Caprine genital leiomyosarcoma     

Whitney KM  Valentine BA  Schlafer DH 《Veterinary pathology》2000,37(1):89-94

An aged Saanen doe was euthanized following repeated severe hemorrhage from the vulva. Necropsy examination revealed mural thickening of tubular genitalia with firm, protruding intralumenal masses containing blood-filled cavitations, and effacement of normal cervical architecture. Histologically, uterine and cervical masses comprised a variably dense population of mildly pleomorphic spindle cells forming interlacing streams supported by variably dense collagenous stroma. Immunoperoxidase staining of neoplastic cells was positive for muscle-specific actin, supporting the diagnosis of low-grade leiomyosarcoma. Months later, the doe's twin was likewise euthanized due to persistent bleeding from the vulva associated with a large vulvar mass having histopathologic features similar to those of the previous case. The clinical, gross, and histologic findings are similar to five cases of caprine genital leiomyosarcoma identified in retrospectively analyzed case material. Analysis of caprine tumor accessions over 20 years demonstrated a significantly higher incidence of genital leiomyosarcoma within the Saanen breed.  相似文献   

Release of slow-reacting substance of anaphylaxis in the rat: polymorphonuclear leukocyte   总被引：5，自引：0，他引：5  

R P Orange  M D Valentine  K F Austen 《Science (New York, N.Y.)》1967,157(786):318-319

The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.  相似文献   

Understanding exertional rhabdomyolysis     

B. A. Valentine 《Equine Veterinary Education》2008,20(10):539-541

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Fibrous vaginal hamartoma in a newborn calf     

Lafond JF  Mulon PY  Drolet R 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(1):61-62

A 2-day-old female Holstein calf was presented for abnormal structures protruding from the vulva at birth. A diagnosis of fibrous vaginal hamartoma was made, based on macroscopic and histologic examinations of the abnormal tissue. Management of this case involved surgical mass ablation.  相似文献   

Pathologic findings in equine muscle (excluding polysaccharide storage): a necropsy study     

Beth A Valentine 《Journal of veterinary diagnostic investigation》2008,20(5):572-579

Gross and histopathologic evaluation of skeletal muscle was performed in 229 equids (217 horses, 8 ponies, 3 donkeys, and 1 mule) 1 year of age or older undergoing postmortem examination at Oregon State University in a 2.5-year period. Animals were evaluated for grossly evident muscle lesions, and muscle samples were fixed in formalin, processed routinely, and stained with hematoxylin and eosin (HE) and periodic acid-Schiff (PAS) for glycogen. Muscle lesions were detected in 149 animals (65%). Chronic myopathic change (excessive fiber size variation and internal nuclei) was evaluated in horses without polysaccharide storage myopathy and was the most common finding (36 animals; 15.7%). Chronic myopathic change was more common in older animals. Generalized muscle atrophy was present in 30 animals (13.1%). Myonecrosis was attributed to endotoxic injury (11 animals; 4.8%), bone fracture (8 animals; 3.5%), bacterial infection (5 animals; 2.2%), muscle rupture (3 animals; 1.3%), selenium deficiency (2 animals; 0.9%), and exertional rhabdomyolysis (1 horse; 0.4%); cause was not determined in 9 animals (3.9%). Intramyofiber protozoa were detected in 19 horses and ponies (8.3%). Denervation atrophy was detected in 14 animals (6.1%). Neoplasia involving muscle occurred in 3 animals (1.3%), injection site reactions were detected in 4 animals (1.7%), and focal lymphocytic infiltrates were found in 6 animals (2.6%). Other findings were ring fibers (2 horses; 0.9%), fiber splitting (2 horses; 0.9%), and fat infiltration (1 horse; 0.4%). Skeletal muscle lesions are common in equids examined at postmortem. Transverse sections stained with HE and PAS are invaluable when evaluating equine muscle.  相似文献   

Neurotropic T-cell-rich B-cell lymphoma in a 14-year-old Morgan gelding     

Trina L. Westerman  Keith P. Poulsen  John W. Schlipf  Jr.  Beth A. Valentine 《The Canadian veterinary journal. La revue veterinaire canadienne》2014,55(4):379-382

A 14-year-old Morgan gelding was presented for progressive weakness and muscle atrophy. The horse was initially diagnosed with equine protozoal myelitis based on history, physical examination, and laboratory diagnostics. Despite therapy, the horse declined clinically and was euthanized. Necropsy revealed a rare form of neurotropic lymphoma, described in this report.  相似文献   

Transplant experiments on rare plant species from Upper Teesdale     

D.M. Cranston  D.H. Valentine 《Biological conservation》1983,26(2):175-191

An account is given of an attempt, over a period of 10 years, to preserve, in cultivation, living plants of the Upper Teesdale flora. The plants, many of which are arctic-alpines, were grown at the Experimental Grounds of Manchester University at Jodrell Bank, Cheshire.The most successful species were Carex paupercula, C. capillaris, Viola rupestris, V. rupestris × riviniana, Galium boreale, Draba incana and Tofieldia pusilla. Limited success was achieved with Antennaria dioica, Carex ericetorum, Juncus alpinoarticulatus and Thalictrum alpinum. In spite of showing promise in the early stages, Gentiana verna and Primula farinosa were failures.Cultural methods and possible improvements are discussed. Observations on growth and reproduction are made and briefly compared with a parallel experiment at Durham University. The value of the project is assessed.  相似文献