Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide     

Mestorino N  Formentini EA  Lucas MF  Fernandez C  Modamio P  Hernández EM  Errecalde JO 《Veterinary research communications》2008,32(1):21-33

A comparative pharmacokinetic study was conducted to determine the order and the rate of absorption of triclabendazole (TCBZ) in cattle and sheep. A commercial suspension of TCBZ (Biofasiolex, Biogénesis S.A., Argentina) was administered at a dose rate of 10 mg/kg by the oral route to six Holstein female calves and six Corriedale female sheep. The plasma concentration profiles of the metabolites triclabendazole sulfoxide (TCBZ-SO) and triclabendazole sulfone (TCBZ-SO₂) were analysed by means of the non-compartmental method. The order of the absorption process of the active metabolite, TCBZ-SO, was determined by construction of curves of cumulative absorbed fraction of the drug by means of the Wagner-Nelson method. The appearance of TCBZ-SO in plasma of cattle and sheep resembles the entry of a constant quantity of drug into the organism per unit time. This is explained by the reservoir effect of the rumen, which acts as a biological slow-release system for TCBZ-SO and its precursor TCBZ to the posterior digestive tract where they are absorbed. The plasma concentration profiles of TCBZ-SO in both species were well described by a one-compartment open model with zero-order process of absorption and first-order process of elimination. The values of AUC_0-∞ and C _max of TCBZ-SO did not differ between species, while other kinetic parameters except for λ _z had higher values in calves than in sheep. In the case of TCBZ-SO₂, t _max was the only parameter that did not differ between species, while other kinetic parameters except for λ _z had higher values in calves than in sheep.  相似文献   

Effect of biotin supplementation on hoof health and ceramide composition in dairy cattle     

Randhawa SS  Dua K  Randhawa CS  Randhawa SS  Munshi SK 《Veterinary research communications》2008,32(8):599-608

The effect of biotin supplementation on various foot lesions and hoof ceramide composition of toe (wall) and sole portions of hooves was studied in crossbred dairy cattle. Biotin supplementation was done for five months in 14 cattle at a farm and the other 14 animals kept as control. A significant decline was observed in heel erosions and sole avulsions along with total disappearance of white line fissures and double soles in the biotin supplemented cattle resulting in decrease in the overall disease score. Thin layer chromatographs of the hoof lipids revealed 11 types of ceramides in sole lipids and 6 types of ceramides in toe (wall) lipids. The ceramides were typed and identified according to their Rf values. A qualitative increase in the density of thin layer chromatographs of sole lipids was observed in biotin supplemented cattle whereas a non-significant difference in density of thin layer chromatographs of toe lipids was observed after supplementation of biotin.  相似文献   

Comparison of demographic data,disease severity and response to treatment,between dogs with atopic dermatitis and atopic‐like dermatitis: a retrospective study     

Larissa S. Botoni  Sheila M. F. Torres  Sandra N. Koch  Marcos B. Heinemann  Adriane P. Costa‐Val 《Veterinary dermatology》2019,30(1):10-e4

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Partitioning the multi-scale effects of human activity on the occurrence of riparian forest birds     

Robert J. FletcherJr.  Richard L. Hutto 《Landscape Ecology》2008,23(6):727-739

Conservationists, managers, and land planners are faced with the difficult task of balancing many issues regarding humans impacts on natural systems. Many of these potential impacts arise from local-scale and landscape-scale changes, but such changes often covary, which makes it difficult to isolate and compare independent effects arising from humans. We partition multi-scale impacts on riparian forest bird distribution in 105 patches along approximately 500 km of the Madison and Missouri Rivers, Montana, USA. To do so, we coupled environmental information from local (within-patch), patch, and landscape scales reflecting potential human impacts from grazing, invasive plant species, habitat loss and fragmentation, and human development with the distribution of 28 terrestrial breeding bird species in 2004 and 2005. Variation partitioning of the influence of different spatial scales suggested that local-scale vegetation gradients explained more unique variation in bird distribution than did information from patch and landscape scales. Partitioning potential human impacts revealed, however, that riparian habitat loss and fragmentation at the patch and landscape scales explained more unique variation than did local disturbances or landscape-scale development (i.e., building density in the surrounding landscape). When distribution was correlated with human disturbance, local-scale disturbance had more consistent impacts than other scales, with species showing consistent negative correlations with grazing but positive correlations with invasives. We conclude that while local vegetation structure best explains bird distribution, managers concerned with ongoing human influences in this system need to focus more on mitigating the effects of large-scale disturbances than on more local land use issues. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.  相似文献   

