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1.
共轭亚油酸降低脂肪沉积的分子机制研究进展   总被引:1,自引:0,他引:1  
共轭亚油酸(CLA)因在降低体脂沉积中的生物学功能而成为近年来的研究热点。研究显示,CLA对机体脂肪代谢的调控机制具有复杂性,胞内钙离子、G蛋白偶联受体和炎症反应等通路均可介导CLA对脂肪细胞分化、凋亡、脂质合成的调控作用。本文将综述介导CLA调控脂肪代谢的通路及其相关机制,旨在为进一步的CLA介导的抗肥胖机制研究提供参考。  相似文献   

2.
介绍了共轭亚油酸(CLA)的来源和在人体中的生理作用,重点阐述影响牛乳中CLA含量的因素,包括在日粮中添加油脂、饲喂制度、季节变化和地理位置,提出了调控牛乳中CLA的含量的两种途径:改变日粮和饲养管理方式。  相似文献   

3.
调控牛乳中共轭亚油酸含量的研究进展   总被引:1,自引:0,他引:1  
肖浩 《草业与畜牧》2007,(11):48-50
介绍了共轭亚油酸(CLA)的来源和在人体中的生理作用,重点阐述影响牛乳中CLA含量的因素,包括在日粮中添加油脂、饲喂制度、季节变化和地理位置,提出了调控牛乳中CLA的含量的两种途径改变日粮和饲养管理方式.  相似文献   

4.
《中国家禽》2013,(12):36
近日,中国农业科学院饲料研究所齐广海研究团队在共轭亚油酸(Conjugated linoleic acid,CLA)调控产蛋鸡抗氧化机能的作用机理研究取得重要进展。该研究结果为阐述CLA的抗氧化作用提供新的研究思路和研究方向,研究结论可为生产营养健康鸡蛋、调控和改善产蛋鸡健康状况提供依据。  相似文献   

5.
科学家发现共轭亚油酸(CLA)是一种对人类健康有益的脂肪酸,由此引发了世界各国科学家对CLA研究的极大兴趣,人们试图通过日粮中脂肪酸的调控来提高牛奶中CLA的含量.世界上许多国家(特别是欧盟国家)已投入巨资进行研究.笔者对反刍动物的脂肪营养研究动态和CLA的营养作用及其调控途径作了综述,并提出今后的研究方向.  相似文献   

6.
科学家发现共轭亚油酸(CLA)是一种对人类健康有益的脂肪酸,由此 引发了世界各国科学院对CLA研究的极大兴趣,人们试图通过日粮中脂肪酸的调控来提高牛奶中CLA的含量,世界上许多国家(特别是欧盟国家)已投入巨资进行研究。笔者对反刍动物的脂肪营养研究动态和CLA的营养作用及调控途径作了综述,并提出今后的研究方向。  相似文献   

7.
随着科学技术的不断发展,人们对CLA保健功能的认识越来越清楚,都希望摄取富含CLA多的食品。我国人均每天CLA的摄入量不足5mg,即使发达国家(如德国人均每天摄食CLA为043g)也达不到CLA发挥生物功效的有效剂量。美国研究委员会已在1996年把CLA列为唯一一种具有抗癌作用的动物源脂肪酸,所以提高牛奶中CLA含量成为现在研究的新热点。本文就影响牛奶中CLA含量的几个因素(奶牛个体选择、营养调控和科学管理)进行论述。  相似文献   

8.
共轭亚油酸(CLA)因具有抗癌、抗糖尿病及增强机体免疫力等功能而备受研究人员关注,近年来,针对备受消费者青睐的羊肉和羊奶等产品中CLA含量的研究越来越多。作者简述了反刍动物产品中CLA生物合成机制,并重点回顾了多种营养调控措施对瘤胃中CLA和十八碳烯酸积累的影响结果;进一步探讨了这几种营养调控方式对羊乳和羊肉中CLA含量的影响。分析认为,利用油脂底物和调控剂混合添加有利于加强瘤胃纤维菌群和原虫区系对CLA、十八碳烯酸的积累和过瘤胃率,并可在提高动物产品中CLA含量的同时,避免乳脂率下降。今后还需通过营养、分子生物学及生理学等角度全面揭示CLA合成机理,为生产富含CLA的动物产品提供参考。  相似文献   

