Clinical response of nasal adenocarcinoma to cisplatin chemotherapy in 11 dogs.     

K A Hahn  D W Knapp  R C Richardson  C L Matlock 《Journal of the American Veterinary Medical Association》1992,200(3):355-357

In 11 dogs with nasal adenocarcinoma, IV treatment with 2 to 8 cycles of cisplatin at a dosage of 60 mg/m2 of body surface, given at 3-week intervals, resulted in a survival time of 8 to 128 weeks (mean, 32.7 weeks; median, 20 weeks). Radiography revealed complete remission in 2 dogs and partial remission in 1 dog, for an overall response rate of 27%. Clinical problems such as nasal discharge (n = 11), sneezing (n = 6), and epistaxis (n = 4) resolved in 1 to 2 weeks in all dogs after beginning chemotherapy.  相似文献   

Limits and risks of biotechnology in veterinary medicine from the viewpoint of the reproductive biologist     

J Hahn 《DTW. Deutsche tier?rztliche Wochenschrift》1989,96(2):72-73

New biotechnical methods in reproduction have been introduced in animal breeding via embryo transfer. There are no serious objections against these methods as long as the variety of species is reassured and the animal protection law is considered. More substantial objections exist against genetic engineering methods which alter the genome of animals. Beside for legal protection there is a strong public demand for the adequete awareness and responsibility of scientists who are active in this field. Comprehensive information on such research projects can lead to a better understanding of the aims and methods and might, therefore, help to reduce inadequate apprehensions.  相似文献   

Ultrastructure of a spindle cell carcinoma in the mammary gland of a dog.     

D F Kusewitt  F F Hahn  B A Muggenburg 《Veterinary pathology》1992,29(2):179-181

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Effect of ruminal heating on thyroid function and heat production of cattle     

M K Yousef  W D Robertson  H D Johnson  L Hahn 《Journal of animal science》1968,27(3):677-683

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Marked neutropenia in five tumor-bearing cats one week following single-agent vincristine sulfate chemotherapy     

Hahn KA KA  Fletcher CM  Legendre AM 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1996,25(4):121-123

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Male pseudohermaphroditism of the testicular feminization type in a heifer   总被引：1，自引：1，他引：0       下载免费PDF全文

Peter AT  Scheidt AB  Campbell JW  Hahn KA 《The Canadian veterinary journal. La revue veterinaire canadienne》1993,34(5):304-305

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Melatonin reduces apoptotic cells,SOD2 and HSPB1 and improves the in vitro production and quality of bovine blastocysts          下载免费PDF全文

TC Marques  EC da Silva Santos  TO Diesel  LO Leme  CF Martins  MAN Dode  BG Alves  FPH Costa  EB de Oliveira  ML Gambarini 《Reproduction in domestic animals》2018,53(1):226-236

Effects of adding different concentrations of melatonin (10^?7, 10^?9 and 10^?11 M) to maturation (Experiment 1; Control, IVM  + 10^?7, IVM  + 10^?9, IVM  + 10^?11) and culture media (Experiment 2; Control, IVC  + 10^?7, IVC  + 10^?9, IVC  + 10^?11) were evaluated on in vitro bovine embryonic development. The optimal concentration of melatonin (10^?9 M) from Experiments 1–2 was tested in both maturation and/or culture media of Experiment 3 (Control, IVM  + 10^?9, IVC  + 10^?9, IVM /IVC  + 10^?9). In Experiment 1, maturated oocytes from Control and IVM  + 10^?9 treatments showed increased glutathione content, mitochondrial membrane potential and percentage of Grade I blastocysts (40.6% and 43%, respectively). In Experiment 2, an increase in the percentage of Grade I blastocysts was detected in IVC  + 10^?7 (43.5%; 56.7%) and IVC  + 10^?9 (47.4%; 57.4%). Moreover, a lower number and percentage of apoptotic cells in blastocysts were observed in the IVC  + 10^?9 group compared to Control (3.8 ± 0.6; 3.6% versus 6.1 ± 0.6; 5.3%). In Experiment 3, the IVC  + 10^?9 treatment increased percentage of Grade I blastocysts with a lower number of apoptotic cells compared to IVM /IVC  + 10^?9 group (52.6%; 3.0 ± 0.5 versus 46.0%; 5.4 ± 1.0). The IVC  + 10^?9 treatment also had a higher mRNA expression of antioxidant gene (SOD 2) compared to the Control, as well as the heat shock protein (HSPB 1) compared to the IVM  + 10^?9. Reactive oxygen species production was greater in the IVM /IVC  + 10^?9 treatment group. In conclusion, the 10^?9 M concentration of melatonin and the in vitro production phase in which it is used directly affected embryonic development and quality.  相似文献   

