IX. RESEARCH INFORMATION SERVICE     

West CJ 《Science (New York, N.Y.)》1933,78(2019):203-206

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Insulators and boundaries: versatile regulatory elements in the eukaryotic genome     

Bell AC  West AG  Felsenfeld G 《Science (New York, N.Y.)》2001,291(5503):447-450

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Human embryonic stem cells     

Wilmut I  West MD  Lanza RP  Gearhart JD  Smith A  Colman A  Trounson AO  Campbell KH 《Science (New York, N.Y.)》2005,310(5756):1903

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms     

Bonni A  Brunet A  West AE  Datta SR  Takasu MA  Greenberg ME 《Science (New York, N.Y.)》1999,286(5443):1358-1362

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Urinary Flow,Excretion of Solutes,and Osmotic Work During Diuresis of Solute Loading in Hydropenia in Man     

Rapoport S  Brodsky WA  West CD  Mackler B 《Science (New York, N.Y.)》1948,108(2814):630-632

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Comment on "Molecular correlates of primate nuclear transfer failures"     

Lanza R  Chung Y  West MD  Campbell KH 《Science (New York, N.Y.)》2003,301(5639):1482; author reply 1482

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ROBERT GREENLEAF LEAVITT (1865-1942)     

West RL 《Science (New York, N.Y.)》1943,97(2513):195

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Field Scale Mapping of Surface Soil Clay Concentration     

Chen  Feng  Kissel  David E.  West  Larry T.  Adkins  W.  Clark  Rex  Rickman  Doug  Luvall  J. C. 《Precision Agriculture》2004,5(1):7-26

The surface soil clay concentration is a useful soil property to map soils, interpret soil properties, and guide irrigation, fertilizer, and agricultural chemical applications. The objective of this study was to determine whether surface soil clay concentrations could be predicted from remotely sensed imagery of bare surface soil or from soil electrical conductivity for a 115 ha field located in Crisp County, Georgia. The soil clay concentrations were determined for soil samples taken at 28 field locations. Three different data sources–an aerial color photograph image, two infrared bands from an ATLAS data set, and the electrical conductivity of the surface soil layer were used in the research. Principal components analysis was applied to the color photograph image, whereas the ratio of two infrared bands was applied to the ATLAS data set. Filtering was applied to both resulting images. The distribution of soil electrical conductivity was derived from the measured soil electrical conductivity data by spatial analysis. Statistical relationships between soil clay concentrations and the principal component 3, the ratio of two ATLAS infrared bands, and the soil electrical conductivity were analyzed, and three linear equations were derived with r ² values 0.83, 0.52, and 0.78, respectively. The distribution of the soil clay concentrations was derived based on these three equations. Six levels of soil clay concentrations were classified in these three methods, and the advantages and disadvantages were discussed. The predicted and measured soil clay concentrations, based on additional soil samples from 30 field locations, were compared using linear regression (r ²=0.76, 0.45, and 0.77 for the three methods). The overall accuracy for these methods were 84%, 66%, and 76%, respectively. The principal components method had the highest accuracy in our research, while the result for the depressional areas is the best from the ratio method.  相似文献   

Two-dimensional Mott-Hubbard electrons in an artificial honeycomb lattice     

Singha A  Gibertini M  Karmakar B  Yuan S  Polini M  Vignale G  Katsnelson MI  Pinczuk A  Pfeiffer LN  West KW  Pellegrini V 《Science (New York, N.Y.)》2011,332(6034):1176-1179

Artificial crystal lattices can be used to tune repulsive Coulomb interactions between electrons. We trapped electrons, confined as a two-dimensional gas in a gallium arsenide quantum well, in a nanofabricated lattice with honeycomb geometry. We probed the excitation spectrum in a magnetic field, identifying collective modes that emerged from the Coulomb interaction in the artificial lattice, as predicted by the Mott-Hubbard model. These observations allow us to determine the Hubbard gap and suggest the existence of a Coulomb-driven ground state.  相似文献   

Discovery of a viral NLR homolog that inhibits the inflammasome     

Gregory SM  Davis BK  West JA  Taxman DJ  Matsuzawa S  Reed JC  Ting JP  Damania B 《Science (New York, N.Y.)》2011,331(6015):330-334

The NLR (nucleotide binding and oligomerization, leucine-rich repeat) family of proteins senses microbial infections and activates the inflammasome, a multiprotein complex that promotes microbial clearance. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several human malignancies. We found that KSHV Orf63 is a viral homolog of human NLRP1. Orf63 blocked NLRP1-dependent innate immune responses, including caspase-1 activation and processing of interleukins IL-1β and IL-18. KSHV Orf63 interacted with NLRP1, NLRP3, and NOD2. Inhibition of Orf63 expression resulted in increased expression of IL-1β during the KSHV life cycle. Furthermore, inhibition of NLRP1 was necessary for efficient reactivation and generation of progeny virus. The viral homolog subverts the function of cellular NLRs, which suggests that modulation of NLR-mediated innate immunity is important for the lifelong persistence of herpesviruses.  相似文献