SYMPOSIUM     

Albert C. Strafuss 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1988,17(4):86-86

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Editorial     

Cornelissen AW 《The Veterinary quarterly》1993,15(2):41-42

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Pharmacokinetics,metabolism and excretion of celecoxib,a selective cyclooxygenase‐2 inhibitor,in horses     

Michael Benedict Subhahar  Jaipaul Singh  Peter Henry Albert  Ahmed Mahmoud Kadry 《Journal of veterinary pharmacology and therapeutics》2019,42(5):518-524

Celecoxib, a nonsteroidal anti‐inflammatory drug, is frequently used to treat arthritis in humans with minimal gastrointestinal side effect compared to traditional NSAIDs. The primary aim of this study was to determine the pharmacokinetic profile of celecoxib—a selective cyclooxygenase‐2 (COX‐2) inhibitor in horses. Six horses were administered a single oral dose of celecoxib at 2 mg/kg (body weight). After oral dosing, the drug reached a maximum concentration (mean ± SD) in blood of 1,088 ± 324 ng/ml in 4.58 hr. The elimination half‐life was 13.60 ± 3.18 hr, and the area under the curve was 24,142 ± 1,096 ng hr ml^?1. The metabolism of celecoxib in horses was via a single oxidative pathway in which the methyl group of celecoxib is oxidized to a hydroxymethyl metabolite and is further oxidized to form a carboxylic acid metabolite. Celecoxib is eliminated mainly through faeces as unchanged drug and as metabolites in urine. Therefore, instructions for a detection time following therapeutic dosing of celecoxib can be set by the racing practitioner and veterinarians to control illegal use in horse racing based on the results of this study.  相似文献   

Scintigraphic Tracking of Allogeneic Mesenchymal Stem Cells in the Distal Limb After Intra‐Arterial Injection in Standing Horses          下载免费PDF全文

Pablo Espinosa  Mathieu Spriet  Albert Sole  Naomi J. Walker  Betsy Vaughan  Larry D. Galuppo 《Veterinary surgery : VS》2016,45(5):619-624

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Narrative review of therapies for chronic enteropathies in dogs and cats     

Kelly Makielski  Jonah Cullen  Annette O'Connor  Albert E. Jergens 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(1):11-22

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Evolution of rotavirus C in humans and several domestic animal species     

Nídia S. Trovo  Frances K. Shepherd  Katerina Herzberg  Matthew C. Jarvis  Ham C. Lam  Albert Rovira  Marie R. Culhane  Martha I. Nelson  Douglas G. Marthaler 《Zoonoses and public health》2019,66(5):546-557

Rotavirus C (RVC) causes enteric disease in multiple species, including humans, swine, bovines, and canines. To date, the evolutionary relationships of RVC populations circulating in different host species are poorly understood, owing to the low availability of genetic sequence data. To address this gap, we sequenced 45 RVC complete genomes from swine samples collected in the United States and Mexico. A phylogenetic analysis of each genome segment indicates that RVC populations have been evolving independently in human, swine, canine, and bovine hosts for at least the last century, with inter‐species transmission events occurring deep in the phylogenetic tree, and none in the last 100 years. Bovine and canine RVC populations clustered together nine of the 11 gene segments, indicating a shared common ancestor centuries ago. The evolutionary relationships of RVC in humans and swine were more complex, due to the extensive genetic diversity and multiple RVC clades identified in pigs, which were not structured geographically. Topological differences between trees inferred for different genome segments occurred frequently, including at nodes deep in the tree, indicating that RVC's evolutionary history includes multiple reassortment events that occurred a long time ago. Overall, we find that RVC is evolving within host‐defined lineages, but the evolutionary history of RVC is more complex than previously recognized due to the high genetic diversity of RVC in swine, with a common ancestor dating back centuries. Pigs may act as a reservoir host for RVC, and a source of the lineages identified in other species, including humans, but additional sequencing is needed to understand the full diversity of this understudied pathogen across multiple host species.  相似文献   

Climate-sensitive modelling of site-productivity relationships for Norway spruce (Picea abies (L.) Karst.) and common beech (Fagus sylvatica L.)     

