Elective Caesarean Operation in the Bitch Using Aglepristone Before the Pre-Partum Decline in Peripheral Progesterone Concentration     

X Levy  E Fontaine  V Segalini  A Fontbonne 《Reproduction in domestic animals》2009,44(S2):182-184

The aim of this study was to investigate caesarean operation (CO) undertaken before the pre-partum decrease of progesterone but following administration of a progesterone receptor antagonist and to evaluate the innocuity of this procedure for the dam and pups. Thirty seven bitches of 15 different breeds, received an injection of 15 mg/kg aglepristone 59 or 60 days after the estimated day of ovulation, determined by progesterone quantitative assays, and caesarean section (CS) was performed between 20 and 24 h after administration. Progesterone remained above 6 nmol/l at the time of CS (mean = 15.75, SD = 3.84). No post-operative clinical complications were reported in any of the bitches. All bitches were able to nurse and feed their puppies in the first 24 h following surgery. No pups showed any signs of prematurity and 5 out of 188 pups (2.6) died in the first 2 weeks after delivery. This small study demonstrates that a CS may be safely and successfully performed an average of 2 days before the expected date of parturition following the administration of aglepristone, without any harmful consequence for the dam and her neonates.  相似文献   

Patient characteristics influencing the variability of distributed parameter‐based models in DCE‐CT kinetic analysis          下载免费PDF全文

M. D. La Fontaine  L. S. McDaniel  L. N. Kubicek  R. J. Chappell  L. J. Forrest  R. Jeraj 《Veterinary and comparative oncology》2017,15(1):105-117

Kinetic parameter variability may be sensitive to kinetic model choice, kinetic model implementation or patient‐specific effects. The purpose of this study was to assess their impact on the variability of dynamic contrast‐enhanced computed tomography (DCE‐CT) kinetic parameters. A total of 11 canine patients with sinonasal tumours received high signal‐to‐noise ratio, test‐double retest DCE‐CT scans. The variability for three distributed parameter (DP)‐based models was assessed by analysis of variance. Mixed‐effects modelling evaluated patient‐specific effects. Inter‐model variability (CV_inter) was comparable to or lower than intra‐model variability (CV_intra) for blood flow (CV_inter:[4–28%], CV_intra:[28–31%]), fractional vascular volume (CV_inter:[3–17%], CV_intra:[16–19%]) and permeability‐surface area product (CV_inter:[5–12%], CV_intra:[14–15%]). The kinetic models were significantly (P<0.05) impacted by patient characteristics for patient size, area underneath the curve of the artery and of the tumour. In conclusion, DP‐based models demonstrated good agreement with similar differences between models and scans. However, high variability in the kinetic parameters and their sensitivity to patient size may limit certain quantitative applications.  相似文献   

Determinants of fenhexamid effectiveness against grey mould on grapevine: Respective role of spray timing,fungicide resistance and plant defences     

Anne-Noëlle Petit  Nathalie Vaillant-Gaveau  Anne-Sophie Walker  Pierre Leroux  Fabienne Baillieul  Marie-Laure Panon  Christophe Clément  Florence Fontaine 《Crop Protection》2010

Botrytis bunch rot of grapes is mainly controlled by applying fungicides at three crop growth stages: the end of flowering (BBCH 68), bunch closure (BBCH 77) and the beginning of veraison (BBCH 81). The hydroxyanilide derivative fenhexamid is among the most effective fungicides registered to control Botrytis cinerea. Its effectiveness was examined in relation to spray timing, fungicide resistance and defense responses of grapevine. Overall, the earlier fenhexamid was applied, the more effective it was at controlling B. cinerea. Frequencies of B. cinerea strains which were resistant to fungicides were evaluated at harvest. The frequencies of resistant phenotypes were similar among treatments and years with the exception of a class of multidrug resistant strain (MDR 2) whose frequency appeared to increase after fenhexamid applications. If current spray programs including fenhexamid appear to control bunch rot at the current MDR frequency, a propagation of MDR 2 strains might lead to a decline in disease control. Finally, defense responses were studied in grapevine flowers/berries following fenhexamid application. None of the defense processes tested was induced in flowers/berries at stages 68 and 77. Only an increase in chitinase activity was observed in treated-berries at stage 81, suggesting that fenhexamid effectiveness was not related to a stimulation of defense responses.  相似文献   

Les tumeurs stromales gastro-intestinales du chien : état des connaissances et rôle diagnostique du pathologiste     

A. Girard-Luc  E. Reyes-Gomez  J.-J. Fontaine  M. Lagadic  F. Bernex 《Pratique Médicale et Chirurgicale de l'Animal de Compagnie》2010,45(1):19-25

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BSAFs for freshwater fish and derivation of a sediment quality guideline for PCBs in the Rhone basin, France     

Marc Babut  Christelle Lopes  Sébastien Pradelle  Henri Persat  Pierre-Marie Badot 《Journal of Soils and Sediments》2012,12(2):241-251

