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Arlen Avakian Joseph Alroy Elizabeth Rozanski John Keating Andrew Rosenberg 《Journal of veterinary diagnostic investigation》2008,20(5):665-667
An 11-year-old, neutered, male Golden Retriever cross dog was euthanized following a history of recurrent pericardial effusions. At necropsy, blood-tinged pericardial and intrathoracic effusions were seen along with numerous firm to hard plaque-like masses that studded the epicardial, pericardial, mediastinal, and costal pleural surfaces. Within the right thorax, the lesions coalesced into a large mass that occupied most of the cavity. Histologically, the masses were composed of solid sheets and papillary aggregates of medium-sized polygonal cells that contained abundant vacuolated to clear cytoplasm. Some of the cytoplasmic vacuoles stained positive with oil red O. The stroma contained metaplastic trabeculae of woven and lamellar bone. Immunohistochemically, the neoplastic cells expressed vimentin, pancytokeratin, and S-100 protein. Transmission electron microscopy corroborated the presence of intracytoplasmic vacuoles and demonstrated prominent intercellular junctional complexes and apically located microvilli. These findings are consistent with a lipid-rich variant of mesothelioma. To the authors' knowledge, this is the first report of a lipid-rich mesothelioma in a dog. 相似文献
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Transpalpebral ultrasonographic measurement of the optic nerve sheath diameter in healthy dogs 下载免费PDF全文
Joshua J. Smith DVM Daniel J. Fletcher PhD DVM DACVECC Stacy D. Cooley DVM DACVR Margret S. Thompson DVM DACVR 《Journal of Veterinary Emergency and Critical Care》2018,28(1):31-38
Objective
To develop a reference range for ultrasonographically measured optic nerve sheath diameter (ONSD‐US) in dogs. We hypothesized that ONSD‐US can be measured reliably and is associated with weight but not age, sex, or body condition score (BCS), and that the relationship between weight and ONSD‐US in dogs is allometric due to canine size variations.Design
Prospective, observational study.Setting
University teaching hospital.Animals
Seventy‐eight healthy adult dogs.Interventions
The ONSD was measured by a standardized transpalpebral approach.Measurements and Main Results
Regression analysis showed the relationship between weight and ONSD was better fit with a linear model (R2 = 0.8510) than an allometric model (R2 = 0.7917). Multiple regression analysis showed ONSD is associated with weight (P < 0.0001), age (P = 0.0021), and BCS (P = 0.0007), but not with sex. Dominance analysis showed 94.6% of the variance explained by the model was due to weight. Intraclass correlation coefficient (ICC) analysis showed excellent interobserver (ICC = 0.9338–0.9608) and intraobserver (ICC = 0.9893) reliability.Conclusions
These results suggest that ONSD‐US may be reliably measured in dogs using our described transpalpebral approach, and we have calculated prediction intervals based on body weight. Future studies are needed to determine if ONSD‐US measurements are associated with intracranial hypertension as shown in human medicine. 相似文献56.
Valrie Chetboul D. Tessier D. Rosenberg M. Boussouf L. Escoffier B. Lugardon J-L. Pouchelon 《Journal of Veterinary Cardiology》1999,1(1):143
Definitive diagnosis of mitral and aortic valvular endocarditis in a dog was based on echocardiograpic findings and was then confirmed by positive blood culture. Abdominal ultrasound examination revealed a renal abcess. This case illustrates that echocardiography associated with abdominal ultrasound has become an essential tool for the diagnosis of bacterial endocarditis and for the detection of sequela or initial source of bacteriemia, while waiting for blood culture results. A short review of echocardiographic and Doppler abnormalities associated with bacterial endocarditis is presented. 相似文献
57.
Summary The EVIKA Research Centre has developed a disease eradication system for the initial material of seed potato, which consists
of 1. Selection of the initial material for eradication, plant thermotherapy, meristem tip cultivation and testing for viruses;
2. Re-eradication (thermotherapy of test-tube plants, cultivation of meristem tips, testing for viruses, testing of varietal
quality and yield of disease-free meristem clones, and the selection of meristem clones with best varietal characteristics;
3. Renewing of the initial material (all processes as above, but the initial material is selected from the seed potatoes grown
for at least 3 years in the field).
Field trials were conducted after the second cycle of eradiaction to determine whether the plantlets were true-to-type and
to assess the yield, disease resistance and tuber dry matter. Recently we have also started in vitro testing of meristem plants
resistance to late blight, hoping that this approach will improve the selection efficiency.