The influence of topography and fire in controlling landscape composition and structure in Sierra de Gredos (Central Spain)     

Olga Viedma 《Landscape Ecology》2008,23(6):657-672

Mediterranean landscapes are dynamic systems that undergo temporal changes in composition and structure in response to disturbances, such as fire. Neither landscape patterns nor driving factors that affect them are evenly distributed in space. Accordingly, disturbances and biophysical factors interact in space through time. The aim of this paper is to assess the relative influence of topography and fire on the landscape patterns of a large forested area located in Sierra de Gredos (Central Spain) through time. A series of Landsat MSS images from 1975 to 1990, and a digital elevation model (DEM) were used to map fires, assess topographical complexity and evaluate changes in landscape composition and structure. Functional regions across the entire landscape were identified using different classification criteria (i.e., percentage burned area and topographic properties) to model topographic and fire impacts at regional scales. A canonical variance partition method, with a time series split-plot design, quantified the relative influence and co-variation of topography and fire on land cover patterns through time. Main results indicated that analyzing portions of the landscape under similar environmental conditions and fire histories, the effects of different fire regimes on the spatio-temporal dynamics of main land covers can be highlighted. However, the impact of fire on landscape patterns was high variable among regions due to the different regeneration abilities of main land covers, the topographic constraints and the fire histories of each region. Hence, broad patterns of fire related variance and co-variation with topography emerged across the entire area due to the different conditions of each landscape portion in which this large Mediterranean landscape was divided. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.  相似文献   

Response of mountain plovers to plague-driven dynamics of black-tailed prairie dog colonies     

David J. Augustine  Stephen J. Dinsmore  Michael B. Wunder  Victoria J. Dreitz  Fritz L. Knopf 《Landscape Ecology》2008,23(6):689-697

Sylvatic plague is a major factor influencing the dynamics of black-tailed prairie dog (Cynomys ludovicianus) colonies in the western Great Plains. We studied the nesting response of the mountain plover (Charadrius montanus), a grassland bird that nests on prairie dog colonies, to plague-driven dynamics of prairie dog colonies at three sites in the western Great Plains. First, we examined plover nest distribution on colonies that were previously affected by plague, but that had been recovering (expanding) for at least 6 years. Plovers consistently nested in both young (colonized in the past 1–2 years) and old (colonized for 6 or more years) portions of prairie dog colonies in proportion to their availability. Second, we examined changes in plover nest frequency at two sites following plague epizootics, and found that mountain plover nest numbers declined relatively rapidly (≤2 years) on plague-affected colonies. Taken together, our findings indicate that available plover nesting habitat associated with prairie dog colonies closely tracks the area actively occupied by prairie dogs each year. Given the presence of plague throughout most of the mountain plover’s breeding range in the western Great Plains, important factors affecting plover populations likely include landscape features that determine the scale of plague outbreaks, the distance that plovers move in response to changing breeding habitat conditions, and the availability and quality of alternate breeding habitat within the landscape.  相似文献   

Predicting land cover changes and their impact on the sediment influx in the Lake Balaton catchment   总被引：2，自引：0，他引：2  

Wim Van Dessel  Anton Van Rompaey  Lien Poelmans  Peter Szilassi 《Landscape Ecology》2008,23(6):645-656

The land cover pattern in the Lake Balaton catchment (Hungary) has been changing since decollectivization in the 1990s. These land cover changes significantly impact the landscape connectivity, controlling the influx of sediments into the lake. A comparison of high resolution land cover maps from 1981, 2000 and 2005 showed a significant extensification of the agriculture with land cover conversions from arable land and vineyards to grassland and forest. For each land unit transition probabilities were assessed using logistic regression techniques to evaluate to which extent land cover changes are controlled by physical or socio-economic parameters. A stochastic land cover allocation algorithm was applied to generate future land cover patterns. The landscape connectivity for each of the simulated land cover patterns was assessed by means of a distributed routing algorithm. The simulations suggest that further land abandonment in the upslope parts of the catchment will cause a non-linear reduction of average soil erosion rates. The changes, however, have a relatively low impact on the sediment volume entering the lake because of the land unit’s poor connectivity with permanent river channels. The major contributors to the lakes sediment load are the vineyards near the lakeshore. They are likely to be maintained because of their touristic value. A significant reduction of the total sediment input in the lake can be expected only if soil conservation measures in the vineyards near the shorelines are undertaken.  相似文献   

