Search for low-mass exoplanets by gravitational microlensing at high magnification     

Abe F  Bennett DP  Bond IA  Eguchi S  Furuta Y  Hearnshaw JB  Kamiya K  Kilmartin PM  Kurata Y  Masuda K  Matsubara Y  Muraki Y  Noda S  Okajima K  Rakich A  Rattenbury NJ  Sako T  Sekiguchi T  Sullivan DJ  Sumi T  Tristram PJ  Yanagisawa T  Yock PC  Gal-Yam A  Lipkin Y  Maoz D  Ofek EO  Udalski A  Szewczyk O  Zebrun K  Soszynski I  Szymanski MK  Kubiak M  Pietrzynski G  Wyrzykowski L 《Science (New York, N.Y.)》2004,305(5688):1264-1266

Observations of the gravitational microlensing event MOA 2003-BLG-32/OGLE 2003-BLG-219 are presented, for which the peak magnification was over 500, the highest yet reported. Continuous observations around the peak enabled a sensitive search for planets orbiting the lens star. No planets were detected. Planets 1.3 times heavier than Earth were excluded from more than 50% of the projected annular region from approximately 2.3 to 3.6 astronomical units surrounding the lens star, Uranus-mass planets were excluded from 0.9 to 8.7 astronomical units, and planets 1.3 times heavier than Saturn were excluded from 0.2 to 60 astronomical units. These are the largest regions of sensitivity yet achieved in searches for extrasolar planets orbiting any star.  相似文献   

Rapid deformation of the South flank of kilauea volcano, hawaii     

Owen S  Segall P  Freymueller J  Mikijus A  Denlinger R  Arnadóttir T  Sako M  Bürgmann R 《Science (New York, N.Y.)》1995,267(5202):1328-1332

The south flank of Kilauea volcano has experienced two large [magnitude (M) 7.2 and M 6.1] earthquakes in the past two decades. Global Positioning System measurements conducted between 1990 and 1993 reveal seaward displacements of Kilauea's central south flank at rates of up to about 10 centimeters per year. In contrast, the northern side of the volcano and the distal ends of the south flank did not displace significantly. The observations can be explained by slip on a low-angle fault beneath the south flank combined with dilation deep within Kilauea's rift system, both at rates of at least 15 centimeters per year.  相似文献   

Studies on hemorrhagic diathesis of experimental bovine bracken poisoning. I. Detection of circulating anticoagulants.     

O Yamane  T Hayashi  S Sako  T Kihara  M Koyama 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1975,37(4):335-340

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Transepidermal water loss in cats: comparison of three differently clipped sites to assess the influence of hair coat on transepidermal water loss values     

Yutaka Momota  Kenichiroh Shimada  Akina Takami  Harumi Akaogi  Mariko Takasaki  Kana Mimura  Daigo Azakami  Katsumi Ishioka  Yuka Nakamura  Toshinori Sako 《Veterinary dermatology》2013,24(4):450-e101

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Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats     

A. Mori  T. Sako  P. Lee  Y. Nishimaki  H. Fukuta  H. Mizutani  T. Honjo  T. Arai 《Veterinary research communications》2009,33(7):669-680

Dietary therapy is an important treatment component for diabetes mellitus (DM). In this study, the impact of three different commercially available diet regiments (1 general use and 2 aimed for treating obesity and DM) on short-term post-prandial serum glucose and insulin concentrations of five healthy cats to better understand what impact each of these diets may have for diabetic cats. The diet regiments used in this study were as follows: C/D dry (General Use- Low protein, High fat, High carbohydrate, and Low fiber), M/D dry (DM- High protein, High fat, Low carbohydrate, and High Fiber), and W/D dry (DM- Low Protein, Low Fat, High Carbohydrate, and High Fiber). No significant difference in post-prandial serum glucose levels were observed with the C/D (84.6 ± 1.5 mg/dl) and W/D (83.8 ± 1.4 mg/dl) dry diets when compared to pre-prandial fasting levels (83.9 ± 1.4 mg/dl). However, a significant reduction was observed with the M/D diet (78.9 ± 0.8 mg/dl) which had 50-60% less carbohydrates than either C/D or W/D diet. Unlike what was observed with post-prandial glucose levels, an interesting pattern emerged with post-prandial insulin levels, which were increasing with W/D, C/D, and M/D diets in that order (1.1 ± 0.2, 1.7 ± 0.2, and 2.3 ± 0.2 ng/ml respectively). Most surprising, though, was the fact that the W/D diet did not seem to stimulate insulin secretion as compared to pre-prandial levels (1.1 ± 0.1 ng/ml) in healthy cats. Interestingly, the W/D diet had high levels of carbohydrate and low levels of protein. Coincidentally, the only diet (M/D) which had a significant reduction in post-prandial glucose also showed the highest increase in post-prandial insulin in healthy cats. Therefore, dietary amounts of carbohydrate, fat, protein and fiber can all have an individual impact on post-prandial glycemia and subsequent insulin requirement levels. Just as concepts regarding dietary management of people with DM are evolving, investigators are reassessing what constitutes the ideal diet for the diabetic feline. As such, having a better understanding for each dietary component, may lead us to better understand how we can synergize certain dietary components to aid in DM management.  相似文献   