Purpose  

Since 2005, freshwater fish contamination by polychlorobiphenyls (PCBs), polychlorodibenzodioxins, and polychlorodibenzofurans has been assessed in the Rhone River basin (France). A large database of surface sediment contamination by PCBs is also available, opening the way to the study of biota-to-sediment accumulation factor (BSAF) distribution throughout this basin. The ultimate goal of the study was to determine a sediment quality guideline (SQG) corresponding to the regulatory fish consumption limit.  相似文献   

A systematic review of criteria used to report complications in soft tissue and oncologic surgical clinical research studies in dogs and cats     

Christelle M. Follette DVM  Michelle A. Giuffrida VMD  MSCE  DACVS  Ingrid M. Balsa DVM  MEd  DACVS  William T. N. Culp VMD  DACVS  Philipp D. Mayhew BVM&S  DACVS  Michelle L. Oblak DVM  DVSc  DACVS  Ameet Singh DVM  DVSc  DACVS  Michele A. Steffey DVM  DACVS 《Veterinary surgery : VS》2020,49(1):61-69

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Paramedian incisional complications after prophylactic laparoscopy-assisted gastropexy in 411 dogs     

Jessica K. Baron DVM  DACVS-SA  Sue A. Casale DVM  DACVS  Eric Monnet DVM  PhD  FAHA  DACVS  DECVS  Philipp D. Mayhew BVM&S  DACVS  Jeffrey J. Runge DVM  DACVS  Christelle M. Follette DVM  Kevin Phipps DVM  Margaret E. Powell DVM  Alicja I. Reczynska DVM  Nathan T. Squire VMD  Bruce A. Barton PhD  John Berg DVM  DACVS 《Veterinary surgery : VS》2020,49(Z1):O148-O155

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A New,Quick, and Simple Protocol to Evaluate Microalgae Polysaccharide Composition     

Antoine Decamp  Orane Michelo  Christelle Rabbat  Cline Laroche  Dominique Grizeau  Jrmy Pruvost  Olivier Gonalves 《Marine drugs》2021,19(2)

In this work, a new methodological approach, relying on the high specificity of enzymes in a complex mixture, was developed to estimate the composition of bioactive polysaccharides produced by microalgae, directly in algal cultures. The objective was to set up a protocol to target oligomers commonly known to be associated with exopolysaccharides’ (EPS) nutraceutical and pharmaceutical activities (i.e., rhamnose, fucose, acidic sugars, etc.) without the constraints classically associated with chromatographic methods, while maintaining a resolution sufficiently high to enable their monitoring in the culture system. Determination of the monosaccharide content required the application of acid hydrolysis (2 M trifluoroacetic acid) followed by NaOH (2 M) neutralization. Quantification was then carried out directly on the fresh hydrolysate using enzyme kits corresponding to the main monosaccharides in a pre-determined composition of the polysaccharides under analysis. Initial results showed that the enzymes were not sensitive to the presence of TFA and NaOH, so the methodology could be carried out on fresh hydrolysate. The limits of quantification of the method were estimated as being in the order of the log of nanograms of monosaccharides per well, thus positioning it among the chromatographic methods in terms of analytical performance. A comparative analysis of the results obtained by the enzymatic method with a reference method (high-performance anion-exchange chromatography) confirmed good recovery rates, thus validating the closeness of the protocol. Finally, analyses of raw culture media were carried out and compared to the results obtained in miliQ water; no differences were observed. The new approach is a quick, functional analysis method allowing routine monitoring of the quality of bioactive polysaccharides in algal cultures grown in photobioreactors.  相似文献   

Long-term feeding ecology and habitat use in harbour porpoises Phocoena phocoena from Scandinavian waters inferred from trace elements and stable isotopes     

Micha?l C Fontaine  Krystal A Tolley  Ursula Siebert  Sylvie Gobert  Gilles Lepoint  Jean-Marie Bouquegneau  Krishna Das 《BMC ecology》2007,7(1):1

Background  

We investigated the feeding ecology and habitat use of 32 harbour porpoises by-caught in 4 localities along the Scandinavian coast from the North Sea to the Barents Sea using time-integrative markers: stable isotopes (δ¹³C, δ¹⁵N) and trace elements (Zn, Cu, Fe, Se, total Hg and Cd), in relation to habitat characteristics (bathymetry) and geographic position (latitude).  相似文献   

Can scale-dependent landcover relationships explain canid community composition independent of intraguild occupancy?     

Corral  Lucia  Stuber  Erica F.  Frink  Teresa J.  Bishop  Andrew A.  Fontaine  Joseph J. 《Landscape Ecology》2022,37(1):249-266

Landscape Ecology - Niche theory is frequently used as a framework to integrate environmental variables and species interactions to describe species geographic distribution. Yet, the scale at which...  相似文献