Ingestion of water-soluble soybean fiber prevents osteopenia and hypercholesterolemia induced by ovariectomy in rats   总被引：2，自引：0，他引：2  

Mitamura R  Hara H  Aoyama Y  Takahashi T  Furuta H 《Journal of agricultural and food chemistry》2003,51(4):1085-1089

This study examined the effects of feeding water-soluble soybean fiber (WSSF), a highly fermentable dietary fiber with low viscosity, on intestinal calcium (Ca) absorption, bone mineral content, and serum total cholesterol levels using female Sprague-Dawley rats (5 weeks old) with or without ovariectomy (OVX). The rats in each group were fed a WSSF (50 g/kg of diet) or WSSF-free diet for 4 weeks. Ca absorption was higher in OVX rats fed the WSSF diet than in OVX rats fed the WSSF-free diet. Femoral Ca content in both sham and OVX rats fed the WSSF diet was higher than that in rats fed the WSSF-free diet. The serum total cholesterol levels were elevated after OVX compared with that in the sham rats, and this elevation was prevented by the WSSF diet. In conclusion, ingestion of WSSF prevented osteopenia and hypercholesterolemia induced by ovariectomy in rats.  相似文献   

Consequences of the spatial configuration of resources for the distribution and dynamics of the endangered Parnassius apollo butterfly     

Marianne S. Fred  Robert B. O’Hara 《Biological conservation》2006,130(2):183-192

Based on several years of data from two populations of the endangered Apollo butterfly (Parnassius apollo, L. 1758), we study how the amount and spatial location of patches of larval (host-plant) and adult (nectar plant) resources affects the distribution of females and their larval offspring in the following year. In the coastal population (nectar-plant and host-plant patches spatially segregated), females moved frequently between patches to aggregate on larger host-plant patches close to nectar-plant patches. In the archipelago population (where nectar-plants and host-plants co-occur), the abundance of females increased with higher proximity to other host-plant patches and with more nectar-plants on the patch. Next year’s larval abundance correlated with the abundance of females in the previous season in both populations. A model of the population dynamics in the two populations in relation to the spatial configuration of nectar and host-plant patches showed that the spatial configuration of larval and adult resources had population-dynamical consequences. In many organisms, different life-history stages use different resources. Incorporation of information on the location and abundance of adult resources can provide additional insight for the suitability of a particular landscape in harbouring a population.  相似文献   

Effect of 3-O-octanoyl-(+)-catechin on the responses of GABA(A) receptors and Na+/glucose cotransporters expressed in xenopus oocytes and on the oocyte membrane potential     

Aoshima H  Okita Y  Hossain SJ  Fukue K  Mito M  Orihara Y  Yokoyama T  Yamada M  Kumagai A  Nagaoka Y  Uesato S  Hara Y 《Journal of agricultural and food chemistry》2005,53(6):1955-1959

Recently, 3-O-octanoyl-(+)-catechin (OC) was synthesized from (+)-catechin (C) by incorporation of an octanoyl chain into C in the light of (-)-epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg), which are the major polyphenols found in green tea and have strong physiological activities. OC was found to inhibit the response of ionotropic gamma-aminobutyric acid (GABA) receptors (GABA(A) receptors) and Na+/glucose cotransporters expressed in Xenopus oocytes in a noncompetitive manner more strongly than does C. OC also induced a nonspecific membrane current and decreased the membrane potential of the oocyte, and thus death of the oocyte occurred even at lower concentrations than that induced by C or EGCg. Although EGCg produced H2O2 in aqueous solution, OC did not. This newly synthesized catechin derivative OC possibly binds to the lipid membrane more strongly than does C, Ecg, or EGCg and as a result perturbs the membrane structure.  相似文献   

Precipitation chemistry in Japan 1989–1993     

Hiroshi Hara  Moritsugu Kitamura  Atsuko Mori  Izumi Noguchi  Tsuyoshi Ohizumi  Sinya Seto  Tadashi Takeuchi  Teruyuki Deguchi 《Water, air, and soil pollution》1995,85(4):2307-2312

