Integration analysis of quantitative trait loci for resistance to Sclerotinia sclerotiorum in Brassica napus     

Jiqiang Li  Zunkang Zhao  Alice Hayward  Hongyu Cheng  Donghui Fu 《Euphytica》2015,205(2):483-489

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Comprehensive screening study of pesticide degradation via oxidation and hydrolysis     

Chamberlain E  Shi H  Wang T  Ma Y  Fulmer A  Adams C 《Journal of agricultural and food chemistry》2012,60(1):354-363

This comprehensive study focused on the reactivity of a set of 62 pesticides via oxidization by free chlorine, monochloramine, chlorine dioxide, hydrogen peroxide, ozone, and permanganate; photodegradation with UV(254); and hydrolysis at pH 2, 7, and 12. Samples were analyzed using direct injection liquid chromatography-mass spectrometry detection or gas chromatography-electron capture detection after liquid-liquid extraction. Many pesticides were reactive via hydrolysis and/or chlorination and ozonation mechanisms under typical drinking water treatment conditions, with less reactivity exhibited on average for chlorine dioxide, monochloramine, hydrogen peroxide, and UV(254). The pyrazole and organophosphorous pesticides were most reactive in general, whereas carbamates and others were less reactive. The screening study provides guidance for the pesticide/oxidation systems that are most likely to lead to degradates in water treatment and the environment.  相似文献   

Presidential address. Passions     

Huang AS 《Science (New York, N.Y.)》2011,334(6061):1362-1366

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Signal transduction. Decoding NF-kappaB signaling     

Ting AY  Endy D 《Science (New York, N.Y.)》2002,298(5596):1189-1190

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Differential antigen processing by dendritic cell subsets in vivo   总被引：2，自引：0，他引：2  

Dudziak D  Kamphorst AO  Heidkamp GF  Buchholz VR  Trumpfheller C  Yamazaki S  Cheong C  Liu K  Lee HW  Park CG  Steinman RM  Nussenzweig MC 《Science (New York, N.Y.)》2007,315(5808):107-111

Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.  相似文献   

Complement factor H polymorphism in age-related macular degeneration   总被引：4，自引：0，他引：4  

Klein RJ  Zeiss C  Chew EY  Tsai JY  Sackler RS  Haynes C  Henning AK  SanGiovanni JP  Mane SM  Mayne ST  Bracken MB  Ferris FL  Ott J  Barnstable C  Hoh J 《Science (New York, N.Y.)》2005,308(5720):385-389

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H gene (CFH) is strongly associated with AMD (nominal P value <10(-7)). In individuals homozygous for the risk allele, the likelihood of AMD is increased by a factor of 7.4 (95% confidence interval 2.9 to 19). Resequencing revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402. This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies.  相似文献   

Rural participatory buffer zone management in northeastern Thailand     

Alice Sharp  Nobukazu Nakagoshi  Colin McQuistan 《Journal of Forest Research》1999,4(2):87-92

The past protected area management system which emphasized the ownership and control of forest by the state and overlooked the interaction between human and resources has failed because the annual rate of deforestation in Thailand is still as high as 2.6%. This paper aims to introduce a new approach to protected area management that would involve local people in the process. A case of buffer zone management through collaborative efforts is examined here. The project is located at the southeastern corner of the buffer zone of Phu Kheio Wildlife Sanctuary, Northeastern Thailand. Participatory Rural Appraisal (PRA) techniques including secondary data study, physical survey, participatory meeting, and semi-structured interviewing were employed in data gathering. The results discussed here suggest that there is a chance to create a better understanding among rural people of the importance of afforestation and nature conservation that will lead to a better management of resources in the future.  相似文献   

Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge Cliona celata from the Portuguese Coastline     

Joana Alves  Helena Gaspar  Joana Silva  Celso Alves  Alice Martins  Fernando Teodoro  Patrícia Susano  Susete Pinteus  Rui Pedrosa 《Marine drugs》2021,19(11)

Inflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a source of effective anti-inflammatory therapeutic agents. Within this framework, the purpose of this study was to evaluate the antioxidant and the anti-inflammatory potential of the marine sponge Cliona celata. For this purpose, their organic extracts (C1–C5) and fractions were evaluated concerning their radical scavenging activity through 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and anti-inflammatory activity through a (lipopolysaccharides (LPS)-induced inflammation on RAW 264.7 cells) model. Compounds present in the two most active fractions (F5 and F13) of C4 were tentatively identified by gas chromatography coupled to mass spectrometry (GC-MS). Even though samples displayed low antioxidant activity, they presented a high anti-inflammatory capacity in the studied cellular inflammatory model when compared to the anti-inflammatory standard, dexamethasone. GC-MS analysis led to the identification of n-hexadecanoic acid, cis-9-hexadecenal, and 13-octadecenal in fraction F5, while two major compounds, octadecanoic acid and cholesterol, were identified in fraction F13. The developed studies demonstrated the high anti-inflammatory activity of the marine sponge C. celata extracts and fractions, highlighting its potential for further therapeutic applications.  相似文献