Propagation and growing of the seed tubers consists of 3 main steps: 1. Plantlet propagation in vitro; 2. Greenhouse propagation
in plastic rolls; and 3. Planting the first generation tubers in the field. Under our conditions it is the cheapest, simplest
and most effective way.
Multiplication of the meristem-derived plants is done by shoot tip cuttings in a greenhouse in plastic rolls with peat as
the growing medium. The first generation of seed tubers is grown in the field. In our trials plant productivity was affected
by the method of multiplication, growing conditions and genotype. The highest yield per hectare was obtained with plants multiplied
in plastic rolls. The in vitro plants had more tubers per plant than plants multiplied in plastic rolls. In seed production
fields the productivity of plants was more influenced by following our instructions than by multiplication and growing methods.
The number of tubers per plant obtained with over 0.5 million plants was 6.5–9.0.
In the second generation of seed tubers, grown under equal density, the greater-sized tubers gave more tubers with lower weight
than the smaller-sized tubers. Cutting tubers had no effect on the plant development and tuberization. 相似文献
58.
Stacy N. Galleher Matthew R. Gilg Kelly J. Smith 《Fish physiology and biochemistry》2010,36(3):731-740
Fundulus heteroclitus and F. grandis are resident salt marsh fishes that overlap in distribution over a narrow range in northeastern Florida. The objective of
the present study was to examine whether the limits of the species’ ranges could be explained by differences in thermal tolerance.
Two populations of each species were collected and then spawned in the laboratory, and 9-day-old larvae were used for critical
thermal maxima trials. Mean LOE temperatures of larvae ranged from 43.04 to 43.65°C and showed little difference between species.
Therefore, differences in high temperatures experienced cannot account for the differences of the distributions of the two
species. Condition-specific competition may play a greater role in determining the observed range of the two species. 相似文献
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60.
Clinical efficacy and safety of a once-daily formulation of carbimazole in cats with hyperthyroidism
R. Frénais D. Rosenberg S. Burgaud L. J. I. Horspool 《The Journal of small animal practice》2009,50(10):510-515
O bjective : Evaluation of efficacy and safety of a novel controlled-release formulation of carbimazole in feline hyperthyroidism.
M ethods : A multicentre, self-controlled study in 44 client-owned cats with history and clinical signs of hyperthyroidism, and total thyroxine concentration greater than or equal to 50 nmol/l. Treatment was started at 15 mg once daily, response assessed after 10 days, and 3, 5, 8, 26 and 53 weeks and dose adjusted as required.
R esults : The median dose of carbimazole was 10 mg (range 10 to 15 mg) and 15 mg (5 to 25 mg) once daily after 3 and 53 weeks, respectively. Median total thyroxine concentration dropped significantly from 118 nmol/l (50 to 320 nmol/l) at presentation to 33 nmol/l (n=40) after 10 days, 31 nmol/l (n=34) at 3 weeks and 21 nmol/l (n=18) at 53 weeks. Clinical signs improved or resolved in almost all cats within three weeks after starting treatment. Twenty-one adverse reactions possibly (20) or probably (1) related to treatment were reported. During treatment, increased blood urea nitrogen concentration was observed in 25 per cent of the cats, eosinophilia in 20 per cent and lymphopenia in 16 per cent, while liver enzymes tended to improve.
C linical S ignificance : Once daily administration of controlled-release carbimazole tablets was effective and had expected tolerance in hyperthyroid cats during short- and long-term treatment. 相似文献
M ethods : A multicentre, self-controlled study in 44 client-owned cats with history and clinical signs of hyperthyroidism, and total thyroxine concentration greater than or equal to 50 nmol/l. Treatment was started at 15 mg once daily, response assessed after 10 days, and 3, 5, 8, 26 and 53 weeks and dose adjusted as required.
R esults : The median dose of carbimazole was 10 mg (range 10 to 15 mg) and 15 mg (5 to 25 mg) once daily after 3 and 53 weeks, respectively. Median total thyroxine concentration dropped significantly from 118 nmol/l (50 to 320 nmol/l) at presentation to 33 nmol/l (n=40) after 10 days, 31 nmol/l (n=34) at 3 weeks and 21 nmol/l (n=18) at 53 weeks. Clinical signs improved or resolved in almost all cats within three weeks after starting treatment. Twenty-one adverse reactions possibly (20) or probably (1) related to treatment were reported. During treatment, increased blood urea nitrogen concentration was observed in 25 per cent of the cats, eosinophilia in 20 per cent and lymphopenia in 16 per cent, while liver enzymes tended to improve.
C linical S ignificance : Once daily administration of controlled-release carbimazole tablets was effective and had expected tolerance in hyperthyroid cats during short- and long-term treatment. 相似文献