Effect of beclomethasone dipropionate and dexamethasone isonicotinate on lung function, bronchoalveolar lavage fluid cytology, and transcription factor expression in airways of horses with recurrent airway obstruction     

Couëtil LL  Art T  de Moffarts B  Becker M  Mélotte D  Jaspar F  Bureau F  Lekeux P 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(2):399-406

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The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene   总被引：1，自引：0，他引：1  

Duret L  Chureau C  Samain S  Weissenbach J  Avner P 《Science (New York, N.Y.)》2006,312(5780):1653-1655

The Xist noncoding RNA is the key initiator of the process of X chromosome inactivation in eutherian mammals, but its precise function and origin remain unknown. Although Xist is well conserved among eutherians, until now, no homolog has been identified in other mammals. We show here that Xist evolved, at least partly, from a protein-coding gene and that the loss of protein-coding function of the proto-Xist coincides with the four flanking protein genes becoming pseudogenes. This event occurred after the divergence between eutherians and marsupials, which suggests that mechanisms of dosage compensation have evolved independently in both lineages.  相似文献   

Glucocorticoids can induce PTSD-like memory impairments in mice     

Kaouane N  Porte Y  Vallée M  Brayda-Bruno L  Mons N  Calandreau L  Marighetto A  Piazza PV  Desmedt A 《Science (New York, N.Y.)》2012,335(6075):1510-1513

Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.  相似文献   

Computed tomographic evaluation of a bronchogenic cyst in a German shepherd dog     

Gadbois J  Blond L  Lapointe C  Collard F 《The Canadian veterinary journal. La revue veterinaire canadienne》2012,53(1):86-88

A German shepherd dog was referred for further evaluation of a cavitary pulmonary lesion. Computed tomography identified a well-defined rounded radiolucent area in the left cranial lung lobe in continuity with the bronchial lumen. These findings were consistent with a bronchogenic cyst.  相似文献   

Effect of acquisition time and chemical fat suppression on meningeal enhancement on MR imaging in dogs     

D'Anjou MA  Carmel EN  Blond L  Beauchamp G  Parent J 《Veterinary radiology & ultrasound》2012,53(1):11-20

Our purpose was to characterize meningeal gadolinium enhancement on magnetic resonance (MR) imaging in dogs with inflammatory and neoplastic diseases, and to assess interobserver variability and the impact of delayed acquisition and chemical fat saturation on its conspicuity. Transverse T1-weighted FLAIR images were acquired prior to, and immediately following gadolinium injection (T0), and at 5 (T5) and 15-20 min delay (TD), with and without fat suppression, in 155 consecutive dogs imaged for suspected brain disease. The agreement on meningeal enhancement was globally substantial (kappa = 0.61) and the likelihood of obtaining a definite diagnosis was significantly increased with the use of fat suppression (P < or = 0.004). Meningeal enhancement was judged definitively present by consensus in 46 of 155 (30%) dogs. Of these, meningeal enhancement was characterized qualitatively and quantitatively in 30 dogs with a clinical diagnosis (18 inflammatory, 11 neoplastic, 1 infarct), and image sequences were compared. Meningeal enhancement was more often diffuse and leptomeningeal in animals with inflammation versus neoplasia (50% vs. 42%, and 69% vs. 48%, respectively), but significant associations were not found. Meningeal thickness and contrast ratio were higher with neoplasia (P < or = 0.02), but results did not vary significantly between series for either group. Yet, images with fat suppression were most useful 50% of the time for definite diagnosis and/or characterization of meningeal enhancement. While delayed image acquisition following gadolinium injection does not improve characterization of meningeal enhancement in dogs, fat suppression is beneficial qualitatively.  相似文献   

Water availability is a stronger driver of soil microbial processing of organic nitrogen than tree species composition     

Tania L. Maxwell  Laurent Augusto  Ye Tian  Wolfgang Wanek  Nicolas Fanin 《European Journal of Soil Science》2023,74(1):e13350

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Pulmonary thromboembolism associated with Blastomyces dermatitidis in a dog     

McGuire NC  Vitsky A  Daly CM  Behr MJ 《Journal of the American Animal Hospital Association》2002,38(5):425-430

An 8-year-old, male castrated golden retriever presented for cough and increased respiratory effort. Radiographs revealed an alveolar pattern in the right caudal lung lobe and an opacity at the carina suspected to be enlarged tracheobronchial lymph nodes. The disease progressed to involve the right middle lung lobe. Cytopathology of a fine-needle aspirate and bronchoalveolar lavage fluid were nondiagnostic. Surgical removal of the right caudal lung lobe and biopsy of the perihilar lymph nodes revealed pulmonary thromboembolism and reactive lymph nodes. The dog died several days postoperatively, and necropsy revealed diffuse pulmonary thromboembolism. Additionally, Blastomyces dermatitis organisms were identified in a pyogranulomatous mass surrounding the trachea near the carina. In an extensive literature search, no reports of pulmonary thromboembolism associated with blastomycosis were identified. It is suspected that the inflammation secondary to blastomycosis caused the thromboembolism.  相似文献   

Identification of relevant morphological, topological and geometrical variables to characterize the architecture of rose bushes in relation to plant shape     

Laurent Crespel  Monique Sigogne  Nicolas Donès  Daniel Relion  Philippe Morel 《Euphytica》2013,191(1):129-140

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Assessment of hydraulic properties of technosols using Beerkan and multiple tension disc infiltration methods     

Deniz Yilmaz  Sofia Bouarafa  Pierre‐Emmanuel Peyneau  Rafael Angulo‐Jaramillo  Laurent Lassabatere 《European Journal of Soil Science》2019,70(5):1049-1062

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Suspected transient pseudohypoaldosteronism in a 10-day-old quarter horse foal     

Arroyo LG  Vengust M  Dobson H  Viel L 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(5):494-498

A 10-day-old quarter horse colt was presented for signs of disorientation and inability to nurse. Hydronephrosis/hydroureters, with concomitant pyelonephritis and a severe electrolytes disturbance, were diagnosed. The clinical findings closely resembled those described for a syndrome of transient pseudohypoaldosteronism in human neonates.  相似文献