Space applications: Earth-oriented applications of unmanned satellites     

Rosenberg P 《Science (New York, N.Y.)》1968,162(3856):939-940

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Periocular sarcoid in a horse     

Komáromy AM  Andrew SE  Brooks DE  Detrisac CJ  Gelatt KN 《Veterinary ophthalmology》2004,7(3):141-146

A periocular nodular sarcoid of the right upper and lower eyelids was diagnosed in an 11-year-old Thoroughbred mare. Computed tomography scan revealed the extent of the tumor. The mass was surgically debulked under general anesthesia, and the affected periocular region was injected intralesionally with Bacillus of Calmette and Guerin (BCG). An emulsion of cell wall fractions was used, which has been modified to reduce the toxic and allergic effect, but retain the antitumor activity. In total, five injections were performed at 2-week intervals. At follow-up 7 months after the last BCG injection, the tumor was completely resolved. Two years after the last treatment, the horse remains tumor-free.  相似文献   

Meta-analysis in plant pathology: synthesizing research results     

Rosenberg MS  Garrett KA  Su Z  Bowden RL 《Phytopathology》2004,94(9):1013-1017

ABSTRACT Meta-analysis is a set of statistical procedures for synthesizing research results from a number of different studies. An estimate of a statistical effect, such as the difference in disease severity for plants with or without a management treatment, is collected from each study along with a measure of the variance of the estimate of the effect. Combining results from different studies will generally result in increased statistical power so that it is easier to detect small effects. Combining results from different studies may also make it possible to compare the size of the effect as a function of other predictor variables such as geographic region or pathogen species. We present a review of the basic methodology for meta-analysis. We also present an example of meta-analysis of the relationship between disease severity and yield loss for foliar wheat diseases, based on data collected from a decade of fungicide and nematicide test results.  相似文献   

Carpal valgus in llamas and alpacas: Retrospective evaluation of patient characteristics,radiographic features and outcomes following surgical treatment     

Barbara Hunter  Katja F. Duesterdieck-Zellmer  Michael J. Huber  Jill E. Parker  Stacy A. Semevolos 《The Canadian veterinary journal. La revue veterinaire canadienne》2014,55(12):1153-1159

This study evaluated outcomes of surgical treatment for carpal valgus in New World camelids and correlated successful outcome (absence of carpal valgus determined by a veterinarian) with patient characteristics and radiographic features. Univariable and multivariable analyses of retrospective case data in 19 camelids (33 limbs) treated for carpal valgus between 1987 and 2010 revealed that procedures incorporating a distal radial transphyseal bridge were more likely (P = 0.03) to result in success after a single surgical procedure. A greater degree of angulation (> 19°, P = 0.02) and younger age at surgery (< 4 months, P = 0.03) were associated with unsuccessful outcome. Overall, 74% of limbs straightened, 15% overcorrected, and 11% had persistent valgus following surgical intervention. To straighten, 22% of limbs required multiple procedures, not including implant removal. According to owners, valgus returned following implant removal in 4 limbs that had straightened after surgery.  相似文献   

Ex vivo evaluation of 7 polydioxanone for closure of equine ventral midline celiotomies     

Stacy L. Anderson  Jose L. Bracamonte  Steve Hendrick 《Canadian journal of veterinary research》2014,78(2):156-160

The objective of this study was to compare the bursting strength (BS) and mode of failure (MF) of ventral midline (VM) celiotomies closed with USP 7 polydioxanone (7PD) in 1 or 2 simple continuous sections. A bursting strength model, consisting of inserting and inflating a 200-L polyurethane bladder through a 25-cm VM celiotomy, was used on 15 fresh equine cadavers. Celiotomies were closed using 7PD in 2 separate sections (4 knots), 2 continuous sections (3 knots), or a single section (2 knots) using a simple continuous pattern. The horses’ signalment, body weight, number of total knots, MF, and BS were recorded and analyzed statistically for interactions. No difference was found between the BS of VM celiotomies closure types (P = 0.4). All celiotomy/ suture constructs failed at the abdominal wall. The celiotomy closure types evaluated in this study provided a secure method of closure in VM celiotomies in vivo.  相似文献   

Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating   总被引：13，自引：0，他引：13  

R L Rosenberg  P Hess  J P Reeves  H Smilowitz  R W Tsien 《Science (New York, N.Y.)》1986,231(4745):1564-1566

Electrophysiological recordings were used to analyze single calcium channels in planar lipid bilayers after membranes from bovine cardiac sarcolemmal vesicles had been incorporated into the bilayer. In these cell-free conditions, channels in the bilayer showed unitary barium or calcium conductances, gating kinetics, and pharmacological responses that were similar to dihydropyridine-sensitive calcium channels in intact cells. The open channel current varied in a nonlinear manner with voltage under asymmetric (that is, physiological) ionic conditions. However, with identical solutions on both sides of the bilayer, the current-voltage relation was linear. In matched experiments, calcium channels from skeletal muscle T-tubules differed significantly from cardiac calcium channels in their conductance properties and gating kinetics.  相似文献   

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis     

Winn MP  Conlon PJ  Lynn KL  Farrington MK  Creazzo T  Hawkins AF  Daskalakis N  Kwan SY  Ebersviller S  Burchette JL  Pericak-Vance MA  Howell DN  Vance JM  Rosenberg PB 《Science (New York, N.Y.)》2005,308(5729):1801-1804

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6). The proline-to-glutamine substitution at position 112, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II and appears to alter the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease.  相似文献   

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes   总被引：1，自引：0，他引：1  

Dudley ME  Wunderlich JR  Robbins PF  Yang JC  Hwu P  Schwartzentruber DJ  Topalian SL  Sherry R  Restifo NP  Hubicki AM  Robinson MR  Raffeld M  Duray P  Seipp CA  Rogers-Freezer L  Morton KE  Mavroukakis SA  White DE  Rosenberg SA 《Science (New York, N.Y.)》2002,298(5594):850-854

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases.  相似文献   

Cytochalasin B: microfilaments and "contractile" processes     

Estensen RD  Rosenberg M  Sheridan JD  Wessells NK  Spooner BS  Ash JF  Ludueña MA  Wrenn JT 《Science (New York, N.Y.)》1971,173(3994):356-359

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Proton magnetic resonance of proteins fully deuterated except for 1H-leucine side chains   总被引：1，自引：0，他引：1  

H L Crespi  R M Rosenberg  J J Katz 《Science (New York, N.Y.)》1968,161(843):795-796

The fully deuterated proteins C-phycocyanin, C-phycoerythrin, and cytochrome c have been obtained by biosynthesis with the leucine side chains, and only the leucine side chains, of normal ((1)H) isotopic composition. In these (isotopic hybrid) proteins, proton magnetic resonance analysis shows that the (1)H-leucine side chains are in a variety of environments. During protein biosynthesis, the alpha hydrogen of leucine is exchanged with a hydrogen ((2)H) from the aqueous medium.  相似文献