Results from crossing beef with beef and beef with dairy breeds: calf performance to weaning     

O F Pahnish  J S Brinks  J J Urick  B W Knapp  T M Riley 《Journal of animal science》1969,28(3):291-299

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Heterosis in postweaning traits among lines of Hereford cattle     

J J Urick  J S Brinks  O F Pahnish  B W Knapp  T M Riley 《Journal of animal science》1968,27(2):323-330

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Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers     

Raghavan M  Knapp DW  Bonney PL  Dawson MH  Glickman LT 《Journal of the American Veterinary Medical Association》2005,227(1):94-100

OBJECTIVE: To evaluate the effects of vegetable consumption and vitamin supplementation on the risk of developing transitional cell carcinoma (TCC) of the urinary bladder in Scottish Terriers. DESIGN: Case-control study. ANIMALS: 92 adult Scottish Terriers with TCC (cases) and 83 Scottish Terriers with other conditions (controls). PROCEDURE: Owners of dogs with TCC completed a questionnaire regarding their dogs' diet and intake of vitamin supplements in the year prior to diagnosis of TCC; owners of control dogs completed the questionnaire for a comparable time period. The risk (odds ratio [OR]) of developing TCC associated with diet and vitamin supplementation was determined by use of logistic regression. RESULTS: After adjustment for age, weight, neuter status, and coat color, there was an inverse association between consumption of vegetables at least 3 times/wk (OR, 0.30; 95% confidence interval [CI], 0.15 to 0.62) and risk of developing TCC. For individual vegetable types, the risk of developing TCC was inversely associated with consumption of green leafy vegetables (OR, 0.12; 95% CI, 0.01 to 0.97) and yellow-orange vegetables (OR, 0.31; 95% CI, 0.14 to 0.70). Consumption of cruciferous vegetables was not significantly associated with a similar reduction in risk of developing TCC (OR, 0.22; CI, 0.04 to 1.11). The power of the study to detect a 50% reduction in TCC risk associated with daily vitamin supplementation was considered low (25%). CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that consumption of certain vegetables may prevent or slow the development of TCC in Scottish Terriers.  相似文献   

Expression of cyclooxygenase-2 in canine renal cell carcinoma   总被引：11，自引：0，他引：11  

Khan KN  Stanfield KM  Trajkovic D  Knapp DW 《Veterinary pathology》2001,38(1):116-119

Cyclooxygenase-2 (COX-2) has been shown to be the primary enzyme responsible for prostaglandin production during inflammation but is absent in most tissues under normal physiological states. High levels of COX-2 expression have been observed in the macula densa and thick ascending limbs of fetal kidneys; this expression declines to minimal levels during renal maturation. We hypothesized that the neoplastic cells of renal cell carcinoma (RCC) may revert to high expression of COX-2, and we evaluated its expression in three spontaneous cases of canine RCC by using immunohistochemical methods. The neoplastic cells of two of the three cases exhibited moderate to marked COX-2 immunoreactivity. These results suggest that some canine renal cell carcinomas express high levels of COX-2, which may play a role in the modulation of neoplastic cell growth.  相似文献   

Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog     

Michels GM  Knapp DW  David M  Lantz GC  Munjar TA  Blevins WE  DeNicola DB 《Journal of the American Animal Hospital Association》2001,37(5):474-477

A 5-year-old Chihuahua presented for clinical signs of dysuria and penile prolapse. Radiographic studies identified a urethral obstruction distal to the junction of the proximal and middle third of the os penis that appeared to be secondary to swelling of the penis. Penile resection combined with a scrotal urethrostomy was performed. Histopathological examinations of tissue samples of the body of the penis revealed lymphosarcoma. Lymphosarcoma of the penis is a rare finding in all species. It can occur as a primary tumor of the penis in dogs. Penile lymphosarcoma should be considered in the differential diagnosis of dogs affected with penile prolapse and dysuria.  相似文献   

Selection for postweaning growth in inbred Hereford cattle: the Fort Keogh, Montana line 1 example.     

