Multiple eyelid apocrine hidrocystomas in two Persian cats     

Cantaloube B  Raymond-Letron I  Regnier A 《Veterinary ophthalmology》2004,7(2):121-125

Abstract Two middle-aged Persian cats were presented for evaluation of periocular masses. On examination, multiple pigmented nodules, 2-10 mm in diameter, were found in the periocular skin. Excisional biopsy revealed unilocular cystic lesions derived from apocrine sweat glands and resembling apocrine hidrocystomas of the eyelids described in humans. Immunostaining for Ki67 identified actively proliferating epithelial cells and demonstrated, for the first time, that these cystic lesions are adenomatous proliferative tumors (cystadenomas) rather than retention cysts. In both cases, additional lesions appeared within 6 to 9 months at affected and previously unaffected sites on the eyelids.  相似文献   

Mixed mycoplasma mastitis outbreak in a dairy herd     

Mackie DP  Finlay D  Brice N  Ball HJ 《The Veterinary record》2000,147(12):335-336

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Isolation of Mycoplasma bovis from bovine clinical samples in the Republic of Ireland     

Byrne WJ  McCormack R  Brice N  Egan J  Markey B  Ball HJ 《The Veterinary record》2001,148(11):331-333

Mycoplasma bovis was detected in 134 (18 per cent) of 736 samples of bovine lung tissue collected from fatal pneumonia cases in the Republic of Ireland between April 1995 and December 1998. The cases occurred in 95 herds and recurred in four of them. Other respiratory pathogens were identified in 66 per cent of the M bovis-positive cases, with Pasteurella species, infectious bovine rhinotracheitis and parainfluenza 3 virus being most frequently detected. Mastitis and arthritis were less common clinical signs associated with M bovis infection; 22 cases of M bovis mastitis and five cases of M bovis arthritis were diagnosed in five herds.  相似文献   

Adult-onset primary open-angle glaucoma caused by mutations in optineurin     

Rezaie T  Child A  Hitchings R  Brice G  Miller L  Coca-Prados M  Héon E  Krupin T  Ritch R  Kreutzer D  Crick RP  Sarfarazi M 《Science (New York, N.Y.)》2002,295(5557):1077-1079

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism     

Bonifati V  Rizzu P  van Baren MJ  Schaap O  Breedveld GJ  Krieger E  Dekker MC  Squitieri F  Ibanez P  Joosse M  van Dongen JW  Vanacore N  van Swieten JC  Brice A  Meco G  van Duijn CM  Oostra BA  Heutink P 《Science (New York, N.Y.)》2003,299(5604):256-259

The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.  相似文献   

Helix-rod host-guest complexes with shuttling rates much faster than disassembly     

Gan Q  Ferrand Y  Bao C  Kauffmann B  Grélard A  Jiang H  Huc I 《Science (New York, N.Y.)》2011,331(6021):1172-1175

Dynamic assembly is a powerful fabrication method of complex, functionally diverse molecular architectures, but its use in synthetic nanomachines has been hampered by the difficulty of avoiding reversible attachments that result in the premature breaking apart of loosely held moving parts. We show that molecular motion can be controlled in dynamically assembled systems through segregation of the disassembly process and internal translation to time scales that differ by four orders of magnitude. Helical molecular tapes were designed to slowly wind around rod-like guests and then to rapidly slide along them. The winding process requires helix unfolding and refolding, as well as a strict match between helix length and anchor points on the rods. This modular design and dynamic assembly open up promising capabilities in molecular machinery.  相似文献