Intracellular calcium release mediated by sphingosine derivatives generated in cells   总被引：22，自引：0，他引：22  

T K Ghosh  J Bian  D L Gill 《Science (New York, N.Y.)》1990,248(4963):1653-1656

Soluble and hydrophobic lipid breakdown products have a variety of important signaling roles in cells. Here sphingoid bases derived in cells from sphingolipid breakdown are shown to have a potent and direct effect in mediating calcium release from intracellular stores. Sphingosine must be enzymically converted within the cell to a product believed to be sphingosine-1-phosphate, which thereafter effects calcium release from a pool including the inositol 1,4,5-trisphosphate-sensitive calcium pool. The sensitivity, molecular specificity, and reversibility of the effect on calcium movements closely parallel sphingoid base-mediated inhibition of protein kinase C. Generation of sphingoid bases in cells may activate a dual signaling pathway involving regulation of calcium and protein kinase C, comparable perhaps to the phosphatidylinositol and calcium signaling pathway.  相似文献   

A theoretical investigation on the generation of strength in staple yarns     

Anindya Ghosh 《Fibers and Polymers》2006,7(3):310-316

In this article, an attempt has been made to explain the failure mechanism of spun yarns. The mechanism includes the aspects of generation and distribution of forces on a fibre under the tensile loading of a yarn, the free body diagram of forces, the conditions for gripping and slipping of a fibre, and the initiation, propagation, and ultimate yarn rupture in its weakest link. A simple mathematical model for the tenacity of spun yarns has been proposed. The model is based on the translation of fibre bundle tenacity into the yarn tenacity.  相似文献   

Basal stem rot of oil palm incited by Ganoderma species: A review     

Supramani  Sugenendran  Rejab  Nur Ardiyana  Ilham  Zul  Wan-Mohtar  Wan Abd Al Qadr Imad  Ghosh  Soumya 《European journal of plant pathology / European Foundation for Plant Pathology》2022,162(1):1-17

European Journal of Plant Pathology - Populus davidiana × Populus bolleana (PdPap) root rot caused by Fusarium oxysporum is a major disease in China. Controlling this disease...  相似文献   

Influence of nitrogen and weed management on the productivity of upland rice     

Chandra Vir Singh  Bidhan Chandra Ghosh  Bishwa Nath Mittra  Rama Kant Singh 《植物养料与土壤学杂志》2008,171(3):466-470

Nitrogen and weeds are two important factors that influence the productivity of rainfed upland rice (Oryza sativa L.) in tropical Asia. A low recovery of applied fertilizer N in rainfed uplands is generally associated with high nitrate leaching losses and weed interferences. Field experiments were conducted during the wet seasons of 2002 and 2003 at the research farm of Central Rainfed Upland Rice Research Station, Hazaribag, Jharkhand, India, to determine the response of upland rice to nitrogen applied at 60 kg N ha^–1 as different forms of urea (single pre‐plant application of controlled‐release urea, single pre‐plant application of urea supergranules, and split application of prilled urea with or without basal N) against no N application under three weed‐control regimes (unweeded, pre‐emergence application of butachlor at 1.5 kg a.i. ha^–1 supplemented with one single hand weeding or two hand weedings). The response of rice to applied N varied greatly among the three weed‐control regimes. Across the different N treatments, the application of 60 kg N ha^–1 resulted in a grain‐yield increase above the unfertilized control of only 0.24 Mg ha^–1 in unweeded treatments, whereas yields increased by 1.07 Mg ha^–1 when butachlor application was supplemented with a single hand weeding and by 1.28 Mg ha^–1 with two hand weedings. Among the weed‐control measures, hand weeding twice produced highest grain yield in both years. The comparison of different forms of urea showed that a single pre‐plant application of controlled‐release urea resulted in average grain yields of 1.57 and 1.87 Mg ha^–1 compared to 1.32 and 1.30 Mg ha^–1 in the case of the recommended practice of split‐applied prilled urea in the years 2002 and 2003, respectively. The highest agronomic N use efficiency of 15–20 kg grain per kg N applied and the highest apparent N recovery of 39%–45% were attained with controlled‐release urea, suggesting that this N form is particularly beneficial for upland‐rice cultivation under variable rainfall conditions, provided weeds are controlled.  相似文献   

Double Health Risk in Arsenic Contaminated Drinking Water – Evidence of Enhanced Alpha Radioactivity     

Dipak Ghosh  Argha Deb  Kanchan Kumar Patra  Rosalima Sengupta  Sukumar Bera 《Water, air, and soil pollution》2008,187(1-4):81-87

The presence of alpha emitting radionuclides in the environment assumes importance since they are found to be carcinogenic. This paper reports the results of an exhaustive and systematic measurement of alpha radioactivity using solid state nuclear track detector (SSNTD) in drinking water in different parts of India covering the entire Ganges Basin – West Bengal, Bihar and Uttar Pradesh where arsenic contamination is severe. The alpha activity in the samples was found in the range of 8 to 800 Bq/l in West Bengal, 90 to 1,000 Bq/l in Uttar Pradesh and 60 to 1,000 Bq/l in Bihar – much higher alpha activity value than MCL value given by US EPA. The concentration of alpha activity has a positive correlation with that of arsenic.  相似文献   

Polymorphism in 5′ untranslated region of heat‐shock protein 70 gene as marker of post‐partum anoestrus in Murrah buffaloes          下载免费PDF全文