9.
影响反刍动物产品中共轭亚油酸含量的饲粮因素探讨   总被引:2,自引:0,他引:2  
共轭亚油酸(CLA)具有抗癌、抗动脉粥样硬化、抗氧化、降低脂肪沉积、促进生长以及调节免疫等重要的生理功能。人类食物中的CLA主要来源于反刍动物产品。影响反刍动物产品CLA含量的因素主要包括:(1)饲粮中的脂类底物;(2)瘤胃内环境的改变;(3)饲喂方式;(4)饲粮中CLA的供给。生产中可以通过饲粮来调控瘤胃微生物区系,以增加CLA的合成;也可以给饲粮提供富含亚油酸的原料,通过增加底物来提高反刍动物产品中的CLA含量。  相似文献   

10.
共轭亚油酸对脂肪细胞成熟调控机理研究   总被引:1,自引:0,他引:1  
共轭亚油酸(CLA.Conjugated linoleic acid)是一类具有顺、反异构体的十八碳二烯酸的统称,当前,CLA的生物学功能已成为研究热点,尤其在脂肪代谢调控上,具有降低脂肪沉积和血液胆固醇水平的功效。通过对CLA的脂肪细胞成熟(包括对脂肪细胞的增殖、分化,脂肪的沉积、甘油三磷酸的沉积等过程)调控机理的综合论述,以便为CLA更深入的研究提供参考。  相似文献   

11.
共轭亚油酸对猪脂肪沉积的影响   总被引:1,自引:0,他引:1  
周杰 《中国饲料》2005,(14):19-21
本文就共轭亚油酸对猪脂肪沉积、脂肪组织中脂肪酸的组成、脂肪代谢的影响作一综述,并探讨共轭亚油酸可能的作用机理。  相似文献   

12.
Feeding mice conjugated linoleic acid (CLA) reduces body fat. Soluble fibre decreases apparent lipid digestibility. The objective of the present study was to examine whether a combination of dietary CLA and soluble fibre would further decrease the proportion of body fat than a diet with CLA alone. Therefore, we fed mice diets with CLA and different amounts of Nutrim, containing 10% soluble fibre. CLA was added to the control diet at the expense of high oleic acid sunflower oil (HOSF) component and Nutrim was added at the expense of an isoenergetic combination of starch, dextrose and cellulose. The diets were fed for 28 days. Weight gain after 28 days was less in CLA-fed animals than in HOSF-fed animals. Both CLA and Nutrim increased the body water content. CLA reduced total body fat and epidydymal fat but Nutrim did not. No interaction of CLA and fibre was detected. We, therefore, must conclude that under the present experimental conditions dietary CLA and fibre do not interact to reduce body fat deposition.  相似文献   

13.
本文就共轭亚油酸的生物学功能及其对肉鸡生产性能、脂肪沉积、脂肪酸组成、免疫机能、屠宰性能和胴体品质影响方面进行综述。  相似文献   

14.
This study was performed to assess the effects of rumen-protected conjugated linoleic acid (CLA) on hepatic lipid metabolism in heifers. In particular, it was of interest whether feeding CLA causes development of fatty liver as observed recently in mice. Thirty-six growing heifers with an initial body weight of 185 kg were allotted to three treatment groups and fed daily 250 g of different rumen-protected fats for 16 weeks: The control group received 250 g of a CLA-free control fat, the CLA100 group received 100 g of a CLA fat containing 2.4% of cis-9, trans-11 CLA and 2.1% of trans-10, cis-12 CLA and 150 g control fat and the CLA250 group received 250 g of the CLA fat. CLA supplementation had no effect on animal performance parameters, liver weight and hepatic triglyceride concentration. Moreover, mRNA expression of hepatic genes involved in lipogenesis, β-oxidation and fatty acid transport was not influenced by dietary CLA. The fatty acid composition of hepatic total lipids, with particular consideration of ratios of fatty acids indicative of Δ9-, Δ6- and Δ5-desaturation, was also less influenced by dietary CLA. In conclusion, the study shows that dietary rumen-protected CLA has less effect on hepatic lipid metabolism in young heifers and does not induce the development of a fatty liver such as in mice.  相似文献   

