Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs     

Gabriel A  Poncelet L  Van Ham L  Clercx C  Braund KG  Bhatti S  Detilleux J  Peeters D 《The Journal of small animal practice》2006,47(3):144-149

OBJECTIVES: To characterise clinical, electrophysiological and histopathological findings. To analyse pedigree information in six young related Pyrenean mountain dogs with laryngeal paralysis-polyneuropathy complex (LP-PNC). METHODS: A retrospective study of clinical records and pedigrees of six young related Pyrenean mountain dogs with LP-PNC was carried out. RESULTS: All dogs were presented with laryngeal paralysis and concurrent megaoesophagus. Electrodiagnostic testing was performed in three dogs and showed electrophysiological abnormalities in the distal appendicular muscles. Histopathological findings of peripheral nerve samples were dominated by distal axonal degeneration. Clinical, electrophysiological and histopathological findings were supportive of a diagnosis of degenerative, sensorimotor LP-PNC, similar to that reported in young dalmatians and rottweilers. All dogs died or were euthanased by two years of age. An autosomal recessive mode of inheritance was suspected based on pedigree analysis. CLINICAL SIGNIFICANCE: Congenital LP-PNC should be suspected in any young dog presenting with laryngeal dysfunction and other concurrent neurological abnormalities. The prognosis is usually poor.  相似文献   

Effects of food intake and food withholding on plasma ghrelin concentrations in healthy dogs   总被引：1，自引：0，他引：1  

Bhatti SF  Hofland LJ  van Koetsveld PM  Van Ham LM  Duchateau L  Mol JA  van der Lely AJ  Kooistra HS 《American journal of veterinary research》2006,67(9):1557-1563

OBJECTIVE: To investigate the physiologic endocrine effects of food intake and food withholding via measurement of the circulating concentrations of acylated ghrelin, growth hormone (GH), insulin-like growth factor-I (IGF-I), glucose, and insulin when food was administered at the usual time, after 1 day's withholding, after 3 days' withholding and after refeeding the next day in healthy Beagles. ANIMALS: 9 healthy Beagles. PROCEDURES: Blood samples were collected from 8:30 AM to 5 PM from Beagles when food was administered as usual at 10 AM, after 1 day's withholding, after 3 days' withholding, and after refeeding at 10 AM the next day. RESULTS: Overall mean plasma ghrelin concentrations were significantly lower when food was administered than after food withholding. Overall mean plasma GH and IGF-I concentrations did not differ significantly among the 4 periods. Circulating overall mean glucose and insulin concentrations were significantly higher after refeeding, compared with the 3 other periods. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, food withholding and food intake were associated with higher and lower circulating ghrelin concentrations, respectively, suggesting that, in dogs, ghrelin participates in the control of feeding behavior and energy homeostasis. Changes in plasma ghrelin concentrations were not associated with similar changes in plasma GH concentrations, whereas insulin and glucose concentrations appeared to change reciprocally with the ghrelin concentrations.  相似文献   

U.S. elections. Scientists urge Obama, Romney to address key S&T issues     

E Lane  B Ham 《Science (New York, N.Y.)》2012,337(6098):1059

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沟渠回灌渗漏补给量的试验研究   总被引：1，自引：1，他引：0  

丁昆仑 《中国农村水利水电》1998,(1):22-24

通过渠道注水渗漏试验,得出了渠道渗漏强度与渠中水深的关系;将试验结果与理论计算比较,模拟求出了渠道土壤的渗透系数,与用双环法测得的渗透系数相比,此法能较好地反映渠道实际渗漏情况;在此基础上,计算了雄县回灌区渠系各年实际引水补给量,为该区域地下水回灌分析提供了可靠的依据。  相似文献   

