Canine mammary gland tumours; a histological continuum from benign to malignant; clinical and histopathological evidence*     

K. U. Sorenmo  V. M. Kristiansen  M. A. Cofone  F. S. Shofer  A.‐M. Breen  M. Langeland  C. M. Mongil  A. M. Grondahl  J. Teige  M. H. Goldschmidt 《Veterinary and comparative oncology》2009,7(3):162-172

This study describes the clinical and histopathological findings in dogs with mammary gland tumours, and compares the histopathological and clinical evidence consistent with progression from benign to malignant to human breast cancer epidemiology. Clinical and histopathological data on 90 female dogs with 236 tumours was included. Dogs with malignant tumours were significantly older than dogs with benign tumours (9.5 versus 8.5 years), P = 0.009. Malignant tumours were significantly larger than benign tumours (4.7 versus 2.1 cm), P = 0.0002. Sixty‐six percent had more than one tumour, and evidence of histological progression was noted with increasing tumour size. Dogs with malignant tumours were significantly more likely to develop new primary tumours than dogs with benign tumours, P = 0.015. These findings suggest that canine mammary tumours progress from benign to malignant; malignant tumours may be the end stage of a histological continuum with clinical and histopathological similarities to human breast carcinogenesis.  相似文献   

Notes on Propagation of Butterfly Peacock Bass Cichla ocellaris (Bloch & Schneider, 1801) in a Tropical Fish Hatchery          下载免费PDF全文

J Wesley Neal  Karina M Olivieri‐Velázquez 《Aquaculture Research》2015,46(7):1785-1787

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Tolerability and pharmacokinetic profile of a novel benzene‐poly‐carboxylic acids complex with cis‐diammineplatinum (II) dichloride in dogs with malignant mammary tumours          下载免费PDF全文

V. M. Kristiansen  S. Dewi  T. E. Horsberg  T. J. Jonasdottir  L. Moe  B. Berlinger  S. Lindkær‐Jensen  S. Larsen 《Veterinary and comparative oncology》2017,15(1):118-132

The pharmacokinetic profile, tolerability and efficacy of benzene‐poly‐carboxylic acids complex with cis‐diammineplatinum (II) dichloride (BP‐C1) were studied in dogs with mammary cancer. A three‐level response surface pathway designed trial was performed on seven dogs. At each level BP‐C1 was administered subcutaneously daily for 7 days followed by a 7‐day rest period in a dose escalating manner. Adverse events according to VCOG‐CTCAE, performance status and tumour progression were recorded. The pharmacokinetic profile followed a two‐compartment model with rapid absorption, short distribution, and a slow elimination phase. The overall elimination half‐life was 125 h. The maximum tolerated dose of BP‐C1 was estimated to be above 0.46 mg kg^?1. A significant reduction in VCOG‐CTCAE toxicity which correlated negatively with increasing dose was found. The dogs' general performance status remained unchanged. No decrease in total tumour burden was found, although temporary tumour reduction was seen in some target tumours.  相似文献   

Experimental evaluation of four airway devices in anaesthetized New Zealand White rabbits     

Sandra Wenger  Désirée Müllhaupt  Stefanie Ohlerth  Sarah Prasse  Karina Klein  Bianca da Silva Valente  Martina Mosing 《Veterinary anaesthesia and analgesia》2017,44(3):529-537

Objective

To compare airway management during induction of anaesthesia, spontaneous ventilation (SV) and controlled mechanical ventilation (CMV), using an endotracheal tube (ETT), laryngeal mask (LM), rabbit-specific supraglottic airway device (v-gel) or facemask (FM).

Study design

Prospective randomized crossover experiment.

Animals

Ten New Zealand White rabbits.

Methods

After premedication, rabbits were randomly allocated to four groups: 1) ETT; 2) LM; 3) v-gel or 4) FM. The required dose of propofol, duration and number of attempts to place an airway device and leakage during SV and CMV at different peak inspiratory pressures (6, 10, 12, 14 and 16 cmH₂O) were recorded. Computed tomography (CT) of the head, neck and abdomen were performed before and after CMV.