A neurologic syndrome in Golden Retrievers presenting as a sensory ataxic neuropathy   总被引：1，自引：0，他引：1  

Jäderlund KH  Orvind E  Johnsson E  Matiasek K  Hahn CN  Malm S  Hedhammar A 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(6):1307-1315

BACKGROUND: A sensory ataxic neuropathy has been observed in Swedish Golden Retrievers recently. ANIMALS: Twenty-one affected Golden Retrievers. METHODS: Clinical and neurologic status, electrophysiologic, and pathologic status as well as pedigree analyses were evaluated. RESULTS: Clinical signs had an insidious onset between 2 and 8 months of age and a slowly progressive course. Affected dogs were ataxic and dysmetric. They had abnormal postural reactions and decreased spinal reflexes but no apparent muscle atrophy. Clinical pathology, radiography, and electrophysiology of motor systems were all within reference values. Sensory nerve conduction results of affected dogs were significantly different from those of a group of control dogs. Necropsy revealed a chronic progressive central and peripheral sensorimotor axonopathy; the proprioceptive pathways were most severely affected. CONCLUSIONS AND CLINICAL IMPORTANCE: This disease in these Golden Retrievers is distinct from other canine breed-related neurodegenerative diseases or hereditary neurodegenerative diseases described in humans. Pedigree analyses indicated a hereditary background, but the mode of inheritance could not be established.  相似文献   

Application of urease inhibitor improves protein composition and bread‐baking quality of urea fertilized winter wheat     

Azin Rekowski  Monika A. Wimmer  Bernd Hitzmann  Bernhard Hermannseder  Heike Hahn  Christian Zrb 《植物养料与土壤学杂志》2020,183(2):260-270

Background: Nitrogen losses is an economic problem for wheat production and a high risk to the environment. Therefore, improved N fertilizer management is a key to increasing the N efficiency and minimizing N losses. To increase N efficiency, enhanced fertilizers such as urea combined with urease inhibitor can be used. Aims: The aim of present study was to evaluate the effects of different N forms on grain storage protein subunits in winter wheat and to examine whether the observed changes correlate with parameters of baking quality. Methods: The investigation was performed over two consecutive years at two locations in Germany. Protein subunits were analyzed by SDS‐PAGE. Results: Protein concentrations were similarly increased after fertilization with ammonium nitrate and urea + urease inhibitor. Analysis of the individual storage protein fractions indicated that both fertilizers specifically enhanced ω‐gliadins and HMW glutenins, but the effect was more pronounced in the ammonium nitrate treatment. Application of urea + urease inhibitor had greater influence on the protein composition and resulted in higher specific baking volume as well as the best fresh keeping ability, in comparison with urea treatment. Conclusion: Considering that the urea + urease inhibitor treatment resulted in almost comparable improvements of NUE and baking quality, with the additional benefit of reduced N losses in combination with easy handling, urea + urease inhibitor can be recommended as a viable alternative to both urea alone and ammonium nitrate treatments. This opens up an opportunity for the reduction of N loss in wheat production when use of urea is preferred.  相似文献   

Identification of a RAPD marker linked to a brown planthopper resistance gene in rice   总被引：12，自引：0，他引：12  

Yong-Hee Jeon  Sang-Nag Ahn  Hae-Chune Choi  Tae-Ryong Hahn  Huhn-Pal Moon 《Euphytica》1999,107(1):23-28

We report the tagging of a brown planthopper (BPH) resistance gene (Bph–1) in rice using RAPD and RFLP markers. The Korean rice variety ‘Gayabyeo’ has dominant duplicate genes including Bph–1 conferring resistance to biotype 1 of BPH. Bulked segregant RAPD analysis was employed for rapid identification of DNA markers linked to resistance genes. For tagging these two genes, an F2F3 population from a ‘Gayabyeo’ × ‘Nagdongbyeo’ cross was developed and evaluated for BPH resistance. Three bulked DNAs from two groups of homozygous BPH resistant (each for Bph–1 and the other unknown gene) and homozygous susceptible F2 plants were analyzed by RAPD using 140 random oligomers. One primer, OPD–7 yielded a 700-bp fragment that was present in Gayabyeo and resistant F2 plants (homozygous for Bph-1 locus) but absent in Nagdongbyeo and susceptible F2 plants. Cosegregation of this marker with Bph-1 was verified using an F2 population segregating for Bph-1. Chromosomal regions surrounding the Bph-1 were examined with additional RFLP and microsatellite markers on chromosome 12 to define the location of the RAPD marker and Bph-1. Use of this RAPD marker could facilitate early selection of resistant lines for BPH. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献