Precipitation chemistry in Japan was discussed on a wet-only sample database obtained in a nationwide survey from April 1989 to March 1993. Wet-only samples were collected at 29 stations over Japan on a biweekly basis. Commonly determined chemical parameters were measured in laboratories. The volume-weighted annual mean pH at each site ranged from 4.50 to 5.83 with a mean of 4.76. Concentration ranges and means (parenthesized) on an equivalent basis for major ions were as follows: nss-SO₄ ^2–; 5.2–58.9 (38.6), NO₃ ^–; 1.8–25.0 (14.1), NH₄ ⁺; 0.55–29.8 (18.3), nss-Ca²⁺; 2.0–34.5(14.2), Na⁺; 6.4–275.3 (49.1), Cl^–; 13.7–322.4 (63.5) eq L^–1. Acid-base relationships for Phase-II records were quantitatively discussed in terms of three measures: pH, fractional acidity, and our proposed pA_i.  相似文献   

Preparation of antibodies recognizing the new group antigens of feline red blood cell     

H Ejima  Y Hara  S Ikemoto 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1988,50(3):763-768

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Serum concentration and properties of alpha-fetoprotein and serum level of albumin in sucking piglets     

T Fujimoto  A Hara  Y Maede  S Namioka 《Research in veterinary science》1984,36(2):212-216

Porcine alpha-fetoprotein (AFP) was purified from the sera of four-day-old piglets using an immunoadsorbent column. The molecular weight of the AFP was 80,000 when determined by gel filtration on Sephadex G-200 and 75,000 when determined by sodium dodecylsulphate polyacrylamide gel electrophoresis. The isoelectric point of the AFP was pH 4.85 at 0 degree C. The maximum concentration of serum AFP was reached on the fourth day after birth (mean value 1.1 mg ml-1), and it then decreased to 10 micrograms ml-1 when the piglets were 35 days old. The concentration of serum albumin increased rapidly between birth and seven days old, reaching 16 to 17 mg ml-1 at seven days old. Between birth and seven days old, the serum concentrations of AFP and albumin were approximately inversely proportional.  相似文献   

Studies on the isomer of succinic acid. II. Anticancer activity of the isomer of succinic acid     

T Hara 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1967,29(3):117-131

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Bedsonian pneumonia in sheep     

F Baradi  G Ilchmann  M Baghdady  T Hara 《Monatshefte für Veterin?rmedizin》1972,27(5):179-183

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Direct and indirect markers of cartilage metabolism in synovial fluid obtained from dogs with hip dysplasia and correlation with clinical and radiographic variables     

Fujita Y  Hara Y  Nezu Y  Yamaguchi S  Schulz KS  Tagawa M 《American journal of veterinary research》2005,66(12):2028-2033

OBJECTIVE: To compare activities of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and matrix metalloproteinase (MMP)-3 and contents of sulfated glycosaminoglycan (S-GAG) in joint fluid obtained from dogs with hip dysplasia (HD) and clinically normal dogs, evaluate correlations among these markers in joint fluid obtained from dogs with HD, and evaluate correlations between each marker and clinical and radiographic variables. Animals-26 dogs with HD (clinical group) and 43 clinically normal Beagles (control group). PROCEDURE: Joint fluid was aseptically collected from the hip joints of all dogs. For each dog in the clinical group, age, duration of lameness, radiographic osteoarthritis (OA) score, and Norberg angle in each affected joint were recorded. Activities of IL-1beta, IL-6, TNF-alpha, and MMP-3 and S-GAG contents were measured. Values were compared between groups by use of Mann-Whitney U tests, and the Spearman rank correlation test was used to evaluate correlations among markers and between each marker and clinical or radiographic variables. RESULTS: Values of all markers were significantly higher for the clinical group, compared with values for the control group. There was a moderate positive correlation between lameness duration and IL-6 activity and a strong negative correlation between the Norberg angle and IL-1beta activity. CONCLUSIONS AND CLINICAL RELEVANCE: Analysis of our results indicated that there was a significant increase in markers of OA in dogs with HD. Activities of IL-1beta and IL-6 in joint fluid of dogs with HD may be influenced by the severity of laxity in the hip joint and lameness duration, respectively.  相似文献   

Studies on the isomer of succinic acid. I. Production and identification of deodorizing active substance     

T Hara 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1967,29(2):55-70

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