67% of farms respectively, with both fully effective against C. oncophora. The finding of Haemonchus placei on several properties was unexpected but the egg counts were low and there is no suggestion of pathogenic effects. An indication of reduced efficacy of the pour-on ivermectin formulation compared to the injectable was apparent against both C. oncophora and O. ostertagi, and this may have implications for resistance development, given the widespread use of topical treatments reported in this region. This survey confirms that anthelminthic resistance in nematodes of beef cattle is common in Western Australia and the pattern of occurrence is in general agreement with surveys elsewhere in Australia and in other countries. 相似文献
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Bettencourt P.S. Capece Guillermo L. Virkel Carlos E. Lanusse 《Veterinary journal (London, England : 1997)》2009,181(3):241-250
Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals. 相似文献
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Savlík M Fimanová K Szotáková B Lamka J Skálová L 《Research in veterinary science》2006,80(3):267-274
Fenbendazole (FEN) and flubendazole (FLU) are benzimidazole anthelmintics often used in pig management for the control of nematodoses. The in vivo study presented here was designed to test the influence of FLU and FEN on cytochrome P4501A and other cytochrome P450 (CYP) isoforms, UDP-glucuronosyl transferase and several carbonyl reducing enzymes. The results indicated that FEN (in a single therapeutic dose as well as in repeated therapeutic doses) caused significant induction of pig CYP1A, while FLU did not show an inductive effect towards this isoform. Some of the other hepatic and intestinal biotransformation enzymes that were assayed were moderately influenced by FEN or FLU. Strong CYP1A induction following FEN therapy in pigs may negatively affect the efficacy and pharmacokinetics of FEN itself or other simultaneously or consecutively administered drugs. From the perspective of biotransformation enzyme modulation, FLU would appear to be a more convenient anthelmintic therapy of pigs than FEN. 相似文献
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J. Cabaret H. M. Baudet J. Devos J. Hubert J. Cortet C. Sauv 《Veterinary parasitology》1995,60(3-4):331-337
Multispecific resistance to benzimidazoles was studied in three selected farms. These farms had bred dairy goats for more than 15 years. The helminths were introduced with the goats at the establishment of the farms which afterwards remained isolated. Nematode resistance could then be related to their own management practices. Faecal egg count tests and egg hatch assays were performed to assess intensity of resistance. The generic (infective larvae in faecal cultures) and specific richness (adult worms) were assessed. The resistant species were Trichostrongylus colubriformis, Teladorsagia circumcincta, Haemonchus contortus and Oesophagostomum venulosum. Faecal egg count reduction tests and egg-hatch assays did not match exactly. Faecal larval counts after treatments gave a distorted picture of multispecific resistance: Haemonchus and Oesophagostomum were very largely over represented. The number of species found in the three farms was relatively low compared with other reports in goat farms of the area. This reduction of diversity might also be due in part to characteristics of breeding management and history (use of permanent pasture and introduction of goats at the establishment of farm). 相似文献
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Traversa D Klei TR Iorio R Paoletti B Lia RP Otranto D Sparagano OA Giangaspero A 《Preventive veterinary medicine》2007,82(3-4):314-320
In the present survey, 276 horses bred on 16 farms located in central and southern Italy were investigated for the presence of drug resistant cyathostomes by a Fecal Egg Count Reduction Test (FECRT). Sixteen to 20 animals were selected on each farm and randomly assigned to one of four equally sized treatment groups. Groups were treated with fenbendazole, pyrantel pamoate, ivermectin or moxidectin. Resistance to fenbendazole was declared on six farms (37.5%) and suspected in two farms (12.5%), with FECR values ranging from 41% to 88.3%. Resistance to pyrantel was found in two farms (12.5%) and was suspected in one case (6.2%), with FECR values ranging from 43% to 85.4%. Macrocyclic lactones remained effective on all farms. Only cyathostome third stage larvae (L3) were found in fecal cultures after treatment. This paper reports the first wide survey conducted in Italy for anthelmintic resistance in equine cyathostomes. The results indicate that multiple drug resistant equine cyathostomes are present in the central and southern regions of Italy. These data call for a geographically and numerically broader investigation of horse farms in all regions and for the development and implementation -among veterinarians, owners and managers of a plan to reduce the expansion of these anthelmintic resistant populations and control these important parasites. 相似文献
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Four experiments, two with sheep and two with goats, were carried out to determine the efficacy of ivermectin, fenbendazole, levamisole, closantel and some of their combinations by faecal egg count reduction tests. In the first experiment, injectable ivermectin, oral ivermectin, fenbendazole and levamisole were tested in 6-month-old lambs, and their reduction percentages were 77%, 13%, 42% and 92%, respectively. In the second experiment, with yearling sheep, the reduction percentages were 35% for injectable ivermectin, 32% for fenbendazole, 99% for levamisole, 48% for closantel, 92% for injectable ivermectin combined with fenbendazole, 99% for injectable ivermectin combined with levamisole, and 100% for fenbendazole combined with levamisole. In the study with 18-month-old goats given the same dose rates as those recommended for sheep, the reduction percentages were 73% for injectable ivermectin, 25% for fenbendazole, and 78% for levamisole. Another group of 14-month-old goats was treated with dose rates 1.5 times those recommended for sheep and the reduction percentages were 93% for levamisole, 92% for injectable ivermectin, and 97% for a combination of levamisole and ivermectin. In all experiments with sheep and goats the gastrointestinal nematode parasites identified by larval cultures were Haemonchus contortus, Trichostrongylus spp. and Oesophagostomum spp. The gastrointestinal nematodes of both sheep and goats on this farm are resistant to ivermectin and fenbendazole, whereas levamisole is still effective in sheep, but not in goats. The results are discussed in relation to the farm as a source of breeding stock to smallholder farmers and its potential to spread anthelmintic resistance. 相似文献