黄河下游灌区农田排水再利用效应模拟评价   总被引：6，自引：2，他引：4  

许迪  丁昆仑  蔡林根  P S Minhas 《灌溉排水学报》2004,23(5):1-5

在田间试验观测基础上,采用SWAP模型分析黄河下游簸箕李引黄灌区农田排水再利用下的土壤盐分季节性变化以及地下水位对土壤盐分剖面分布的影响,模拟农田排水补灌对作物产量的效应。研究结果表明,咸排水补灌引起的土壤盐分积聚主要在冬小麦生长期,夏玉米生长期内并不明显,有效地控制地下水位有助于减少土壤盐分累积量,维系作物根区的盐分平衡。利用含盐量为4mg/cm3以下的农田排水在冬小麦生长后期水分亏缺阶段进行补灌,可在基本不影响随后夏玉米产量的基础上,不同程度地改善冬小麦产量。对缺水严重的黄河下游引黄灌区,农田排水再利用是缓解水资源供需矛盾、改善作物产量的一种有效水管理措施。  相似文献   

Magnetic resonance imaging vertebral canal and body ratios in Doberman Pinschers with and without disk-associated cervical spondylomyelopathy and clinically normal English Foxhounds     

De Decker S  Gielen IM  Duchateau L  Saunders JH  van Bree HJ  Polis I  Van Ham LM 《American journal of veterinary research》2011,72(11):1496-1504

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中国的农田排水技术进展与研究展望   总被引：11，自引：0，他引：11  

王少丽  王修贵  丁昆仑  瞿兴业 《灌溉排水学报》2008,27(1):108-111

涝渍盐碱灾害是我国不少地区农业生产发展的主要障碍,提高防御涝渍盐碱灾害的能力,对加速发展农业生产有着重要的现实意义和战略意义。长期的实践证明,农田排水在防御涝渍灾害和土壤盐碱化、改善田间耕作管理、增加农作物产量、促进国民经济发展等方面起着积极的作用。阐述了农田排水技术的重要性,回顾了排水技术的发展与主要实践,指出排水领域存在的问题和差距,结合我国国情,提出今后农田排水领域的研究发展方向。  相似文献   

Reference values and clinical application of magnetic peripheral nerve stimulation in cats     

Van Soens I  Struys MM  Bhatti SF  Van Ham LM 《Veterinary journal (London, England : 1997)》2012,193(1):290-292

Magnetic stimulation of radial (RN) and sciatic (SN) nerves was performed bilaterally in 40 healthy cats. Reference values for onset latency and peak-to-peak amplitude of magnetic motor evoked potentials (MMEPs) were obtained and compared with values of electric motor evoked potentials (EMEPs) in 10/40 cats. Onset latencies and peak-to-peak amplitudes of the MMEPs of three cats with polyneuropathy (PNP) were compared to the reference values. Magnetic motor evoked responses were easily recorded in all normal cats. Significant differences were found in onset latencies between MMEPs and EMEPs, but peak-to-peak amplitudes were equal. The MMEPs of three cats with PNP can be seen as outliers in comparison to the reference values. MMEPs from the RN and SN were easily obtained and reproducible in normal cats. The technique could represent a useful adjunct in the assessment of peripheral nerve disorders.  相似文献   

Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer     

Lai CL  van den Ham R  Mol J  Teske E 《Veterinary journal (London, England : 1997)》2009,181(3):256-260

Prostate cancer in the dog (cPC) has many features in common with hormone refractory human prostate cancer. As cPC is seen more often in castrated dogs, the contribution of the androgen receptor (AR) to the development of prostate cancer remains questionable. The aim of the present study was to evaluate the presence of the AR by immunohistochemistry in cPC. AR staining was observed in most tumors from intact and castrated dogs, but the proportion of positive cells and the staining intensity were much lower than in the prostate of healthy, non-castrated dogs. Most of the positive staining was seen in the cytoplasm rather than in the nuclei of the tumor cells. The predominant cytoplasmic localization was not related to mutations in exon 3 of the DNA-binding domain of the AR, as shown by sequence analysis of microdissected AR positive tumor cells. Other mechanisms that lead to an impaired androgen-AR signaling or a basal/stem cell like origin may explain the low cytoplasmic AR staining in cPC.  相似文献   

Evolution of clinical signs and predictors of outcome after conservative medical treatment for disk-associated cervical spondylomyelopathy in dogs     

De Decker S  Gielen IM  Duchateau L  Oevermann A  Polis I  Van Soens I  van Bree HJ  Van Ham LM 《Journal of the American Veterinary Medical Association》2012,240(7):848-857

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