Acute blindness in dogs: Sudden acquired retinal degeneration syndrome versus neurological disease (140 cases, 2000–2006)     

Keith W. Montgomery  Alexandra van der Woerdt  Nancy B. Cottrill† 《Veterinary ophthalmology》2008,11(5):314-320

Objective  To evaluate dogs with amaurosis and compare signalment, history, ophthalmic examination and neurologic abnormalities between dogs diagnosed with sudden acquired retinal degeneration syndrome (SARDS) versus neurological disease (ND). Animals Studied-140 dogs with acute vision loss and ocular abnormalities insufficient to account for visual deficits. An electroretinogram (ERG) was performed on each dog.
Procedures  Medical records were reviewed and information was collected for all dogs meeting the inclusion criteria. Dogs diagnosed with SARDS were compared to those with ND based on signalment, duration of clinical signs, past medical problems, clinicopathologic findings, and ophthalmic and physical examination abnormalities.
Results  120 dogs were diagnosed with SARDS and 20 dogs with ND based on ERG results. Mixed-breed dogs were most commonly diagnosed with SARDS as well as ND. Pure breed dogs frequently diagnosed with SARDS included the Miniature Schnauzer and Dachshund. Dogs with SARDS did not differ significantly from those with ND based on age or sex distribution. Cushing's-like symptoms were reported more frequently in SARDS dogs as well as conjunctival hyperemia and retinal vascular attenuation. Papilledema and asymmetric visual deficits were observed more frequently in dogs with ND. Dogs with ND were no more likely than SARDS dogs to have additional neurological deficits.
Conclusions  Appreciable overlap of clinical signs exists between dogs with SARDS and dogs with ND resulting in acute vision loss. As a significant portion of dogs (14%) in the present study were diagnosed with ND, an ERG to rule out ND is indicated in dogs with amaurosis.  相似文献   

The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: a pilot study     

Johnstone McLean NS  Ward DA  Hendrix DV 《Veterinary ophthalmology》2008,11(3):158-161

Objective To determine the effects of 0.005% latanoprost and 2% dorzolamide/0.5% timolol on the blood‐aqueous barrier (BAB) in normal dogs. Animals studied Eight mixed‐breed and pure‐breed dogs. Procedures Baseline anterior chamber fluorophotometry was performed on eight normal dogs. Sodium fluorescein was injected and the dogs were scanned 60–90 min post‐injection. Seventy‐two hours following the baseline scan, one eye received one drop of latanoprost. Fluorophotometry was repeated 4 h after drug administration. Following a washout period, the identical procedure was performed 4 h after the administration of dorzolamide/timolol. The degree of BAB breakdown was determined by comparing the concentrations of fluorescein within the anterior chamber before and after drug administration. BAB breakdown was expressed as a percentage increase in the post‐treatment fluorescein concentration over the baseline concentration: %INC [Fl] = {([Fl]_post – [Fl]_baseline)/[Fl]_baseline} × 100. The percentage increase in fluorescein concentration in the treated eye was compared to that in the nontreated eye using a paired t‐test with significance set at P ≤ 0.05. Results Following administration of latanoprost, the fluorescein in the treated eyes increased 49% (± 58%) from baseline compared to 10% (± 31%) in the untreated eyes (P = 0.016). Following administration of dorzolamide/timolol, the fluorescein concentration increased 38% (± 54%) compared to baseline vs. 24% (± 38%) in the untreated eyes (P = 0.22). Conclusions The results of this study show that topical latanoprost may cause BAB disruption in normal dogs while topical dorzolamide/timolol may have no effect on the BAB in normal dogs.  相似文献   

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls          下载免费PDF全文

E. J. Laws  A. Kathrani  T. R. Harcourt‐Brown  N. Granger  J. H. Rose 《The Journal of small animal practice》2018,59(4):222-227

  相似文献   

Surgical technique for tubal ligation in white-tailed deer (Odocoileus virginianus).     

Robert A MacLean  Nancy E Mathews  Daniel M Grove  Elizabeth S Frank  Joanne Paul-Murphy 《Journal of zoo and wildlife medicine》2006,37(3):354-360

Surgical tubal ligation was used to sterilize urban free-ranging white-tailed deer (Odocoileus virginianus) as a methodology of a larger study investigating the influences of intact, sterile females on population dynamics and behavior. Deer were either trapped in clover traps (n = 55) and induced with an i.m. injection of xylazine and tiletamine/zolazepam or induced by a similar protocol by dart (n = 12), then intubated and maintained on isoflurane in oxygen. Over 3 yr, individual female deer (n = 103) were captured in Highland Park, Illinois, with a subset of females sterilized using tubal ligation by ventral laparotomy (n = 63). Other sterilization procedures included tubal transection by ventral (n = 1) or right lateral (n = 2) laparoscopy and ovariohysterectomy by ventral laparotomy (n = 1). One mortality (1/ 67, 1.5%) of a doe with an advanced pregnancy was attributed to a lengthy right lateral laparoscopic surgery that was converted to a right lateral laparotomy. The initial surgical modality of laparoscopy was altered in favor of a ventral laparotomy for simplification of the project and improved surgical access in late-term gravid does. Laparotomy techniques included oviductal ligation and transection (n = 14), application of an oviductal mechanical clip (n = 9), ligation and partial salpingectomy (n = 40), and ovariohysterectomy (n = 1). As of 2 yr poststerilization, no surgical does were observed with fawns, indicating that these procedures provide sterilization with low mortality in urban white-tailed deer.  相似文献   