M D MacNeil  J J Urick  S Newman  B W Knapp 《Journal of animal science》1992,70(3):723-733

Demographic characteristics and genetic trends in birth weight and pre- and postweaning ADG were examined in a population of Hereford cattle (Line 1). Line 1 was founded largely from two paternal half-sib sires and has been selected for postweaning growth. There were pedigree records on 951 members of the base population that predated 1935, when data collection began. Numbers of records analyzed using mixed-model methodology were 4,716 birth weight, 4,427 preweaning ADG, and 3,579 postweaning ADG. Birth weight and preweaning ADG were considered to have direct and maternal genetic components. Inbreeding accumulated rapidly from 1935 to 1960 and more slowly (.22%/yr) thereafter. Any reduction in additive genetic variance due to inbreeding and selection may have been offset by a concurrent reduction in generation interval that was observed as time progressed. Expected selection differential for 365-d weight, averaged over sexes, was 31.2 kg per generation. For birth weight, annual genetic trends in direct and maternal effects were 42 +/- 3 g and 15 +/- 3 g, respectively. Annual direct and maternal genetic trends for preweaning ADG were .70 +/- .06 g/d and .63 +/- .06 g/d, respectively. Direct response in postweaning ADG was linear and equal to 5.3 +/- .6 g.d-1.yr-1. As a result, estimated breeding values of birth weight, 200-d weight, and 365-d weight increased by 3.2 kg, 14.5 kg, and 62.4 kg, respectively, from 1935 to 1989. Selection within Line 1 was effective in increasing genetic potential for growth over 13 generations. No selection plateau was observed in any of the traits examined.  相似文献   

Anthelmintic effect of rafoxanide against immature Fasciola hepatica in calves     

P J Presidente  S E Knapp 《American journal of veterinary research》1972,33(8):1603-1610

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Pelvic limb removal by coxofemoral disarticulation in 13 dogs     

D. W. Knapp  J. L. Tomlinson  G. M. Constantinescu 《The Journal of small animal practice》1990,31(11):561-567

Hindlimb amputation may be necessary in cases of neoplasia, neurogenic atrophy, permanent functional impairment from chronic orthopaedic disease and severe soft tissue injury. Midshaft femoral amputation may not be satisfactory when wide tissue margins are required. This report describes the procedure and the results of two techniques of hindlimb removal. The first disarticulation technique leaves the thigh musculature attached to the body and the second technique is an ‘en bloc’ resection of the rear leg. Five clinical cases leaving the thigh musculature intact and eight clinical cases of en bloc resection are summarised. Indications and complications are discussed. Although not curative in all cases, all owners were satisfied with the end surgical results and functional outcome.  相似文献   

Moraxella septicaemiae-Infektion bei Gänsen     

K.-H. Hinz  H. Grebe  M. Knapp 《Zoonoses and public health》1976,23(4):341-345

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18F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin          下载免费PDF全文

Megan Grobman  Leah Cohn  Stephanie Knapp  Jeffrey N. Bryan  Carol Reinero 《Veterinary radiology & ultrasound》2018,59(1):107-115

Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, ¹⁸F‐fluoro‐2‐deoxyglucose positron emission tomography (¹⁸F‐FDG‐PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe ¹⁸F‐FDG‐PET or ¹⁸F‐FDG‐PET/CT findings in a group of dogs with fever of unknown origin. Dogs presenting to a single center between April 2012 and August 2015 were included. A total of four dogs met inclusion criteria and underwent either positron emission tomography (n = 2) or positron emission tomography/CT (n = 2) as a part of their diagnostic investigation. All subjects underwent extensive diagnostic testing prior to ¹⁸F‐FDG‐PET/CT. Initial diagnostic evaluation failed to identify either a cause of fever or an anatomic location of disease in these four dogs. In each dog, positron emission tomography or positron emission tomography/CT was either able to localize or rule out the presence of focal lesion thereby allowing for directed sampling and/or informed disease treatment. Follow up ¹⁸F‐FDG‐PET/CT scans performed in two patients showed improvement of observed abnormalities (n = 1) or detected recurrence of disease allowing for repeated treatment before clinical signs recurred (n = 1). Fever resolved after specific treatment in each dog. Findings from the current study supported the use of positron emission tomography or positron emission tomography/CT as adjunctive imaging modalities for diagnosis and gauging response to therapy in dogs with fever of unknown origin.  相似文献