R Kumar  M Ghosh  N Kumar  AK Balhara  M Gupta  RK Sharma  I Singh 《Reproduction in domestic animals》2017,52(3):505-512

The enormous production potential of buffaloes has never been accomplished due to various reproductive insufficiencies. Among them, post‐partum anoestrus, a multifactorial disorder, is predominant but any genetic association is yet to be established. This study focused to identify novel polymorphisms in heat‐shock protein 70 (HSP70) gene and its possible association with post‐partum anoestrus in Murrah buffaloes. A 579‐bp fragment from 5′ untranslated region of HSP70 gene was amplified by polymerase chain reaction from blood genomic DNA of 614 animals maintained under similar management conditions. In phase‐I experiment, custom sequencing and restriction enzyme (RE) digestion of the amplified fragment were performed in 40 buffaloes with similar post‐partum oestrous conditions over previous consecutive three or more gestations—20 animals each showing post‐partum anoestrus (>120 days after parturition) and normal cyclicity (<65 days after parturition). While in phase‐II experiment, herd screening by RE analysis was performed in remaining 574 animals. Four transversions at T‐75G, C+31G, T+38G and C+97A and three transition mutations at T‐153C, T+33C and A+44G positions were observed. Polymorphism at T+38G site revealed significant (p < .05) variation, where homozygous G was present only in post‐partum anoestrous animals while nucleotide T was present randomly in both groups of phase‐I animals whereas phase‐II experiments revealed homozygous G in 55 animals. Regression analysis in relation to average post‐partum interval against genotypic frequencies at T+38G also depicted significant association. HSP70 gene polymorphism at T+38G position can therefore be used as genetic marker for excluding probable post‐partum anoestrous buffaloes from herd for breeding programmes.  相似文献   

Depth dynamics of soil N contents and natural abundances of 15N after 43 years of long-term fertilization and liming in sub-tropical Alfisol     

Avijit Ghosh  Brahma Swaroop Dwivedi  Dipak Ranjan Biswas  Mahesh Chandra Meena  Abhijit Sarkar 《Archives of Agronomy and Soil Science》2018,64(9):1290-1301

The aim of this study was to understand impacts of long-term (43 years) fertilization on soil aggregation, N accumulation rates and δ¹⁵N in surface and deep layers in an Alfisol. Soil samples from seven treatments were analysed for N stocks, aggregate-associated N in 0–30 cm and the changes in δ¹⁵N in 0–90 cm depths. The treatments were: unfertilized control (control); recommended N dose (N); recommended N and phosphorus doses (NP); recommended N, P and potassium doses (NPK); 150% of recommended N, P and K doses (150% NPK); NPK + 10 Mg FYM ha^?1 (NPK + FYM) and NPK + 0.4 Mg lime ha^?1 (NPK + L). Results revealed that plots under NPK + FYM had ~39% higher total N concentrations than NPK + L in 0–30 cm soil layers. In NPK + L, macro-aggregates had 35 and 11% and microaggregates had 20 and 9% lower δ¹⁵N values than NPK + FYM in 0–15 and 15–30 cm soil layers, respectively. However, plots receiving NPK + FYM had ~39% greater deep soil (30–90 cm) N accumulation than NPK + L. These results would help understanding N supplying capacity by long-term fertilization and assist devising N management strategies in sub-tropical acidic Alfisols.  相似文献   

A Non‐Reciprocal Autosomal Translocation 64,XX,t(4;10)(q21;p15) in an Arabian Mare with Repeated Early Embryonic Loss          下载免费PDF全文

S Ghosh  PJ Das  F Avila  BK Thwaits  BP Chowdhary  T Raudsepp 《Reproduction in domestic animals》2016,51(1):171-174

Balanced autosomal translocations are a known cause for repeated early embryonic loss (REEL) in horses. In most cases, carriers of such translocations are phenotypically normal, but the chromosomal aberration negatively affects gametogenesis giving rise to both genetically balanced and unbalanced gametes. The latter, if involved in fertilization, result in REEL, whereas gametes with the balanced form of translocation will pass the defect into next generation. Therefore, in order to reduce the incidence of REEL, identification of translocation carriers is critical. Here, we report about a phenotypically normal 3‐year‐old Arabian mare that had repeated resorption of conceptuses prior to day 45 of gestation and was diagnosed with REEL. Conventional and molecular cytogenetic analyses revealed that the mare had normal chromosome number 64,XX but carried a non‐mosaic and non‐reciprocal autosomal translocation t(4;10)(q21;p15). This is a novel translocation described in horses with REEL and the first such report in Arabians. Previous cases of REEL due to autosomal translocations have exclusively involved Thoroughbreds. The findings underscore the importance of routine cytogenetic screening of breeding animals.  相似文献   

Necessity for quantified measurement of soil sodicity and selection of suitable gypsum amendment for proper reclamation of sodic soils     

Arup Kumar MANDAL 《土壤圈》2023,33(1):231-235

<正>Dear Editor,Soil sodicity is the primary limiting factor in sustainable crop production in arid and semiarid regions, where the water scarcity, low rainfall, and poor-quality (salty) groundwater are common occurrence (Datta et al., 2019; Hosain,2019; Minhas et al., 2019; Kumar and Sharma, 2020).Globally, five categories of salt-affected soils have been identified, based on the nature and composition of salts(Szabolcs and Várallyay, 1971; Kovda, 1973; Szabolcs,1989). These soils are sali...  相似文献