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The medical records of 12 horses with septic arthritis of a distal interphalangeal joint were reviewed to determine clinical features and response to treatment. Sepsis was caused by trauma or an injection that resulted in an open or contaminated distal interphalangeal joint. All horses were severely lame. Treatment included broad-spectrum parenterally administered antimicrobial drugs (ten horses), percutaneous through-and-through joint lavage (eight horses), indwelling drains (three horses), immobilization of the limb in a cast (three horses), intraarticular injection of sodium hyaluronate (one horse), intraarticular injection of antimicrobial drugs (five horses), curettage of the distal phalanx (one horse), and cancellous bone grafting to promote fusion (one horse). Five horses were euthanatized. Ankylosis of the affected joint developed in five horses, four of which are pasture sound. Two horses treated medically are sound although one underwent subsequent palmar digital neurectomy for treatment of navicular syndrome.  相似文献   
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This project compared the effects of hydrocolloid (HC) and hydrogel (HG) occlusive dressings and a polyethylene (PE) semi-occlusive dressing on the healing of acute full-thickness skin wounds on the forelimbs of 10 dogs. All treatments resulted in a similar degree of healing at postoperative days 4 and 7. No significant differences existed in the number of wounds that were more than 90% healed at postoperative day 28 between the group treated with the HG dressing and the group treated with the PE dressing. There were significantly fewer wounds more than 90% healed at postoperative day 28 in the group treated with the HC dressing. Wounds under the HG dressing had the largest mean percentage of contraction at postoperative days 21 and 28. Wounds under the HG dressing also had the largest contraction/re-epithelialization ratio (postoperative days 21 and 28) compared with wounds under the PE and HC dressings. Wounds under the PE dressing had a significantly higher mean percentage of re-epithelialization than wounds under both occlusive dressings on postoperative days 14, 21, and 28. Wounds under the two occlusive dressings had exuberant granulation tissue present more often than wounds under the PE dressing. The two occlusive dressings had significantly higher bacterial counts on wounds compared with wounds under the PE dressing; analysis of variance (ANOVA), P = .0008. Wounds under the HC dressing showed the poorest healing in all parameters.  相似文献   
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This study determined the effect of the polypeptide growth factors transforming growth factor-beta (TGF-β), insulin-like growth factor-I (IGF-I), and growth hormone (GH) alone and in combination with dietary L-Arginine HCL (ARG) on skin flap survival in rats. Caudally based dorsal skin flaps were created in 110 Sprague-Dawley rats. The rats were randomly assigned into three treatment groups, based on drinking water supplementation. Group 1 (n = 50) received ARG in their drinking water, group 2 (n = 50) received tap water alone, and group 3 (n = 10) received N-omega-nitro-L-arginine (L-NA) and hydralazine. Groups 1 and 2 were divided into subgroups of 10 rats each based on treatment with either: TGF-β, IGF-I, GH, or IGF-I + GH. All subgroups that received GH had significantly greater ( P <.0001) median body weight gains when compared with subgroups not receiving GH. L-arginine HCL when added to IGF-I negated the positive effects of IGF-I on both flap survival and weight gain. Although the rats in all subgroups from groups 1 and 2 had an increase in mean percent skin flap survival when compared with the water alone subgroup, only rats receiving IGF-I, or the combination of ARG with either TGF-β or GH, had statistically significant enhanced skin flap survival. Rats in group 3 did not show an increase in skin flap survival when compared with the control subgroup.  相似文献   
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Some aspects of the incidence, breed distribution, examination and the macroscopic and microscopic pathology of interdigital cysts are described. The aetiology and pathogenesis of this condition are discussed.
  • (a). Ninety-five dogs (1.6 per cent) of a total of 5923 dogs were presented for examination with interdigital cysts.
  • (b). The Pekingese, West Highland White Terrier and Scotch Terrier are predisposed to interdigital cysts.
  • (c). The incidence of interdigital cysts in the Border Collie is very low.
  • (d). Interdigital cysts occur most regularly in the 3/4, 4/5 interdigital space of one or both fore-feet.
  • (e). Interdigital cysts are essentially granulomatous lesions containing abscesses and sinus tracks.
  • (f). Staphylococcus aureus and β haemolytic streptococci are common secondary bacterial invaders.
  • (g). Interdigital cysts probably originate from a pedal dermatitis and folliculitis.
  • (h). It is suggested that the conformation of the interdigital web plays a part in the susceptibility of a dog to interdigital cyst.
