Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth   总被引：114，自引：0，他引：114  

P W Finch  J S Rubin  T Miki  D Ron  S A Aaronson 《Science (New York, N.Y.)》1989,245(4919):752-755

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Oxytocin selectively gates fear responses through distinct outputs from the central amygdala     

Viviani D  Charlet A  van den Burg E  Robinet C  Hurni N  Abatis M  Magara F  Stoop R 《Science (New York, N.Y.)》2011,333(6038):104-107

Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.  相似文献   

Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex     

Shema R  Haramati S  Ron S  Hazvi S  Chen A  Sacktor TC  Dudai Y 《Science (New York, N.Y.)》2011,331(6021):1207-1210

Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mζ (PKMζ) enhances long-term memory, whereas a dominant negative PKMζ disrupts memory, even long after memory has been formed.  相似文献   

Swedish coffee (Astragalus boeticus L.), a neglected coffee substitute with a past and a potential future     

Jaime Prohens  Isabel Andújar  Santiago Vilanova  Mariola Plazas  Pietro Gramazio  Rafael Prohens  Francisco J. Herraiz  Antonio M. De Ron 《Genetic Resources and Crop Evolution》2014,61(1):287-297

Swedish coffee (Astragalus boeticus) seeds have been used as a coffee substitute, in particular during the nineteenth century and in times of scarcity. A. boeticus is found in the wild in a wide range of environments in the Mediterranean and Middle Eastern regions and is able to grow in areas with low and irregular rainfall. It is well-adapted to cultivated and disturbed environments, has indehiscent pods and high yield potential, and is therefore pre-adapted to cultivation and domestication. Swedish coffee is an annual that flowers in spring and produces small (3–6 mm × 3–5 mm) kidney-shaped seeds that can be harvested in summer. The genetic diversity of the species has not been studied, but evidence (wide range of environments, insect pollination) suggests that considerable diversity exists in the species. The genetic resources of Swedish coffee conserved in germplasm banks are very limited, with only 49 accessions conserved in six genebanks. Although no cultivated varieties exist at present and no breeding studies are underway, evidence suggests that limited breeding could result in considerable genetic advances. The cultivation of A. boeticus was very important during the nineteenth century in several countries of Europe, in particular in Sweden, where the cultivation was promoted as a coffee substitute by the monarchy. Several reports exist on its cultivation in several countries of Northern, Central and Southern Europe during the nineteenth century and beginning of the twentieth century. However, its cultivation gradually lost importance and was eventually abandoned. Swedish coffee can be grown in different types of soils as a regular winter or spring legume crop, and thanks to symbiosis with rhizobia may be able to perform well with reduced N fertilization. Several historical accounts report an excellent quality of the coffee substitute prepared with roasted Swedish coffee seeds. However, no investigations have been carried out to study the process of roasting and its influence on the final quality. The information presented here indicates that limited efforts in A. boeticus breeding, cultivation, and industrial processing potentially might result in the recovery of this neglected coffee substitute.  相似文献   

The stomach as a "bioreactor": when red meat meets red wine     

Gorelik S  Ligumsky M  Kohen R  Kanner J 《Journal of agricultural and food chemistry》2008,56(13):5002-5007

To determine the stomach bioreactor capability for food oxidation or antioxidation, rats were fed red turkey meat cutlets (meal A) or red turkey meat cutlets and red wine concentrate (meal B). The hydroperoxides (LOOH) and malondialdehyde (MDA) levels of the stomach contents were evaluated during and after digestion; the postprandial plasma MDA level was also evaluated. In independently fed rats, the stomach LOOH concentration fell substantially 90 min following the meal, and the addition of red wine polyphenols enhanced LOOH reduction 3-fold. A similar trend was obtained for MDA. After pyloric ligation, the stomach contents of rats fed red meat homogenate showed >2-fold increases in LOOH and MDA accumulation. The postprandial plasma MDA level increased significantly by 50% following meal A and was maintained or even fell by 34% below basal level following meal B. The findings show that consumption of partially oxidized food could increase lipid peroxidation in the stomach and the absorption of cytotoxic lipid peroxidation products into the body. The addition of antioxidants such as red wine polyphenols to the meal may alter these outcomes. These findings explain the potentially harmful effects of oxidized fats in foods and the important benefit of consuming dietary polyphenols during the meal.  相似文献   

Cell biology. Stressed cells cope with protein overload     

Ron D 《Science (New York, N.Y.)》2006,313(5783):52-53

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Global patterns of influenza a virus in wild birds   总被引：1，自引：0，他引：1  

Olsen B  Munster VJ  Wallensten A  Waldenström J  Osterhaus AD  Fouchier RA 《Science (New York, N.Y.)》2006,312(5772):384-388

The outbreak of highly pathogenic avian influenza of the H5N1 subtype in Asia, which has subsequently spread to Russia, the Middle East, Europe, and Africa, has put increased focus on the role of wild birds in the persistence of influenza viruses. The ecology, epidemiology, genetics, and evolution of pathogens cannot be fully understood without taking into account the ecology of their hosts. Here, we review our current knowledge on global patterns of influenza virus infections in wild birds, discuss these patterns in the context of host ecology and in particular birds' behavior, and identify some important gaps in our current knowledge.  相似文献   

Evaluation of assays for quantification of DNA in canine plasma as an indirect marker of NETosis          下载免费PDF全文

Stephanie A. Smith  Corinne M. Lawson  Maureen A. McMichael  Katrina Jung  Mauria O'Brien  Ron Achiel 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2017,46(2):278-286

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A historical perspective on the effects of trapping and controlling the muskrat (Ondatra zibethicus) in the Netherlands          下载免费PDF全文

E Emiel van Loon  Daan Bos  Caspara J van Hellenberg Hubar  Ron C Ydenberg 《Pest management science》2017,73(2):305-312

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