Discovery of novel (N-aryl-4-methylpiperidinyl)pyrazoles: a new class of potent lepidopteran insecticides     

Thomas F. Pahutski  Omar K. Ahmad  Eric A. Marshall  Kathleen Joraski  James D. Barry  Craig Keathley  Daniel Cordova  Eric Benner  David Nesnow  Laurie Christianson  Rachel D. Slack  George P. Lahm 《Pest management science》2023,79(5):1743-1749

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Assessment of the socio-economic impacts associated with the arrival of apple snail (Pomacea canaliculata) in Mwea irrigation scheme,Kenya     

Kate L. Constantine  Fernadis Makale  Idah Mugambi  Duncan Chacha  Harrison Rware  Alexander Muvea  Vincent K. Kipngetich  Justice Tambo  Adewale Ogunmodede  Djami Djeddour  Corin F. Pratt  Ivan Rwomushana  Frances Williams 《Pest management science》2023,79(11):4343-4356

Background

In Kenya, rice (Oryza sativa L.) is mainly produced under irrigation by small-scale farmers. Mwea irrigation scheme (MIS) in Kirinyaga County accounts for 80–88% of rice production. Here, rice is the main source of livelihood and a source of revenue generation for the county. However, a recently established invasive freshwater snail, Pomacea canaliculata (Lamarck) (family: Ampullariidae), a species of apple snail, presents a serious threat to rice production.

Results

Household surveys, focus group discussions and key informant interviews highlight apple snail as a serious problem in MIS. Households that observed at least a moderate level of infestation (>20% of cultivated area) experienced significant reductions in rice yield (~14%) and net rice income (~60%). Farmers reported increased use of chemical pesticides for management of apple snail. In addition, the cost of hired labor for physical removal of egg masses and snails is resulting in substantial negative effects on net income. Farmer age, area of land owned, responsibility for decision-making, receipt of extension advice, training, and membership of a farmer organization, were all statistically significant variables to explain farmers awareness of the need for area-wide apple snail management.

Conclusion

Strategies to limit the spread of apple snail are urgently needed. A Multi-Institutional Technical Team (MITT) has been established to spearhead management efforts and consolidate advice to farmers on how to manage apple snail. However, without action to mitigate spread, the consequences could be disastrous for rice production and food security in Kenya, and for other rice growing regions across Africa. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.  相似文献   

Extracellular heat shock protein 70 levels in tumour-bearing dogs and cats treated with radiation therapy and hyperthermia     

K. J. Nytko  M. S. Weyland  S. Dressel-Böhm  S. Scheidegger  L. Salvermoser  C. Werner  S. Stangl  A. C. Carpinteiro  B. Alkotub  G. Multhoff  S. Bodis  C. Rohrer Bley 《Veterinary and comparative oncology》2023,21(4):605-615

Hyperthermia is a form of a cancer treatment which is frequently applied in combination with radiotherapy (RT) to improve therapy responses and radiosensitivity. The mode of action of hyperthermia is multifactorial; the one hand by altering the amount of the blood circulation in the treated tissue, on the other hand by modulating molecular pathways involved in cell survival processes and immunogenic interactions. One of the most dominant proteins induced by hyperthermia is the major stress-inducible heat shock protein 70 (Hsp70). Hsp70 can be found in the blood either as a free-protein (free HSP70) derived from necrotic cells, or lipid-bound (liposomal Hsp70) when it is actively released in extracellular vesicles (EVs) by living cells. The aim of the study was to evaluate the levels of free and liposomal Hsp70 before and after treatment with RT alone or hyperthermia combined with radiotherapy (HTRT) in dogs and cats to evaluate therapy responses. Peripheral blood was collected from feline and canine patients before and at 2, 4, 6 and 24 h after treatment with RT or HTRT. Hsp70 enzyme-linked immunosorbent assays (ELISAs) were performed to determine the free and liposomal Hsp70 concentrations in the serum. The levels were analysed after the first fraction of radiation to study immediate effects and after all applied fractions to study cumulative effects. The levels of free and liposomal Hsp70 levels in the circulation were not affected by the first singular treatment and cumulative effects of RT in cats however, after finalizing all treatment cycles with HTRT free and liposomal Hsp70 levels significantly increased. In dogs, HTRT, but not treatment with RT alone, significantly affected liposomal Hsp70 levels during the first fraction. Free Hsp70 levels were significantly increased after RT, but not HTRT, during the first fraction in dogs. In dogs, on the other hand, RT alone resulted in a significant increase in liposomal Hsp70, but HTRT did not significantly affect the liposomal Hsp70 when cumulative effects were analysed. Free Hsp70 was significantly induced in dogs after both, RT and HTRT when cumulative effects were analysed. RT and HTRT treatments differentially affect the levels of free and liposomal Hsp70 in dogs and cats. Both forms of Hsp70 could potentially be further investigated as potential liquid biopsy markers to study responses to RT and HTRT treatment in companion animals.  相似文献   

