Infants' discrimination of the duration of a rapid spectrum change in nonspeech signals   总被引：1，自引：0，他引：1  

P W Jusczyk  D B Pisoni  M A Reed  A Fernald  M Myers 《Science (New York, N.Y.)》1983,222(4620):175-177

Two-month-old infants discriminated complex sinusoidal patterns that varied in the duration of their initial frequency transitions. Discrimination of these nonspeech sinusoidal patterns was a function of both the duration of the transitions and the total duration of the stimulus pattern. This contextual effect was observed even though the information specifying stimulus duration occurred after the transitional information. These findings parallel those observed with infants for perception of synthetic speech stimuli. Specialized speech processing capacities are thus not required to account for infants' sensitivity to contextual effects in acoustic signals, whether speech or nonspeech.  相似文献   

An expanded approach to the problem of disappearing species     

Myers N 《Science (New York, N.Y.)》1976,193(4249):198-202

Assistance for disappearing species is at present too localized and dispersed to make much impact on the problem with its growing dimensions. Species are threatened primarily because of their status as common property. Institutional deficiencies, notably those of free markets and property rights, promote depletion of species. Conversely, present institutional mechanisms offer little scope for society to express its preferences for goods without price or to establish responsibility for common-heritage resources. The situation postulates corrective measures on the part of collective authority at the international level. These measures would require a joint commitment by the developed and developing worlds, on a scale to reflect the increasingly interdependent needs and opportunities of the community at large. Whether the community perceives itself as a community or not, it functions as such in many of its ecological relationships and economic interactions. The community will sooner or later be obliged to respond to the problem of vanishing species: either sooner, through protective measures of sufficient scope, or later, when it finds that the disappearance of large numbers of species represents a loss through which it is indivisibly impoverished.  相似文献   

Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes   总被引：69，自引：0，他引：69  

D R Cox  M Burmeister  E R Price  S Kim  R M Myers 《Science (New York, N.Y.)》1990,250(4978):245-250

Radiation hybrid (RH) mapping, a somatic cell genetic technique, was developed as a general approach for constructing long-range maps of mammalian chromosomes. This statistical method depends on x-ray breakage of chromosomes to determine the distances between DNA markers, as well as their order on the chromosome. In addition, the method allows the relative likelihoods of alternative marker orders to be determined. The RH procedure was used to map 14 DNA probes from a region of human chromosome 21 spanning 20 megabase pairs. The map was confirmed by pulsed-field gel electrophoretic analysis. The results demonstrate the effectiveness of RH mapping for constructing high-resolution, contiguous maps of mammalian chromosomes.  相似文献   

Altered response to pneumococcal polysaccharide in offspring of immunologically paralyzed mice   总被引：3，自引：0，他引：3  

R Kerman  D Segre  W L Myers 《Science (New York, N.Y.)》1967,156(781):1514-1516

The dose of pneumococcal polysaccharide type III required to induce immunologic paralysis in newborn offspring of immunologically paralyzed mice was one-tenth of the corresponding paralyzing dose for newborn offspring of normal mice. Similarly, immunization of the offsprinig of the paralyzed mice was accomplished with one-tenth the dose of polysaccharide necessary to immunize normal newborn mice. The altered susceptibility of newborn mice from paralyzed mothers to the induction of both paralysis and immunity was predicted from theories of antibody formation which postulate that the induction of tolerance or immunity is controlled by the concentration of natural antibodies specific for the antigen used.  相似文献   

Navy F-14: New Fighter's Cost, Sophistication, Stir Controversy     

Myers HR 《Science (New York, N.Y.)》1972,176(4030):35-37

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Who fights in little wars?     

Myers JM 《Science (New York, N.Y.)》1967,156(3778):1035

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Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk     

Abtahian F  Guerriero A  Sebzda E  Lu MM  Zhou R  Mocsai A  Myers EE  Huang B  Jackson DG  Ferrari VA  Tybulewicz V  Lowell CA  Lepore JJ  Koretzky GA  Kahn ML 《Science (New York, N.Y.)》2003,299(5604):247-251

Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.  相似文献   

A MOUTH PIPETTE AND CONTAINERS FOR SMALLER ORGANISMS     

Myers EH 《Science (New York, N.Y.)》1933,77(2008):609-610

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A high-resolution radiation hybrid map of the human genome draft sequence     

Olivier M  Aggarwal A  Allen J  Almendras AA  Bajorek ES  Beasley EM  Brady SD  Bushard JM  Bustos VI  Chu A  Chung TR  De Witte A  Denys ME  Dominguez R  Fang NY  Foster BD  Freudenberg RW  Hadley D  Hamilton LR  Jeffrey TJ  Kelly L  Lazzeroni L  Levy MR  Lewis SC  Liu X  Lopez FJ  Louie B  Marquis JP  Martinez RA  Matsuura MK  Misherghi NS  Norton JA  Olshen A  Perkins SM  Perou AJ  Piercy C  Piercy M  Qin F  Reif T  Sheppard K  Shokoohi V  Smick GA  Sun WL  Stewart EA  Fernando J  Tejeda  Tran NM  Trejo T  Vo NT  Yan SC  Zierten DL  Zhao S 《Science (New York, N.Y.)》2001,291(5507):1298-1302

We have constructed a physical map of the human genome by using a panel of 90 whole-genome radiation hybrids (the TNG panel) in conjunction with 40,322 sequence-tagged sites (STSs) derived from random genomic sequences as well as expressed sequences. Of 36,678 STSs on the TNG radiation hybrid map, only 3604 (9.8%) were absent from the unassembled draft sequence of the human genome. Of 20,030 STSs ordered on the TNG map as well as the assembled human genome draft sequence and the Celera assembled human genome sequence, 36% of the STSs had a discrepant order between the working draft sequence and the Celera sequence. The TNG map order was identical to one of the two sequence orders in 60% of these discrepant cases.  相似文献   

It's time for a change, one way or another     

Myers JR 《Journal of agricultural safety and health》2004,10(1):3-5

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