15.
杨媚  马杰  杨泰  闫昭明  陈清华 《中国畜牧兽医》2019,46(11):3216-3224
共轭亚油酸(CLA)作为一种天然的新型功能性脂肪酸,具有抗高血压、抗癌、抗糖尿病等生物学特性,其发挥不同作用的主要活性异构体不同。近年来,随着CLA人工合成成本的降低及动物营养领域研究的深入,发现CLA既可抑制促炎因子的表达和产生,促进抑炎因子的产生,达到抗炎的效果;又可调控淋巴细胞的增殖和分化、巨噬细胞的活性、促进抗体合成,调节机体体液免疫和细胞免疫,进而增强动物免疫力;CLA还可调节多种核转录因子的表达,影响脂肪酸的摄取和氧化及脂质的合成代谢,从而降低体脂沉积,提高肌内脂肪含量,改变脂肪酸组成,改善肉品质等。因此CLA在畜牧业生产中具有潜在的应用价值和广阔的市场前景。作者主要介绍了CLA在抗炎、免疫功能、脂质代谢和抗氧化等方面的作用,综述了CLA的生物学功能及其在动物生产上的应用研究进展。此外,还探讨了CLA作为饲料添加剂,其合成纯度,在不同种类动物、不同年龄阶段的最适添加量、饲喂方式等问题,旨在为其在动物生产中的合理应用提供理论参考。  相似文献   

16.
This study was conducted to estimate the effect of dietary conjugated linoleic acids (CLA) on intramuscular and subcutaneous fat deposition in Yellow Breed × Simmental cattle. The experiment was conducted for 60 days. The results showed that the average backfat thickness, (testicles + kidney + pelvic) fat percentage and subcutaneous fat percentage in dietary CLA were significantly lower than in the control group, while intramuscular the fat percentage was significantly higher. Compared to the control group, the Longissimus muscle enzyme activities of lipoprotein lipase (LPL), fatty acid synthase (FAS) and acetyl‐coenzyme A carboxylase (ACC) in dietary CLA and the subcutaneous fat enzyme activities of LPL, hormone‐sensitive lipase (HSL) and carnitine palmitoyltransferase‐1 (CPT‐1) were significantly increased. Similarly, compared to the control group, the Longissimus muscle sterol regulatory element binding protein 1 (SREBP‐1), FAS, stearoyl‐coenzyme A desaturase (SCD), ACC, peroxisome proliferator‐activated receptor γ (PPARγ), heart fatty‐acid binding protein (H‐FABP) and LPL gene expression in dietary CLA were significant increased, as were the subcutaneous fat of PPARγ, H‐FABP, LPL, CPT‐1 and HSL in dietary CLA. These results indicated that dietary CLA increases IMF deposition mainly by the up‐regulation of lipogenic gene expression, while decreasing subcutaneous fat deposition mainly by the up‐regulation of lipolytic gene expression.  相似文献   

17.
脂肪酸合成酶基因的研究进展   总被引:1,自引:0,他引:1  
在脂肪酸的合成过程中,脂肪酸合成酶(fatty acid synthase,FAS)是一种多功能的复合酶,是合成脂肪酸的关键酶,因此,动物体内脂肪酸合成酶蛋白的多寡、活性的高低对动物脂肪酸的合成及体脂的沉积具有重要的意义。近年来,国内外大量的研究报道了脂肪酸合成酶对脂肪合成、代谢的调控。作者将从脂肪酸合成酶基因结构特征,其与能量代谢及体脂沉积的关系,以及日粮养分与激素对脂肪酸合成酶基因的表达调控研究进行综述。  相似文献   

18.
Researcher pay attention to the conjugated linoleic acid (CLA) because of its function of anticancer,antidiabetic and immunological competence in the body.A lot of researches on contents of CLA in goat that enjoy high favor among people has been carried out in recent years.The article presents the biosynthsis process of CLA in ruminal,and focus on reviewing the result of many sdudies on the effects of the contents of CLA and vaccine acid in rumen;Further treat of the effects of nutrition regulation on CLA in goat's milk and mutton.Result show that the microflora and protozoa could increase the contents of CLA in rumen by using grease mixed of regulator,and increasing the contents of CLA in animal products at the same time,and avoiding to decline the contents of milk fat.we should reveal synthesis mechanism of CLA through nutrition,molecular biology,and physiology fully in the future,to provides a theoretical basis for producting CLA-enriched mutton and milk.  相似文献   

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