Clinical presentation,treatment and outcome in 31 dogs with presumed primary colorectal lymphoma (2001–2013)          下载免费PDF全文

I. Desmas  J. H. Burton  G. Post  O. Kristal  M. Gauthier  J. F. Borrego  A. Di Bella  A. Lara‐Garcia 《Veterinary and comparative oncology》2017,15(2):504-517

The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n = 18) and immunophenotype B (n = 24). Most dogs were substage b (n = 25) with higher prevalence of haematochezia (n = 20). One dog had surgery only. Thirty dogs received chemotherapy; amongst them 13 had surgery or radiotherapy. Progression free survival (PFS) was 1318 days and disease‐related median survival time (MST) was 1845 days. Fourteen dogs were alive at the end of the study with a median follow‐up time of 684 days (3–4678 days). Younger dogs had longer PFS (P = 0.031) and disease‐related MST (P = 0.01). Presence of haematochezia corresponded with longer PFS (P = 0.02). Addition of local treatment to chemotherapy did not significantly improve the outcome (P = 0.584). Canine PCRL has considerably longer PFS and MST than other forms of non‐Hodgkin's lymphoma.  相似文献   

Effect of Synthetic Colloid Administration on Coagulation in Healthy Dogs and Dogs with Systemic Inflammation          下载免费PDF全文

V. Gauthier  M.K. Holowaychuk  C.L. Kerr  A.M.E. Bersenas  R. Darren Wood 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2015,29(1):276-285

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Interactions between bovine beta-lactoglobulin and peptides under different physicochemical conditions     

Noiseux I  Gauthier SF  Turgeon SL 《Journal of agricultural and food chemistry》2002,50(6):1587-1592

The aim of this study was to determine if peptides could interact with beta-lactoglobulin (beta-LG) and what the physicochemical conditions promoting their interaction with the protein are. The binding of negatively charged (beta-LG 125-135 and 130-135), positively charged (beta-LG 69-83 and 146-149), and hydrophobic (alphaS1-CN 23-34 and beta-LG 102-105, both bioactive peptides) peptides to bovine beta-LG was determined using an ultrafiltration method under different physicochemical conditions: pH 3.0, 6.8, and 8.0; buffers of 0.05 and 0.1 M; 4, 25, and 40 degrees C; beta-LG/peptide ratios of 1:5 and 1:10. At pH 3.0, none of the peptides interacted with beta-LG at any temperature, buffer molarity, or beta-LG/peptide ratio probably due to electrostatic repulsions between the highly protonated species. At pH 6.8 and 8.0, charged peptides beta-LG 130-135, 69-83, and 146-149 bound to beta-LG under some physicochemical conditions, possibly by nonspecific binding. However, both hydrophobic peptides probably bind to the inner cavity (beta-barrel) of beta-LG, provoking the release of materials absorbing at 214 nm. Given the known biological activities of the hydrophobic peptides used in this study (opioid and ACE-inhibitory activities), their binding to beta-LG may be relevant to a better understanding of the physiological function of the protein.  相似文献   

Assessment of N₂ fixation by Casuarina equisetifolia inoculated with Frankia ORS021001 using ¹⁵N methods     

D. Gauthier  H.G. Diem  Y.R. Dommergues  F. Ganry 《Soil biology & biochemistry》1985,17(3):375-379

Casuarina equisetifolia seedlings, uninoculated or inoculated with Frankia strain ORS021001 were grown for 4.5 months in pouches, then transplanted into 1 m³ concrete containers forming 1 m² microplots. Trees were harvested 6.5 months later when they were 11 months old. N₂ fixation was measured using three methods of assessment: the direct isotopic method, the A-value method and the difference method. Estimations of N₂ fixation during the 6.5 months following transplantation were respectively 3.27, 2.31 and 3.07g N₂ per tree. From these values it was calculated that about 40–60 kg N₂ would be fixed per hectare in a year at normal densities of 10,000 trees ha^?1. The results of this experiment confirm that Frankia strain ORS021001 can be confidently recommended to inoculate casuarinas in the field. Means to improve nodulation and subsequently N₂ fixation by casuarinas are discussed.  相似文献   

Dynamics of the free-living populations of gastrointestinal trichostrongyles of cattle in a natural grazing system in Guadeloupe (French West Indies)     

Gilles Aumont  Dominique Gauthier  Lucas Gruner  Grard Matheron 《Preventive veterinary medicine》1992,12(3-4):245-258

