Minocycline prevents primary duck neurons from duck Tembusu virus-induced death     

Sittinee KULPRASERTSRI  Keisuke AOSHIMA  Atsushi KOBAYASHI  Takashi KIMURA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):734

Duck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second-generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection.  相似文献   

Infection rates of Theileria sergenti in Haemaphysalis longicornis ticks collected from the field in Japan     

T Kamio  Y Ito  K Fujisaki  T Minami 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1990,52(1):43-48

For a period of one year Haemaphysalis longicornis ticks were collected in a pasture from vegetation by dragging flannel cloth and from soil samples at monthly intervals. Nymphal ticks were assessed for Theileria infection. Salivary glands were stained with methylgreen-pyronin and examined for parasite masses. Nymphal H. longicornis infected with Theileria sergenti were found in all samples during 12 months including the winter. After shortening the prefed period on rabbits to 24 hours, the parasite masses could be detected in the salivary glands of nymphs collected in the grazing season, from May to October, while no parasite masses were detected in other season. It was suggested that the environmental factors in the grazing season might influence on the maturation of parasites in the salivary glands of ticks.  相似文献   

Comparison of the inhibitory effect of sulfamonomethoxine and other sulfonamides on capsule formation of Bordetella bronchiseptica.     

A Kuwano  T Ito  H Tachi  T Hiramune 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(5):1057-1059

The inhibitory effect of sulfamonomethoxine and other sulfonamides on the capsule formation of sulfonamide-resistant Bordetella bronchiseptica was investigated. All the sulfonamides having MeO(-OCH3) groups inhibited the capsule formation of B. bronchiseptica. Strong inhibition was obtained with sulfamonomethoxine. Inhibition was not seen with sulfonamides having no MeO groups.  相似文献   

Weight-based virtual population analysis of Pacific cod Gadus macrocephalus off the Pacific coast of southern Hokkaido, Japan     

Yuji  UEDA  Yasuji  KANNO  Takashi  MATSUISHI 《Fisheries Science》2004,70(5):829-838

ABSTRACT:   Age-based population assessment is widely used, but there are cases where information on age or even body length of landed fish is difficult to collect. In the present study, the biomass and fishing mortality of the southern Hokkaido stock of Pacific cod Gadus macrocephalus was estimated directly from body weight composition, using weight-based virtual population analysis, from 1994 to 2000. The estimated biomass over 1 kg body weight was 5607 t in 1994 and increased to 7908 t in 2000. The increase was explained by an increase in recruitment.  相似文献   

Clinico-hematological observation of calves experimentally infected with Theileria sergenti     

S Shimizu  Y Yagi  Y Nakamura  K Shimura  K Fujisaki  T Onodera  T Minami  S Ito 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1990,52(6):1337-1339

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Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection     

Kawakubo M  Ito Y  Okimura Y  Kobayashi M  Sakura K  Kasama S  Fukuda MN  Fukuda M  Katsuyama T  Nakayama J 《Science (New York, N.Y.)》2004,305(5686):1003-1006

Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O-glycans are expressed that have terminal alpha1,4-linked N-acetylglucosamine, we tested whether these O-glycans might affect H. pylori growth. Here, we report that these O-glycans have antimicrobial activity against H. pylori, inhibiting its biosynthesis of cholesteryl-alpha-D-glucopyranoside, a major cell wall component. Thus, the unique O-glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection.  相似文献   

Multifunctional Alloys Obtained via a Dislocation-Free Plastic Deformation Mechanism     

Saito T  Furuta T  Hwang JH  Kuramoto S  Nishino K  Suzuki N  Chen R  Yamada A  Ito K  Seno Y  Nonaka T  Ikehata H  Nagasako N  Iwamoto C  Ikuhara Y  Sakuma T 《Science (New York, N.Y.)》2003,300(5618):464-467

We describe a group of alloys that exhibit "super" properties, such as ultralow elastic modulus, ultrahigh strength, super elasticity, and super plasticity, at room temperature and that show Elinvar and Invar behavior. These "super" properties are attributable to a dislocation-free plastic deformation mechanism. In cold-worked alloys, this mechanism forms elastic strain fields of hierarchical structure that range in size from the nanometer scale to several tens of micrometers. The resultant elastic strain energy leads to a number of enhanced material properties.  相似文献   

玉树组织培养中的器官形成与植株再生(英文)     

刘永立  龙自立  高月  原田隆 《浙江大学学报(农业与生命科学版)》2007,33(6):591-596

以玉树的茎、叶、根为外植体,研究不同培养基和植物生长调节剂对其再生的影响.结果表明,在附加0.1～10 μmol·L-1 NAA和10 μmol·L-1 BA的MS培养基上,不定芽形成率达到100%,每1个外植体再生芽数达到10个以上.将再生芽转接到含有1 μmol·L-1 NAA或者1 μmol·L-1 IBA的1/2MS培养基上,发育成健壮小植株.生根植株移栽到大田,生长良好,8个月后株高达27 cm.  相似文献   

Application of the elution centrifuge to separation of polynucleotides with the use of polymer phase systems     

Y Ito  R L Bowman 《Science (New York, N.Y.)》1973,182(110):391-393

A flow-through centrifuge without rotating seals enables the use of polymer phase systems for chromatographic separation of macromolecules. The capability of the technique is demonstrated on partition of polynucleotides.  相似文献   

Extended durotomy to treat severe spinal cord injury after acute thoracolumbar disc herniation in dogs     

Nick D. Jeffery BVSc  PhD  MSc  DECVN  DECVS  FRCVS  Joe M. Mankin DVM  DACVIM  Daisuke Ito DVM  PhD  DAiCVIM  C. Elizabeth Boudreau DVM  PhD  DACVIM  Sharon C. Kerwin DVM  DACVS  DACVIM  Jon M. Levine DVM  DACVIM  Maya S. Krasnow DVM  Melissa N. Andruzzi DVM  Cody J. Alcott DVM  DACVIM  Nicolas Granger DVM  PhD  DECVN 《Veterinary surgery : VS》2020,49(5):884-893

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