M. Albert  M. Schmidt 《Forest Ecology and Management》2010,259(4):739-749

The aim of the presented research project is to fit a site index model capable for predicting changes in site-productivity in a changing climate. A generalized additive model is used to predict site index as a function of soil and climate variables. The climate parameter values are estimated using the regional climate model WETTREG, based on global climate simulations with the global circulation model ECHAM5/MPI-OM for the reference period from 1961 to 1990. The climate values are further regionalized on a 200 m × 200 m grid. The generalized additive model quantifies the partial linear and non-linear effects of the predictor variables on site index. The model is parameterized for Norway spruce (Picea abies (L.) Karst.) and common beech (Fagus sylvatica L.) in Lower Saxony, Germany. Two case studies investigate the model's ability to generate information in order to support forest management planning decisions under a changing climate. One example analyzes the possible shift in site index of spruce along a precipitation gradient under the International Panel on Climate Change (IPCC) emission scenario A1B in the period from 2041 to 2050. The other case study shows possible future changes in site index of beech along a temperature gradient.  相似文献   

Correction to: Population genetic structure of lumpfish along the Norwegian coast: aquaculture implications     

Ólöf Dóra Bartels Jónsdóttir  Julia Schregel  Snorre B. Hagen  Camilla Tobiassen  Siv Grethe Aarnes  Albert K. D. Imsland 《Aquaculture International》2018,26(1):61-61

The original version of this article unfortunately contained an error where the figure caption for Figures 3 and 4 was mixed.  相似文献   

Feeding of juvenile cobia,Rachycentron canadum: Evaluation of practical feeds,comparison of commercial fishmeal replacers,and estimation of essential amino acid requirements     

Thiago Raggi  Albert G. J. Tacon  Daniel Lemos 《Journal of the World Aquaculture Society》2019,50(2):317-335

Three studies were conducted with juvenile cobia, Rachycentron canadum: (Study 1) a 10‐week feeding trial within floating net cages to test the nutritional efficacy of different dietary feeding regimes (trash‐fish control diet, a semimoist diet, an in‐house dry formulated diet, and a commercial cobia feed); (Study 2) a 10‐week feeding trial within an indoor water‐recirculating tank‐based system to test the nutritional efficiency of different potential dietary fishmeal replacers (poultry byproduct meal, soy protein concentrate, feather meal), a diet without taurine supplementation, and a commercial cobia feed; and (Study 3) estimation of the essential amino acid (EAA) requirements of cobia based on EAA whole‐body composition in fast‐growing cobia fed a trash‐fish‐based diet. Fish performance in terms of growth and feed efficiency was the greatest within the outdoor net‐cage feeding trial, with fish fed the control trash‐fish‐based diet exhibiting the best performance. Although fish growth was poorer within the indoor feeding trials, fish performance was similar for most diets, with apparent crude protein digestibility coefficients of over 75% being obtained in all experimental diets in both feeding trials. The estimated EAA requirements of cobia obtained during this study were similar to those reported for other similar marine carnivorous fish species.  相似文献   

Odor-active alcohols from the fungal transformation of alpha-farnesene     

Krings U  Hardebusch B  Albert D  Berger RG  Maróstica M  Pastore GM 《Journal of agricultural and food chemistry》2006,54(24):9079-9084

Submerged microbial cultures were screened for their potential to oxifunctionalize alpha-farnesene. The major oxidation product in all transforming cultures, 3,7,11-trimethyldodeca-1,3(E),5(E)10-tetraen-7-ol, showed a pleasant citrus-like odor and peak concentrations of 170 mg L-1. An Aspergillus niger isolate from mango generated another two terpene alcohols identified as diastereomeric menth-1-en-3-[2-methyl-1,3-butadienyl]-8-ol, a new natural compound with an apricot-like odor. The regiospecifity of the oxygen attack with concurrent lack of stereoselectivity suggested that the initial step of the bioconversion resembled the chemical autoxidation starting with the generation of an intermediate resonance-stabilized carbon-centered radical or carbocation.  相似文献