The variations in the population size of trichostrongyle infective larvae (L3) in a cow-calf system were recorded for two years in Guadeloupe (humid and hot tropical climate). Calvings were pooled during the dry season for two herds and during the rainy season for two others. Each herd grazed three paddocks of natural pasture according to a rotational system (14 days of grazing per paddock). At the time the animals entered each paddock, the numbers of L3 on pasture were assessed around fecal pats (L3_ap) and within a 1 m radius of pats (L3_1rfp). Seventy-one regressor variables were tested to explain variations in the size of L3 populations: combinations of variables linked to animals (e.g. weight, fecal eggs, stocking rate) and combinations of ecological variables (e.g. rainfall, global radiation, herbage mass). L3_1rfp were highly correlated to L3_ap. However, when the mean global radiation during the third week after the entrance of animals exceeded 20 MJ m⁻² day⁻¹, L3_1rfp was undetectable even with large L3 burdens around pats. Multiple-component analysis and hierarchical classification used on regressor variables led to four classes which were characterized basically by fecal eggs and stocking rate, but not by climatic conditions. Within these classes, there was a limit of global radiation between 8 and 14 days after the entrance of animals; beyond this limit (20 MJ m⁻² day⁻¹), the L3_ap decreased from 1.3 to 27.1 times. The classification factor and global radiation factor explained 50–57% of the variance of L3_ap. From these results, it can be concluded that animal husbandry is just as important as climatic conditions in explaining the number of L3 on pasture in Guadeloupe. Global radiation, fecal eggs and stocking rates appeared to be useful in predicting the level of infectivity of pastures.  相似文献   

Preliminary evaluation of an osteochondral autograft,a prosthetic implant,and a biphasic absorbable implant for osteochondral reconstruction in a sheep model     

Mélanie Olive DVM  Cécile Boyer PhD  Julie Lesoeur MS  Chantal Thorin PhD  Pierre Weiss DDS  PhD  Marion Fusellier DVM  PhD  Olivier Gauthier DVM  PhD 《Veterinary surgery : VS》2020,49(3):570-581

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Polycythemia and inappropriate erythropoietin concentrations in two dogs with renal T-cell lymphoma     

Durno AS  Webb JA  Gauthier MJ  Bienzle D 《Journal of the American Animal Hospital Association》2011,47(2):122-128

Two dogs presented with suspected renal disease and polycythemia. Abdominal ultrasound examinations performed on both dogs revealed coalescing masses causing bilateral renomegaly. Serum erythropoietin (EPO) concentrations were physiologically inappropriate. Postmortem examinations revealed renal T-cell lymphoma in both dogs. One of the two dogs also had involvement of the liver and mesentery. EPO-immunohistochemistry on tissue samples demonstrated positive staining in tumor cells and occasional normal renal cells. This report illustrates that paraneoplastic EPO production may induce polycythemia. The pattern of EPO-immunohistochemistry staining suggested that the mechanism of production was due to tumor production of EPO and local hypoxia-induced EPO production from compression of normal renal cells and vasculature.  相似文献   

First report of the Q biotype of <Emphasis Type="Italic">Bemisia tabaci</Emphasis> in Argentina and Uruguay     

Gabriela Grille  Nathalie Gauthier  José Buenahora  César Basso  Olivier Bonato 《Phytoparasitica》2011,39(3):235-238

Bemisia tabaci adults were collected from pepper and melon at different commercial production greenhouses in Argentina and Uruguay. The biotype status of adults was then established using cytochrome oxidase I gene (mtCOI) as molecular marker. Only the Q biotype was found on all plants sampled. This is the first report of the Q biotype in Argentina and Uruguay.  相似文献   

Walnut (Juglans spp.) ecophysiology in response to environmental stresses and potential acclimation to climate change   总被引：1，自引：0，他引：1  

Martin-Michel Gauthier  Douglass F. Jacobs 《Annals of Forest Science》2011,68(8):1277-1290

? Context

Walnuts (Juglans spp.) are ecologically and commercially important trees, yet synthesis of past and current research findings on walnut ecophysiology is lacking, especially in terms of potential acclimation to climate change.

? Aims

This study aims to (1) investigate walnut ecophysiology by comparing its attributes to associated deciduous angiosperms, (2) address potential acclimation of walnut to climate change, and (3) identify areas for prioritization in future research.

? Results

There is considerable uncertainty regarding the magnitude of potential effects of climate change on walnut. Some studies tend to indicate walnut could be negatively impacted by climate change, while others do not. Walnut may be at a disadvantage due to its susceptibility to drought and frost injury in current growing regions given the projected increases in temperature and extreme climatic events. Other regions that are currently considered cold for walnut growth may see increased establishment and growth depending upon the rate of temperature increase and the frequency and severity of extreme climatic events.

? Conclusion

Research investigating a combination of environmental factors, such as temperature, carbon dioxide, ozone, water, and nitrogen is needed to (1) better project climate change effects on walnut and (2) develop management strategies for walnut acclimation and adaptation to climate change.  相似文献   

Stored light in an optical fiber via stimulated Brillouin scattering     

Zhu Z  Gauthier DJ  Boyd RW 《Science (New York, N.Y.)》2007,318(5857):1748-1750

We describe a method for storing sequences of optical data pulses by converting them into long-lived acoustic excitations in an optical fiber through the process of stimulated Brillouin scattering. These stored pulses can be retrieved later, after a time interval limited by the lifetime of the acoustic excitation. In the experiment reported here, smooth 2-nanosecond-long pulses are stored for up to 12 nanoseconds with good readout efficiency: 29% at 4-nanosecond storage time and 2% at 12 nanoseconds. This method thus can potentially store data packets that are many bits long. It can be implemented at any wavelength where the fiber is transparent and can be incorporated into existing telecommunication networks because it operates using only commercially available components at room temperature.  相似文献