Evaluation of visual impact of multiple image characteristics observed in edge-grain patterns     

Masashi Nakamura  Saki Nakagawa  Takato Nakano 《Journal of Wood Science》2015,61(1):19-27

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Oxidative stress inducers potentiate 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated pre-cardiac edema in larval zebrafish     

Katsuki TANAKA  Hikaru ADACHI  Hironobu AKASAKA  Junya TAMAOKI  Yuji FUSE  Makoto KOBAYASHI  Takio KITAZAWA  Hiroki TERAOKA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(7):1050

We reported the involvement of oxidative stress and prostaglandins including thromboxane and prostacyclin in pre-cardiac edema (early edema) caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). While the involvement of oxidative stress in TCDD-induced toxicity has been frequently reported, the mechanism of its action is still unclear. In the present study, oxidative stress inducers including paraquat, hydrogen peroxide (H₂O₂) and rotenone augmented early edema (edema) induced by a low concentration of TCDD (0.1 ppb) at 55 hr post fertilization (hpf), while each of them alone did not cause edema. Edema caused by TCDD plus oxidative stress inducers was almost abolished by antioxidants, an antagonist for thromboxane receptor (ICI-192,605) and an agonist for prostacyclin receptor (beraprost), suggesting that the site of action of these inducers was in the regular signaling pathway after activation of aryl hydrocarbon receptor type 2 (AHR2) by TCDD. Oxidative stress inducers also enhanced edema caused by an agonist for the thromboxane receptor (U46619), and the enhancement was also inhibited by antioxidants. Sulforaphane and auranofin, activators of Nrf2 that is a master regulator of anti-oxidative response, did not affect U46619-evoked edema but almost abolished TCDD-induced edema and potentiation by paraquat in both TCDD- and U46619-induced edema. Taken together, the results suggest that oxidative stress augments pre-cardiac edema caused by TCDD via activation of thromboxane receptor-mediated signaling in developing zebrafish. As paraquat and other oxidative stress inducers used also are environmental pollutants, interaction between dioxin-like compounds and exogenous source of oxidative stress should also be considered.  相似文献   

Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes     

Fujii H  Nakagawa T  Nishioka H  Sato E  Hirose A  Ueno Y  Sun B  Yokozawa T  Nonaka G 《Journal of agricultural and food chemistry》2007,55(4):1525-1531

Controlled acid-catalyzed degradation of proanthocyanidin polymers in grape seeds together with L-cysteine led to oligomeric proanthocyanidin-L-cysteine complexes along with monomeric flavan-3-ol derivatives being isolated, and their structures were confirmed on the basis of spectroscopic data and by chemical means. In addition, comparative studies on the antioxidative and survival effects of oligomeric proanthocyanidin-L-cysteine complexes and proanthocyanidin polymers were performed. The oligomeric proanthocyanidin-L-cysteine complexes showed higher bioavailability and antioxidant capacity and enhanced survival time in the animal test groups. In addition, it is suggested that the oligomeric complexes may help to prevent oxidative stress and may reduce free radical production.  相似文献   

Quantitative analysis of pattern of gonial proliferation during sexual maturation in Japanese scallop <Emphasis Type="Italic">Patinopecten yessoensis</Emphasis>     

Makoto Osada  Satoshi Nakamura  Akihiro Kijima 《Fisheries Science》2007,73(6):1318-1324

ABSTRACT:   This study was undertaken to describe and quantitatively analyze the pattern of development of gametes in the Japanese scallop Patinopecten yessoensis . Incorporation of 5-bromo-2'-deoxyuridine (BrdU) into gonial cells was used to quantitatively detect mitotically active gonial cells. Oogonia increased in number from November to December and decreased rapidly to March. A small number of oocytes was detected in November. Oocytes steadily increased in number and size up to March. The number of spermatogonia slightly increased from November to December, and increased markedly from January to March. Both ratios of BrdU-immunopositive gonial cells in the ovary and testis to gonial cells moderately increased from September to December. The ratio of BrdU-immunopositive spermatogonia to gonial cells drastically increased from January to February and kept an elevated level in March, whereas the oogonia started to disappear in January. The results suggest that the pattern of proliferation of gonial cells can be divided into two phases: (i) phase I, oogonia and spermatogonia slowly proliferate through the growing stage; and (ii) phase II, oogonia develop into oocytes and spermatogonia begin to proliferate rapidly through the mature and spawning stages. The proliferation of gonial cells is likely under different endocrine controls in phases I and II.  相似文献   

Mycobacteriosis in a Domestic Ferret (Mustela putorius furo)     

Makoto NAKATA  Yasutsugu MIWA  Masaya TSUBOI  Kazuyuki UCHIDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(5):705-709

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Individual-level analysis of damage to residual trees after single-tree selection harvesting in northern Japanese mixedwood stands     