Résumé. Certaines questions concernant la fréquence, la distribution d'après les races des signes cliniques et l'anatomie pathologique macroscopique et microscopique des kystes inter-digitaux sont évoqués. L'étiologie et la pathogénie de cette affection sont discutées.
  • (a). 95 chiens (1,6%) sur un total de 5 923 animaux présentés à l'examen étaient atteints de kystes interdigitaux.
  • (b). Les Pékinois, West Highland White Terrier et Scotch Terrier sont particulièrement prédisposés à cette affection.
  • (c). La fréquence des kystes interdigitaux chez le Border Collie est très basse.
  • (d). Les kystes interdigitaux s'observent avec prédilection dans les espaces interdigitaux 3/4 et 4/5 d'une ou des deux pattes antérieures.
  • (e). Les kystes interdigitaux présentent essentiellement des lésions granulomateuses contenant des abcès et des trajets fistuleux.
  • (f). Le Staphylocoque doré et le streptocoque β-hémolytique sont les germes d'infection secondaire les plus fréquents.
  • (g). Les kystes interdigitaux tirent probablement leur origine d'une dermatite et d'une folli-culite du pied.
  • (h). On estime que la conformation de la membrane interdigitale joue un rôle dans la sensibilité du chien aux kystes interdigitaux.
Zusammenfassung. Einige Aspeckte der Häufigkeit, der Verteilung auf die Hunderassen, der Untersuchung und der makroskopischen und mikroskopischen Pathologie der Interdigital-cysten werden beschrieben. Die Ätiologie und die Pathogenese dieses Zustands werden be-sprochen.
  • (a). 95 Hunde (1,6%) von insgesamt 5923 Hunden wurden mit Interdigitalcysten zur Untersuchung vorgeführt.
  • (b). Der Pekinese, der West-Highland-White-Terrier und der Scotch-Terrier sind für Interdigitalcysten prädisponiert.
  • (c). Die Häufigkeit von Interdigitalcysten beim Border Collie ist sehr gering.
  • (d). Interdigitalcysten treten am regelmässigsten im 3/4– und 4/5-Interdigitalraum einer oder beider Vorderpfoten auf.
  • (e). Interdigitalcysten sind im wesentlichen granulomatöse Läsionen, die Abszesse und Fistelgänge enthalten.
  • (f). Staphylococcus aureus und β-Hämolyse-Streptokokken sind häufig die Ursachen von Sekun-därinfektionen.
  • (g). Interdigitalcysten werden wahrscheinlich durch Fussdermatitis und Folliculitis verursacht.
  • (h). Es wird der Vermutung Amdruck gegeben, dass die Art der Ausbildung des Interdigital-gewebes eine Rolle bei der Empfindlichkeit eines Hundes fur die Entstehung von Interdigitalcysten spielt.
  相似文献   
38.
Pharmacokinetics of sulfamethazine in male, female and castrated male swine   总被引:1,自引:0,他引:1  
The concentration of sulfamethazine in plasma and sulfamethazine and its metabolites in urine were compared in male, female and castrated male swine. A surgical technique for placement of catheters in the urinary bladder was used to facilitate the collection of urine in males and castrated males. The elimination rate of sulfamethazine from plasma and the excretion of parent drug and metabolites into urine did not differ significantly among females, males and castrated male swine.  相似文献   
39.
Summary. An experiment was made to determine the effect of the removal of grasses on the behaviour of populations of Plantago lanceolata , P. media and P. major in three grassland habitats. Treatments included the addition of seed of all three species to the existing vegetation. The grasses were removed by treatment with 2,2-dichloropropionic acid (dalapon), a herbicide selective against the Gramineae. The chemical appears to be slightly toxic to the Plantago species at the dose used (12 Ib/ac a.e.). The removal of the grasses was followed by a marked increase in the plantain populations shown both in counts of the numbers of plants and seedlings and in increased seed output per unit area. Deliberate sowing of seed into the habitats in autumn resulted in increased numbers of seedlings in the following spring, particularly in those plots where the grasses had been removed. Species of Plantago not occurring naturally in the communities were frequently established by sowing seed, if the grasses had been removed, but not otherwise. The overall results of the experiment suggest that in two of the communities the grasses played an important role in determining the presence or absence of particular Plantagn species and also in controlling the size of the existing plantain populations. The experiment is discussed in the wider context of population control in plants.
Tentative de modification de populations naturelles de Plantago lanceolata, P. major et P. media.  相似文献   
40.
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