Risk factors and select cardiac characteristics in dogs naturally infected with Trypanosoma cruzi presenting to a teaching hospital in Texas     

Alyssa C. Meyers  Sarah A. Hamer  Derek Matthews  Sonya G. Gordon  Ashley B. Saunders 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(4):1695-1706

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Immediate effect of transmucosal application of corn syrup or 50% dextrose solution on blood glucose concentrations in healthy dogs     

Rhonda L. Holt  Jana M. Gordon  Craig Ruaux 《Journal of Veterinary Emergency and Critical Care》2019,29(6):630-634

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Gadolinium contrast medium administration does not adversely affect T2*‐weighted gradient recalled echo magnetic resonance imaging of the canine brain at 1.5 Tesla     

Janina Bartels  Silke Hecht  Gordon A. Conklin  Sun Xiaocun 《Veterinary radiology & ultrasound》2019,60(2):184-191

As gadolinium‐based contrast agents are paramagnetic and have T2 shortening effects, they have the potential to adversely affect gradient recalled echo sequences. The aim of this prospective, cross‐sectional study was to evaluate the effects of gadolinium administration on T2*‐weighted sequence diagnostic quality and signal intensity when imaging the canine brain. A total of 100 dogs underwent brain magnetic resonance imaging (MRI) including pre‐ and postcontrast T2*‐weighted sequences acquired with a delay (Group A) or immediately (Group B) following gadolinium administration. Pre‐ and postcontrast images were subjectively compared. In dogs with intracranial enhancing masses, regions of interest were drawn on corresponding images and signal intensity ratios were calculated. The effect of degree and pattern of contrast enhancement, susceptibility artifacts, and time between contrast injection and T2*‐weighted sequence acquisition on signal intensity ratio was evaluated. Overall 31 dogs had contrast enhancing intracranial masses. Subjectively, there was no difference in image quality of T2*‐weighted sequences obtained before and after contrast medium administration. No significant signal intensity differences of intracranial contrast enhancing masses were found (Group A P = 0.9999; Group B P = 0.9992). Susceptibility artifacts did not differ in appearance, and there was no effect on calculated signal intensity ratio (P = 0.8142). Similarly, there was no effect of degree of enhancement or contrast heterogeneity on signal intensity ratio (P = 0.4413). No correlation was found between signal intensity ratio and the time to acquisition (P = 0.199). Administration of gadolinium‐based MRI contrast agents does not adversely affect T2*‐weighted imaging of the brain in dogs at 1.5 T even in the presence of contrast enhancing lesions.  相似文献   

Longitudinal Analysis of Quality of Life,Clinical, Radiographic,Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study          下载免费PDF全文

A. Boswood  S.G. Gordon  J. Häggström  G. Wess  R.L. Stepien  M.A. Oyama  B.W. Keene  J. Bonagura  K.A. MacDonald  M. Patteson  S. Smith  P.R. Fox  K. Sanderson  R. Woolley  V. Szatmári  P. Menaut  W.M. Church  M.L. O'Sullivan  J.‐P. Jaudon  J.‐G. Kresken  J. Rush  K.A. Barrett  S.L. Rosenthal  A.B. Saunders  I. Ljungvall  M. Deinert  E. Bomassi  A.H. Estrada  M.J. Fernandez Del Palacio  N.S. Moise  J.A. Abbott  Y. Fujii  A. Spier  M.W. Luethy  R.A. Santilli  M. Uechi  A. Tidholm  C. Schummer  P. Watson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):72-85

Background

Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD ) and cardiomegaly have not been described.

Objectives

To investigate the effect of pimobendan on clinical variables and the relationship between a change in heart size and the time to congestive heart failure (CHF ) or cardiac‐related death (CRD ) in dogs with MMVD and cardiomegaly. To determine whether pimobendan‐treated dogs differ from dogs receiving placebo at onset of CHF .

Animals

Three hundred and fifty‐four dogs with MMVD and cardiomegaly.

Materials and Methods

Prospective, blinded study with dogs randomized (ratio 1:1) to pimobendan (0.4–0.6 mg/kg/d) or placebo. Clinical, laboratory, and heart‐size variables in both groups were measured and compared at different time points (day 35 and onset of CHF ) and over the study duration. Relationships between short‐term changes in echocardiographic variables and time to CHF or CRD were explored.

Results

At day 35, heart size had reduced in the pimobendan group: median change in (Δ) LVIDDN ?0.06 (IQR : ?0.15 to +0.02), P  < 0.0001, and LA :Ao ?0.08 (IQR : ?0.23 to +0.03), P  < 0.0001. Reduction in heart size was associated with increased time to CHF or CRD . Hazard ratio for a 0.1 increase in ΔLVIDDN was 1.26, P  = 0.0003. Hazard ratio for a 0.1 increase in ΔLA :Ao was 1.14, P  = 0.0002. At onset of CHF , groups were similar.

Conclusions and Clinical Importance

Pimobendan treatment reduces heart size. Reduced heart size is associated with improved outcome. At the onset of CHF , dogs treated with pimobendan were indistinguishable from those receiving placebo.

