Pyogenic bacterial infections in humans with IRAK-4 deficiency     

Picard C  Puel A  Bonnet M  Ku CL  Bustamante J  Yang K  Soudais C  Dupuis S  Feinberg J  Fieschi C  Elbim C  Hitchcock R  Lammas D  Davies G  Al-Ghonaium A  Al-Rayes H  Al-Jumaah S  Al-Hajjar S  Al-Mohsen IZ  Frayha HH  Rucker R  Hawn TR  Aderem A  Tufenkeji H  Haraguchi S  Day NK  Good RA  Gougerot-Pocidalo MA  Ozinsky A  Casanova JL 《Science (New York, N.Y.)》2003,299(5615):2076-2079

Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. We describe three unrelated children with inherited IRAK-4 deficiency. Their blood and fibroblast cells did not activate nuclear factor kappaB and mitogen-activated protein kinase (MAPK) and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. The otherwise healthy children developed infections caused by pyogenic bacteria. These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms.  相似文献   

A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response     

Lebreton A  Lakisic G  Job V  Fritsch L  Tham TN  Camejo A  Matteï PJ  Regnault B  Nahori MA  Cabanes D  Gautreau A  Ait-Si-Ali S  Dessen A  Cossart P  Bierne H 《Science (New York, N.Y.)》2011,331(6022):1319-1321

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.  相似文献   

Somatic embryogenesis in cotyledons of Picea abies is enhanced by an adventitious bud-inducing treatment     

Marie-Anne P. Lelu  Michel P. Boulay  Chris H. Borivman 《New Forests》1990,4(2):125-135

Somatic embryos were obtained from young, isolated cotyledons of Picea abies. A bud-inductive treatment for one week before transfer to a callus induction medium, resulted in a tenfold increase in the percentage of cotyledons in which embryonic tissues could be induced. The degree of expression of somatic embryogeny depends on whether cotyledons are first subjected to a callus-inducing medium or first exposed to a cytokinin treatment followed by a callus-inducing medium. It is hypothesized that two populations of cells exist, both with the inherent potential of becoming embryogenic after treatment with plant growth regulators.  相似文献   

Seroprevalence of Lawsonia intracellularis in different swine populations in 3 provinces in Canada          下载免费PDF全文

Paradis MA  Gottschalk M  Rajic A  Ravel A  Wilson JB  Aramini J  McClure CA  Dick CP 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(1):57-62

Porcine proliferative enteropathy caused by Lawsonia intracellularis is an important enteric disease in swine throughout the world. Information regarding the distribution of this pathogen in Canadian swine herds would be beneficial for the creation of control protocols. Pigs from Ontario, Quebec, and Alberta were tested by using an indirect immunofluorescence assay for antibodies to L. intracellularis. Pig seroprevalence was calculated as the proportion of pigs positive from total pigs tested in the targeted population. Seroprevalence (+/- standard error [s(x)]) in market hogs in Ontario from farrow-finish (FF) farms and finishing (FIN) farms were significantly different at 77% (s(x) = 7%) and 29% (s(x) = 15%), respectively. Seroprevalence for sows and gilts in FF and farrowing and nursery (FAR + NUR) farms in Ontario were 90% (s(x) = 3%) and 93% (s(x) = 6%), respectively. Seroprevalence in breeding females in Quebec from FF and FAR farms was 82% (s(x) = 5%) and 87% (s(x) = 3%), respectively. Seroprevalence (57%, s(x) = 8%) in finishing pigs in Alberta from FF farms was significantly different from that of multisite (MS) farms and FIN farms, 6% (s(x) = 6%) and 9% (s(x) = 5%), respectively. Lawsonia intracellularis appears to be widespread in Canada and the seroprevalence on FF farms is higher than that on FIN and MS farms, possibly due to the presence of breeding females or management differences.  相似文献   

Behaviour of fipronil in soil under Sahelian Plain field conditions     

Alain Bob  Jean-Franois Cooper  Camille M. Coste  Marie-Anne Muller 《Pest management science》1998,52(3):275-281

The behaviour of fipronil, a phenylpyrazole insecticide used for locust control, was studied under sub-Saharan conditions in soils of the Niamey region of Niger. A formulation of fipronil (Adonis^®) was applied to uncultivated soils at Banizoumbou and Saguia. Soil was sampled at 0–10, 10–20 and 20–30 cm depths for up to two months after treatment. Residues were analysed by gas chromatography using electron capture and mass detectors. For both soils, a rapid initial decrease of fipronil was observed, with rapid formation for the most part of a photodegradate. Three other metabolites of fipronil were also detected throughout the study. These metabolites displayed different dissipation kinetics. Fipronil and its metabolites did not move beyond 10 cm depth, except for the amide, which is not considered a toxicologically significant metabolite. © 1998 SCI.  相似文献   

The use of pulsed-field gel electrophoresis to investigate the epidemiology of Mycoplasma bovis in French calf feedlots     

Arcangioli MA  Aslan H  Tardy F  Poumarat F  Le Grand D 《Veterinary journal (London, England : 1997)》2012,192(1):96-100

Mycoplasma bovis is a major cause of respiratory outbreaks in cattle feedlots. In this study pulsed-field gel electrophoresis (PFGE) was used to trace field strains and provide information on M. bovis patterns of spread in calf feedlots. The suitability of KpnI, MluI and SmaI restriction enzymes was assessed on different sets of strains. The discriminative power of the first two enzymes was first assessed using 28 epidemiologically unrelated strains; stability was 100% on multiple isolates from in vivo experimental infection. Thirty-nine field isolates from six feedlots were then evaluated. In contrast to the unique fingerprints displayed by the unrelated strains, the isolates from the feedlots showed identical patterns at the time of the outbreak of respiratory disease and 4 weeks later. The PFGE typing results suggest that M. bovis strains follow a clonal epidemic spread pattern at the herd level and that the same strain persists in calves of the herd after the clinical signs have disappeared.  相似文献   

Forest tree genomics: 10 achievements from the past 10 years and future prospects     

Christophe Plomion  Catherine Bastien  Marie-Béatrice Bogeat-Triboulot  Laurent Bouffier  Annabelle Déjardin  Sébastien Duplessis  Bruno Fady  Myriam Heuertz  Anne-Laure Le Gac  Grégoire Le Provost  Valérie Legué  Marie-Anne Lelu-Walter  Jean-Charles Leplé  Stéphane Maury  Alexandre Morel  Sylvie Oddou-Muratorio  Gilles Pilate  Léopoldo Sanchez  Ivan Scotti  Caroline Scotti-Saintagne  Vincent Segura  Jean-François Trontin  Corinne Vacher 《Annals of Forest Science》2016,73(1):77-103

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