Higher education. Harvard pledges $50 million to boost diversity on campus     

Lawler A 《Science (New York, N.Y.)》2005,308(5725):1102

  相似文献   

Expanded repeat in canine epilepsy     

Lohi H  Young EJ  Fitzmaurice SN  Rusbridge C  Chan EM  Vervoort M  Turnbull J  Zhao XC  Ianzano L  Paterson AD  Sutter NB  Ostrander EA  André C  Shelton GD  Ackerley CA  Scherer SW  Minassian BA 《Science (New York, N.Y.)》2005,307(5706):81

Epilepsy afflicts 1% of humans and 5% of dogs. We report a canine epilepsy mutation and evidence for the existence of repeat-expansion disease outside humans. A canid-specific unstable dodecamer repeat in the Epm2b (Nhlrc1) gene recurrently expands, causing a fatal epilepsy and contributing to the high incidence of canine epilepsy. Tracing the repeat origins revealed two successive events, starting 50 million years ago, unique to canid evolution. A genetic test, presented here, will allow carrier and presymptomatic diagnosis and disease eradication. Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy.  相似文献   

Oops, that's not really a diamond     

Whipple AP 《Science (New York, N.Y.)》2007,316(5825):690-691

  相似文献   

HIV/AIDS. HLA leaves its footprints on HIV     

McMichael A  Klenerman P 《Science (New York, N.Y.)》2002,296(5572):1410-1411

  相似文献   

Why conservationists should heed Pokémon     

Balmford A  Clegg L  Coulson T  Taylor J 《Science (New York, N.Y.)》2002,295(5564):2367

  相似文献   

Stress and fold localization in thin elastic membranes     

Pocivavsek L  Dellsy R  Kern A  Johnson S  Lin B  Lee KY  Cerda E 《Science (New York, N.Y.)》2008,320(5878):912-916

Thin elastic membranes supported on a much softer elastic solid or a fluid deviate from their flat geometries upon compression. We demonstrate that periodic wrinkling is only one possible solution for such strained membranes. Folds, which involve highly localized curvature, appear whenever the membrane is compressed beyond a third of its initial wrinkle wavelength. Eventually the surface transforms into a symmetry-broken state with flat regions of membrane coexisting with locally folded points, reminiscent of a crumpled, unsupported membrane. We provide general scaling laws for the wrinkled and folded states and proved the transition with numerical and experimental supported membranes. Our work provides insight into the interfacial stability of such diverse systems as biological membranes such as lung surfactant and nanoparticle thin films.  相似文献   

Evolution and faith: empathy is crucial     

Whipple A 《Science (New York, N.Y.)》2008,320(5877):745-746

  相似文献   

U.S. astronomy. You make the call, NASA chief tells scientists     

Gramling C  Lawler A 《Science (New York, N.Y.)》2005,310(5747):425

  相似文献   

Photoinduced plasticity in cross-linked polymers     

Scott TF  Schneider AD  Cook WD  Bowman CN 《Science (New York, N.Y.)》2005,308(5728):1615-1617

Chemically cross-linked polymers are inherently limited by stresses that are introduced by post-gelation volume changes during polymerization. It is also difficult to change a cross-linked polymer's shape without a corresponding loss of material properties or substantial stress development. We demonstrate a cross-linked polymer that, upon exposure to light, exhibits stress and/or strain relaxation without any concomitant change in material properties. This result is achieved by introducing radicals via photocleavage of residual photoinitiator in the polymer matrix, which then diffuse via addition-fragmentation chain transfer of midchain functional groups. These processes lead to photoinduced plasticity, actuation, and equilibrium shape changes without residual stress. Such polymeric materials are critical to the development of microdevices, biomaterials, and polymeric coatings.  相似文献   

We're so sorry, Uncle Albert     

Seife C  Lawler A 《Science (New York, N.Y.)》2005,307(5711):869-870

  相似文献