Human settlement ecology and chimpanzee habitat selection in Mali     

Chris S. Duvall 《Landscape Ecology》2008,23(6):699-716

Customary land-use practices create distinctive cultural landscapes, including landscapes where abandoned settlements host vegetation that attracts wild animals. Understanding how landscape patterns relate to land-use history can help clarify the ecological effects of particular land uses. This study examines relationships between chimpanzee habitat selection and Maninka settlement practice, to determine how settlement history has affected chimpanzee habitat in Mali’s Bafing Biosphere Reserve, where conservation practitioners assume that the characteristic settlement pattern reflects a process of settlement expansion into undisturbed habitat. Three types of data are reported: (1) ethnographic interviews on settlement history and practice; (2) systematic sampling of chimpanzee habitat use; and (3) ground-based mapping of settlement sites, surface water, and fruit-tree patches. These data show that the Maninka have a shifting settlement system, meaning that most sites are occupied for only relatively brief periods; and that some abandoned settlement sites host fruit-tree patches that are seasonally important chimpanzee habitat. Two main conclusions are: (1) settlement expansion has not occurred; instead, historic settlement has created habitat that is both attractive and available to chimpanzees. Anthropogenic habitat does not appear to be vital for chimpanzee survival, but it spatially and temporally supplements natural habitats. (2) Conservation policies meant to reduce the presumed threat of settlement expansion may have initiated an unintended, long-term threat of habitat loss for chimpanzees. While settlement practices may be a component of short-term threats to chimpanzees, such as hunting, when addressing these threats conservation practitioners should consider long-term settlement processes to avoid creating new threats.  相似文献   

Animal behavioral adaptation to changing landscapes: spring-staging geese habituate to wind farms     

Jesper Madsen  David Boertmann 《Landscape Ecology》2008,23(9):1007-1011

Wind farms are positioned in open landscapes and may cause loss of wildlife habitat due to disturbance, fragmentation, and infrastructure development. Especially flocking geese, swans, ducks and waders are regarded as vulnerable to wind farm development. We compared past and current displacement effects of two onshore wind farms and a line of land-based turbines on spring-staging pink-footed geese (Anser brachyrhynchus) to see if there was evidence of habituation. In one wind farm area, geese previously (1998) (Larsen and Madsen 2000) kept a distance of c. 200 m (the distance at which 50% of peak densities is reached) and they did not go between the turbines; today (2008) they keep a distance of c. 100 m, but do still not enter the wind farm area. In another wind farm, where foraging geese previously (2000) kept a distance of more than 100 m and did not enter the wind farm, they now (2008) forage between the wind turbines and keep a distance of c. 40 m to turbines. In 1998, geese kept a distance of 125 m to a line of turbines, compared to 50 m now. We conclude that geese have behaviorally adapted to changing landscapes created by wind farms. The difference in avoidance between the sites may be due to the sizes of the turbines which in this study were small in both rotor-swept area and in height compared to more recent “industry standard” of 2.5 and 3.0 MW turbines. The study points to the need for longer term studies to properly assess the impact of wind farms on wildlife, including consequent increased risks from inclement weather events of feeding, rafting, and migrating waterfowl.  相似文献   

Historical change in coastal sage scrub in southern California,USA in relation to fire frequency and air pollution     

Matt V. Talluto  Katharine N. Suding 《Landscape Ecology》2008,23(7):803-815

Invasions resulting in the transformation of one ecosystem to another are an increasingly widespread phenomenon. While it is clear that these conversions, particularly between grassland and shrubland systems, have severe consequences, it is often less clear which factors are associated with these conversions. We resampled plots from the 1930s (Weislander VTMs) to test whether two widely assumed factors, changes in fire frequency and nitrogen deposition, are associated with the conversion of coastal sage scrublands to exotic grasslands in southern California. Over the 76-year period, coastal sage scrub cover declined by 49%, being replaced predominantly by exotic grassland species. Grassland encroachment was positively correlated with increased fire frequency and, in areas with low fire frequencies, air pollution (percent fossil carbon as indicated by ∂¹⁴C, likely correlated with nitrogen deposition). We conclude that increases in fire frequency and air pollution over the last several decades in southern California may have facilitated the conversion of coastal sage shrubland to exotic grassland systems.  相似文献