Shinichi Tatsumi  Toshiaki Owari  Hisatomi Kasahara  Yuji Nakagawa 《Journal of Forest Research》2014,19(4):369-378

Quantifying tree damage and mortality caused by single-tree selection harvesting is critical to understanding postharvest forest dynamics and management. In this study, we quantified the effects of tree size and species and the distance from residual trees to felled trees and skid trails on damage to residual trees and mortality in mixed coniferous–broadleaved stands of Hokkaido, northern Japan. Among the 4,961 trees that we studied, 373 (7.5 %) were damaged, and 148 of these trees (3.0 %) died during or immediately after logging. Hierarchical Bayesian modeling showed that the risk of damage to residual trees increased with increasing size of the felled trees and with increasing proximity to felled trees and skid trails. Smaller residual trees had the greatest risk of damage. Species differed in their susceptibility to damage; Abies sachalinensis (Fr. Schm.) Masters and Picea jezoensis (Sieb. et Zucc.) Carr. were the most susceptible species in our sample plots. Smaller damaged trees had the highest risk of mortality. The damaged trees that did not die at the time of logging had a higher risk of postharvest mortality than undamaged trees. Our results indicate that, to minimize logging-induced damage and mortality: (1) the spatial arrangement of skid trails should be optimized and fixed, (2) the risk of skidding damage should be considered before marking the trees to be harvested and choosing the felling direction, and (3) logging operators should be instructed to avoid damaging small trees, especially those of the species that are most susceptible to damage.  相似文献   

Distribution of free L-cysteine and glutathione in seaweeds   总被引：1，自引：0，他引：1  

Makoto Kakinuma  Chan Sun Park  Hideomi Amano 《Fisheries Science》2001,67(1):194-196

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Inhibitory effects of seaweeds on histamine release from rat basophile leukemia cells (RBL-2H3)     

Yoshimasa Sugiura  Yoshirou Takeuchi  Makoto Kakinuma  Hideomi Amano 《Fisheries Science》2006,72(6):1286-1291

ABSTRACT:   The effects of 80% methanol extracts from frozen samples of 41 macroalgae and one sea grass collected in the Ise-Shima region of Japan were investigated on histamine release from rat basophile leukemia cells (RBL-2H3) sensitized with antidinitrophenyl (DNP) IgE and stimulated with DNP-BSA. Of the 21 brown algae, five green and 15 red algae, and one sea grass tested, only extracts from seven brown algae suppressed histamine release from RBL cells, as determined by high-performance liquid chromatography (HPLC) analysis. When the cytotoxic effects of the seven brown algal extracts were investigated by Trypan blue staining, only Eisenia arborea and Sargassum thunbergii did not show cytotoxic effects. Therefore, we conclude that E. arborea and S. thunbergii may contain compounds that have antiallergic effects without inducing cell death.  相似文献   

Localization of Eimeripain,an Eimeria tenella Cathepsin B-Like Cysteine Protease,during Asexual and Sexual Intracellular Development in Chicken Ceca     

Makoto MATSUBAYASHI  Takeshi HATTA  Takeharu MIYOSHI  ANISUZZAMAN  Kazumi SASAI  Kayoko YAMAJI  Kameo SHIMURA  Takashi ISOBE  Kiyoshi KITA  Naotoshi TSUJI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(4):531-537

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Effect of retinoic acid on gene expression profiles of bovine intramuscular preadipocytes during adipogenesis     

Yasushi Mizoguchi  Makoto Moriya  Daiki Taniguchi  Akira Hasegawa 《Animal Science Journal》2014,85(2):101-111

To investigate genes involved in intramuscular adipogenesis in ruminants, 16 genes with dramatic variable expression were selected. These were selected from the differentiation‐ and proliferation‐phase libraries of our previous serial analysis of gene expression (SAGE) studies of a clonal bovine intramuscular preadipocyte (BIP) cell line. We harvested the BIP cells over 12 days after adipogenic stimulation with all‐trans retinoic acid (ATRA). Quantitative real‐time PCR confirmed the earlier SAGE study results of the expression patterns of 15 of the genes. On day 6, TG accumulation increased significantly in the BIP cells but was completely inhibited in the 3T3‐L1 cells (the monogastric reference). ATRA enhanced expression levels of six genes whereas it suppressed expression of eight genes on day 3 of adipogenesis in the BIP cells. Forty‐eight hours after transfection, the messenger RNA expression level of the adipose differentiation‐related protein (ADFP), encoded by one of the upregulated genes, in the ADFP small interference RNA (siRNA)‐transfected cells was 3.5% of that in negative control‐transfected cells. Also, 6 days after induction the TG level in the ADFP siRNA‐transfected cells was 21.8% lower than that in negative control‐transfected cells. This analysis of gene expression profiles after ATRA treatment will contribute to our understanding of the molecular mechanisms involved in bovine intramuscular adipogenesis.  相似文献