WHY HAS THE DOCTRINE OF LAISSEZ FAIRE BEEN ABANDONED?     

Fisher I 《Science (New York, N.Y.)》1907,25(627):18-27

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Serum alpha globulin fraction: survival-and-recovery effect in irradiated mice   总被引：3，自引：0，他引：3  

M G Hanna  P Nettesheim  W D Fisher  L C Peters  M W Francis 《Science (New York, N.Y.)》1967,157(795):1458-1461

An alpha macroglobulin fraction (19S) was isolated from the serum of rats and BC(3)F(1) mice by zonal ultracentrifugation. Both the isologous and heterologous macroglobulin fractions increased survival among BC(3)F(1) mice x-irradiated with 750 roentgens. The mouse macroglobulin fraction also enhanced radiation recovery of hematopoietic tissue as measured by colony-forming assay and iron-59 incorporation into erythropoietic cells. The overall difference in hematopoietic activity in the irradiated (400 roentgens) mice treated with the macroglobulin fraction, in comparison with this activity in the controls, was three- to fivefold in the bone marrow and nine- to tenfold in the spleen between days 4 and 7 after irradiation. This effect was not obtained with the isologous serum protein fraction containing proteins of smaller molecular weight.  相似文献   

Wireless power transfer via strongly coupled magnetic resonances   总被引：4，自引：0，他引：4  

Kurs A  Karalis A  Moffatt R  Joannopoulos JD  Fisher P  Soljacic M 《Science (New York, N.Y.)》2007,317(5834):83-86

Using self-resonant coils in a strongly coupled regime, we experimentally demonstrated efficient nonradiative power transfer over distances up to 8 times the radius of the coils. We were able to transfer 60 watts with approximately 40% efficiency over distances in excess of 2 meters. We present a quantitative model describing the power transfer, which matches the experimental results to within 5%. We discuss the practical applicability of this system and suggest directions for further study.  相似文献   

Enzyme-coenzyme complexes of pyridine nucleotide-linked dehydrogenases     

H F Fisher  D G Cross 《Science (New York, N.Y.)》1966,153(734):414-415

Enzyme-reduced coenzyme binary complexes produce previously unreported shifts in the spectrum of the free coenzyme. These shifts give rise to difference spectra which resemble a general environmental change for reduced diphosphopyridine nucleotide (DPNH) in the glutamic dehydrogenase-DPNH complex, and indicate a more specific enzyme-coenzyme interaction for yeast alcohol dehydrogenase-DPNH, isocitrate dehydrogenase-TPNH, and lactic dehydrogenase-DPNH complexes.  相似文献   

THE WESTERN COOPERATIVE OIL SPRAY PROJECT (1929)     

Robinson RH  Fisher DF  Spuler A 《Science (New York, N.Y.)》1930,71(1843):440-441

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Molecular Growth Requirements of Single Mammalian Cells     

Sato G  Fisher HW  Puck TT 《Science (New York, N.Y.)》1957,126(3280):461-464

The molecular nutritional requirements exhibited by mammalian cells can vary with the following conditions: whether the cells are plated singly or in massive inoculum; whether a clonal strain or a mixture of different genotypes is employed; whether the macromolecular fraction of serum used as a supplement was previously exposed to prolonged dialysis or other procedures which may release bound micromolecules. In addition, the nature of the medium in which the cells were previously grown, the time permitted for incubation of the cells in the test medium, and the presence of substances or conditions which may specifically introduce the need for certain molecules to preserve balance can strongly influence nutritional requirements. This great versatility may reflect the ability of the mammalian cell to assume different metabolic states characteristic of specific types of differentiation. Under certain conditions, growth of single HeLa cells of the S3 clonal strain requires the presence of cholesterol at a level of 0.5 to 1 microgram per milliliter.  相似文献   

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor     

Changelian PS  Flanagan ME  Ball DJ  Kent CR  Magnuson KS  Martin WH  Rizzuti BJ  Sawyer PS  Perry BD  Brissette WH  McCurdy SP  Kudlacz EM  Conklyn MJ  Elliott EA  Koslov ER  Fisher MB  Strelevitz TJ  Yoon K  Whipple DA  Sun J  Munchhof MJ  Doty JL  Casavant JM  Blumenkopf TA  Hines M  Brown MF  Lillie BM  Subramanyam C  Shang-Poa C  Milici AJ  Beckius GE  Moyer JD  Su C  Woodworth TG  Gaweco AS  Beals CR  Littman BH  Fisher DA  Smith JF  Zagouras P  Magna HA  Saltarelli MJ  Johnson KS  Nelms LF  Des Etages SG  Hayes LS  Kawabata TT 《Science (New York, N.Y.)》2003,302(5646):875-878

Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prolonged survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings.  相似文献   

Instruction-level parallel processing     

Fisher JA  Rau R 《Science (New York, N.Y.)》1991,253(5025):1233-1241

The performance of microprocessors has increased steadily over the past 20 years at a rate of about 50% per year. This is the cumulative result of architectural improvements as well as increases in circuit speed. Moreover, this improvement has been obtained in a transparent fashion, that is, without requiring programmers to rethink their algorithms and programs, thereby enabling the tremendous proliferation of computers that we see today. To continue this performance growth, microprocessor designers have incorporated instruction-level parallelism (ILP) into new designs. ILP utilizes the parallel execution ofthe lowest level computer operations-adds, multiplies, loads, and so on-to increase performance transparently. The use of ILP promises to make possible, within the next few years, microprocessors whose performance is many times that of a CRAY-IS. This article provides an overview of ILP, with an emphasis on ILP architectures-superscalar, VLIW, and dataflow processors-and the compiler techniques necessary to make ILP work well.  相似文献   

Tropical trees     

Fisher JB 《Science (New York, N.Y.)》1981,214(4521):654-655

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Oceans. Mitigating local causes of ocean acidification with existing laws     

Kelly RP  Foley MM  Fisher WS  Feely RA  Halpern BS  Waldbusser GG  Caldwell MR 《Science (New York, N.Y.)》2011,332(6033):1036-1037

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