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Status of Macrophomina phaseolina on Strawberry in California and Preliminary Characterization of the Pathogen     

Steven T. Koike  Renee S. Arias  Cliff S. Hogan  Frank N. Martin  Thomas R. Gordon 《International Journal of Fruit Science》2016,16(4):148-159

ABSTRACT

Macrophomina crown and root rot has become a significant soil-borne disease issue in California. For many locations in the state, the disease is associated with fields that are no longer pre-plant, flat field fumigated with methyl bromide + chloropicrin. Inoculation experiments indicated that some differences in strawberry cultivar susceptibility to Macrophomina phaseolina were seen a short time after the inoculation, but as disease progressed such differences did not persist. Preliminary characterization studies of Macrophomina phaseolina isolates from strawberry indicated that such isolates may have a host preference for strawberry. Macrophomina phaseolina isolates from watermelon, thyme, and apple failed to cause disease in strawberry. Five cover crop species, which can be rotated with strawberry, did not develop disease when inoculated with strawberry isolates. In preliminary analysis using simple sequence repeat markers, isolates obtained from strawberry formed a separate group compared to isolates recovered from other known Macrophomina phaseolina hosts.  相似文献   

Structural and functional changes in mouse fibroblast cells treated with 2,3-dichloro-1,4-naphthoquinone (dichlone)     

J. Saxena  H.C. Sikka  G. Zweig  G.B. Gordon 《Pesticide biochemistry and physiology》1974,4(2):185-200

When strain L mouse fibroblasts were treated with the substituted quinone pesticide dichlone (2,3-dichloro-1,4-naphthoquinone), a rapid loss of intracellular potassium, ATP, and protein with a concomitant increase in intracellular water and volume occurred. Electron microscopic examination showed a nonreversible swelling of the cells associated with the formation of large protruding blebs. The findings indicate that dichlone can alter the permeability of the cell membrane which may be one of the sites of action of the pesticide in the fibroblast cells. Menadione (2-methyl-1,4-naphthoquinone), a synthetic vitamin K, also a substituted quinone, was found to be less effective in short-term incubation at corresponding concentrations, althought it did produce loss of K⁺ ions and protein from the cell.The action of dichlone was compared with that of model compounds which are known to act on plasma membranes (p-chloromercuribenzene sulfonate—PCMBS) and those which interfere with intracellular energy metabolism (combination of antimycin A plus iodoacetate). From the results reported in this paper it appears that dichlone acts in most respects, like PCMBS, by a direct interaction with membrane components, but unlike PCMBS, dichlone enters the cell rapidly and stimulates oxygen uptake probably by constituting a bypass of electron transfer.  相似文献   

Thermodynamics and society     

Gordon GE 《Science (New York, N.Y.)》1981,211(4488):1340-1341

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Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs     

Gordon IK  Ye F  Kent MS 《American journal of veterinary research》2008,69(8):1079-1084

OBJECTIVE: To investigate activation of the mammalian target of rapamycin (mTOR) pathway and the antitumor effect of rapamycin in canine osteosarcoma cells. SAMPLE POPULATION: 3 established primary canine osteosarcoma cell lines generated from naturally developing tumors. PROCEDURES: Expression of total and phosphorylated mTOR and p70S6 kinase was assessed by use of western blot analysis in canine osteosarcoma cells with and without the addition of rapamycin. A clonogenic assay was performed to determine the surviving fraction of osteosarcoma cells at various concentrations of rapamycin. RESULTS: Total and phosphorylated mTOR and p70S6 kinase expression was evident in all 3 cell lines evaluated, which was indicative of activation of this pathway. Treatment with rapamycin resulted in a time-dependent decrease in phosphorylated mTOR expression and a lack of detectable phosphorylated p70S6 kinase. No detectable change in expression of total mTOR and total p70S6 kinase was identified after rapamycin treatment. The clonogenic assay revealed a significant dose-dependent decrease in the surviving fraction for all 3 cell lines when treated with rapamycin. CONCLUSIONS AND CLINICAL RELEVANCE: These data indicated that mTOR and its downstream product are present and active in canine osteosarcoma cells. The pathway can be inhibited by rapamycin, and treatment of cells with rapamycin decreased the surviving tumor cell fraction. These data support the molecular basis for further investigation into the use of mTOR inhibitors as an antineoplastic approach for dogs with osteosarcoma.  相似文献   

Quantitative polymerase chain reaction for Porcine circovirus-2 in swine feces in a Porcine circovirus disease-affected commercial herd and a nonaffected commercial herd     

Kathleen A. McIntosh  John C.S. Harding  Sarah Parker  Steven Krakowka  Gordon Allan  John A. Ellis 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(12):1189-1194

This study examined if pigs in a Porcine circovirus disease (PCVD)-affected herd (n = 100) had shed more Porcine circovirus-2 (PCV-2) in their feces than pigs in a PCVD-nonaffected herd (n = 101), and if differences in shedding among production stages within and between the herds existed. The PCV-2 shedding was quantified by real-time polymerase chain reaction. The highest median PCV-2 shedding was found in the nursery of the PCVD-affected herd and in the grower of the PCVD-nonaffected herd. The PCV-2 shedding was significantly higher in earlier stages (newly weaned, nursery, and pregrower) in the PCVD-affected herd (Wilcoxon rank sum; P < 0.001) compared with the PCVD-nonaffected herd. Porcine circovirus-2 DNA was not detected in a significant proportion of lactating sows (parity ≥ 3) in the PCVD-nonaffected herd (Fisher’s exact test; P = 0.001). The results of this study suggest there may be an association between the presence of PCV-2 in the feces of lactating sows and increased PCV-2 shedding in younger pigs.  相似文献   

Differential Diagnosis of the Larvæ of Ostertagia spp. and Trichostrongylus spp. of Sheep     

Hugh McL.  Gordon  B.V.Sc. 《Australian veterinary journal》1933,9(6):223-227

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