Results

Significantly less propofol and time [2.0 ± 0.5 mg kg^?1, 82 ± 34 seconds, p < 0.001] were needed to place the FM compared to the three other groups [v-gel 5.1 ± 2.1 mg kg^?1, 302 ± 124 seconds; LM 4.8 ± 1.2 mg kg^?1, 275 ± 89 seconds; ETT 5.5 ± 1.4 mg kg^?1, 315 ± 147 seconds]. A leak > 25% of the tidal volume occurred at the lowest pressure in FM [median (range), 6 (6–8) cmH₂O], which was significantly lower than with v-gel [16 (6–no leak at 16) cmH₂O], LM [>16 (6–no leak at 16)] or ETT [>16 (no leak at 16) cmH₂O] (p < 0.001). On CT images, the height and width of the larynx were significantly smaller with v-gel in comparison to FM and LM (p = 0.004). A significant increase in the amount of gas in the stomach (p = 0.007), but not gastric volume, was detected in FM and LM.

Conclusions and clinical relevance

The v-gel is a practical alternative to LM and ETT for airway management and CMV, but can compress the larynx. The FM is easily placed, but significant leakage occurs during CMV.  相似文献   

Melanin granules melanophages and a fully‐melanized epidermis are common traits of odontocete and mysticete cetaceans          下载免费PDF全文

Blanca Morales‐Guerrero  Cecilia Barragán‐Vargas  German R. Silva‐Rosales  Christian D. Ortega‐Ortiz  Diane Gendron  Laura M. Martinez‐Levasseur  Karina Acevedo‐Whitehouse 《Veterinary dermatology》2017,28(2):213-e50

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Fruit and vegetables are similarly categorised by 8-13-year-old children     

Sepulveda KK  Beltran A  Watson K  Baranowski T  Baranowski J  Islam N  Missaghian M 《Public health nutrition》2009,12(2):175-187

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Performance and Ruminal Characteristics of Beef Cattle Fed Four Different Hybrids Sorghum Silages     

Andreia Santos  Cezario Odilon  Gomes Pereira  Sebastiao de  Campos Valadares  Filho Karina  Guimarfies Ribeiro  Stefanie Alvarenga  Santos Wender  Ferreira de  Souza 《农业科学与技术》2013,(4):312-320

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Monitoring of artemisinin, dihydroartemisinin, and artemether in environmental matrices using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)     

Jessing KK  Juhler RK  Strobel BW 《Journal of agricultural and food chemistry》2011,59(21):11735-11743

The area cultivated with Artemisia annua for the extraction of the antimalarial compound artemisinin is increasing, but the environmental impact of this cultivation has not yet been studied. A sensitive and robust method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of artemisinin in soil. Dihydroartemisinin and artemether were included in the method, and performance on analytical columns of both traditional C(18) phenyl-hexyl and porous shell particles-based Kinetex types was characterized. The versatility of the method was demonstrated on surface water and groundwater samples and plant extracts. The limit of detection was 55, 30 (25 ng/g soil), and 4 ng/mL for dihydroartemisinin, artemisinin, and artemether, respectively. Method performance was demonstrated using naturally contaminated soil samples from A. annua fields in Kenya. The highest observed concentrations were above EC(10) for lettuce growth. Monitoring of artemisinin in soil with A. annua crop production seems necessary to further understand the impact in the environment.  相似文献   

Conception rate following artificial insemination with sexed semen in Holstein heifers under artificial cooling during summer compared with winter season     

Correa-Calderón  Abelardo  Angulo-Valenzuela  Ismael  Betancourth  Fernando  Oroz-Rojo  Francisco  Fierros-Castro  Karina  Macías-Cruz  Ulises  Díaz-Molina  Raúl  Avendaño-Reyes  Leonel 《Tropical animal health and production》2020,52(1):203-209

Tropical Animal Health and Production - The objective of this study was to compare the fertility of Holstein heifers under cooling and inseminated with sexed semen during the summer versus winter...  相似文献   

A comparison of thyroid hormone levels and plasma capillary zone electrophoresis in red-eared sliders (Trachemys scripta elegans) and map turtles (Graptemys spp.) depending on season and sex     

Christoph Leineweber  Sabine Öfner  Anke C. Stöhr  Rachel E. Marschang  Karina Mathes 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2020,49(1):78-90

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