Another observation on foie gras production     

Bischof NL 《Journal of the American Veterinary Medical Association》2007,231(5):690

  相似文献   

Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy     

Foust AL  Marsella R  Akucewich LH  Kunkle G  Stern A  Moattari S  Szabo NJ 《Veterinary dermatology》2007,18(4):246-251

This study determined the residual concentration of terbinafine in cat hair after 14 days of oral treatment. Ten clinically normal cats were administered terbinafine orally at a daily dose of 34-45.7 mg kg(-1) for a total of 14 days. Areas of 15 cm(2) were shaved on the lateral thorax at day 0 and weekly for 8 weeks after the last dose of terbinafine. The hair samples were analysed by high-pressure liquid chromatography to determine the persistence of terbinafine over time. The mean terbinafine concentration in hair was 2.30 ng mg(-1) after 14 days of therapy. The half life was 1.84 weeks after the last dose of terbinafine. With a 99% confidence interval, the concentration of terbinafine remained in the cat hair at or above 0.03 ng mg(-1) (minimal inhibitory concentration (MIC)(90) = 0.03 microg mL(-1)) for 5.3 weeks. Slight deviations in the complete blood cell count and serum chemistry values were not attributed to terbinafine. Four cats experienced vomiting during the terbinafine treatment; two of these cats also experienced intense facial pruritus followed by a macular to papular skin reaction 7-14 days after the discontinuation of terbinafine. In summary, terbinafine persists in hair at concentrations above the MIC for several weeks after stopping medication, even after short-term therapy (14 days). These results suggest that pulse therapy of terbinafine should be further researched and potentially considered as a treatment modality for feline dermatophytosis, an approach that would decrease treatment duration while maintaining effectiveness.  相似文献   

Characterization of free amino acid QTLs in maize opaque2 recombinant inbred lines     

Karen V. Pineda-Hidalgo  Marilyn Lavin-Aramburo  Nancy Y. Salazar-Salas  Jeanett Chavez-Ontiveros  Cuauhtemoc Reyes-Moreno  María D. Muy-Rangel  Brian A. Larkins  Jose A. Lopez-Valenzuela   《Journal of Cereal Science》2011,53(2):250-258

The opaque2 (o2) mutation in maize (Zea mays L.) increases the content of free amino acids (FAA) in the endosperm. We investigated the basis of this trait by using recombinant inbred lines from a cross of Oh545o2 (high FAA) and Oh51Ao2 (low FAA) to identify quantitative trait loci (QTL) for FAA content and to determine their effect on FAA composition and protein accumulation. Mapping identified six QTLs that accounted for 71% of the phenotypic variation. Two QTLs in bins 4.01 and 7.02 are close to α-zein genes; high FAA individuals with these QTLs had reduced accumulation of α-zein 19 kDa isoforms and increased FAA abundant in α-zeins. A QTL in bin 3.03 is close to a gene encoding triose phosphate isomerase (tpi4) and a higher expression of this enzyme was found in high FAA individuals. Other differentially expressed proteins included vicilin-like globulins and the enzymes glyceraldehyde-3-phosphate dehydrogenase, enolase-2, sorbitol dehydrogenase and granule-bound starch synthase. The results suggest that the increased levels of FAA in o2 endosperm are mainly due to the reduction of storage proteins and the failure to incorporate their amino acids into other proteins, as well as the alteration of carbohydrate metabolism that may favor amino acid biosynthesis.  相似文献   

Reserve site selection for data‐poor invertebrate fisheries using patch scale and dispersal dynamics: a case study of sea cucumber (Cucumaria frondosa)     

Nancy L. Shackell  David W. Brickman  Kenneth T. Frank 《水产资源保护:海洋与淡水生态系统》2013,23(5):723-731

Hatchery cultivation of the common cockle (Cerastoderma edule L.): from conditioning to grow‐out          下载免费PDF全文

Anna Elisabeth Pronker  Frank Peene  Silke Donner  Sander Wijnhoven  Pieter Geijsen  Peter Bossier  Nancy Marie Nevejan 《Aquaculture Research》2015,46(2):302-312

This study describes for the first time the cultivation of Cerastoderma edule on a commercial scale. A protocol to grow F₂ generation cockles was developed, which led to fine‐tuning experiments for broodstock conditioning and spat growth. Broodstock animals were conditioned with diets of Isochrysis galbana (T‐Iso) or Tetraselmis suecica, whereas a third group was not fed. The best diet, T. suecica, induced 12 females out of 100 animals to spawn a total of 3 380 000 eggs. The non‐fed group did not spawn. Cockle spat (4.9 ± 1.0 mm) grew best when given a mixed diet of C. muelleri, T‐Iso and Sceletonema costatum, or a mixture of P. tricornutum and S. costatum at a concentration of 240 cells μl^?1 day^?1, resulting in a tripling of their wet weight after 14 days. The impact of density, burrowing substrate and food availability on cockle spat growth (41 days old, 5.6 ± 1.2 mm) was studied for 11 weeks. Best results were obtained by culturing spat at ad libitum food conditions at 500 ind m^?2, resulting in an average growth rate of 168 μm day^?1, an average final size of 19.0 ± 1.9 mm and a total final biomass of 1040 g m^?2.  相似文献   

What is your diagnosis? A zygomatic salivary gland mucocele     

Atkins RM  Hecht S  Westermeyer HD  McLean NJ 《Journal of the American Veterinary Medical Association》2010,237(12):1375-1376

  相似文献