Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity   总被引：1，自引：0，他引：1  

Jaroenporn S  Nagaoka K  Ohta R  Watanabe G  Taya K 《The Journal of reproduction and development》2007,53(4):887-893

Prolactin (PRL) has been proposed to directly stimulate corticosterone release. However, the role of PRL on adrenocortical function in male HAA rats has not been fully clarified. The aim of this study was to investigate the effect of PRL on the secretion of corticosterone and progesterone using an in vitro cell culture system in male rats. Administration of PRL (10(-7) and 10(-6) M) resulted in dose-dependent increases in corticosterone and progesterone release. Cotreatment with PRL produced an increase in the stimulatory effects of ACTH-induced corticosterone and progesterone secretion. However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor. In addition, administration of AG490 blunted the significant inhibition of ACTH-induced corticosterone and progesterone secretion by PRL. These results demonstrated that PRL could act directly on the adrenal gland to drive corticosterone and progesterone secretion in male rats. Additionally, the results emphasize that PRL stimulation of adrenal steroid release may be mediated through Jak2 activity.  相似文献   

Assessment of fertility and reproductive toxicity in adult female mice after long-term exposure to Pueraria mirifica herb   总被引：1，自引：0，他引：1  

Jaroenporn S  Malaivijitnond S  Wattanasirmkit K  Watanabe G  Taya K  Cherdshewasart W 《The Journal of reproduction and development》2007,53(5):995-1005

The present study investigated the effects of long-term administration of Pueraria mirifica (PM) at non-toxic doses on the ovarian function and fertility of adult female mice based on evaluation of hematological and biochemical parameters. Female mice were divided into 4 groups (36 mice/group). Groups 1-3 were orally treated with a dose of 0 (PM-0), 10 (PM-10) or 100 mg/kg BW/day PM (PM-100), and group 4 was subcutaneously injected with 200 mug/kg BW/day of synthetic estrogen diethylstilbestrol (DES). The treatment schedule was separated into treatment and post-treatment periods. The duration of each period was 8 weeks. The PM-10 mice exhibited regular estrous cycles, while the PM-100 and DES treatments induced prolonged estrous cycles. Although no changes were observed in the uterus and ovary weights of the mice after the PM-100 and DES treatments, hyperplasia of the uterine endothelium and a decrease in the number of growing ovarian follicles were detected. The changes in the ovarian histologies of the PM-100 and DES mice were related to reductions in the levels of LH and FSH, which subsequently caused a decrease in mating efficiency. Once the PM mice were able to copulate, they were capable of successfully becoming pregnant and mothering offspring. No abnormalities were observed in the external morphologies and reproductive organ weights of the 50-day-old offspring. In conclusion, our results suggest that long-term exposure to 100 mg/kg BW of PM has adverse effects on the mating efficiency and reproduction of adult female mice and that administration of 10 mg/kg BW of PM does not induce any changes in the hypothalamic-pituitary-ovarian-uterine axis.  相似文献   

Effects of diesel exhaust particles on the male reproductive system in strains of mice with different aryl hydrocarbon receptor responsiveness   总被引：1，自引：0，他引：1  

Izawa H  Kohara M  Watanabe G  Taya K  Sagai M 《The Journal of reproduction and development》2007,53(6):1191-1197

Diesel exhaust particles (DEPs) contain polycyclic aromatic hydrocarbons (PAH) that bind to aryl hydrocarbon receptors (AhRs) and decrease sperm production. Since it is not clear if AhR mediates DEP toxicity, we investigated the effect of DEPs in four strains of mice that have different AhR responsiveness. We treated BALB/c, C57BL/6, ICR and DBA/2 mice with DEP suspensions and compared their toxicity in each strain. In both the vehicle- and DEP-treated groups, ethoxyresorufin-O-deethylase (EROD) activity, as an indirect index of AhR activity, was increased in the order of BALB/c > C57BL/6 > ICR > DBA/2. Only BALB/c and C57BL/6 mice had significantly lower daily sperm production (DSP) than vehicle-treated mice. All strains exhibited increased sperm abnormalities. In particular, the C57BL/6, ICR and DBA/2 mice exhibited significantly increased abnormalities. A significant correlation was found between EROD activity and DSP or incidence of morphologically abnormal sperm. These data suggest that DEP toxicity may affect the male reproductive system in an AhR-dependent manner.  相似文献   