Highly recurrent BRAF p.V595E mutation in canine papillary oral squamous cell carcinoma     

Santiago Peralta  Suzin M. Webb  William P. Katt  Jennifer K. Grenier  Gerald E. Duhamel 《Veterinary and comparative oncology》2023,21(1):138-144

Oral squamous cell carcinoma (OSCC) is the most common oral epithelial malignancy in dogs. It exhibits locally aggressive biological behaviour with the potential to metastasize, and a reported 1-year survival rate of 0% when left untreated. Expression studies suggest that aberrant MAPK signalling plays a key role in canine OSCC tumorigenesis, which is consistent with BRAF and HRAS MAPK-activating mutations reported in some tumours. Several morphological subtypes of canine OSCC have been described, with papillary, conventional, and basaloid as the most common patterns. We hypothesized that mutational differences may underlie these phenotypic variations. In this study, targeted Sanger sequencing and restriction fragment length polymorphism assays demonstrate that up to 85.7% of canine papillary OSCC (n = 14) harbour a BRAF p.V595E mutation. Assessment of neoplastic epithelial cell proliferation using Ki67 immunolabelling (n = 10) confirmed a relatively high proliferation activity, consistent with their known aggressive clinical behaviour. These findings underscore a consistent genetic feature of canine papillary OSCC and provide a basis for the development of novel diagnostic and targeted therapeutic approaches that can improve the quality of veterinary care.  相似文献   

Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog     

Aria L. Guarino DVM  DACVIM  Laura A. Cagle DVM  PhD  DACVECC  Caryn M. Ehrhardt DVM  Sarah S. K. Beatty DVM  DACVP  Jere K. Stern DVM  Chen Gilor DVM  DACVIM  Andrew J. Specht DVM  DACVIM  Leo A. Londoño DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(2):247-256

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Clinical features and long-term management of cats with primary hypoadrenocorticism using desoxycorticosterone pivalate and prednisolone     

Nadja S. Sieber-Ruckstuhl  Livia Harburger  Natalie Hofer  Claudia Kümmerle  Claudia Müller  Barbara Riond  Regina Hofmann-Lehmann  Claudia E. Reusch  Felicitas S. Boretti 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):420-427

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Clinical utility of an immunoglobulin A-based serological panel for the diagnosis of chronic enteropathy in dogs     

Daniel K. Langlois  Jessica C. Pritchard  M. Katherine Tolbert  Albert E. Jergens  Gary Block  Andrew S. Hanzlicek  Jared A. Jaffey  Jörg M. Steiner  Sina Marsilio  Sara A. Jablonski 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):446-454

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Onchocerca sp. in an imported Zangersheide gelding causing suspensory ligament desmitis     

Kara A. Brown  Amy L. Johnson  Susan J. Bender  Thomas J. Nolan  Bianca Pfisterer  JoAnn Slack  Elinor Willis  Emily K. Rule 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):735-739

A 5-year-old imported Zangersheide gelding was evaluated for SC swellings over both forelimbs and lameness localized to the distal metacarpus. Ultrasound examination of the SC masses was compatible with verminous granulomas. Linear hyperechoic foci were present within the suspensory ligament branches of both forelimbs, suggestive of ligamentous parasitic infiltrates. A diagnosis of onchocerciasis was confirmed on biopsy of a SC mass. The gelding was treated with ivermectin and a tapering course of PO dexamethasone but was eventually euthanized. Necropsy confirmed the presence of SC eosinophilic granulomas and degenerative suspensory ligament desmitis, both with intralesional nematodes. Given the location and appearance of the nematode, a diagnosis of Onchocerca sp., most likely O. reticulata, was made. Onchocerciasis should be included as a differential diagnosis for multifocal suspensory ligament desmitis with these sonographic characteristics when paired with SC masses in imported European Warmbloods.  相似文献   

Ostreid herpesvirus-1 microvariant surveillance in Pacific oysters (Magallana gigas,Thunberg, 1793) in Australia in 2011     

BJ Moloney  M Deveney  K Ellard  P Hick  PD Kirkland  NJG Moody  J Frances 《Australian veterinary journal》2023,101(9):345-355

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Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features     

Claudia Cueni  Natalie Hofer-Inteeworn  Claudia Kümmerle-Fraune  Claudia Müller  Peter Hendrik Kook 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(1):70-79

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