Assessing the immune state of dogs suffering from pituitary gland dependent hyperadrenocorticism by determining changes in peripheral lymphocyte subsets     

A. Mori  P. Lee  T. Izawa  H. Oda  H. Mizutani  H. Koyama  T. Arai  T. Sako 《Veterinary research communications》2009,33(7):757-769

In order to evaluate the immune state of dogs suffering from pituitary-dependent hyperadrenocorticism (PDH), peripheral lymphocyte subsets were examined. Twenty seven PDH dogs and eight healthy control dogs were used in the current study. Eight healthy dogs served as the control group. Twenty seven PDH dogs were categorized into 4 groups based on their post serum cortisol concentrations by ACTH stimulation test: 2−5, excellent control (n = 8); 5−20, fair control (n = 7); >20, poor control (n = 4); and untreated (n = 8). Cell counts were executed with white blood cells (WBC), lymphocytes, CD3⁺ (T lymphocytes), CD4⁺ (Helper T lymphocytes), CD8⁺ (Cytotoxic T lymphocytes), CD21⁺ (B lymphocytes) cells in addition to calculating CD4⁺/CD8⁺ ratio. Results indicated a significant difference in lymphocyte numbers and lymphocyte subset populations (CD3⁺, CD4⁺, CD8⁺, and CD21⁺ cells) between PDH and control dogs. Moreover, comparison of the PDH groups (excellent control; fair control; poor control; untreated) demonstrated that all groups had a significant decrease in lymphocytes numbers (CD3⁺, CD4⁺ and CD21⁺ cell counts) as compared to control group. Meanwhile, no significant differences were observed in WBC counts and CD4⁺/CD8⁺ ratio between groups. Furthermore, lymphocyte subset distribution in excellent control PDH dogs without concurrent disease (n = 4) better resembled that of control dogs as compared to PDH dogs with concurrent disease (n = 4). PDH dogs may be suffering from an immuno-depressed state as evidenced by significant differences in lymphocyte subset populations. Furthermore, treatment of both PDH and concurrent disease might improve lymphocyte subset distribution.  相似文献   

Properties of the feline tumour suppressor reduced expression in immortalized cells (REIC/Dkk‐3)          下载免费PDF全文

K. Ochiai  H. Oda  S. Shono  Y. Kato  S. Sugihara  S. Nakazawa  D. Azakami  M. Michishita  E. Onozawa  M. Bonkobara  T. Sako  L. Shun‐Ai  H. Ueki  M. Watanabe  T. Omi 《Veterinary and comparative oncology》2017,15(4):1181-1186

Reduced expression in immortalized cells (REIC/Dkk‐3), a member of the human Dickkopf (Dkk) family, is a growth suppressor in human and canine mammary tumours. Mammary gland tumours are common neoplasms with high malignancy in female cats. The purpose of this study was to clone the feline REIC/Dkk‐3 homolog, investigate its expression in cell lines established from feline mammary gland tumours, and test its tumour suppressor function. Western blot analysis revealed that expression of the REIC/Dkk‐3 protein was reduced in feline mammary carcinoma cell lines. Forced expression of REIC/Dkk‐3 induced apoptosis in feline mammary tumour cell lines. These results demonstrate that REIC/Dkk‐3 expression, which is downregulated in feline mammary tumour cell lines, results in the induction of apoptosis in these cells. Our findings suggest that feline REIC/Dkk‐3 represents a potential molecular target for the development of therapies against feline mammary cancers.  相似文献   

Application of three hygrometers under different skin conditions in dogs: dry,moist and haired skin          下载免费PDF全文

Yutaka Momota  Kenichiro Shimada  Naoyuki Minorikawa  Azusa Gin  Takako Matsubara  Yuka Nakamura  Masaaki Katayama  Toshinori Sako 《Veterinary dermatology》2017,28(6):554-e131

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Systemic kappaAL amyloidosis associated with bovine leukocyte adhesion deficiency     

Taniyama H  Yamamoto S  Sako T  Hirayama K  Higuchi H  Nagahata H 《Veterinary pathology》2000,37(1):98-100

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The Intravenous Xylitol Tolerance Test in Non-Lactating Cattle   总被引：2，自引：0，他引：2  

Mizutani H  Sako T  Toyoda Y  Fukuda H  Urumuhang N  Koyama H  Hirose H 《Veterinary research communications》2003,27(8):633-641

Xylitol is a five-carbon sugar alcohol that is often used for treatment of ketosis in dairy cattle in Japan. An intravenous xylitol tolerance test (IVXTT, 0.1 g/kg, bolus injection through the jugular vein) was performed in 4 non-lactating cows (n = 4) and the results were compared with those of an intravenous glucose tolerance test (IVGTT) performed under equivalent conditions. The serum xylitol concentration reached a peak value (41.4±9.0 mg/dl) at 5 min, and then rapidly decreased and almost disappeared within 2 h. The C ₀ for xylitol was 56.9±16.6 mg/dl and the t _1/2was 8.5±0.9 min. The administration of xylitol appeared to cause similar secretion of insulin to that caused by glucose. There was also a reduction in the concentration of free fatty acids. It seems that xylitol has value for the treatment of ketosis. However, rapid administration of xylitol appeared to have an osmotic diuretic action and might be a cause of dehydration.  相似文献