微热光电系统燃烧室内截面突变对燃烧的影响   总被引：1，自引：0，他引：1  

潘剑锋  唐维新  黄俊  李德桃  杨文明 《农业机械学报》2007,38(3):44-46

微燃烧室是微热光电（MTPV）系统的重要组成部分。微燃烧室的外表面必须产生一个高而均匀的温度分布，以尽可能高地输出辐射能。通过对截面突变的微燃烧室的试验研究，得到了不同氢氧混合气流量、氢氧体积混合比下燃烧室内的燃烧状况，壁面和出口端面的温度分布。试验结果表明：采用截面突变的燃烧室能很好地控制火焰中心位置，获得稳定的外壁面温度分布规律，可以在截面突变处产生涡流，增强氢气和氧气的混合。  相似文献   

明甪直天王殿松木斗拱振动台试验研究   总被引：2，自引：0，他引：2  

阙泽利  李哲瑞  张贝贝  侯同宇  潘彪 《保鲜与加工》2015,(3):26-34

以甪直保圣寺天王殿斗拱为参考对象,进行无缩尺松木斗拱模型的地震台试验研究。通过对斗拱的加速度与动力放大系数变化趋势、斗拱在振动过程中位移响应变化特征、斗拱变形最大时刻和各构件变形最大时刻的滑移位移和回转位移数值对比分析,得出以下结论：地震加速度用于衡量地震烈度,并不能直接反映斗拱试件的最大变形;振动频率的变化对斗拱回转变形的变化起重要作用,振幅是决定各构件水平滑移的主要因素;各构件变形最大值与斗拱整体变形最大值具有很强相关性,其中栌斗和华拱的回转变形对斗拱的整体变形而言,处于支配地位;斗拱的华拱连下昂部分主要起装饰作用,其榫卯连接节点位置在振动过程中较为薄弱,在对实际文物维护修缮过程中应引起重视并采取相关加固措施。  相似文献   

Micromodel of Computer Emulational Simulation on Twin-roll Casting Strip Solidification Structure     

HOU Shi-dong  PENG Xiao-dong  YANG Ming-bo  Pan Fu-sheng 《保鲜与加工》2001,(2):24-27

Based on the research on the solidifiation of twin-roll casting strip,the analytical model and emulational model of nucleation,the growth of dendrity tip and colunar dendrity transformation to equiaxis dendrity (CET)of twin-roll casting strip solidification are established by means of the principle of metal solidification and modern computer emulational technology.The foundation for the emulational simulation of twin-roll casting strip solidification structure is laid.  相似文献   

CALCULATION OF ULTIMATE STRESS OF UNBONDED PRESTRESSED TENDONS IN UNSYMMETRICAL DEFLECTED BEAMS     

Pan Li Institute of Building Structures  China Academy of Building Research 《保鲜与加工》1989,(3)

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Requirement Model Based on UML 2.0 for Equipment MIS     

LI Pan  YU Ji-hui  FU Zhi-hong 《保鲜与加工》2005,(7):47-50

This paper introduces the modeling of Unified Modeling Language with use case diagram and active diagram based on Rational Unified Process for Equipment Managemet Information System. It discusses the modeling mechanism and character of UML and develops the Computer Equipment management Information System Based Web using Rational Rose of UML CASE Tool. First, it is describe the authors how to analyze the structure of organize and build the model of structure organize. Second, they abstract the workflow of main operation in organize and build workflow model by active diagram. Finally, they abstract actor, use case with case diagram and finish the requirement model.  相似文献   

直墙拱形巷道围岩应力场分析     

唐治  潘一山  朱小景  崔乃鑫 《保鲜与加工》2015,(3):79-85

为得出直墙拱形巷道围岩应力分布规律,应用复变函数弹性理论推导了直墙拱形巷道围岩应力分布的解析表达式。对直墙拱形巷道边界的围岩应力和巷道水平线方向的围岩应力分布规律进行分析,并考虑直墙拱形巷道断面高宽比和侧压系数对其影响规律。研究表明：在不同巷道断面高宽比、侧压系数下,直墙拱形巷道围岩应力集中区域主要集中在直墙底部底角处、拱形顶板中点附近和底板中部3个位置。不同巷道断面高宽比下,直墙拱形巷道沿水平线的应力分布规律基本相同。侧压系数大于1时,采用巷道断面高宽比小于1较有利于巷道稳定;侧压系数小于等于1时,采用巷道断面高宽比大于1较有利于巷道稳定。  相似文献   

A PRACTICAL METHOD OF DESIGNING WALL BEAMS IN FRAMES     

Pan Lili  Peng Huiqin 《保鲜与加工》1988,(3)

Brick masonry wall-beams in frames are girders,carrying brick masonrywalls in buildings with only one or two storied reinforced concrete frames atthe bottom of it.How to anaIyse and design such an element is an outstand-ing problem.In this case,there are no analytical and designing rules in thestate code in force.Therefore,designers have to seek other methods,in whichmost are very conservative and expensive.In order to change this case,thispaper provides an analytical and practical mathod for designers.  相似文献