Reference values for serum levels of vitamin B12 and folic acid in a population-based sample of adults between 35 and 80 years of age     

Wahlin A  Bäckman L  Hultdin J  Adolfsson R  Nilsson LG 《Public health nutrition》2002,5(3):505-511

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Growth and carbon sequestration by ectomycorrhizal fungi in intensively fertilized Norway spruce forests     

H. Wallander  A. Ekblad  J. Bergh 《Forest Ecology and Management》2011,262(6):999-1007

A substantial portion of the carbon (C) fixed by the trees is allocated belowground to ectomycorrhizal (EM) symbionts, but this fraction usually declines after fertilization. The aim of the present study was to estimate the effect of optimal fertilization (including all the necessary nutrients) on the growth of EM fungi in young Norway spruce forests over a three year period. In addition, the amount of carbon sequestered by EM mycelia was estimated using a method based on the difference in δ¹³C between C₃ and C₄ plants. Sand-filled ingrowth mesh bags were used to estimate EM growth, and similar bags amended with compost made from maize leaves (a C₄ plant) were used to estimate C sequestration. Fertilizers had been applied either every year or every second year since 2002 and the estimates of EM growth started in 2007. The application of fertilizer reduced EM growth to between 0% and 40% of the growth in the control plots at one site (Ebbegärde), while no significant effect was found at the other three sites studied. The effect of the fertilizer was similar in sand-filled and maize-compost-amended mesh bags, but the total production of EM fungi was 3-4 times higher in maize-compost-amended mesh bags. The fertilizer tended to reduce EM growth more when applied every year than when applied every second year. The amount of C sequestered in maize-compost-amended mesh bags collected from unfertilized treatments was estimated to be between 0.2 and 0.7 mg C g sand⁻¹ at Ebbegärde and between 0.2 and 0.5 mg C g sand⁻¹ at Grängshammar. This corresponds to between 300 and 1100 kg C per ha, assuming a similar production in the soil as in the mesh bags. Fertilization at the Ebbegärde site reduced carbon sequestration, which confirmed the results based on estimates of fungal growth (ergosterol levels). A correlation was found between fungal biomass and δ¹³C in mesh bags amended with maize compost. Based on this, it was estimated that a fungal production of 1 μg ergosterol corresponded to 0.33 mg of sequestered carbon. In conclusion, the effect of the fertilizer on EM growth seemed to be dependent on the effect of the fertilizer on tree growth. Thus, at Ebbegärde, were tree growth was less stimulated by the fertilizer, EM growth was reduced upon fertilization. At other sites, where tree growth was more stimulated, the fertilizer did not influence EM growth. The large amounts of carbon sequestered during the experiment may be a result of fungal residues remaining in the soil after the death of the hyphae.  相似文献   

Development of the Regional Policy Process for Air Pollution in South Asia,Southern Africa and Latin America     

Hicks  W. Kevin  Kuylenstierna  Johan C.I.  Mathur  Vikrom  Mazzucchelli  Sergio  Burijson  Viviana  Shrestha  Surendra  Iyngararasan  Mylvakanam  Simukanga  Stephen  Van Tienhoven  A. Mieke 《Water, air, and soil pollution》2001,130(1-4):211-216

Projections indicate that large increases in emissions may occur in developing countries during the next twenty to fifty years if current development patterns persist. This paper describes the development of co-operation regarding air pollution issues in three sub-regions of three continents. Experiences gained through activities within a programme on Regional Air Pollution in Developing Countries are used to illustrate progress. The sub-regional process in South Asia developed through a series of meetings that led to the Malé Declaration. In southern Africa a policy dialogue led to the Harare Resolution targeted towards progress in the SADC region. A policy dialogue in Buenos Aires concentrated on issues related to regional harmonisation of legal frameworks in the Mercosur region. In all regions the link between scientific information required to support decision making has been emphasised. The sub-regional policy processes are analysed in relation to availability of required scientific information and compared to the process that led to protocol development in Europe.  相似文献   

Retraction     

Tomkins JL  Penrose MA  Greeff J  Lebas NR 《Science (New York, N.Y.)》2011,333(6047):1220

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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase   总被引：1，自引：0，他引：1  

Du J  Zhou Y  Su X  Yu JJ  Khan S  Jiang H  Kim J  Woo J  Kim JH  Choi BH  He B  Chen W  Zhang S  Cerione RA  Auwerx J  Hao Q  Lin H 《Science (New York, N.Y.)》2011,334(6057):806-809

Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectable or very weak deacetylase activity. We found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. The preference for succinyl and malonyl groups was explained by the presence of an arginine residue (Arg(105)) and tyrosine residue (Tyr(102)) in the acyl pocket of Sirt5. Several mammalian proteins were identified with mass spectrometry to have succinyl or malonyl lysine modifications. Deletion of Sirt5 in mice appeared to increase the level of succinylation on carbamoyl phosphate synthase 1, which is a known target of Sirt5. Thus, protein lysine succinylation may represent a posttranslational modification that can be reversed by Sirt5 in vivo.  相似文献   

Selective charging of tRNA isoacceptors explains patterns of codon usage     

Elf J  Nilsson D  Tenson T  Ehrenberg M 《Science (New York, N.Y.)》2003,300(5626):1718-1722

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Modulation of postendocytic sorting of G protein-coupled receptors   总被引：1，自引：0，他引：1  

Whistler JL  Enquist J  Marley A  Fong J  Gladher F  Tsuruda P  Murray SR  Von Zastrow M 《Science (New York, N.Y.)》2002,297(5581):615-620

Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensitization of signal transduction, whereas targeting of the delta opioid receptor (DOR) to lysosomes causes proteolytic down-regulation. We identified a protein that binds preferentially to the cytoplasmic tail of the DOR as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP). Disruption of the DOR-GASP interaction through receptor mutation or overexpression of a dominant negative fragment of GASP inhibited receptor trafficking to lysosomes and promoted recycling. The GASP family of proteins may modulate lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors.  相似文献   

Deuterium on Mars: The Abundance of HDO and the Value of D/H     

Owen T  Maillard JP  de Bergh C  Lutz BL 《Science (New York, N.Y.)》1988,240(4860):1767

Deuterium on Mars has been detected by the resolution of several Doppler-shifted lines ofHDO near 3.7 micrometers in the planet's spectrum. The ratio of deuterium to hydrogen is (9 +/- 4) x 10(-4); the abundance of H(2)0 was derived from lines near 1.1 micrometers. This ratio is enriched on Mars over the teiluric value by a factor of6 +/- 3. The enrichment implies that hydrogen escaped more rapidly from Mars in the past than it does now, consistent with a dense and warm ancient atmosphere on the planet.  相似文献   

Surface ices and the atmospheric composition of pluto     

Owen TC  Roush TL  Cruikshank DP  Elliot JL  Young LA  de Bergh C  Schmitt B  Geballe TR  Brown RH  Bartholomew MJ 《Science (New York, N.Y.)》1993,261(5122):745-748

Observations of the 1.4- to 2.4-micrometer spectrum of Pluto reveal absorptions of carbon monoxide and nitrogen ices and confirm the presence of solid methane. Frozen nitrogen is more abundant than the other two ices by a factor of about 50; gaseous nitrogen must therefore be the major atmospheric constituent. The absence of carbon dioxide absorptions is one of several differences between the spectra of Pluto and Triton in this region. Both worlds carry information about the composition of the solar nebula and the processes by which icy planetesimals formed.  相似文献   

Size and age of the universe     

van den Bergh S 《Science (New York, N.Y.)》1981,213(4510):825-830

The age of the universe based on abundances of isotopes is in the range 10 billion to 15 billion years. This is consistent with the age range 12 billion to 20 billion years calculated from the evolution of the oldest galactic stars. A third estimate of the age of the universe is based on the Hubble relation between the velocities of galaxies and their distances from us, where the inverse of the Hubble parameter H is a measure of the age of a uniformly expanding universe. Evidence that has been accumulating over the past few years indicates that the expansion of the universe may exhibit a rather large local perturbation due to the gravitational attraction of the Virgo supercluster. Different types of observations still produce conflicting evidence about the velocity with which the Local Group of galaxies (of which our Milky Way system is a member) is falling into the Virgo cluster. The results to date indicate that this velocity lies somewhere in the range 0 to 500 kilometers per second. The resulting ambiguity in the flow pattern for relatively nearby galaxies makes values of H derived from galaxies with radial velocities less than 2000 kilometers per second particularly uncertain, and this restricts determinations of H to distant galaxies, for which distances are particularly uncertain. The best that can be said at present is that H(-1) yields a maximum time scale in the range 10 billion to 20 billion years.  相似文献